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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
41	UTILIZATION OF PHOSPHOKETOLASE IN THE PRODUCTION OF MEVALONATE, ISOPRENOID PRECURSORS, AND ISOPRENE	US14625487	2015-02-18	US20150225744A1	2015-08-13	Zachary Q. BECK; Andrew C. Eliot; Caroline M. Peres; Dmitrii V. Vaviline
The invention provides for methods for the production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in cells via the heterologous expression of phosphoketolase enzymes.
42	Biosynthetic Systems Producing Fungal Indole Alkaloids	US14390360	2013-04-03	US20150044735A1	2015-02-12	Shengying Li; Krithika Anand Srinivasan; Robert M. Williams; David H. Sherman
The biosynthesis of fungal bicyclo[2.2.2]diazaoctane indole alkaloids with a wide spectrum of biological activities have attracted increasing interest. Their intriguing mode of assembly has long been proposed to feature a non-ribosomal peptide synthetase, a presumed intramolecular Diels-Alderase, a variant number of prenyltransferases, and a series of oxidases responsible for the diverse tailoring modifications of their cyclodipeptide-based structural core. Until recently, the details of these biosynthetic pathways have remained largely unknown due to lack of information on the fungal derived biosynthetic gene clusters. Herein, we report a comparative analysis of four natural product metabolic systems of a select group of bicyclo[2.2.2]diazaoctane indole alkaloids including (+)/(−)-notoamide, paraherquamide and malbrancheamide, in which we propose an enzyme for each step in the biosynthetic pathway based on deep annotation and on-going biochemical studies.
43	METHODS FOR PRODUCING ISOBUTENE FROM 3-METHYLCROTONIC ACID	EP16809650.1	2016-11-17	EP3377639A2	2018-09-26	ALLARD, Mathieu; ANISSIMOVA, Maria; MARLIERE, Philippe
Described are methods for the production of isobutene comprising the enzymatic conversion of 3-methylcrotonic acid into isobutene wherein said 3-methylcrotonic acid is obtained by the enzymatic conversion of 3-methylcrotonyl-CoA into 3- methylcrotonic acid or wherein said 3-methylcrotonic acid is obtained by the enzymatic conversion of 3-hydroxyisovalerate (HIV) into 3-methylcrotonic acid. It is described that the enzymatic conversion of 3-methylcrotonic acid into isobutene can, e.g., be achieved by making use of a 3-methylcrotonic acid decarboxylase, preferably an FMN-dependent decarboxylase associated with an FMN prenyl transferase, an aconitate decarboxylase (EC 4.1.1.6), a methylcrotonyl-CoA carboxylase (EC 6.4.1.4), or a geranoyl-CoA carboxylase (EC 6.4.1.5).
44	CYTOKININ SYNTHASE ENZYMES, CONSTRUCTS, AND RELATED METHODS	EP15796311	2015-05-21	EP3146055A4	2017-10-25	BEESON IV WILLIAM T; WESTFALL PATRICK JOHN
The present disclosure relates to a new class of cytokinin biosynthetic enzymes, cytokinin synthases, which have two domains: an isopentenyl transfer (IPT)-like domain and a cytokinin nucleotide phosphoribohydrolase (PRH)-like domain. The invention provides compositions and methods for the recombinant production of cytokinin synthase, host cells and transformants that include the cytokinin synthases, as well as compositions and formulations that include the disclosed cytokinin synthase.
45	METHODS FOR RECOMBINANT PRODUCTION OF SAFFRON COMPOUNDS	EP15708225.6	2015-03-06	EP3114210A2	2017-01-11	KUMAR, A.S. Sathish
Recombinant microorganisms and methods for producing saffron compounds including crocetin, crocetin dialdehyde, crocin or picrocrocin are disclosed herein.
46	METHOD FOR PRODUCING TERPENES	EP13788057	2013-05-13	EP2847331A4	2015-11-25	BROMANN KIRSI; TOIVARI MERVI; NAKARI-SETÄLÄ TIINA; RUOHONEN LAURA
The present invention concerns a method for producing terpenes in fungi comprising the steps of (a) providing a modified terpene biosynthetic gene cluster inside a host cell, wherein one or more of the naturally occurring genes or promoters of the cluster have been replaced, truncated or removed, (b) providing a transcription factor inside the host cell, the transcription factor activating the terpene biosynthetic gene cluster; (c) cultivating said host in conditions allowing the expression of the transcription factor activating the cluster; and optionally (d) recovering the thus produced terpene product.
47	METHOD FOR PRODUCING TERPENES	EP13788057.1	2013-05-13	EP2847331A1	2015-03-18	BROMANN, Kirsi; TOIVARI, Mervi; NAKARI-SETÄLÄ, Tiina; RUOHONEN, Laura
The present invention concerns a method for producing terpenes in fungi comprising the steps of (a) providing a modified terpene biosynthetic gene cluster inside a host cell, wherein one or more of the naturally occurring genes or promoters of the cluster have been replaced, truncated or removed, (b) providing a transcription factor inside the host cell, the transcription factor activating the terpene biosynthetic gene cluster; (c) cultivating said host in conditions allowing the expression of the transcription factor activating the cluster; and optionally (d) recovering the thus produced terpene product.
48	NUCLEIC ACID STRUCTURE CONTAINING A PYRIPYROPENE BIOSYNTHESIS GENE CLUSTER AND A MARKER GENE	EP11736900	2011-01-19	EP2530149A4	2014-01-15	AIHARA SATO; SUMIDA NAOMI; MURASHIMA KOICHIRO; YANAI KOUJI; ANZAI HIROYUKI; YAMAMOTO KENTARO

49	METHOD FOR MANUFACTURING A PYRIPYROPENE	EP11736899	2011-01-19	EP2530164A4	2013-12-25	ANZAI HIROYUKI; YAMAMOTO KENTARO; OYAMA KAZUHIKO; TSUCHIDA MARIKO; GOTO KIMIHIKO; MITOMI MASAAKI
There is provided a method for culturing a microorganism in which a particular polynucleotide or a recombinant vector comprising it/them is introduced with an intermediate compound necessary for biosynthesis of pyripyropene A. The method of the present invention allows for the production of pyripyropene.
50	CYTOKININ SYNTHASE ENZYMES, CONSTRUCTS, AND RELATED METHODS	EP15796311.7	2015-05-21	EP3146055A2	2017-03-29	BEESON, IV, William T.; WESTFALL, Patrick John
The present disclosure relates to a new class of cytokinin biosynthetic enzymes, cytokinin synthases, which have two domains: an isopentenyl transfer (IPT)-like domain and a cytokinin nucleotide phosphoribohydrolase (PRH)-like domain. The invention provides compositions and methods for the recombinant production of cytokinin synthase, host cells and transformants that include the cytokinin synthases, as well as compositions and formulations that include the disclosed cytokinin synthase.
51	PLANTS HAVING INCREASED TOLERANCE TO HERBICIDES	EP14791106	2014-04-28	EP2992090A4	2017-01-11	PASTERNAK MACIEJ; TRESCH STEFAN; KRAUS HELMUT; HUTZLER JOHANNES; LERCHL JENS; MIETZNER THOMAS; PAULIK JILL MARIE
The present invention refers to a method for controlling undesired vegetation at a plant cultivation site, the method comprising the steps of providing, at said site, a plant that comprises at least one nucleic acid comprising a nucleotide sequence encoding a wild-type hydroxyphenyl pyruvate dioxygenase or a mutated hydroxyphenyl pyruvate dioxygenase (mut-HPPD) which is resistant or tolerant to a HPPD-inhibiting herbicide and/or a nucleotide sequence encoding a wild-type homogentisate solanesyl transferase or a mutated homogentisate solanesyl transferase (mut-HST) which is resistant or tolerant to a HPPD-inhibiting herbicide, applying to said site an effective amount of said herbicide. The invention further refers to plants comprising mut-HPPD, and methods of obtaining such plants.
52	GENES AND PROCESSES FOR THE PRODUCTION OF CLAVINE-TYPE ALKALOIDS	EP13831449	2013-08-13	EP2888351A4	2016-04-27	NAESBY MICHAEL; FOLLY CHRISTOPHE; NIELSEN CURT AIMÉ FRIIS; HATSCH ANAELLE; SCHWAB MARKUS; ZELDER OSKAR; HAEFNER STEFAN; SCHRÖDER HARTWIG; HOFF BIRGIT; MOLT ANDREA; DITRICH KLAUS; BREUER MICHAEL; HARTMANN HOLGER; KÖRBER KARSTEN
Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.
53	GENES AND PROCESSES FOR THE PRODUCTION OF CLAVINE-TYPE ALKALOIDS	EP13831449.7	2013-08-13	EP2888351A2	2015-07-01	NAESBY, Michael; FOLLY, Christophe; NIELSEN, Curt Aimé Friis; HATSCH, Anaelle; SCHWAB, Markus; ZELDER, Oskar; HAEFNER, Stefan; SCHRÖDER, Hartwig; HOFF, Birgit; MOLT, Andrea; DITRICH, Klaus; BREUER, Michael; HARTMANN, Holger; KÖRBER, Karsten
Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.
54	METHODS FOR STABILIZING PRODUCTION OF ACETYL-COENZYME A DERIVED COMPOUNDS	EP13750244.9	2013-08-07	EP2882856A1	2015-06-17	JIANG, Hanxiao; MEADOWS, Adam
The present disclosure relates to the use of a switch for the production of heterologous non-catabolic compounds in microbial host cells. In one aspect, provided herein are genetically modified microorganisms that produce non-catabolic compounds more stably when serially cultured under aerobic conditions followed by microaerobic conditions, and methods of producing non-catabolic compounds by culturing the genetically modified microbes under such culture conditions. In another aspect, provided herein are genetically modified microorganisms that produce non-catabolic compounds more stably when serially cultured in the presence of maltose followed by the reduction or absence of maltose, and methods of producing non-catabolic compounds by culturing the genetically modified microbes under such culture conditions.
55	METHOD FOR MANUFACTURING A PYRIPYROPENE	EP11736899.3	2011-01-19	EP2530164A1	2012-12-05	ANZAI Hiroyuki; YAMAMOTO Kentaro; OYAMA Kazuhiko; TSUCHIDA Mariko; GOTO Kimihiko; MITOMI Masaaki
There is provided a method for culturing a microorganism in which a particular polynucleotide or a recombinant vector comprising it/them is introduced with an intermediate compound necessary for biosynthesis of pyripyropene A. The method of the present invention allows for the production of pyripyropene.
56	미어신 생산용 벡터 및 균주, 및 이를 이용한 미어신의 생산방법	KR1020150097250	2015-07-08	KR101782891B1	2017-09-29	우한민; 김은미; 엄영순; 공경택; 이선미; 김연제
본명세서에는미어신을발현시킬수 있는발현벡터, 상기벡터로형질전환되어향상된미어신생산능을갖는대장균균주, 이를이용한미어신의생산방법및 글리세롤의재활용방법이개시된다. 일측면에있어서, 본발명의형질전환된대장균() 균주는, 글리세롤또는포도당을탄소원으로사용하여, 대량의미어신을고순도로생산할수 있다. 또한, 본발명의대장균균주는폐글리세롤을탄소원으로사용하여, 고부가가치의미어신을생산할수 있으므로, 경제적이고, 친환경적이다. 또한, 휘발성이강한미어신을생산과동시에분리할수 있는장점이있다.
57	시토키닌 신타제 효소, 구축물, 및 관련 방법	KR1020167031965	2015-05-21	KR1020170007299A	2017-01-18	비슨윌리엄티4세; 웨스트폴패트릭존
본개시내용은하기 2개의도메인: 이소펜테닐트랜스퍼라제 (IPT)-유사도메인및 시토키닌뉴클레오티드포스포리보히드롤라제 (PRH)-유사도메인을갖는새로운부류의시토키닌생합성효소인시토키닌신타제에관한것이다. 본발명은시토키닌신타제의재조합생산을위한조성물및 방법, 상기시토키닌신타제를포함하는숙주세포및 형질전환체, 뿐만아니라개시된시토키닌신타제를포함하는조성물및 제제를제공한다.
58	Method for producing terpenes	US14400346	2013-05-13	US10072279B2	2018-09-11	Kirsi Bromann; Mervi Toivari; Tiina Nakari-Setälä; Laura Ruohonen
The present invention concerns a method for producing terpenes in fungi comprising the steps of (a) providing a modified terpene biosynthetic gene cluster inside a host cell, wherein one or more of the naturally occurring genes or promoters of the cluster have been replaced, truncated or removed, (b) providing a transcription factor inside the host cell, the transcription factor activating the terpene biosynthetic gene cluster; (c) cultivating said host in conditions allowing the expression of the transcription factor activating the cluster; and optionally (d) recovering the thus produced terpene product.
59	GERANYLGERANYL PYROPHOSPHATE SYNTHASE	US15567620	2016-04-21	US20180132515A1	2018-05-17	ADAM G. LAWRENCE; JOHN ROYER
The present invention relates to a recombinant host capable of producing a steviol glycoside comprising a recombinant nucleic acid sequence encoding a polypeptide having geranylgeranyl pyrophosphate (GGPP) synthase activity which comprises the amino acid sequence set forth in SEQ ID NO: 1 or an amino acid sequence having at least about 45% sequence identity thereto.
60	Production of cannabinoids in yeast	US14795816	2015-07-09	US09822384B2	2017-11-21	Jason L. Poulos; Anthony N. Farnia
Exemplary embodiments provided herein include genetically engineering microorganisms, such as yeast or bacteria, to produce cannabinoids by inserting genes that produce the appropriate enzymes for the metabolic production of a desired compound.

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