| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | SEQUESTRATION OF CARBON DIOXIDE WITH HYDROGEN TO USEFUL PRODUCTS | US14426290 | 2013-09-06 | US20150211030A1 | 2015-07-30 | Michael W.W. Adams; Robert M. Kelly; Aaron B. Hawkins; Angeli Lal Menon; Gina Pries Lipscomb; Gerrit Jan Schut |
| Provided herein are genetically engineered microbes that include at least a portion of a carbon fixation pathway, and in one embodiment, use molecular hydrogen to drive carbon dioxide fixation. In one embodiment, the genetically engineered microbe is modified to convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof at levels greater than a control microbe. Other products may also be produced. Also provided herein are cell free compositions that convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof. Also provided herein are methods of using the genetically engineered microbes and the cell free compositions. | ||||||
| 2 | Method for the enzymatic production of 3-buten-2-one | US14902565 | 2014-07-02 | US09850504B2 | 2017-12-26 | Philippe Marliere; Maria Anissimova; Mathieu Allard |
| Described is a method for the production of 3-buten-2-one comprising the enzymatic conversion of 4-hydroxy-2-butanone into 3-buten-2-one by making use of an enzyme catalyzing 4-hydroxy-2-butanone dehydration, wherein said enzyme catalyzing 4-hydroxy-2-butanone dehydration is (a) a 3-hydroxypropiony-CoA dehydratase (EC 4.2.1.116), (b) a 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55), (c) an enoyl-CoA hydratase (EC 4.2.1.17), (d) a 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59), (e) a crotonyl-[acyl-carrier-protein] hydratase (EC 4.2.1.58), (f) a 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.60), (g) a 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61), (h) a long-chain-enoyl-CoA hydratase (EC 4.2.1.74), or (i) a 3-methylglutaconyl-CoA hydratase (EC 4.2.1.18). The produced 3-buten-2-one can be further converted into 3-buten-2-ol and finally into 1,3-butadiene. | ||||||
| 3 | Sequestration of carbon dioxide with hydrogen to useful products | US14426290 | 2013-09-06 | US09587256B2 | 2017-03-07 | Michael W. W. Adams; Robert M. Kelly; Aaron B. Hawkins; Angeli Lal Menon; Gina Lynette Pries Lipscomb; Gerrit Jan Schut |
| Provided herein are genetically engineered microbes that include at least a portion of a carbon fixation pathway, and in one embodiment, use molecular hydrogen to drive carbon dioxide fixation. In one embodiment, the genetically engineered microbe is modified to convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof at levels greater than a control microbe. Other products may also be produced. Also provided herein are cell free compositions that convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof. Also provided herein are methods of using the genetically engineered microbes and the cell free compositions. | ||||||
| 4 | METHODS FOR PRODUCING 3-HYDROXY-3-METHYLBUTYRIC ACID | US15511684 | 2015-09-16 | US20170253896A1 | 2017-09-07 | Philippe MARLIERE; Maria ANISSIMOVA; Mathieu ALLARD |
| Described is a method for the conversion of 3-methylcrotonyl-CoA into 3-hydroxy-3-methylbutyric acid comprising the steps of:(a) enzymatically converting 3-methylcrotonyl-CoA into 3-hydroxy-3-methylbutyryl-CoA; and (b) further enzymatically converting the thus produced 3-hydroxy-3-methylbutyryl-CoA into 3-hydroxy-3-methylbutyric acid wherein the enzymatic conversion of 3-hydroxy-3-methylbutyryl-CoA into 3-hydroxy-3-methylbutyric acid according to step (b) is achieved by first converting 3-hydroxy-3-methylbutyryl-CoA into 3-hydroxy-3-methylbutyryl phosphate and then subsequently converting the thus produced 3-hydroxy-3-methylbutyryl phosphate into 3-hydroxy-3-methylbutyric acid. | ||||||
| 5 | SEQUESTRATION OF CARBON DIOXIDE WITH HYDROGEN TO USEFUL PRODUCTS | US15410205 | 2017-01-19 | US20170226542A1 | 2017-08-10 | Michael W.W. Adams; Robert M. Kelly; Aaron B. Hawkins; Angeli Lal Menon; Gina Lynette Pries Lipscomb; Gerrit Jan Schut |
| Provided herein are genetically engineered microbes that include at least a portion of a carbon fixation pathway, and in one embodiment, use molecular hydrogen to drive carbon dioxide fixation. In one embodiment, the genetically engineered microbe is modified to convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof at levels greater than a control microbe. Other products may also be produced. Also provided herein are cell free compositions that convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof. Also provided herein are methods of using the genetically engineered microbes and the cell free compositions. | ||||||
| 6 | METHOD FOR THE ENZYMATIC PRODUCTION OF 3-BUTEN-2-ONE | US14902565 | 2014-07-02 | US20160369306A1 | 2016-12-22 | Philippe Marliere; Maria Anissimova; Mathieu Allard |
| Described is a method for the production of 3-buten-2-one comprising the enzymatic conversion of 4-hydroxy-2-butanone into 3-buten-2-one by making use of an enzyme catalyzing 4-hydroxy-2-butanone dehydration, wherein said enzyme catalyzing 4-hydroxy-2-butanone dehydration is (a) a 3-hydroxypropiony-CoA dehydratase (EC 4.2.1.116), (b) a 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55), (c) an enoyl-CoA hydratase (EC 4.2.1.17), (d) a 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59), (e) a crotonyl-[acyl-carrier-protein] hydratase (EC 4.2.1.58), (f) a 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.60), (g) a 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61), (h) a long-chain-enoyl-CoA hydratase (EC 4.2.1.74), or (i) a 3-methylglutaconyl-CoA hydratase (EC 4.2.1.18). The produced 3-buten-2-one can be further converted into 3-buten-2-ol and finally into 1,3-butadiene. | ||||||
| 7 | ３−ブテン−２−オンの酵素的製造のための方法 | JP2016522608 | 2014-07-02 | JP2016526382A | 2016-09-05 | マルリエール，フィリップ; アニシオバ，マリア; アラード，マテュー |
| 4−ヒドロキシ−2−ブタノン脱水を触媒する酵素を利用することによる4−ヒドロキシ−2−ブタノンから3−ブテン−2−オンへの酵素的変換を含む、3−ブテン−2−オンの製造のための方法であって、前記4−ヒドロキシ−2−ブタノン脱水を触媒する酵素が、(a)3−ヒドロキシプロピオニルCoA脱水酵素(EC4.2.1.116)、(b)3−ヒドロキシブチリルCoA脱水酵素(EC4.2.1.55)、(c)エノイルCoA加水酵素(EC4.2.1.17)、(d)3−ヒドロキシオクタノイル−[アシルキャリアータンパク質]脱水酵素(EC4.2.1.59)、(e)クロトニル−[アシルキャリアータンパク質]加水酵素(EC4.2.1.58)、(f)3−ヒドロキシデカノイル−[アシルキャリアータンパク質]脱水酵素(EC4.2.1.60)、(g)3−ヒドロキシパルミトイル−[アシルキャリアータンパク質]脱水酵素(EC4.2.1.61)、(h)長鎖エノイルCoA加水酵素(EC4.2.1.74)、または(i)3−メチルグルタコニルCoA加水酵素(EC4.2.1.18)である、3−ブテン−2−オンの製造のための方法を記載する。製造された3−ブテン−2−オンは、3−ブテン−2−オールに、最終的に1,3−ブタジエンにさらに変換することができる。 | ||||||
| 8 | METHODS FOR PRODUCING 3-HYDROXY-3-METHYLBUTYRIC ACID | EP15778881.1 | 2015-09-16 | EP3194605A1 | 2017-07-26 | MARLIERE, Philippe; ANISSIMOVA, Maria; ALLARD, Mathieu |
| Described is a method for the conversion of 3-methylcrotonyl-CoA into 3-hydroxy-3- methylbutyric acid comprising the steps of: (a) enzymatically converting 3-methylcrotonyl-CoA into 3-hydroxy-3-methylbutyryl-CoA; and (b) further enzymatically converting the thus produced 3-hydroxy-3-methylbutyryl-CoA into 3-hydroxy-3-methylbutyric acid wherein the enzymatic conversion of 3-hydroxy-3-methylbutyryl-CoA into 3-hydroxy-3-methylbutyric acid according to step (b) is achieved by first converting 3-hydroxy-3-methylbutyryl-CoA into 3-hydroxy-3-methylbutyryl phosphate and then subsequently converting the thus produced 3-hydroxy-3-methylbutyryl phosphate into 3-hydroxy-3-methylbutyric acid. | ||||||
| 9 | METHOD FOR THE ENZYMATIC PRODUCTION OF 3-BUTEN-2-ONE | PCT/EP2014064102 | 2014-07-02 | WO2015000981A3 | 2015-02-19 | MARLIERE PHILIPPE; ANISSIMOVA MARIA; ALLARD MATHIEU |
| Described is a method for the production of 3-buten-2-one comprising the enzymatic conversion of 4-hydroxy-2-butanone into 3-buten-2-one by making use of an enzyme catalyzing 4-hydroxy-2-butanone dehydration, wherein said enzyme catalyzing 4-hydroxy-2-butanone dehydration is (a) a 3-hydroxypropiony-CoA dehydratase (EC 4.2.1.116), (b) a 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55), (c) an enoyl-CoA hydratase (EC 4.2.1.17), (d) a 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59), (e) a crotonyl-[acyl-carrier-protein] hydratase (EC 4.2.1.58), (f) a 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.60), (g) a 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61 ), (h) a long-chain-enoyl-CoA hydratase (EC 4.2.1.74), or (i) a 3-methylglutaconyl-CoA hydratase (EC 4.2.1.18). The produced 3-buten-2-one can be further converted into 3-buten-2-ol and finally into 1,3-butadiene. | ||||||
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