| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 通过与辅酶B合成相关的C1碳链延伸生产7-碳化学物的方法 | CN201380073741.6 | 2013-12-23 | CN105189764A | 2015-12-23 | A.L.博特斯; A.V.E.康拉迪; 陈昌林; P.S.珀尔曼 |
| 本申请描述了通过在C7脂族主链底物中形成一个或两个末端官能团来生产庚二酸、7-氨基庚酸、7-羟基庚酸、庚二胺或1,7-庚二醇的生物化学途径，每个官能团包括羧基、胺或羟基。本文所述的这些途径、代谢工程和培养策略依赖于与辅酶B生物合成相关的C1延伸酶或同源物。 | ||||||
| 2 | Methods Of Producing 7-Carbon Chemicals Via C1 Carbon Chain Elongation Associated With Coenzyme B Synthesis | US14138971 | 2013-12-23 | US20140193863A1 | 2014-07-10 | Adriana Leonora Botes; Alex Van Eck Conradie; Changlin Chen; Paul S. Pearlman |
| This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the C1 elongation enzymes or homolog associated with coenzyme B biosynthesis. | ||||||
| 3 | Methods of producing 7-carbon chemicals via c1 carbon chain elongation associated with coenzyme B synthesis | US14138971 | 2013-12-23 | US09580731B2 | 2017-02-28 | Adriana Leonora Botes; Alex Van Eck Conradie; Changlin Chen; Paul S. Pearlman |
| This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the C1 elongation enzymes or homolog associated with coenzyme B biosynthesis. | ||||||
| 4 | METHODS OF PRODUCING 7-CARBON CHEMICALS VIA C1 CARBON CHAIN ELONGATION ASSOCIATED WITH COENZYME B SYNTHESIS | US15405514 | 2017-01-13 | US20170204420A1 | 2017-07-20 | Adriana Leonora Botes; Alex Van Eck Conradie; Changlin Chen; Paul S. Pearlman |
| This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the C1 elongation enzymes or homolog associated with coenzyme B biosynthesis. | ||||||
| 5 | METHODS OF PRODUCING 7-CARBON CHEMICALS VIA C1 CARBON CHAIN ELONGATION ASSOCIATED WITH COENZYME B SYNTHESIS | EP13824707.7 | 2013-12-23 | EP2938736A2 | 2015-11-04 | BOTES, Adriana Leonora; CONRADIE, Alex Van Eck; CHEN, Changlin; PEARLMAN, Paul S. |
| This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the C1 elongation enzymes or homolog associated with coenzyme B biosynthesis. | ||||||
| 6 | METHOD FOR PREPARING ALPHA-KETOPIMELIC ACID BY C1-ELONGATION | PCT/EP2011064718 | 2011-08-26 | WO2012031910A2 | 2012-03-15 | TREFZER AXEL CHRISTOPH; TURK STEFANUS CORNELIS HENDRIKUS JOZEF |
| The invention relates to a method for preparing alpha-ketopimelic acid, comprising converting alpha-ketoglutaric acid into alpha-ketoadipic acid and converting alpha-ketoadipic acid into alpha-ketopimelic acid, wherein at least one of these conversions is carried out using a heterologous biocatalyst catalysing at least one of these conversions, wherein the heterologous biocatalyst comprises a. an NifV enzyme or another Aks enzyme having homo(n)citrate activity or a homologue thereof having homo(n)citrate activity; b. an AksD enzyme having homon-aconitase activity or a homologue thereof having homon-aconitase activity, c. an AksE enzyme having homon-aconitase activity or a homologue thereof having homon-aconitase activity, d. an AksF enzyme having homon- isocitrate dehydrogenase or a homologue thereof having homon-aconitase activity. | ||||||
| 7 | METHODS OF PRODUCING 7-CARBON CHEMICALS VIA C1 CARBON CHAIN ELONGATION ASSOCIATED WITH COENZYME B SYNTHESIS | PCT/US2013077413 | 2013-12-23 | WO2014105790A3 | 2014-10-09 | BOTES ADRIANA LEONORA; CONRADIE ALEX VAN ECK; CHEN CHANGLIN; PEARLMAN PAUL S |
| This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the C1 elongation enzymes or homolog associated with coenzyme B biosynthesis. | ||||||
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