| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | INDOLE-DERIVED COMPOUND PRODUCTION | US15323996 | 2015-07-07 | US20170204424A1 | 2017-07-20 | Aldwin Anterola |
| Among the various aspects of the present disclosure is the provision of a transgenic organism, an artificial DNA construct, and methods for producing a transgenic organism for indigo, indirubin, and other indole-derived compound production. Another aspect of the present disclosure is the provision of a transgenic organism wherein the indole-derived compound imparts color to the transgenic organism or to a portion of the transgenic organism. | ||||||
| 2 | A THERMOPHILIC HOST-VECTOR SYSTEM | EP04770717.9 | 2004-09-10 | EP1678309A1 | 2006-07-12 | EGGERTSSON, Gudmundur; BJORNSDOTTIR, Snaedis |
| A novel host-vector system is provided, which enables efficient cloning, expression and production of desired gene products at elevated temperatures, such as expression of recombinantly produced polypeptides from thermophilic sources. The host-vector system is based on transformable and cultivable Rhodothermus strains and constructed vectors that can transform host cells of said strains. | ||||||
| 3 | METHODS AND ENZYME CATALYSTS FOR THE SYNTHESIS OF NON-CANONICAL AMINO ACIDS | US15970674 | 2018-05-03 | US20180327793A1 | 2018-11-15 | Christina E. Boville; Sabine Brinkmann-Chen; Andrew R. Buller; David K. Romney; Christopher K. Prier; Philipp Koch; Remkes Scheele |
| The present disclosure provides methods for preparing β-substituted tryptophan compounds. The methods include: combining i) an unsubstituted indole or a substituted indole, ii) a β-substituted serine, and iii) a tryptophan synthase β-subunit (i.e., a TrpB); and maintaining the resulting mixture under conditions sufficient to form the β-substituted tryptophan. The TrpB contains at least one amino acid mutation which promotes formation of an amino-acrylate intermediate. New TrpB variants and new β-substituted tryptophan analogs are also described. | ||||||
| 4 | ENGINEERED SYNTHASE FOR PRODUCTION OF TRYPTOPHAN DERIVATIVES AND INTRANSIGENT SUBSTRATES | US15685839 | 2017-08-24 | US20180057806A1 | 2018-03-01 | David K. Romney; Javier Murciano Calles; Jori E. Wehrmuller |
| This disclosure relates to modified tryptophan synthase and more particularly to modified beta-subunits of tryptophan synthase. The disclosure further relates to cells expressing such modified subunits and methods of producing non-canonical amino acids. | ||||||
| 5 | Production of tryptophan by microorganisms | US627696 | 1996-03-29 | US5939295A | 1999-08-17 | Mark S. Dunkak; Richard D. Dancey; Thomas W. McMullin; Paul D. Hanke |
| An improved recombinant DNA plasmid composed of a DNA vector and other DNA fragments containing the tryptophan operon from E. coli, the aroG gene from E. coli and the serA gene from E. coli is shown. The plasmid is transformed into a microorganism belonging to Escherichia coli, and the microorganisms are cultured in a medium and the L-tryptophan accumulated in the culture is recovered. | ||||||
| 6 | INDOLE-DERIVED COMPOUND PRODUCTION | PCT/US2015039392 | 2015-07-07 | WO2016007521A2 | 2016-01-14 | ANTEROLA ALDWIN |
| Among the various aspects of the present disclosure is the provision of a transgenic organism, an artificial DNA construct, and methods for producing a transgenic organism for indigo, indirubin, and other indole-derived compound production. Another aspect of the present disclosure is the provision of a transgenic organism wherein the indole-derived compound imparts color to the transgenic organism or to a portion of the transgenic organism. | ||||||
| 7 | CHLOROPHYTE GENES FOR THE OPTIMIZATION OF PRODUCTIVITY | PCT/US2012060202 | 2012-10-15 | WO2013056212A3 | 2015-06-18 | ABAD MARK SCOTT; COURY DANIEL ADAM; PERRINE ZOEE GOKHALE; POSTIER BRADLEY LYNN |
| The present application is comprised of various genes in Auxenochlorella (Chlorella) protothecoides that can be used to enhance productivity of the algae species. For example, these genes have an impact on photosynthetic efficiency, tolerance to environmental stress, and biomass yield. The present application also includes promoters and terminators which can be used to control gene expression in Auxenochlorella protothecoides. | ||||||
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