| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 新的O-乙酰高丝氨酸硫化氢解酶或其突变体蛋白，和使用其转化成甲硫氨酸的方法 | CN201180065568.6 | 2011-12-21 | CN103328498B | 2015-11-25 | 金素影; 申容旭; 徐昌一; 孙晟光; 许仁庚; 李汉珍; 金朱恩; 金贤雅; 裵智妍; 罗光镐 |
| 本发明涉及具有O-乙酰高丝氨酸硫化氢解酶活性的新的蛋白质、其突变体蛋白、编码其的多核苷酸、包括该多核苷酸的重组载体、通过该重组载体转化的微生物，和使用该蛋白生产甲硫氨酸或乙酸的方法。本发明的生产方法与现有的方法相比，通过具有更高的转化率和降低的反应时间，而具有成本有效地生产L-甲硫氨酸和乙酸的优势，并且当使用突变体蛋白时，其可使添加的酶匀浆的量最小化，从而容易地以高产率生产L-甲硫氨酸和乙酸。 | ||||||
| 2 | 新的O-乙酰高丝氨酸硫化氢解酶或其变体，和使用其转化甲硫氨酸的方法 | CN201180065568.6 | 2011-12-21 | CN103328498A | 2013-09-25 | 金素影; 申容旭; 徐昌一; 孙晟光; 许仁庚; 李汉珍; 金朱恩; 金贤雅; 裵智妍; 罗光镐 |
| 本发明涉及具有O-乙酰高丝氨酸硫化氢解酶活性的新的蛋白质、其变体蛋白、编码其的多核苷酸、包括该多核苷酸的重组载体、通过该重组载体转化的微生物，和使用该蛋白生产甲硫氨酸或乙酸的方法。本发明的生产方法与现有的方法相比，通过具有更高的转化率和降低的反应时间，而具有经济地生产L-甲硫氨酸和乙酸的优势，并且当使用变体蛋白时，通过使注入的酶匀浆的量最小化，其可容易地以高产率生产L-甲硫氨酸和乙酸。 | ||||||
| 3 | METHOD FOR PRODUCING L-METHIONINE | US15763799 | 2016-09-29 | US20180291408A1 | 2018-10-11 | Georges FREMY; Arnaud MASSELIN |
| Provided is a process for the preparation of L-methionine in an enzymatic reaction utilizing dimethyl disulfide (DMDS) a precursor of L-methionine, and an organic reducing compound. In the process, methyl mercaptan can be formed by the enzymatic hydrogenolysis of the DMDS. | ||||||
| 4 | METHOD FOR PRODUCING L-METHIONINE | US15778762 | 2016-11-01 | US20180346946A1 | 2018-12-06 | Ines OCHROMBEL; Daniel FISCHER; Brigitte BATHE; Marleen HASSELMEYER; Michael HAMPEL; Joanne PEDALL |
| The present invention relates to a method for producing L-methionine in which a microorganism is cultured in the presence of L-homoserine and methyl mercaptan, a salt of the same or dimethyl disulfide whereby the L-methionine is accumulated in the culture medium. | ||||||
| 5 | O-acetylhomoserine sulfhydrylase or mutant protein thereof, and method for converting to methionine using the same | US13997054 | 2011-12-21 | US09080155B2 | 2015-07-14 | So Young Kim; Yong Uk Shin; Chang Il Seo; Sung Kwang Son; In Kyung Heo; Han Jin Lee; Ju Eun Kim; Hyun Ah Kim; Jee Yeon Bae; Kwang Ho Na |
| The present invention relates to a novel protein having O-acetylhomoserine sulfhydrylase activity, a mutant protein thereof, a polynucleotide encoding the same, a recombinant vector comprising the polynucleotide, a microorganism transformed with the recombinant vector, and a method for producing methionine or acetic acid using the protein. The production method of the present invention has the advantage of producing L-methionine and acetic acid cost-effectively through having higher conversion rate and reduced reaction time compared to the existing methods, and it can minimize the amount of enzyme homogenate added when using the mutant protein, thereby easily producing L-methionine and acetic acid at high yield. | ||||||
| 6 | METHOD FOR PRODUCING L-METHIONINE | US15764541 | 2016-09-29 | US20180282772A1 | 2018-10-04 | Georges FREMY; Arnaud MASSELIN; Hugo BRASSELET |
| Provided is an enzymatic process for preparing L-methionine from diethyl disulfide. | ||||||
| 7 | PROTEIN THIOCARBOXYLATE-DEPENDENT L-METHIONINE PRODUCTION BY FERMENTATION | US15750516 | 2015-08-07 | US20180223319A1 | 2018-08-09 | Philippe SOUCAILLE; Perrine VASSEUR |
| The present invention relates to a recombinant microorganism useful for the production of L-methionine and process for the preparation of L-methionine. The microorganism of the invention is modified in a way that the L-methionine production is improved by using a thiocarboxylated protein as sulfur donor and by expressing an enzyme having homoserine O-acetyltransferase activity without feedback inhibition by methionine and/or S-adenosylmethionine and an enzyme having O-acetylhomoserine sulfhydrylase activity. | ||||||
| 8 | NOVEL O-ACETYLHOMOSERINE SULFHYDRYLASE OR MUTANT PROTEIN THEREOF, AND METHOD FOR CONVERTING TO METHIONINE USING THE SAME | US13997054 | 2011-12-21 | US20130273614A1 | 2013-10-17 | So Young Kim; Yong Uk Shin; Chang Il Seo; Sung Kwang Son; In Kyung Heo; Han Jin Lee; Ju Eun Kim; Hyun Ah Kim; Jee Yeon Bae; Kwang Ho Na |
| The present invention relates to a novel protein having O-acetylhomoserine sulfhydrylase activity, a mutant protein thereof, a polynucleotide encoding the same, a recombinant vector comprising the polynucleotide, a microorganism transformed with the recombinant vector, and a method for producing methionine or acetic acid using the protein. The production method of the present invention has the advantage of producing L-methionine and acetic acid cost-effectively through having higher conversion rate and reduced reaction time compared to the existing methods, and it can minimize the amount of enzyme homogenate added when using the mutant protein, thereby easily producing L-methionine and acetic acid at high yield. | ||||||
| 9 | 新規O−アセチルホモセリンスルフヒドリラーゼまたはその変異タンパク質およびこれを用いたメチオニン転換方法 | JP2013546020 | 2011-12-21 | JP5907993B2 | 2016-04-26 | キム,ソ ヨン; シン,ヨン ウク; ソ,チャン イル; ソン,ソン グァン; ホ,イン ギョン; イ,ハン ジン; キム,チュ ウン; キム,ヒョン ア; ペ,チ ヨン; ナ,クァン ホ |
| 10 | L−メチオニンの製造方法 | JP2018516708 | 2016-09-29 | JP2018529357A | 2018-10-11 | フレミ,ジョルジュ; マスラン,アルノー; ブラッセル,ユゴー |
| 本発明は、L−メチオニン前駆体であるジメチルジスルフィド(DMDS)と水素との酵素反応を行うことによってL−メチオニンを製造する方法に関する。 | ||||||
| 11 | NOVEL O-ACETYLHOMOSERINE SULFHYDRYLASE OR VARIANT THEREOF, AND METHOD FOR TRANSFORMING METHIONINE USING SAME | EP11850058 | 2011-12-21 | EP2657249A4 | 2014-10-01 | KIM SO YOUNG; SHIN YONG UK; SEO CHANG IL; SON SUNG KWANG; HEO IN KYUNG; LEE HAN JIN; KIM JU EUN; KIM HYUN AH; BAE JEE YEON; NA KWANG HO |
| 12 | L−メチオニンの製造方法 | JP2018516701 | 2016-09-29 | JP2018534919A | 2018-11-29 | フレミ,ジョルジュ; マスラン,アルノー |
| 本発明は、L−メチオニン前駆体であるジメチルジスルフィド(DMDS)と還元有機化合物との酵素反応を行うことによってL−メチオニンを製造する方法に関する。 | ||||||
| 13 | Methionine conversion method using new o- acetyl sulfhydrylase or its mutant protein and this | JP2013546020 | 2011-12-21 | JP2014506129A | 2014-03-13 | ヨン キム，ソ; ウク シン，ヨン; イル ソ，チャン; グァン ソン，ソン; ギョン ホ，イン; ジン イ，ハン; ウン キム，チュ; ア キム，ヒョン; ヨン ペ，チ; ホ ナ，クァン |
| Ｏ−アセチルホモセリンスルフヒドリラーゼ(O-acetylhomoserine sulfhydrylase)の活性を有する新規タンパク質、その変異型タンパク質、これらをコードするポリヌクレオチド、前記ポリヌクレオチドを含む組み換えベクター、前記組み換えベクターで形質転換された微生物、および前記タンパク質を用いてメチオニンまたは酢酸を生産する方法に関する。 本発明の生産方法は、既存の方法より高い転換率および反応時間の短縮によって経済的にＬ−メチオニンおよび酢酸を生産することができるという利点があり、前記変異型タンパク質を用いる場合、酵素破砕液の投入量を最小化してＬ−メチオニンおよび酢酸を高収率かつ容易に生産することができる。 | ||||||
| 14 | 신규 Ｏ-아세틸호모세린 설피드릴라제 또는 변이체 및 이를 이용한 메치오닌 전환 방법 | KR1020100131954 | 2010-12-21 | KR101250651B1 | 2013-04-03 | 김소영; 신용욱; 서창일; 손성광; 허인경; 이한진; 김주은; 김현아; 배지연; 나광호 |
| 본 발명은 로도박터 스페로이드(
Rhodobacter
sphaeroides ) 유래의 O-아세틸호모세린 설피드릴라아제(O-acetylhomoserine sulfhydrylase) 활성을 가지는 폴리펩티드, 이의 변이형 폴리펩티드, 이들을 암호화하는 폴리뉴클레오티드, 상기 폴리펩티드를 포함하는 재조합 균주 및 상기 재조합 균주를 이용하여 L-메치오닌 및 아세트산을 생산하는 방법에 관한 것이다. 본 발명의 생산방법은 기존의 방법보다 높은 전환율 및 반응시간 단축을 통하여 경제적으로 L-메치오닌 및 아세트산을 생산할 수 있는 이점이 있으며, 상기 변이형 폴리펩티드를 이용하는 경우 효소 파쇄액의 투입량을 최소화하여 L-메치오닌 및 아세트산을 고수율로 용이하게 생산할 수 있다.
|
||||||
| 15 | O-아세틸호모세린 설피드릴라제 변이체 및 이를 이용한 L-메치오닌 제조 방법 | KR1020160133134 | 2016-10-13 | KR1020170044048A | 2017-04-24 | 이임상; 손성광; 유혜련; 이재희; 이주희; 장진숙; 최진근; 김소영; 신용욱 |
| 본출원은신규한 O-아세틸호모세린설피드릴라아제 (O-acetylhomoserine sulfhydrylase) 변이체, 이를코딩하는폴리뉴클레오티드, 상기폴리뉴클레오티드를포함하는벡터, 상기변이체를발현할수 있는균주, 및상기변이체를이용하여 L-메치오닌을생산하는방법에관한것이다. | ||||||
| 16 | METHOD FOR PRODUCING L-METHIONINE | EP16790964.7 | 2016-11-01 | EP3380627A1 | 2018-10-03 | OCHROMBEL, Ines; FISCHER, Daniel; BATHE, Brigitte; HASSELMEYER, Marleen; HAMPEL, Michael; PEDALL, Joanne |
| The present invention relates to a method for producing L-methionine in which a microorganism is cultured in the presence of L-homoserine and methyl mercaptan, a salt of the same or dimethyl disulfide whereby the L-methionine is accumulated in the culture medium. | ||||||
| 17 | NOVEL O-ACETYLHOMOSERINE SULFHYDRYLASE OR VARIANT THEREOF, AND METHOD FOR TRANSFORMING METHIONINE USING SAME | EP11850058.6 | 2011-12-21 | EP2657249B1 | 2017-03-15 | KIM, So Young; SHIN, Yong Uk; SEO, Chang Il; SON, Sung Kwang; HEO, In Kyung; LEE, Han Jin; KIM, Ju Eun; KIM, Hyun Ah; BAE, Jee Yeon; NA, Kwang Ho |
| 18 | NOVEL O-ACETYLHOMOSERINE SULFHYDRYLASE OR VARIANT THEREOF, AND METHOD FOR TRANSFORMING METHIONINE USING SAME | EP11850058.6 | 2011-12-21 | EP2657249A2 | 2013-10-30 | KIM, So Young; SHIN, Yong Uk; SEO, Chang Il; SON, Sung Kwang; HEO, In Kyung; LEE, Han Jin; KIM, Ju Eun; KIM, Hyun Ah; BAE, Jee Yeon; NA, Kwang Ho |
The present invention relates to a novel protein having O-acetylhomoserine sulfhydrylase activity, a mutant protein thereof, a polynucleotide encoding the same, a recombinant vector comprising the polynucleotide, a microorganism transformed with the recombinant vector, and a method for producing methionine or acetic acid using the protein. The production method of the present invention has the advantage of producing L-methionine and acetic acid cost-effectively through having higher conversion rate and reduced reaction time compared to the existing methods, and it can minimize the amount of enzyme homogenate added when using the mutant protein, thereby easily producing L-methionine and acetic acid at high yield. |
||||||
| 19 | NOVEL O-ACETYLHOMOSERINE SULFHYDRYLASE OR VARIANT THEREOF, AND METHOD FOR TRANSFORMING METHIONINE USING SAME | PCT/KR2011009965 | 2011-12-21 | WO2012087038A2 | 2012-06-28 | KIM SO YOUNG; SHIN YONG UK; SEO CHANG IL; SON SUNG KWANG; HEO IN KYUNG; LEE HAN JIN; KIM JU EUN; KIM HYUN AH; BAE JEE YEON; NA KWANG HO |
| The present invention relates to a novel protein having O-acetylhomoserine sulfhydrylase activity, a variant protein thereof, a polynucleotide encoding same, a recombinant vector including the polynucleotide, a microorganism transformed by the recombinant vector, and a method for producing methionine or acetic acid using the protein. The method for producing of the present invention has the advantage of economically producing L-methionine and acetic acid by having a higher transformation rate and reduced reaction time compared to existing methods, and can easily produce the L-metionine and the acetic acid with high yield by minimizing the amount of enzyme homogenate injected, when using the variant protein. | ||||||
| 20 | L-메티오닌의 제조 방법 | KR20187011409 | 2016-09-29 | KR20180055887A | 2018-05-25 | FREMY GEORGES; MASSELIN ARNAUD |
| 본발명은 L-메티오닌전구체, 다이메틸다이설파이드(DMDS) 및환원성유기화합물사이의효소반응을수행하여 L-메티오닌의제조방법에관한것이다. | ||||||
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