| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 鞘氨醇单胞菌的虾青素合成酶及其编码基因和鞘氨醇单胞菌遗传操作的方法 | CN201410447259.0 | 2014-09-03 | CN104232595A | 2014-12-24 | 刘天罡; 马田; 周袁杰; 朱发银 |
| 本发明公开了鞘氨醇单胞菌的虾青素合成酶及其编码基因和鞘氨醇单胞菌遗传操作的方法。本发明证实鞘氨醇单胞菌可以产生虾青素，含有能够产生虾青素的生物合成途径，发现鞘氨醇单胞菌中通过MEP途径和类胡萝卜素合成途径生成虾青素；并进一步证明该菌株中存在与现有已知基因同源性较低的crtE、crtZ基因在合成虾青素中的功能。本发明公开的鞘氨醇单胞菌的虾青素生物合成途径所需的酶及其编码基因现有技术均未报道，为生物合成代谢改造类胡萝卜素提供更多资源。鞘氨醇单胞菌可以以pBBR1MCS2为载体、EGFP为报告基因进行遗传操作，为这类环境微生物的遗传改造及降解机制的发现建立了基础。 | ||||||
| 2 | Cells and methods for producing lutein | US14377041 | 2013-02-05 | US10059974B2 | 2018-08-28 | Eleanore T Wurtzel; Rena Quinlan |
| Provided herein are recombinant cells (e.g., recombinant bacteria or plant, insect, mammalian, and yeast cells) containing a nucleic acid encoding a CYP97A protein or a nucleic acid encoding a CYP97B protein; a nucleic acid encoding a CYP97C protein; a nucleic acid encoding a geranylgeranyl pyrophosphate synthase protein; a nucleic acid encoding a phytoene synthase protein; a nucleic acid encoding a phytoene desaturase protein; a nucleic acid encoding a lycopene β-cyclase protein; and a nucleic acid encoding a lycopene ε-cyclase protein. Also provided are methods of producing lutein that include culturing these recombinant cells (e.g., recombinant bacteria and yeast cells), and methods of generating these recombinant cells (e.g., recombinant bacteria and yeast cells). Also provided is lutein produced by these methods, and pharmaceutical compositions, food supplements, food products, and cosmetic compositions that contain lutein produced by these methods. | ||||||
| 3 | Method for modifying carotenoid biosynthesis in plants | US14421661 | 2013-08-15 | US09677056B2 | 2017-06-13 | Eleanore T. Wurtzel; Maria Shumskaya |
| Methods are provided for modifying and screening for carotenoid biosynthesis in a plant. The methods are useful for enhancing plant adaptation to climate change and food security, providing increased carotenoid content to a plant, improving stress resistance to climate changes in a plant, and for selecting plants having improved stress resistance to climate changes. | ||||||
| 4 | METABOLIC TRANSISTOR IN BACTERIA | US15263146 | 2016-09-12 | US20170009241A1 | 2017-01-12 | Ka-Yiu SAN; George N. BENNETT; Hui WU |
| The disclosure relates to a metabolic transistor in microbes such as bacteria and yeast where a competitive pathway is introduced to compete with a product pathway for available carbon so as to control the carbon flux in the microbe. | ||||||
| 5 | METABOLIC TRANSISTOR IN BACTERIA | US14176008 | 2014-02-07 | US20140227745A1 | 2014-08-14 | Ka-Yiu SAN; George N. BENNETT; Hui WU |
| The disclosure relates to a metabolic transistor in bacteria where a competitive pathway is introduced to compete with a product pathway for available carbon so as to control the carbon flux in the bacteria. | ||||||
| 6 | Metabolic transistor in bacteria | US15263146 | 2016-09-12 | US10011839B2 | 2018-07-03 | Ka-Yiu San; George N. Bennett; Hui Wu |
| The disclosure relates to a metabolic transistor in microbes such as bacteria and yeast where a competitive pathway is introduced to compete with a product pathway for available carbon so as to control the carbon flux in the microbe. | ||||||
| 7 | COMPOSITIONS AND METHODS OF BIOSYNTHESIZING XANTHOPHYLLS | US15694443 | 2017-09-01 | US20180105839A1 | 2018-04-19 | Yechun Wang |
| The present invention relates to compositions and methods of producing xanthophylls in microorganisms. | ||||||
| 8 | Metabolic transistor in bacteria | US14176008 | 2014-02-07 | US09441253B2 | 2016-09-13 | Ka-Yiu San; George N. Bennett; Hui Wu |
| The disclosure relates to a metabolic transistor in bacteria where a competitive pathway is introduced to compete with a product pathway for available carbon so as to control the carbon flux in the bacteria. | ||||||
| 9 | Method for Modifying Carotenoid Biosynthesis in Plants | US14421661 | 2013-08-15 | US20150315551A1 | 2015-11-05 | Eleanore T. Wurtzel; Maria Shumskaya |
| Methods are provided for modifying and screening for carotenoid biosynthesis in a plant. The methods are useful for enhancing plant adaptation to climate change and food security, providing increased carotenoid content to a plant, improving stress resistance to climate changes in a plant, and for selecting plants having improved stress resistance to climate changes | ||||||
| 10 | CELLS AND METHODS FOR PRODUCING LUTEIN | US14377041 | 2013-02-05 | US20150005534A1 | 2015-01-01 | Eleanor T Wurtzel; Rena Quinlan |
| Provided herein are recombinant cells (e.g., recombinant bacteria or plant, insect, mammalian, and yeast cells) containing a nucleic acid encoding a CYP97A protein or a nucleic acid encoding a CYP97B protein; a nucleic acid encoding a CYP97C protein; a nucleic acid encoding a geranylgeranyl pyrophosphate synthase protein; a nucleic acid encoding a phytoene synthase protein; a nucleic acid encoding a phytoene desaturase protein; a nucleic acid encoding a lycopene β-cyclase protein; and a nucleic acid encoding a lycopene ε-cyclase protein. Also provided are methods of producing lutein that include culturing these recombinant cells (e.g., recombinant bacteria and yeast cells), and methods of generating these recombinant cells (e.g., recombinant bacteria and yeast cells). Also provided is lutein produced by these methods, and pharmaceutical compositions, food supplements, food products, and cosmetic compositions that contain lutein produced by these methods. | ||||||
| 11 | 発酵によるα−イオノン製造の方法 | JP2018529709 | 2015-08-28 | JP2018526027A | 2018-09-13 | ヤッハ,グイド; アズドウファル,サナエ; シュレーナー,カトリン; ヴェルターズ,ピーター; ナタネク,アンジェラ |
| 本発明は、鏡像異性的に純粋なα−イオノンを製造する方法に関する。さらに、本発明は、リコペン−ε−シクラーゼ(EC)をコードする配列を含む核酸、リコペン−ε−シクラーゼ(EC)、α−イオノン生合成の構成要素をコードするプラスミド、ならびに酵素ゲラニルゲラニル二リン酸シンターゼ、イソペンテニル二リン酸イソメラーゼ(IPI)、フィトエンデサチュラーゼ/デヒドロゲナーゼ(crtI)、フィトエンシンターゼ(crtB)、リコペン−ε−シクラーゼ(EC)、およびカロテノイド酸化開裂酵素(CCD1)をコードする異種性ヌクレオチド配列を含有する微生物に関する。さらに、本発明は、高純度のε−カロテンを製造する方法に関する。 | ||||||
| 12 | Enhancement of carotenoid accumulation in plants | JP2006505998 | 2004-03-22 | JP2006521107A | 2006-09-21 | アン シプトン，キャサリン; レイチェル ドレーク，キャロライン; アン メアリー パイン，ジャクリーン |
| 本発明は、ポリヌクレオチド、及び種子のカロチノイド含量を増大させる方法における該ポリヌクレオチドの使用に関する。 具体的には、本発明は、ポリヌクレオチドであって：(a)(i)種子優先発現を可能にするプロモーターと、(ii)カロチン・デサチュラーゼをコードする細菌由来のヌクレオチド配列と、(iii)転写終止領域とを、作用可能に連結した構成成分として含む領域；及び(b)(i)種子優先発現を可能にするプロモーターと、(ii)トウモロコシ(Zea種)又はイネ(Orzya種)に由来する、フィトエン・シンターゼをコードするヌクレオチド配列と、(iii)転写終止領域とを、作用可能に連結した構成成分として含む別の領域を含む、ポリヌクレオチドを提供する。 開示されたポリヌクレオチドは、高含量の有色カロチノイドを含むイネ種子の製造に使用するのに特に適している。 | ||||||
| 13 | ENHANCED ACCUMULATION OF CAROTENOIDS IN PLANTS | EP04722310.2 | 2004-03-22 | EP1608759B1 | 2008-01-02 | DRAKE, Caroline, Rachel, Syngenta Limited; PAINE, Jacqueline, Ann, Mary, Syngenta Limited; SHIPTON, Catherine, Ann, Syngenta Limited |
| The present invention relates to polynucleotides and their use in methods of increasing the carotenoid content of seeds. In particular the invention provides a polynucleotide comprising: (a) a region which comprises as operably linked components (i) a promoter which provides for seed preferred expression; and (ii) a nucleotide sequence derived from a bacterium which sequence encodes a carotene desaturase; and (iii) a transcription termination region; and (b) a further region which comprises as operably linked components (i) a promoter which provides for seed preferred expression; and (ii) a nucleotide sequence encoding a phytoene synthase which sequence is derived from maize (Zea sp.) or rice (Orzya sp.); and (iii) a transcription termination region. The disclosed polynucleotides are particularly suitable for use in production of rice seed which comprise high amounts of coloured carotenoids. | ||||||
| 14 | ENHANCED ACCUMULATION OF CAROTENOIDS IN PLANTS | EP04722310.2 | 2004-03-22 | EP1608759A2 | 2005-12-28 | DRAKE, Caroline, Rachel,Syngenta Limited; PAINE, Jacqueline, Ann, Mary,Syngenta Limited; SHIPTON, Catherine, Ann,Syngenta Limited |
| The present invention relates to polynucleotides and their use in methods of increasing the carotenoid content of seeds. In particular the invention provides a polynucleotide comprising: (a) a region which comprises as operably linked components (i) a promoter which provides for seed preferred expression; and (ii) a nucleotide sequence derived from a bacterium which sequence encodes a carotene desaturase; and (iii) a transcription termination region; and (b) a further region which comprises as operably linked components (i) a promoter which provides for seed preferred expression; and (ii) a nucleotide sequence encoding a phytoene synthase which sequence is derived from maize (Zea sp.) or rice (Orzya sp.); and (iii) a transcription termination region. The disclosed polynucleotides are particularly suitable for use in production of rice seed which comprise high amounts of coloured carotenoids. | ||||||
| 15 | METHOD OF FERMENTATIVE ALPHA-IONONE PRODUCTION | US15755976 | 2015-08-28 | US20180251796A1 | 2018-09-06 | Guido JACH; Sanae AZDOUFFAL; Katrin SCHULLEHNER; Peter WELTERS; Angela NATANEK |
| The present invention concerns a method of producing and enantiomerically pure alpha-ionone. Further, the invention concerns a nucleic acid that comprises a sequence that encodes a lycopene-epsilon-cyclase (EC), a lycopene-epsilon-cyclase (EC), plasmids, which encode components of the alpha-ionone biosynthesis and a microorganism that contains heterologous nucleotide sequences which encode the enzymes geranylgeranyl-diphosphate-synthase, isopentenyl-diphosphate-isomerase (IPI), phytoene desaturase-dehydrogenase (crtI), phytoene synthase (crtB), lycopene-epsilon-cyclase (EC) and carotenoid-cleavage-dioxygenase (CCD1). Further, the invention concerns a method of producing highly pure epsilon-carotene. | ||||||
| 16 | MUTANT HAVING ABILITY TO OVERPRODUCE CAROTENOIDS AND METHOD FOR PRODUCING CAROTENOIDS BY USING SAME | US15540611 | 2015-12-31 | US20180148728A1 | 2018-05-31 | Pyung Cheon LEE; Bo Hyun CHOI; Sun Hyoung CHOI |
| Provided is a mutant having an ability to overproduce carotenoids and a method for producing carotenoids by using the mutant. The mutant, of which mutations are induced by irradiation after being transformed with a recombinant vector according to the subject matter, has an excellent ability to produce carotenoids and can be mass-produced, and thus can be useful in various industrial fields, which use carotenoids, such as cosmetics, food, and feed. | ||||||
| 17 | ENHANCED ACCUMULATION OF CAROTENOIDS IN PLANTS | US14806226 | 2015-07-22 | US20150322444A1 | 2015-11-12 | Caroline Rachel Drake; Catherine Ann Shipton; Jacqueline Ann Mary Paine |
| The present invention relates to polynucleotides and their use in methods of increasing the carotenoid content of seeds. In particular the invention provides a polynucleotide comprising: (a) a region which comprises as operably linked components (i) a promoter which provides for seed preferred expression; and (ii) a nucleotide sequence derived from a bacterium which sequence encodes a carotene desaturase; and (iii) a transcription termination region; and (b) a further region which comprises as operably linked components (i) a promoter which provides for seed preferred expression; and (ii) a nucleotide sequence encoding a phytoene synthase which sequence is derived from maize (Zea sp.) or rice (Orzya sp.); and (iii) a transcription termination region. The disclosed polynucleotides are particularly suitable for use in production of rice seed which comprise high amounts of coloured carotenoids. | ||||||
| 18 | ENHANCED ACCUMULATION OF CAROTENOIDS IN PLANTS | US13275219 | 2011-10-17 | US20120042417A1 | 2012-02-16 | Caroline Rachel Drake; Jacqueline Ann Mary Paine; Catherine Ann Shipton |
| The present invention relates to polynucleotides and their use in methods of increasing the carotenoid content of seeds. In particular the invention provides a polynucleotide comprising: (a) a region which comprises as operably linked components (i) a promoter which provides for seed preferred expression; and (ii) a nucleotide sequence derived from a bacterium which sequence encodes a carotene desaturase; and (iii) a transcription termination region; and (b) a further region which comprises as operably linked components (i) a promoter which provides for seed preferred expression; and (ii) a nucleotide sequence encoding a phytoene synthase which sequence is derived from maize (Zea sp.) or rice (Orzya sp.); and (iii) a transcription termination region. The disclosed polynucleotides are particularly suitable for use in production of rice seed which comprise high amounts of coloured carotenoids. | ||||||
| 19 | ENHANCED ACCUMULATION OF CAROTENOIDS IN PLANTS | US11873709 | 2007-10-17 | US20080109919A1 | 2008-05-08 | Caroline Drake; Jacqueline Paine; Catherine Shipton |
| The present invention relates to polynucleotides and their use in methods of increasing the carotenoid content of seeds. In particular the invention provides a polynucleotide comprising: (a) a region which comprises as operably linked components (i) a promoter which provides for seed preferred expression; and (ii) a nucleotide sequence derived from a bacterium which sequence encodes a carotene desaturase; and (iii) a transcription termination region; and (b) a further region which comprises as operably linked components (i) a promoter which provides for seed preferred expression; and (ii) a nucleotide sequence encoding a phytoene synthase which sequence is derived from a plant selected from the group consisting of: tomato (Lycopersicon sp.); pepper (Capsicum sp.); maize (Zea sp.) and rice (Orzya sp.) or a bacterium; and (iii) a transcription termination region. The disclosed polynucleotides are particularly suitable for use in production of rice seed which comprise high amounts of coloured carotenoids. | ||||||
| 20 | METHOD FOR MODIFYING CAROTENOID BIOSYNTHESIS IN PLANTS | EP13829454 | 2013-08-15 | EP2885413A4 | 2016-03-23 | WURTZEL ELEANORE T; SHUMSKAYA MARIA |
| Methods are provided for modifying and screening for carotenoid biosynthesis in a plant. The methods are useful for enhancing plant adaptation to climate change and food security, providing increased carotenoid content to a plant, improving stress resistance to climate changes in a plant, and for selecting plants having improved stress resistance to climate changes. | ||||||
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