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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
101	METHODS OF PRODUCING MOGROSIDES AND COMPOSITIONS COMPRISING SAME AND USES THEREOF	EP15839739	2015-09-10	EP3191584A4	2018-07-18	ITKIN MAXIM; DAVIDOVICH-RIKANATI RACHEL; COHEN SHAHAR; PORTNOY VITALY; DORON-FAIGENBOIM ADI; PETREIKOV MARINA; SHEN SHMUEL; TADMOR YAAKOV; BURGER YOSEF; LEWINSOHN EFRAIM; KATZIR NURIT; SCHAFFER ARTHUR A; OREN ELAD
Isolated mogroside and mogrol biosynthetic pathway enzyme polypeptides useful in mogroside biosynthesis are provided. Mogroside biosynthetic pathway enzymes of the invention include squalene epoxidase (SE), expoxy hydratase (EH), cytochrome p450 (Cyp), cucurbitadienol synthase (CDS) and udp-glucosyl-transferase (UGT). Also provided are methods of producing a mogroside using the isolated mogroside and mogrol biosynthetic enzyme polypeptides, the methods comprising contacting a mogrol and/or a glycosylated mogrol (mogroside) with at least one UDP glucose glucosyl transferase (UGT) enzyme polypeptide of the invention catalyzing glucosylation of the mogrol and/or the glucosylated mogrol to produce a mogroside with an additional glucosyl moietie(s), thereby producing the mogroside. Alternatively or additionally provided is a method of synthesizing a mogrol, the method comprising contacting a mogrol precursor substrate with one or more mogrol biosynthetic pathway enzyme polypeptides as described herein catalyzing mogrol synthesis from the mogrol precursor substrate, thereby synthesizing the mogrol.
102	VINYLISOMERASE-DEHYDRATASES, ALKENOL DEHYDRATASES, LINALOOL DEHYDRATASES AND/ CROTYL ALCOHOL DEHYDRATASES AND METHODS FOR MAKING AND USING THEM	EP16804082	2016-05-26	EP3303421A1	2018-04-11	CULLER STEPHANIE J; HASELBECK ROBERT J; NAGARAJAN HARISH; GOUVEA IURI ESTRADA; KOCH DANIEL JOHANNES; LOPES MATEUS SCHREINER GARCEZ; PARIZZI LUCAS PEDERSEN
In alternative embodiments, provided are non-natural or genetically engineered vinylisomerase-dehydratase enzymes, including alkenol dehydratases, linalool dehydratases and crotyl alcohol dehydratases. In alternative embodiments, provided are non-natural or genetically engineered polypeptides having an activity comprising, for example, a vinylisomerase-dehydratase, an alkenol dehydratase, a linalool dehydratase and/or a crotyl alcohol dehydratase activity, or a combination thereof. In alternative embodiments, also provided are non-natural or genetically engineered nucleic acids (polynucleotides) encoding polypeptides described herein, expression or cloning vehicles comprising or having contained therein nucleic acids as described herein, and non-natural or genetically engineered cells comprising or having contained therein nucleic acids as described herein. In alternative embodiments, also provided are are methods for making various organic compounds, including methyl vinyl carbinol and butadiene.
103	METHODS OF PRODUCING MOGROSIDES AND COMPOSITIONS COMPRISING SAME AND USES THEREOF	EP15839739.8	2015-09-10	EP3191584A1	2017-07-19	ITKIN, Maxim; DAVIDOVICH-RIKANATI, Rachel; COHEN, Shahar; PORTNOY, Vitaly; DORON-FAIGENBOIM, Adi; PETREIKOV, Marina; SHEN, Shmuel; TADMOR, Yaakov; BURGER, Yosef; LEWINSOHN, Efraim; KATZIR, Nurit; SCHAFFER, Arthur A.; OREN, Elad
Isolated mogroside and mogrol biosynthetic pathway enzyme polypeptides useful in mogroside biosynthesis are provided. Mogroside biosynthetic pathway enzymes of the invention include squalene epoxidase (SE), expoxy hydratase (EH), cytochrome p450 (Cyp), cucurbitadienol synthase (CDS) and udp-glucosyl-transferase (UGT). Also provided are methods of producing a mogroside using the isolated mogroside and mogrol biosynthetic enzyme polypeptides, the methods comprising contacting a mogrol and/or a glycosylated mogrol (mogroside) with at least one UDP glucose glucosyl transferase (UGT) enzyme polypeptide of the invention catalyzing glucosylation of the mogrol and/or the glucosylated mogrol to produce a mogroside with an additional glucosyl moietie(s), thereby producing the mogroside. Alternatively or additionally provided is a method of synthesizing a mogrol, the method comprising contacting a mogrol precursor substrate with one or more mogrol biosynthetic pathway enzyme polypeptides as described herein catalyzing mogrol synthesis from the mogrol precursor substrate, thereby synthesizing the mogrol.
104	MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING 1,4-BUTANEDIOL RELATED THERETO	EP13832246	2013-08-27	EP2888369A4	2016-08-10	BURGARD ANTHONY P; OSTERHOUT ROBIN E; VAN DIEN STEPHEN J; TRACEWELL CARA ANN; PHARKYA PRITI; ANDRAE STEFAN
Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO.
105	PATHWAYS TO ADIPATE SEMIALDEHYDE AND OTHER ORGANIC PRODUCTS	EP13773490.1	2013-09-20	EP2898082A1	2015-07-29	LAU, Man, Kit; MERCOGLIANO, Christopher, P.
Recombinant microorganisms comprising at least one exogenous nucleic acid sequence and capable of producing adipate semialdehyde are provided. Adipate semialdehyde may be produced in a synthesis pathway utilizing a single thiolase reaction. Adipate semialdehyde may also be produced from intermediates consisting of alpha, omega difunctional aliphatic organic molecules. Methods of using recombinant microorganisms to produce 6-aminocaproic acid, adipic acid, hexamethylenediamine and 1.6-hexanediol are also provided.
106	MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF P-TOLUATE AND TEREPHTHALATE	EP11737470	2011-01-21	EP2529011A4	2015-07-15	OSTERHOUT ROBIN E

107	AN EXPRESSION CONSTRUCT FOR SENSING CELL DENSITY AND SUBSTRATE AVAILABILITY AND ITS USE IN CONVERSION OF HYDROXYCINNAMIC ACIDS	EP13807048.7	2013-06-12	EP2877582A1	2015-06-03	CHANG, Matthew Wook; LO, Tat Ming Samuel; POH, Chueh Loo
An Expression system; isolated nucleic acid molecule or host cell comprising: (i) A first gene encoding for a first enzyme linked to a first promoter, wherein the first promoter is a time delay promoter; (ii) A second gene encoding for a second enzyme capable of using the product generated by the first enzyme as a substrate, wherein the second gene is operably linked to a second promoter, wherein the second promoter is inducible by the product generated by the first enzyme; (iii) Optionally, a third gene encoding a transcription factor that represses expression of the second gene in the absence of the product generated by the first enzyme, wherein the third gene is operably linked to a third promoter that regulates expression of the third gene; and its use in producing a product such as hydroxybenzaldehyde.
108	METHODS OF PRODUCING FOUR CARBON MOLECULES	EP12731825.1	2012-06-15	EP2721164A2	2014-04-23	PEARLMAN, Paul, S.; CHEN, Changlin; BOTES, Adriana, L.
Disclosed are methods for producing butadiene from one or more of several diverse feedstocks including bioderived feedstocks, renewable feedstocks, petrochemical feedstocks and natural gas.
109	ORGANISMS FOR THE PRODUCTION OF 1,3-BUTANEDIOL	EP10770464	2010-04-30	EP2424975A4	2013-05-29	BURGARD ANTHONY P; BURK MARK J; OSTERHOUT ROBIN E; PHARKYA PRITI

110	POLYUNSATURATED FATTY ACID SYNTHASE NUCLEIC ACID MOLECULES AND POLYPEPTIDES, COMPOSITIONS, AND METHODS OF MAKING AND USES THEREOF	EP10754185	2010-03-19	EP2408797A4	2013-01-09	APT KIRK E; RICHTER LESLIE; SIMPSON DAVID; ZIRKLE ROSS

111	ORGANISMS FOR THE PRODUCTION OF 1,3-BUTANEDIOL	EP10770464.5	2010-04-30	EP2424975A2	2012-03-07	BURGARD, Anthony, P.; BURK, Mark, J.; OSTERHOUT, Robin, E.; PHARKYA, Priti
A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-BDO) pathway having at least one exogenous nucleic acid encoding a 1,3- BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. The pathway includes an enzyme selected from a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP dehydrogenase, a 2-amino-4-hydroxypentanoate aminotransferase, a 2-amino-4- hydroxypentanoate oxidoreductase (deaminating), a 2-oxo-4-hydroxypentanoate decarboxylase, a 3-hydroxybutyraldehyde reductase, an AKP aminotransferase, an AKP oxidoreductase (deaminating), a 2,4-dioxopentanoate decarboxylase, a 3-oxobutyraldehyde reductase (ketone reducing), a 3-oxobutyraldehyde reductase (aldehyde reducing), a 4-hydroxy-2-butanone reductase, an AKP decarboxylase, a 4-aminobutan-2-one aminotransferase, a 4-aminobutan-2- one oxidoreductase (deaminating), a 4-aminobutan-2-one ammonia-lyase, a butenone hydratase, an AKP ammonia-lyase, an acetylacrylate decarboxylase, an acetoacetyl-CoA reductase (CoA- dependent, aldehyde forming), an acetoacetyl-CoA reductase (CoA-dependent, alcohol forming), an acetoacetyl-CoA reductase (ketone reducing), a 3-hydroxybutyryl-CoA reductase (aldehyde forming), a 3-hydroxybutyryl-CoA reductase (alcohol forming), a 4-hydroxybutyryl- CoA dehydratase, and a crotonase. A method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO.
112	POLYPEPTIDES FOR CARBON-CARBON BOND FORMATION AND USES THEREOF	PCT/US2016061539	2016-11-11	WO2017083656A8	2017-08-03	BOTES ADRIANA LEONORA; KADI NADIA
This document describes polypeptides with dual CoA transferase and β-ketothioiase activities and variants thereof, use of such polypeptides in biosynthetic methods, and non-naturally occurring hosts comprising such polypeptides.
113	NOVEL POLYPEPTIDES AND USES THEREOF	PCT/US2016019966	2016-02-26	WO2016138498A3	2016-11-24	BOTES ADRIANA L; KADI NADIA
The present disclosure provides novel polypeptides with improved 3-buten-2- ol dehydratase activity, polypeptides with improved linalool dehydratase activity, and polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene. Methods of making and using the polypeptides are also provided.
114	METHODS OF PRODUCING1, 3 - BUTADIENE	PCT/US2012042757	2012-06-15	WO2012174439A3	2013-05-23	PEARLMAN PAUL S; CHEN CHANGLIN; BOTES ADRIANA L
Disclosed are methods for producing butadiene from one or more of several diverse feedstocks including bioderived feedstocks, renewable feedstocks, petrochemical feedstocks and natural gas.
115	POLYUNSATURATED FATTY ACID SYNTHASE NUCLEIC ACID MOLECULES AND POLYPEPTIDES, COMPOSITIONS, AND METHODS OF MAKING AND USES THEREOF	PCT/US2010028009	2010-03-19	WO2010108114A2	2010-09-23	APT KIRK E; RICHTER LESLIE; SIMPSON DAVID; ZIRKLE ROSS
The present invention is directed to isolated nucleic acid molecules and polypeptides of thraustochytrid polyunsaturated fatty acid (PUFA) synthases involved in the production of PUFAs, including PUFAs enriched in docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), or a combination thereof. The present invention is directed to vectors and host cells comprising the nucleic acid molecules, polypeptides encoded by the nucleic acid molecules, compositions comprising the nucleic acid molecules or polypeptides, and methods of making and uses thereof.
116	MICROORGANISMS FOR THE PRODUCTION OF ADIPIC ACID AND OTHER COMPOUNDS	PCT/US2009038663	2009-03-27	WO2009151728A3	2010-05-27	BURGARD ANTHONY P; PHARKYA PRITI; OSTERHOUT ROBIN E
The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid or caprolactam pathway. The invention additionally provides a method for producing adipate, 6- aminocaproic acid or caprolactam. The method can include culturing an adipate, 6-aminocaproic acid or caprolactam producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an adipate, 6-aminocaproic acid or caprolactam pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce adipate, 6-aminocaproic acid or caprolactam.

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