| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | Method and agents for producing N-acetylneuraminic acid (NeuNAc) | US14515120 | 2014-10-15 | US10106827B2 | 2018-10-23 | Astrid Mach-Aigner; Robert Mach; Matthias G. Steiger |
| The invention relates to an isolated nucleic acid molecule comprising at least one promoter that is active in fungal cells of the trichoderma species, wherein a nucleic acid sequence encoding an N-acetylglucosamine-2-epimerase and/or an N-acetylneuraminic acid synthase is operatively bound to each promoter. The at least one promoter that is active in fungal cells is a constitutive promoter. | ||||||
| 2 | Ｎ−アセチルノイラミン酸合成酵素および該酵素をコードするＤＮＡ | JP2002536439 | 2001-10-11 | JPWO2002033070A1 | 2004-02-26 | 小泉 聡司; 溝口 寛; 石川 真理; 遠藤 徹夫 |
| 本発明によれば、N−アセチルノイラミン酸合成酵素活性を有する新規蛋白質、該蛋白質をコードするDNA、該DNAを含有する組換え体DNA、該組換え体DNAを保有する形質転換体、該形質転換体を用いた上記蛋白質あるいはN−アセチルノイラミン酸の製造法を提供することができる。 | ||||||
| 3 | VERFAHREN UND MITTEL ZUR HERSTELLUNG VON N-ACETYLNEURAMINSÄURE (NEUNAC) | EP11808130.6 | 2011-12-22 | EP2655608A1 | 2013-10-30 | MACH-AIGNER, Astrid; MACH, Robert; STEIGER, Matthias, G. |
| The invention relates to an isolated nucleic acid molecule comprising at least one promoter that is active in fungal cells of the trichoderma species, wherein a nucleic acid sequence encoding an N-acetylglucosamine-2-epimerase and/or an N-acetylneuraminic acid synthase is operatively bound to each promoter. The at least one promoter that is active in fungal cells is a constitutive promoter. | ||||||
| 4 | VERFAHREN UND MITTEL ZUR HERSTELLUNG VON N-ACETYLNEURAMINSÄURE (NEUNAC) | EP11808130.6 | 2011-12-22 | EP2655608B1 | 2016-06-29 | MACH-AIGNER, Astrid; MACH, Robert; STEIGER, Matthias, G. |
| 5 | METHOD AND AGENTS FOR PRODUCING N-ACETYLNEURAMINIC ACID (NEUNAC) | US14515120 | 2014-10-15 | US20150167038A1 | 2015-06-18 | Astrid MACH-AIGNER; Robert Mach; Matthias G. Steiger |
| The invention relates to an isolated nucleic acid molecule comprising at least one promoter that is active in fungal cells of the trichoderma species, wherein a nucleic acid sequence encoding an N-acetylglucosamine-2-epimerase and/or an N-acetylneuraminic acid synthase is operatively bound to each promoter. The at least one promoter that is active in fungal cells is a constitutive promoter. | ||||||
| 6 | METHOD AND AGENTS FOR PRODUCING N-ACETYLNEURAMINIC ACID (NEUNAC) | US13993979 | 2011-12-22 | US20130266987A1 | 2013-10-10 | Astrid Mach-Aigner; Robert Mach; Matthias G. Steiger |
| The invention relates to an isolated nucleic acid molecule comprising at least one promoter that is active in fungal cells of the trichoderma species, wherein a nucleic acid sequence encoding an N-acetylglucosamine-2-epimerase and/or an N-acetylneuraminic acid synthase is operatively bound to each promoter. The at least one promoter that is active in fungal cells is a constitutive promoter. | ||||||
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