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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
21	Microorganism for the production of adipic acid and other compounds	JP2014108849	2014-05-27	JP2014147399A	2014-08-21	ANTHONY P BURGARD; PRITI PHARKYA; ROBIN E OSTERHOUT
PROBLEM TO BE SOLVED: To provide microorganisms for the production of adipic acid and other compounds.SOLUTION: The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding enzymes in the respective adipate, 6-aminocaproic acid or caprolactam pathway. The invention additionally provides a method for producing adipate, 6-aminocaproic acid or caprolactam. The method can include culturing an adipate, 6-aminocaproic acid or caprolactam producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding the adipate, 6-aminocaproic acid or caprolactam pathway enzymes in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce adipate, 6-aminocaproic acid or caprolactam.
22	Methods and microorganisms for the biosynthesis of p- toluic acid and terephthalic acid	JP2012551203	2011-01-21	JP2013517796A	2013-05-20	オステルハウト，ロビン，イー．
本発明は、（２−ヒドロキシ−３−メチル−４−オキソブトキシ）ホスホネート経路、ｐ−トルイル酸経路および／またはテレフタル酸経路を有する非天然の微生物を提供する。本発明はさらに、（２−ヒドロキシ−３−メチル−４−オキソブトキシ）ホスホネート経路、ｐ−トルイル酸経路またはテレフタル酸経路を生成するために上記生物を使用する方法を提供する。
23	정액 보존 및 보조 생식을 위한 알렌 옥사이드 신타제의 용도	KR1020167036651	2015-05-27	KR1020170031667A	2017-03-21	박하우스,랄프앤드류; 호지킨슨,스티븐찰스
인간에대한보조생식절차및 소, 말및 다른동물의번식에서특히사용하기위한정액에대한보존제로서의알렌옥사이드신타제의용도가제공된다.
24	1,3−ブタンジオールの産生のための生物	JP2018078301	2018-04-16	JP2018148891A	2018-09-27	アントホンイピー. ブルガルド; マルクジェイ. ブルク; ロビンイー. オステルホウト; プリトイプハルクヤ
【課題】非天然微生物を用いた1,3-ブタンジオール(1,3-BDO)の産生方法及び該非天然微生物の提供。【解決手段】1,3-BDO経路酵素をコードする少なくとも1つの外来性核酸を有する微生物であって、経路には、AKPチオラーゼ、AKP脱水素酵素、各種のアミノトランスフェラーゼ、各種の酸化還元酵素、各種のデカルボキシラーゼ、各種の還元酵素(ケトン還元、アルデヒド還元)、4-アミノブタン-2-オンアミノトランスフェラーゼ、4-アミノブタン-2-オンアンモニア-リアーゼ、ブテノンヒドラターゼ、AKPアンモニア-リアーゼ、アセトアセチル-CoA還元酵素、3-ヒドロキシブチリル-CoA還元酵素、3-ヒドロキシブチリル-CoA還元酵素、4-ヒドロキシブチリル-CoAデヒドラターゼ、及びクロトナーゼから選択される酵素を含む。1,3-BDOの産生方法は、十分な時間でこのような微生物を培養することを含む。【選択図】図1
25	1,3−ブタンジオールの産生のための生物	JP2015231313	2015-11-27	JP6326398B2	2018-05-16	アントホンイピー. ブルガルド; マルクジェイ. ブルク; ロビンイー. オステルホウト; プリトイプハルクヤ

26	アジピン酸および他の化合物を生成するための微生物	JP2011502115	2009-03-27	JP5951990B2	2016-07-13	バーガード, アンソニーピー.; ファルクヤ, プリティ; オステラウト, ロビンイー.

27	1,3−ブタンジオールの産生のための生物	JP2012508804	2010-04-30	JP5876822B2	2016-03-02	アントホンイピー. ブルガルド; マルクジェイ. ブルク; ロビンイー. オステルホウト; プリトイプハルクヤ

28	Microorganisms for producing adipic acid and other compounds	JP2011502115	2009-03-27	JP2011515111A	2011-05-19	ロビンイー．オステラウト，; アンソニーピー．バーガード，; プリティファルクヤ，
本発明は、アジペート、６−アミノカプロン酸またはカプロラクタム経路を有する天然に存在しない微生物を提供する。当該微生物は、そのそれぞれのアジペート、６−アミノカプロン酸またはカプロラクタム経路に酵素をコードする少なくとも１つの外因性核酸を含有する。加えて、本発明は、アジペート、６−アミノカプロン酸またはカプロラクタムを生産するための方法を提供する。この方法は、アジペート、６−アミノカプロン酸またはカプロラクタム生産性微生物であって、アジペート、６−アミノカプロン酸またはカプロラクタム経路酵素をコードする少なくとも１つの外因性核酸をそのそれぞれの産物の生産に十分な量で発現するものである上記微生物を、アジペート、６−アミノカプロン酸またはカプロラクタムを生産する条件下でおよび十分な期間にわたって培養することを含み得る。
29	METHODS OF PRODUCING MOGROSIDES AND COMPOSITIONS COMPRISING SAME AND USES THEREOF	US15510708	2015-09-10	US20170283844A1	2017-10-05	Maxim ITKIN; Rachel DAVIDOVICH-RIKANATI; Shahar COHEN; Vitaly PORTNOY; Adi DORON-FAIGENBOIM; Marina PETREIKOV; Shmuel SHEN; Yaakov TADMOR; Yosef BURGER; Efraim LEWINSOHN; Nurit KATZIR; Arthur A. SCHAFFER; Elad OREN
Isolated mogroside and mogrol biosynthetic pathway enzyme polypeptides useful in mogroside biosynthesis are provided. Mogroside biosynthetic pathway enzymes of the invention include squalene epoxidase (SE), expoxy hydratase (EH), cytochrome p450 (Cyp), cucurbitadienol synthase (CDS) and udp-glucosyl-transferase (UGT). Also provided are methods of producing a mogroside using the isolated mogroside and mogrol biosynthetic enzyme polypeptides, the methods comprising contacting a mogrol and/or a glycosylated mogrol (mogroside) with at least one UDP glucose glucosyl transferase (UGT) enzyme polypeptide of the invention catalyzing glucosylation of the mogrol and/or the glucosylated mogrol to produce a mogroside with an additional glucosyl moietie(s), thereby producing the mogroside. Alternatively or additionally provided is a method of synthesizing a mogrol, the method comprising contacting a mogrol precursor substrate with one or more mogrol biosynthetic pathway enzyme polypeptides as described herein catalyzing mogrol synthesis from the mogrol precursor substrate, thereby synthesizing the mogrol.
30	Methods of producing 6-carbon chemicals using 2,6-diaminopimelate as precursor to 2-aminopimelate	US14714164	2015-05-15	US09745607B2	2017-08-29	Alex Van Eck Conradie; Adriana Leonora Botes
This document describes biochemical pathways for producing 2-aminopimelate from 2,6-diaminopimelate, and methods for converting 2-aminopimelate to one or more of adipic acid, adipate semialdehyde, caprolactam, 6-aminohexanoic acid, 6-hexanoic acid, hexamethylenediamine, or 1,6-hexanediol by decarboxylating 2-aminopimelate into a six carbon chain aliphatic backbone and enzymatically forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in the backbone.
31	Use of Allene Oxide Synthase for Semen Preservation and Assisted Reproduction	US15314428	2015-05-27	US20170196219A1	2017-07-13	Ralph Andrew Backhaus; Steven Charles Hodgkinson
The use of allene oxide synthase as a preservative for semen particularly for use in assisted reproductive procedures for humans and in the breeding of cattle horses and other animals.
32	Methods of producing four carbon molecules	US13524973	2012-06-15	US09663801B2	2017-05-30	Paul S. Pearlman; Changlin Chen; Adriana L. Botes
Disclosed are methods for producing butadiene from one or more of several diverse feedstocks including bioderived feedstocks, renewable feedstocks, petrochemical feedstocks and natural gas.
33	Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 1,4-butanediol related thereto	US13975678	2013-08-26	US09657316B2	2017-05-23	Anthony P. Burgard; Robin E. Osterhout; Stephen J. Van Dien; Cara Ann Tracewell; Priti Pharkya; Stefan Andrae
Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO.
34	NOVEL POLYPEPTIDES AND USES THEREOF	US15055493	2016-02-26	US20160251644A1	2016-09-01	ADRIANA L. BOTES; Nadia Kadi
The present disclosure provides novel polypeptides with improved 3-buten-2-ol dehydratase activity, polypeptides with improved linalool dehydratase activity, and polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene. Methods of making and using the polypeptides are also provided.
35	EXPRESSION CONSTRUCT FOR SENSING CELL DENSITY AND SUBSTRATE AVAILABILITY AND ITS USE IN CONVERSION OF HYDROXYCINNAMIC ACIDS	US14409227	2013-06-12	US20150176039A1	2015-06-25	Matthew Wook Chang; Tat Ming Samuel Lo; Chueh Loo Poh
An Expression system; isolated nucleic acid molecule or host cell comprising: (i) A first gene encoding for a first enzyme linked to a first promoter, wherein the first promoter is a time delay promoter; (ii) A second gene encoding for a second enzyme capable of using the product generated by the first enzyme as a substrate, wherein the second gene is operably linked to a second promoter, wherein the second promoter is inducible by the product generated by the first enzyme; (iii) Optionally, a third gene encoding a transcription factor that represses expression of the second gene in the absence of the product generated by the first enzyme, wherein the third gene is operably linked to a third promoter that regulates expression of the third gene; and its use in producing a product such as hydroxybenzaldehyde.
36	MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF (2-HYDROXY-3METHYL-4-OXOBUTOXY) PHOSPHONATE	US14485040	2014-09-12	US20150004662A1	2015-01-01	Robin E. Osterhout
The invention provides non-naturally occurring microbial organisms having a (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate pathway, p-toluate pathway, and/or terephthalate pathway. The invention additionally provides methods of using such organisms to produce (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate pathway, p-toluate pathway or terephthalate pathway.
37	MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING 1,4-BUTANEDIOL RELATED THERETO	US13975678	2013-08-26	US20140058056A1	2014-02-27	Anthony P. Burgard; Robin E. Osterhout; Stephen J. Van Dien; Cara Ann Tracewell; Priti Pharkya; Stefan Andrae
Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO.
38	Microorganisms for the production of adipic acid and other compounds	US13525129	2012-06-15	US08592189B2	2013-11-26	Anthony P. Burgard; Priti Pharkya; Robin E. Osterhout
The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid or caprolactam pathway. The invention additionally provides a method for producing adipate, 6-aminocaproic acid or caprolactam. The method can include culturing an adipate, 6-aminocaproic acid or caprolactam producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an adipate, 6-aminocaproic acid or caprolactam pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce adipate, 6-aminocaproic acid or caprolactam.
39	METHODS FOR BIOSYNTHESIZING 1,3 BUTADIENE	US13691623	2012-11-30	US20130189753A1	2013-07-25	Paul S. Pearlman; Changlin Chen; Adriana L. Botes; Alex Van Eck Conradie
This document describes biochemical pathways for producing butadiene by forming two vinyl groups in a butadiene synthesis substrate. These pathways described herein rely on enzymes such as mevalonate diphosphate decarboxylase, isoprene synthase, and dehydratases for the final enzymatic step.
40	MICROORGANISMS FOR THE PRODUCTION OF ADIPIC ACID AND OTHER COMPOUNDS	EP09763021.4	2009-03-27	EP2265709B1	2017-11-08	BURGARD, Anthony, P.; PHARKYA, Priti; OSTERHOUT, Robin, E.

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