| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 遗传修饰的宿主细胞及其用于生产类异戊二烯化合物的应用 | CN200580025119.3 | 2005-07-21 | CN101001947A | 2007-07-18 | J·D·基斯林; E·M·帕若蒂斯; J·柯比 |
| 本发明提供了产生类异戊二烯前体或类异戊二烯化合物的遗传修饰的真核宿主细胞。所述遗传修饰的宿主细胞含有活性水平提高的一种或多种甲羟戊酸途径酶、活性水平提高的异戊烯基转移酶和活性水平降低的鲨烯合酶。本发明提供了在所述遗传修饰的真核宿主细胞中产生类异戊二烯化合物或类异戊二烯前体的方法。该方法通常包括在促进产生高水平的类异戊二烯或类异戊二烯前体化合物的条件下培养所述遗传修饰的宿主细胞。 | ||||||
| 2 | GENETICALLY MODIFIED HOST CELLS AND USE OF SAME FOR PRODUCING ISOPRENOID COMPOUNDS | US15722844 | 2017-10-02 | US20180030481A1 | 2018-02-01 | Jay D. Keasling; James Kirby; Eric M. Paradise |
| The present invention provides genetically modified eukaryotic host cells that produce isoprenoid precursors or isoprenoid compounds. A subject genetically modified host cell comprises increased activity levels of one or more of mevalonate pathway enzymes, increased levels of prenyltransferase activity, and decreased levels of squalene synthase activity. Methods are provided for the production of an isoprenoid compound or an isoprenoid precursor in a subject genetically modified eukaryotic host cell. The methods generally involve culturing a subject genetically modified host cell under conditions that promote production of high levels of an isoprenoid or isoprenoid precursor compound. | ||||||
| 3 | Genetically modified host cells and use of same for producing isoprenoid compounds | US14451056 | 2014-08-04 | US09809829B2 | 2017-11-07 | Jay D. Keasling; James Kirby; Eric M. Paradise |
| The present invention provides genetically modified eukaryotic host cells that produce isoprenoid precursors or isoprenoid compounds. A subject genetically modified host cell comprises increased activity levels of one or more of mevalonate pathway enzymes, increased levels of prenyltransferase activity, and decreased levels of squalene synthase activity. Methods are provided for the production of an isoprenoid compound or an isoprenoid precursor in a subject genetically modified eukaryotic host cell. The methods generally involve culturing a subject genetically modified host cell under conditions that promote production of high levels of an isoprenoid or isoprenoid precursor compound. | ||||||
| 4 | Genetically Modified Host Cells and Use of Same for Producing Isoprenoid Compounds | US14451056 | 2014-08-04 | US20150087042A1 | 2015-03-26 | Jay D. Keasling; James Kirby; Eric M. Paradise |
| The present invention provides genetically modified eukaryotic host cells that produce isoprenoid precursors or isoprenoid compounds. A subject genetically modified host cell comprises increased activity levels of one or more of mevalonate pathway enzymes, increased levels of prenyltransferase activity, and decreased levels of squalene synthase activity. Methods are provided for the production of an isoprenoid compound or an isoprenoid precursor in a subject genetically modified eukaryotic host cell. The methods generally involve culturing a subject genetically modified host cell under conditions that promote production of high levels of an isoprenoid or isoprenoid precursor compound. | ||||||
| 5 | Genetically modified host cells and use of same for producing isoprenoid compounds | US11571315 | 2005-07-21 | US08828684B2 | 2014-09-09 | Jay D. Keasling; James Kirby; Eric M. Paradise |
| The present invention provides genetically modified eukaryotic host cells that produce isoprenoid precursors or isoprenoid compounds. A subject genetically modified host cell comprises increased activity levels of one or more of mevalonate pathway enzymes, increased levels of prenyltransferase activity, and decreased levels of squalene synthase activity. Methods are provided for the production of an isoprenoid compound or an isoprenoid precursor in a subject genetically modified eukaryotic host cell. The methods generally involve culturing a subject genetically modified host cell under conditions that promote production of high levels of an isoprenoid or isoprenoid precursor compound. | ||||||
| 6 | Genetically Modified Host Cells And Use Of Same For Producing Isoprenoid Compounds | US11571315 | 2005-07-21 | US20080171378A1 | 2008-07-17 | Jay D. Keasling; James Kirby; Eric M. Paradise |
| The present invention provides genetically modified eukaryotic host cells that produce isoprenoid precursors or isoprenoid compounds. A subject genetically modified host cell comprises increased activity levels of one or more of mevalonate pathway enzymes, increased levels of prenyltransferase activity, and decreased levels of squalene synthase activity. Methods are provided for the production of an isoprenoid compound or an isoprenoid precursor in a subject genetically modified eukaryotic host cell. The methods generally involve culturing a subject genetically modified host cell under conditions that promote production of high levels of an isoprenoid or isoprenoid precursor compound. | ||||||
| 7 | GENETICALLY MODIFIED HOST CELLS AND USE OF SAME FOR PRODUCING ISOPRENOID COMPOUNDS | EP05775484 | 2005-07-21 | EP1778831A4 | 2008-02-13 | KEASLING JAY D; PARADISE ERIC M; KIRBY JAMES |
| The present invention provides genetically modified eukaryotic host cells that produce isoprenoid precursors or isoprenoid compounds. A subject genetically modified host cell comprises increased activity levels of one or more of mevalonate pathway enzymes, increased levels of prenyltransferase activity, and decreased levels of squalene synthase activity. Methods are provided for the production of an isoprenoid compound or an isoprenoid precursor in a subject genetically modified eukaryotic host cell. The methods generally involve culturing a subject genetically modified host cell under conditions that promote production of high levels of an isoprenoid or isoprenoid precursor compound. | ||||||
| 8 | Using the genetically modified host cell and the host cell for the production of isoprenoid compounds | JP2007523676 | 2005-07-21 | JP5590769B2 | 2014-09-17 | ジェイ ディー． キースリング; エリック エム． パラダイス; ジェームズ カービー |
| The present invention provides genetically modified eukaryotic host cells that produce isoprenoid precursors or isoprenoid compounds. A subject genetically modified host cell comprises increased activity levels of one or more of mevalonate pathway enzymes, increased levels of prenyltransferase activity, and decreased levels of squalene synthase activity. Methods are provided for the production of an isoprenoid compound or an isoprenoid precursor in a subject genetically modified eukaryotic host cell. The methods generally involve culturing a subject genetically modified host cell under conditions that promote production of high levels of an isoprenoid or isoprenoid precursor compound. | ||||||
| 9 | Using the genetically modified host cell and the host cell for the production of isoprenoid compounds | JP2007523676 | 2005-07-21 | JP2008507974A | 2008-03-21 | ジェームズ カービー; ジェイ ディー． キースリング; エリック エム． パラダイス |
| 本発明は、イソプレノイド前駆体またはイソプレノイド化合物を生産する、遺伝的に修飾された真核宿主細胞を提供する。 本発明の遺伝的に修飾された宿主細胞は、メバロン酸経路の1つまたは複数の酵素の活性レベルの上昇、プレニルトランスフェラーゼの活性レベルの上昇、およびスクアレンシンターゼの活性レベルの低下を含む。 本発明の遺伝的に修飾された真核宿主細胞におけるイソプレノイド化合物またはイソプレノイド前駆体を生産する方法を提供する。 本方法は概して、本発明の遺伝的に修飾された宿主細胞を、高レベルのイソプレノイド化合物またはイソプレノイド前駆体化合物の生産を促進する条件で培養する段階を含む。 | ||||||
| 10 | GENETICALLY MODIFIED HOST CELLS AND USE OF SAME FOR PRODUCING ISOPRENOID COMPOUNDS | EP05775484.8 | 2005-07-21 | EP1778831B1 | 2012-05-23 | KEASLING, Jay D.; PARADISE, Eric M.; KIRBY, James |
| The present invention provides genetically modified eukaryotic host cells that produce isoprenoid precursors or isoprenoid compounds. A subject genetically modified host cell comprises increased activity levels of one or more of mevalonate pathway enzymes, increased levels of prenyltransferase activity, and decreased levels of squalene synthase activity. Methods are provided for the production of an isoprenoid compound or an isoprenoid precursor in a subject genetically modified eukaryotic host cell. The methods generally involve culturing a subject genetically modified host cell under conditions that promote production of high levels of an isoprenoid or isoprenoid precursor compound. | ||||||
| 11 | Genetically modified host cells and use of same for producing isoprenoid compounds | EP10178049.2 | 2005-07-21 | EP2298859A3 | 2011-05-25 | Keasling, Jay, D.; Paradise, Eric M.; Kirby, James |
The present invention provides genetically modified eukaryotic host cells that produce isoprenoid precursors or isoprenoid compounds. A subject genetically modified host cell comprises increased activity levels of one or more of mevalonate pathway enzymes, increased levels of prenyltransferase activity, and decreased levels of squalene synthase activity. Methods are provided for the production of an isoprenoid compound or an isoprenoid precursor in a subject genetically modified eukaryotic host cell. The methods generally involve culturing a subject genetically modified host cell under conditions that promote production of high levels of an isoprenoid or isoprenoid precursor compound.
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| 12 | Genetically modified host cells and use of same for producing isoprenoid compounds | EP10178049.2 | 2005-07-21 | EP2298859A2 | 2011-03-23 | Keasling, Jay, D.; Paradise, Eric M.; Kirby, James |
The present invention provides genetically modified eukaryotic host cells that produce isoprenoid precursors or isoprenoid compounds. A subject genetically modified host cell comprises increased activity levels of one or more of mevalonate pathway enzymes, increased levels of prenyltransferase activity, and decreased levels of squalene synthase activity. Methods are provided for the production of an isoprenoid compound or an isoprenoid precursor in a subject genetically modified eukaryotic host cell. The methods generally involve culturing a subject genetically modified host cell under conditions that promote production of high levels of an isoprenoid or isoprenoid precursor compound.
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| 13 | GENETICALLY MODIFIED HOST CELLS AND USE OF SAME FOR PRODUCING ISOPRENOID COMPOUNDS | EP05775484.8 | 2005-07-21 | EP1778831A1 | 2007-05-02 | KEASLING, Jay D.; PARADISE, Eric M.; KIRBY, James |
| The present invention provides genetically modified eukaryotic host cells that produce isoprenoid precursors or isoprenoid compounds. A subject genetically modified host cell comprises increased activity levels of one or more of mevalonate pathway enzymes, increased levels of prenyltransferase activity, and decreased levels of squalene synthase activity. Methods are provided for the production of an isoprenoid compound or an isoprenoid precursor in a subject genetically modified eukaryotic host cell. The methods generally involve culturing a subject genetically modified host cell under conditions that promote production of high levels of an isoprenoid or isoprenoid precursor compound. | ||||||
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