| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 生产O-磷酸丝氨酸的微生物和使用该微生物由O-磷酸丝氨酸生产L-半胱氨酸或其衍生物的方法 | CN201180002042.3 | 2011-10-18 | CN102906272B | 2016-07-06 | 申秀安; 严惠媛; 张真淑; 裵贤爱; 全成后; 赵宰贤; 宋秉哲; 李京珉; 梁殷彬; 申容旭; 金蕙园; 金率 |
| 本发明涉及用O-磷酸丝氨酸作为中间体生产半胱氨酸或其衍生物的方法以及用于生产O-磷酸丝氨酸的重组微生物。 | ||||||
| 2 | 生产O-磷酸丝氨酸的微生物和使用该微生物由O-磷酸丝氨酸生产L-半胱氨酸或其衍生物的方法 | CN201180002042.3 | 2011-10-18 | CN102906272A | 2013-01-30 | 申秀安; 严惠媛; 张真淑; 裵贤爱; 全成后; 赵宰贤; 宋秉哲; 李京珉; 梁殷彬; 申容旭; 金蕙园; 金率 |
| 本发明涉及用O-磷酸丝氨酸作为中间体生产半胱氨酸或其衍生物的方法以及用于生产O-磷酸丝氨酸的重组微生物。 | ||||||
| 3 | 利用新O-磷酸丝氨酸巯解酶生产半胱氨酸或其衍生物的方法 | CN201280067058.7 | 2012-12-14 | CN104039963B | 2016-08-31 | 宋秉哲; 张真淑; 赵宰贤; 金蕙园 |
| 本发明涉及一种利用新O-磷酸丝氨酸巯解酶来生产半胱氨酸或其衍生物的方法。根据本发明提供一种利用新O-磷酸丝氨酸巯解酶以O-磷酸丝氨酸为底物生产半胱氨酸的方法，从而具有可利用该方法用简便的方法以高收率容易地生产环保的半胱氨酸的优点。 | ||||||
| 4 | O-磷酸丝氨酸巯解酶突变体以及利用其生产半胱氨酸的方法 | CN201180002041.9 | 2011-10-14 | CN102741400B | 2015-03-18 | 申秀安; 张真淑; 严惠媛; 赵宰贤; 宋秉哲; 李京珉 |
| 本发明公开了一种具有源自耻垢分枝杆菌(Mycobacterium smegmatis)的对应于SEQ ID NO：1氨基酸序列的O-磷酸丝氨酸巯解酶(OPSS)突变体，其缺失三至七个C-末端氨基酸残基。此外，本发明还公开了编码OPSS突变体的核酸分子、含有该核酸分子的表达载体，以及用该表达载体转化得到的转化体。此外，本发明提供一种生产半胱氨酸的方法，其中在OPSS突变体存在下，使O-磷酰-L-丝氨酸(OPS)与硫化物发生反应。OPSS突变体具有改善的酶活性，可通过简单的酶转化反应进行L-半胱氨酸的环保生产。 | ||||||
| 5 | 利用新O-磷酸丝氨酸巯解酶生产半胱氨酸或其衍生物的方法 | CN201280067058.7 | 2012-12-14 | CN104039963A | 2014-09-10 | 宋秉哲; 张真淑; 赵宰贤; 金蕙园 |
| 本发明涉及一种利用新O-磷酸丝氨酸巯解酶来生产半胱氨酸或其衍生物的方法。根据本发明提供一种利用新O-磷酸丝氨酸巯解酶以O-磷酸丝氨酸为底物生产半胱氨酸的方法，从而具有可利用该方法用简便的方法以高收率容易地生产环保的半胱氨酸的优点。 | ||||||
| 6 | O-磷酸丝氨酸巯解酶突变体以及利用其生产半胱氨酸的方法 | CN201180002041.9 | 2011-10-14 | CN102741400A | 2012-10-17 | 申秀安; 张真淑; 严惠媛; 赵宰贤; 宋秉哲; 李京珉 |
| 本发明公开了一种具有源自耻垢分枝杆菌(Mycobacterium smegmatis)的对应于SEQ ID NO：1氨基酸序列的O-磷酸丝氨酸巯解酶(OPSS)突变体，其缺失三至七个C-末端氨基酸残基。此外，本发明还公开了编码OPSS突变体的核酸分子、含有该核酸分子的表达载体，以及用该表达载体转化得到的转化体。此外，本发明提供一种生产半胱氨酸的方法，其中在OPSS突变体存在下，使O-磷酰-L-丝氨酸(OPS)与硫化物发生反应。OPSS突变体具有改善的酶活性，可通过简单的酶转化反应进行L-半胱氨酸的环保生产。 | ||||||
| 7 | ENZYME DESTABILIZERS FOR DESTABILIZING ENZYMES PRODUCING SULFUR CONTAINING COMPOUNDS IN DOWNHOLE FLUIDS | US15431200 | 2017-02-13 | US20170233628A1 | 2017-08-17 | Charles David Armstrong |
| Methods and fluid compositions are provided for decreasing an amount of sulfur-containing compounds in downhole fluids and/or subterranean reservoir wellbores by including at least one enzyme destabilizer in a fluid composition. The fluid composition may then be circulated into a subterranean reservoir wellbore. The fluid composition may further include a base fluid and at least one sulfur producing enzyme. The base fluid may be or include, but is not limited to, drilling fluids, servicing fluids, production fluids, completion fluids, injection fluids, refinery fluids, and combinations thereof. The enzyme destabilizer(s) may be destabilize the sulfur producing enzymes and thereby decrease an amount of sulfur-containing compounds produced vis-à-vis the sulfur producing enzyme(s). | ||||||
| 8 | Method for preparing cysteine or a derivative thereof using a novel O-phosphoserine sulfhydrylase | US14365571 | 2012-12-14 | US09243268B2 | 2016-01-26 | Byeong Cheol Song; Jin Sook Chang; Jae Hyun Jo; Hye Won Kim |
| The present invention relates to a method for producing cysteine or derivatives thereof using novel O-phosphoserine sulfhydrylase. According to the present invention, a method for producing cysteine by novel O-phosphoserine sulfhydrylase (OPSS) using O-phosphoserine as a substrate is provided, and this method is advantageous in that cysteine can be simply and environmental-friendly produced in a high yield. | ||||||
| 9 | O-PHOSPHOSERINE SULFHYDRYLASE MUTANTS AND METHOD FOR PRODUCTION OF CYSTEINE USING THE SAME | US13278100 | 2011-10-20 | US20120190080A1 | 2012-07-26 | Soo An SHIN; Jin Sook CHANG; Hye Won UM; Jae Hyun JO; Byeong Cheol SONG; Kyoung Min LEE |
| Disclosed is an O-phosphoserine sulfhydrylase (OPSS) mutant which has a Mycobacterium smegmatis-derived amino acid sequence corresponding to that of SEQ ID NO: 1 which is devoid of three to seven C-terminal amino acid residues. Also, a nucleic acid molecule encoding the OPSS mutant, an expression vector carrying the nucleic acid molecule, and a transformant transformed with the expression vector are disclosed. In addition, a method is provided for producing cysteine in which O-phospho-L-serine (OPS) is reacted with a sulfide in the presence of the OPSS mutant. The OPSS mutant has improved enzymatic activity and can be applied to the environmentally friendly production of L-cysteine through a simple enzymatic conversion reaction. | ||||||
| 10 | Microorganism producing o-phosphoserine and method of producing L-cysteine or derivatives thereof from O-phosphoserine using the same | US13278106 | 2011-10-20 | US09689009B2 | 2017-06-27 | Jin Sook Chang; Jae Hyun Jo; Hyun Ae Bae; Byeong Cheol Song; Sol Kim; Hye Won Kim; Hye Won Um; Sung Hoo Jhon; Yong Uk Shin; Eun Bin Yang; Kyoung Min Lee; Soo An Shin |
| The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase and the activity of PhnC, PhnD, and PhnE is reduced, and enhanced activity of phosphoglycerate dehydrogenase and/or phosphoserine aminotransferase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having these reduced and enhanced properties noted above are also provided herein. | ||||||
| 11 | METHOD FOR PREPARING CYSTEINE OR A DERIVATIVE THEREOF USING A NOVEL O-PHOSPHOSERINE SULFHYDRYLASE | US14365571 | 2012-12-14 | US20150004657A1 | 2015-01-01 | Byeong Cheol Song; Jin Sook Chang; Jae Hyun Jo; Hye Won Kim |
| The present invention relates to a method for producing cysteine or derivatives thereof using novel O-phosphoserine sulfhydrylase. According to the present invention, a method for producing cysteine by novel O-phosphoserine sulfhydrylase (OPSS) using O-phosphoserine as a substrate is provided, and this method is advantageous in that cysteine can be simply and environmental-friendly produced in a high yield. | ||||||
| 12 | MICROORGANISM PRODUCING O-PHOSPHOSERINE AND METHOD OF PRODUCING L-CYSTEINE OR DERIVATIVES THEREOF FROM O-PHOSPHOSERINE USING THE SAME | US13278102 | 2011-10-20 | US20120190081A1 | 2012-07-26 | Jin Sook CHANG; Jae Hyun JO; Hyun Ae BAE; Byeong Cheol SONG; Sol KIM; Hye Won KIM |
| The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having the properties noted above are also provided herein. | ||||||
| 13 | METHOD FOR PREPARING CYSTEINE OR A DERIVATIVE THEREOF USING A NOVEL O-PHOSPHOSERINE SULFHYDRYLASE | EP12858268.1 | 2012-12-14 | EP2792748B1 | 2017-04-26 | SONG, Byeong Cheol; CHANG, Jin Sook; JO, Jae Hyun; KIM, Hye Won |
| 14 | MICROORGANISM PRODUCING O-PHOSPHOSERINE AND A METHOD FOR PRODUCING O-PHOSPHOSERINE OR L-CYSTEINE USING THE SAME | US15329921 | 2015-08-10 | US20170260556A1 | 2017-09-14 | Sol KIM; In Hwa YOO; Jin Sook CHANG; Hye Won KIM |
| The present invention relates to a microorganism, wherein the activity of a polypeptide capable of exporting O-phosphoserine (OPS) is enhanced, and a method of producing O-phosphoserine, cysteine, or a cysteine derivative using the microorganism. | ||||||
| 15 | MICROORGANISM PRODUCING O-PHOSPHOSERINE AND METHOD OF PRODUCING L-CYSTEINE OR DERIVATIVES THEREOF FROM O-PHOSPHOSERINE USING THE SAME | US15276661 | 2016-09-26 | US20170073715A1 | 2017-03-16 | Jin Sook CHANG; Jae Hyun JO; Hyun Ae BAE; Byeong Cheol SONG; Sol KIM; Hye Won KIM |
| The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having the properties noted above are also provided herein. | ||||||
| 16 | O-phosphoserine sulfhydrylase mutants and method for production of cysteine using the same | US13278100 | 2011-10-20 | US09127324B2 | 2015-09-08 | Soo An Shin; Jin Sook Chang; Hye Won Um; Jae Hyun Jo; Byeong Cheol Song; Kyoung Min Lee |
| Disclosed is an O-phosphoserine sulfhydrylase (OPSS) mutant which has a Mycobacterium smegmatis-derived amino acid sequence corresponding to that of SEQ ID NO: 1 which is devoid of three to seven C-terminal amino acid residues. Also, a nucleic acid molecule encoding the OPSS mutant, an expression vector carrying the nucleic acid molecule, and a transformant transformed with the expression vector are disclosed. In addition, a method is provided for producing cysteine in which O-phospho-L-serine (OPS) is reacted with a sulfide in the presence of the OPSS mutant. The OPSS mutant has improved enzymatic activity and can be applied to the environmentally friendly production of L-cysteine through a simple enzymatic conversion reaction. | ||||||
| 17 | Microorganism producing O-phosphoserine and method of producing L-cysteine or derivatives thereof from O-phosphoserine using the same | US13278105 | 2011-10-20 | US08557549B2 | 2013-10-15 | Jin Sook Chang; Jae Hyun Jo; Hyun Ae Bae; Byeong Cheol Song; Sol Kim; Hye Won Kim |
| The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase and enhanced activity of phosphoglycerate dehydrogenase and/or phosphoserine aminotransferase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having the properties noted above are also provided herein. | ||||||
| 18 | MICROORGANISM PRODUCING O-PHOSPHOSERINE AND METHOD OF PRODUCING L-CYSTEINE OR DERIVATIVES THEREOF FROM O-PHOSPHOSERINE USING THE SAME | US13278106 | 2011-10-20 | US20120190083A1 | 2012-07-26 | Jin Sook CHANG; Jae Hyun JO; Hyun Ae BAE; Byeong Cheol SONG; Sol KIM; Hye Won KIM; Hye Won UM; Sung Hoo JHON; Yong Uk SHIN; Eun Bin YANG; Kyoung Min LEE; Soo An SHIN |
| The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase and the activity of PhnC, PhnD, and PhnE is reduced, and enhanced activity of phosphoglycerate dehydrogenase and/or phosphoserine aminotransferase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having these reduced and enhanced properties noted above are also provided herein. | ||||||
| 19 | MICROORGANISM PRODUCING O-PHOSPHOSERINE AND METHOD OF PRODUCING L-CYSTEINE OR DERIVATIVES THEREOF FROM O-PHOSPHOSERINE USING THE SAME | US13278105 | 2011-10-20 | US20120190082A1 | 2012-07-26 | Jin Sook CHANG; Jae Hyun JO; Hyun Ae BAE; Byeong Cheol SONG; Sol KIM; Hye Won KIM |
| The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase and enhanced activity of phosphoglycerate dehydrogenase and/or phosphoserine aminotransferase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having the properties noted above are also provided herein. | ||||||
| 20 | O−ホスホセリンを生産する微生物およびそれを用いてO−ホスホセリンからL−システインまたはその誘導体を生産する方法 | JP2013534806 | 2011-10-18 | JP5805202B2 | 2015-11-04 | シン ス アン; オム ヘイ ウォン; チャン ジン スク; ペ ヒョン エ; ジョン スン ホ; チョ ジェ ヒョン; ソン ビョン チョル; イ キョン ミン; ヤン ウン ビン; シン ヨン ウク; キム ヘイ ウォン; キム ソル |
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