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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
81	PLANTS HAVING INCREASED TOLERANCE TO HERBICIDES	EP14791106.9	2014-04-28	EP2992090A2	2016-03-09	PASTERNAK, Maciej; TRESCH, Stefan; KRAUS, Helmut; HUTZLER, Johannes; LERCHL, Jens; MIETZNER, Thomas; PAULIK, Jill Marie
The present invention refers to a method for controlling undesired vegetation at a plant cultivation site, the method comprising the steps of providing, at said site, a plant that comprises at least one nucleic acid comprising a nucleotide sequence encoding a wild-type hydroxyphenyl pyruvate dioxygenase or a mutated hydroxyphenyl pyruvate dioxygenase (mut-HPPD) which is resistant or tolerant to a HPPD-inhibiting herbicide and/or a nucleotide sequence encoding a wild-type homogentisate solanesyl transferase or a mutated homogentisate solanesyl transferase (mut-HST) which is resistant or tolerant to a HPPD-inhibiting herbicide, applying to said site an effective amount of said herbicide. The invention further refers to plants comprising mut-HPPD, and methods of obtaining such plants.
82	METHODS OF PRODUCTION OF PRODUCTS OF METABOLIC PATHWAYS	EP13820518.2	2013-07-17	EP2875122A1	2015-05-27	MILO, Ron; ZELCBUCH, Lior; ANTONOVSKY, Niv
A plurality of isolated polynucleotide sequences encoding enzymes of the astaxanthin pathway is disclosed. The polynucleotides include: (i) a polynucleotide which encodes Phytoene dehydrogenase (crtI) and a first transcriptional regulatory sequence; (ii) a polynucleotide which encodes Beta-lycopene cyclase (lcy-B) and a second transcriptional regulatory sequence; (iii) a polynucleotide which encodes Beta-carotene ketolase (crtW) and a third transcriptional regulatory sequence; and wherein the first, second and third regulatory sequence are selected such that the expression of the Icy-B and the crtW is greater than a level of expression of the crtI. Methods of generating astaxanthin using the plurality of polynucleotide are also disclosed as well as bacterial cells comprising high levels of astaxanthin.
83	NUCLEIC ACID STRUCTURE CONTAINING A PYRIPYROPENE BIOSYNTHESIS GENE CLUSTER AND A MARKER GENE	EP11736900.9	2011-01-19	EP2530149A1	2012-12-05	AIHARA Sato; SUMIDA Naomi; MURASHIMA Koichiro; YANAI Kouji; ANZAI Hiroyuki; YAMAMOTO Kentaro
There is provided a nucleic acid construct comprising a pyripyropene biosynthetic gene cluster and a marker gene. The nucleic acid construct according to the present invention provides an inexpensive and highly productive method for producing pyripyropene.
84	GENES AND PROCESSES FOR THE PRODUCTION OF CLAVINE-TYPE ALKALOIDS	PCT/IB2013056604	2013-08-13	WO2014030096A3	2014-04-17	NAESBY MICHAEL; FOLLY CHRISTOPHE; NIELSEN CURT AIMÉ FRIIS; HATSCH ANAELLE; SCHWAB MARKUS; ZELDER OSKAR; HAEFNER STEFAN; SCHRÖDER HARTWIG; HOFF BIRGIT; MOLT ANDREA; DITRICH KLAUS; BREUER MICHAEL; HARTMANN HOLGER; KÖRBER KARSTEN
Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.
85	피리피로펜 생합성 유전자 클러스터 및 표지 유전자를 포함하는 핵산 구성체	KR1020177028393	2011-01-19	KR1020170125947A	2017-11-15	아이하라,사토; 수미다,나오미; 무라시마,코이치로; 야나이,코우지; 안자이,히로유키; 야마모토,켄타로
피리피로펜생합성유전자클러스터및 표지유전자를포함하는핵산구성체가제공된다. 본발명에따른핵산구성체는저렴하고생산성높은피리피로펜제조방법을제공한다.
86	미어신 생산용 벡터 및 균주, 및 이를 이용한 미어신의 생산방법	KR1020150097250	2015-07-08	KR1020170006521A	2017-01-18	우한민; 김은미; 엄영순; 공경택; 이선미; 김연제
본명세서에는미어신을발현시킬수 있는발현벡터, 상기벡터로형질전환되어향상된미어신생산능을갖는대장균균주, 이를이용한미어신의생산방법및 글리세롤의재활용방법이개시된다. 일측면에있어서, 본발명의형질전환된대장균() 균주는, 글리세롤또는포도당을탄소원으로사용하여, 대량의미어신을고순도로생산할수 있다. 또한, 본발명의대장균균주는폐글리세롤을탄소원으로사용하여, 고부가가치의미어신을생산할수 있으므로, 경제적이고, 친환경적이다. 또한, 휘발성이강한미어신을생산과동시에분리할수 있는장점이있다.
87	피리피로펜 생합성 유전자 클러스터 및 표지 유전자를 포함하는 핵산 구성체	KR1020127021871	2011-01-19	KR1020120107519A	2012-10-02	아이하라,사토; 수미다,나오미; 무라시마,코이치로; 야나이,코우지; 안자이,히로유키; 야마모토,켄타로
피리피로펜 생합성 유전자 클러스터 및 표지 유전자를 포함하는 핵산 구성체가 제공된다. 본 발명에 따른 핵산 구성체는 저렴하고 생산성 높은 피리피로펜 제조 방법을 제공한다.
88	토코트리에놀을 생합성하고 항산화 활성이 우수한 형질전환 발아콩	KR1020100134339	2010-12-24	KR1020120072545A	2012-07-04	김율호; 이유영; 박향미; 최만수; 윤홍태; 이춘기; 김욱한
PURPOSE: A method for producing germinated soybeans transformed using a recombinant expression vector is provided to enable tocotrienol synthesis and to enhance vitamin E content. CONSTITUTION: A method for producing germinated soybeans with enhanced tocotrienol and vitamin E content comprises: a step of transforming a recombinant vector containing a promoter and a polynucleotide of sequence number 1 into soybeans and germinating the transformed soybeans for 20-35°C for 1-7 days. The promoter is a beta-conglycine, vicilin, globulin, cauliflower mosaic virus(CaMY) 35S promoter, figwort mosaic virus 35S promoter, sugarcane bacilliform virus promoter, Commelina yellow mottle vitus promoter, light-inducible prooter from ribulose-1,5-bis-phosphate carboxylase subunit(ssRUBISCO), adenine phosphoribosyltransferase(APRT) promoter from Arabidopsis, rice actin 1 gene promoter, or mannopine syntase and octopine syntase prmoter.
89	고수준의 총토코페롤 생산이 가능한 식물 형질전환체의제조방법 및 식물 형질전환체	KR1020050058427	2005-06-30	KR1020070002763A	2007-01-05	윤성중; 박명렬; 박문희; 이효정
A method for preparing a transgenic plant capable of producing higher level of total tocopherol, and the transgenic plant are provided to increase total tocopherol in plants by increasing contents of all tocopherol homologues so that vitamin E level in food is increased. The method for preparing a transgenic plant capable of producing higher level of total tocopherol comprises the steps of: preparing a recombinant vector containing homogentisate phytyltransferase(HPT) gene; and transforming a plant with the recombinant vector, wherein the recombinant vector is introduced into the plant by mediation of Agrobacterium sp., and the homogentisate phytyltransferase(HPT) gene is derived from Synechocystis as photosynthetic bacteria.
90	피리피로펜의 제조 방법	KR1020127020668	2011-01-19	KR101840483B1	2018-05-04	안자이,히로유키; 야마모토,켄타로; 오야마,카즈히코; 츠치다,마리코; 고토,키미히코; 미토미,마사아키
특정폴리뉴클레오티드또는그것(들)을포함하는재조합벡터가도입된미생물을피리피로펜 A의생합성에필요한중간체화합물과배양하는방법이제공된다. 본발명의방법은피리피로펜의제조를허용한다.
91	피리피로펜 생합성 유전자 클러스터 및 표지 유전자를 포함하는 핵산 구성체	KR1020177028393	2011-01-19	KR101831121B1	2018-02-21	아이하라,사토; 수미다,나오미; 무라시마,코이치로; 야나이,코우지; 안자이,히로유키; 야마모토,켄타로
피리피로펜생합성유전자클러스터및 표지유전자를포함하는핵산구성체가제공된다. 본발명에따른핵산구성체는저렴하고생산성높은피리피로펜제조방법을제공한다.
92	클라빈-유형 알칼로이드의 생산을 위한 유전자 및 방법	KR1020157006881	2013-08-13	KR1020150042856A	2015-04-21	내스비,마이클; 폴리,크리스토페; 니일젠,쿠르트아이메프리스; 하트쉬,아넬레; 슈밥,마르쿠스; 첼더,오스카; 해프너,슈테판; 슈뢰더,하트비크; 호프,비르기트; 몰트,안드레아; 디트리흐,클라우스; 브로이어,마이클; 하르트만,홀거; 쾨르버,카르스텐
본발명은원칙적으로클라빈-유형알칼로이드, 예컨대시클로클라빈, 페스투클라빈, 아그로클라빈, 카노클라빈및 카노클라빈알데히드의재조합제조의분야에속한다. 본발명은클라빈-유형알칼로이드의제조를위한방법에적용될수 있는클라빈-유형알칼로이드및 폴리펩티드, 폴리뉴클레오티드및 상기폴리뉴클레오티드를포함하는벡터의제조를위한미생물및 공정을제공한다.
93	피리피로펜의 제조 방법	KR1020127020668	2011-01-19	KR1020120120287A	2012-11-01	안자이,히로유키; 야마모토,켄타로; 오야마,카즈히코; 츠치다,마리코; 고토,키미히코; 미토미,마사아키
특정 폴리뉴클레오티드 또는 그것(들)을 포함하는 재조합 벡터가 도입된 미생물을 피리피로펜 A의 생합성에 필요한 중간체 화합물과 배양하는 방법이 제공된다. 본 발명의 방법은 피리피로펜의 제조를 허용한다.
94	PLANTS HAVING INCREASED TOLERANCE TO HERBICIDES	PCT/IB2014061053	2014-04-28	WO2014177991A2	2014-11-06	PASTERNAK MACIEJ; TRESCH STEFAN; KRAUS HELMUT; HUTZLER JOHANNES; LERCHL JENS; MIETZNER THOMAS; PAULIK JILL MARIE
The present invention refers to a method for controlling undesired vegetation at a plant cultivation site, the method comprising the steps of providing, at said site, a plant that comprises at least one nucleic acid comprising a nucleotide sequence encoding a wild-type hydroxyphenyl pyruvate dioxygenase or a mutated hydroxyphenyl pyruvate dioxygenase (mut-HPPD) which is resistant or tolerant to a HPPD-inhibiting herbicide and/or a nucleotide sequence encoding a wild-type homogentisate solanesyl transferase or a mutated homogentisate solanesyl transferase (mut-HST) which is resistant or tolerant to a HPPD-inhibiting herbicide, applying to said site an effective amount of said herbicide. The invention further refers to plants comprising mut-HPPD, and methods of obtaining such plants.
95	METHODS OF PRODUCTION OF PRODUCTS OF METABOLIC PATHWAYS	PCT/IL2013050606	2013-07-17	WO2014013489A1	2014-01-23	MILO RON; ZELCBUCH LIOR; ANTONOVSKY NIV
A plurality of isolated polynucleotide sequences encoding enzymes of the astaxanthin pathway is disclosed. The polynucleotides include: (i) a polynucleotide which encodes Phytoene dehydrogenase (crtI) and a first transcriptional regulatory sequence; (ii) a polynucleotide which encodes Beta-lycopene cyclase (lcy-B) and a second transcriptional regulatory sequence; (iii) a polynucleotide which encodes Beta-carotene ketolase (crtW) and a third transcriptional regulatory sequence; and wherein the first, second and third regulatory sequence are selected such that the expression of the Icy-B and the crtW is greater than a level of expression of the crtI. Methods of generating astaxanthin using the plurality of polynucleotide are also disclosed as well as bacterial cells comprising high levels of astaxanthin.
96	CYTOKININ SYNTHASE ENZYMES, CONSTRUCTS, AND RELATED METHODS	PCT/US2015031942	2015-05-21	WO2015179621A3	2016-01-21	BEESON IV WILLIAM T; WESTFALL PATRICK JOHN
The present disclosure relates to a new class of cytokinin biosynthetic enzymes, cytokinin synthases, which have two domains: an isopentenyl transfer (IPT)-like domain and a cytokinin nucleotide phosphoribohydrolase (PRH)-like domain. The invention provides compositions and methods for the recombinant production of cytokinin synthase, host cells and transformants that include the cytokinin synthases, as well as compositions and formulations that include the disclosed cytokinin synthase.
97	METHODS FOR RECOMBINANT PRODUCTION OF SAFFRON COMPOUNDS	PCT/EP2015054792	2015-03-06	WO2015132411A3	2015-10-29	KUMAR A S SATHISH
Recombinant microorganisms and methods for producing saffron compounds including crocetin, crocetin dialdehyde, crocin or picrocrocin are disclosed herein.

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