| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 121 | Protein backbone of antibody mimetics and other binding proteins | JP2001563629 | 2001-02-28 | JP4829457B2 | 2011-12-07 | ロバート ジー． クイメリス; ダーサ リポフシェク; リチャード ダブリュ． ワグナー |
| 122 | Generation of artificial binding protein based on the ubiquitin protein | JP2006529936 | 2004-05-27 | JP4803817B2 | 2011-10-26 | フィーデラー、ウルリケ; フィーデラー、マルクス; ルドルフ、ライナー |
| 123 | Generation of artificial binding protein based on ubiquitinprotein | JP2011104112 | 2011-05-09 | JP2011201893A | 2011-10-13 | FIEDLER MARKUS; FIEDLER ULRIKE; RUDOLPH RAINER |
| PROBLEM TO BE SOLVED: To provide modified proteins of proteins having a ubiquitin-like fold motif and expressing a binding affinity with respect to a binding partner.SOLUTION: The modified proteins of the superfamily of ubiquitin-like proteins, proteins having a ubiquitin-like fold, and fragments or fusion proteins thereof, are provided. As a result of the modification, the modified proteins have binding affinity with respect to the predetermined binding partner that has not been previously existed. A method for producing the modified proteins and utilization of the same are also provided. | ||||||
| 124 | Surface display of recombinant proteins in lower eukaryotes | JP2010549709 | 2009-02-20 | JP2011514807A | 2011-05-12 | チヤ，トンシン; ビルト，ステフアン |
| 酵母及び糸状真菌などの下等真核生物の表面上に組換えタンパク質又はタンパク質ライブラリーをディスプレイするための方法が記載されている。 この方法は、ライブラリー中のタンパク質のアレイから所望の特性を有する特定のタンパク質を同定するために、下等真核生物中の組換えタンパク質のライブラリーをスクリーニングするのに有用である。 前記方法は、下等真核生物中に抗体ライブラリーを構築し、スクリーニングするのに特に有用である。 | ||||||
| 125 | Adapter-directed display system | JP2010255231 | 2010-11-15 | JP2011074078A | 2011-04-14 | WANG CAILI; ZHONG PINGYU; WANG XINWEI |
| PROBLEM TO BE SOLVED: To provide an adapter-directed display system for expressing exogenous polypeptide within a host cell and/or displaying the exogenous polypeptide on the outer surface of a genetic package. SOLUTION: This subject systems are particularly useful for displaying a genetically diverse repertoire of monomeric and multimeric polypeptides. The invention also provides both expression and helper vectors and kits containing components of the display systems. Also provided are genetic packages displaying the exogenous polypeptides of particular interest. Further, there is provided method of using the display systems. COPYRIGHT: (C)2011,JPO&INPIT | ||||||
| 126 | Alternate of the scaffolding protein fusion phage display through the fusion to the M13 phage pIX | JP2010539875 | 2008-12-19 | JP2011507529A | 2011-03-10 | ジヤコブス，ステイーブン |
| 本発明は、Ｍ１３ファージのｐＩＸを使用して、非抗体足場タンパク質融合を産生するためのｐＩＸファージ提示ライブラリを作成し、使用するための組成物及び方法に関する。 | ||||||
| 127 | Design and fabrication of Hitodenobo pIX phage display library through the fusion to pIX or pVII, vectors, antibodies, and methods | JP2010539575 | 2008-11-21 | JP2011507519A | 2011-03-10 | アメガジー，バーナード; アルマグロ，ジユアン; ウイーラー，ジヨン; ウイテカー，ブライアン; シー，レイ; スイート，レイモンド; ツイ，ピン; トーネツタ，マーク; ナイト，デイビツド; ボロデイナ−バーチ，リオネラ; ルー，ジン; ルオ，ジンカン; レツデイ，ラマチヤンドラ |
| Described and claimed herein are combinatorial synthetic Fab libraries displayed on a phage pIX protein. The libraries were built on scaffolds representing the most frequently used genes in human antibodies, which were diversified to mirror the variability of natural antibodies. After selection using a diverse panel of proteins, numerous specific and high-affinity Fabs were isolated. By a process called in-line maturation the affinity of some antibodies was improved up to one hundred-fold yielding low pM binders suitable for in vivo use. This work thus demonstrates the feasibility of displaying complex Fab libraries as pIX-fusion proteins for antibody discovery and lays the foundations for studies on the structure-function relationship of antibodies. | ||||||
| 128 | Protein / (poly) peptide library | JP2009218390 | 2009-09-24 | JP4629787B2 | 2011-02-09 | アキム クナピック; リミング ゲ; ピーター パック; アンドレアーズ プラックチェン; シモン モロニー |
| The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries. | ||||||
| 129 | Multi-chain eukaryotic display vector and its use | JP2003532672 | 2002-09-30 | JP4578098B2 | 2010-11-10 | フフトン，シモン・イー; ホーゲンボーム，ヘンドリクス・アール・ジェイ・エム |
| A eukaryotic expression vector capable of displaying a multi-chain polypeptide on the surface of a host cell is provided, such that the biological activity the multi-chain polypeptide is exhibited at the surface of the host cell. Such a vector allows for the display of complex biologically active polypeptides, e.g., biologically active multi-chain polypeptides such as immunoglobulin Fab fragments. The present invention describes and enables the successful display of a multi-chain polypeptide on the surface of a eukaryotic host cell. Preferred vectors are described for expressing the chains of a multi-chain polypeptide in a host cell separately and independently (e.g., under separate vector control elements, and/or on separate expression vectors, thus forming a matched vector set). The use of such matched vector sets provides flexibility and versatility in the generation of eukaryotic display libraries, for example the ability to generate and to display multi-chain polypeptides by combining and recombining vectors that express variegations of the individual chains of a multi-chain polypeptide. Entire repertoires of novel chain combinations can be devised using such vector sets. | ||||||
| 130 | Protein backbone of antibody mimetics and other binding proteins | JP2000587187 | 1999-12-09 | JP4562286B2 | 2010-10-13 | デイサ リポフセク |
| 131 | How to choose a method for manufacturing and protein from the bottom of the protein library | JP2003532674 | 2002-09-27 | JP4553584B2 | 2010-09-29 | キュールヴァイン，トルステン; ブライトリンク，フランク; ポウストカ，アンネマリー; モルデンハウアー，ゲルハルト; ザンドラ リュットガウ， |
| 132 | Method to screen phage display library with different ligand | JP2010074518 | 2010-03-29 | JP2010195798A | 2010-09-09 | TOMLINSON IAN; WINTER GREG |
| <P>PROBLEM TO BE SOLVED: To provide a method for selecting repertoires of polypeptides by using generic ligands and target ligands. <P>SOLUTION: The present invention relates to the method for selecting, from a repertoire of polypeptides, a population of functional polypeptides which bind a target ligand in a first binding site and to a generic ligand in a second binding site (wherein the generic ligand is capable of binding a functional member of the repertoire regardless of the target ligand specificity), and the method includes the steps of: (a) bringing the repertoire into contact with the generic ligand and selecting functional polypeptides bound thereto; and (b) bringing the selected functional polypeptides into contact with the target ligand and selecting a population of polypeptides with bind to the target ligand. <P>COPYRIGHT: (C)2010,JPO&INPIT | ||||||
| 133 | Vectors for gene mutagenesis and gene discovery by gene trapping | JP2000584047 | 1999-11-19 | JP4541555B2 | 2010-09-08 | ティー． サンズ，アーサー; ザンブロウィッズ，ブリアン; エー． フレドリック，グレン; リルレバーグ，スタン |
| 134 | The screening method of phage display libraries with a variety of ligands | JP2000517070 | 1998-10-20 | JP4514949B2 | 2010-07-28 | ウィンター，グレッグ; トムリンソン，イアン |
| 135 | Selection system | JP2009294773 | 2009-12-25 | JP2010148507A | 2010-07-08 | RIECHMANN LUTZ; KRISTENSEN PETER; JESTIN JEAN-LUC; WINTER GREGORY PAUL |
| <P>PROBLEM TO BE SOLVED: To provide a method for using peptide cleavage to exclude undesired virus for the purpose of enabling polypeptides displayed in a phage display system to be selected. <P>SOLUTION: The method for selecting a virus includes: the steps of: (a) providing a virus encoding and displaying a fusion polypeptide comprising a heterologous polypeptide inserted into the sequence of a viral coat protein polypeptide, wherein the virus contains a cleavable site located within a displayed polypeptide; (b) exposing the virus to a cleaving agent; and (c) proliferating the virus comprising intact fusion protein. <P>COPYRIGHT: (C)2010,JPO&INPIT | ||||||
| 136 | Protein/(poly)peptide library | JP2009218390 | 2009-09-24 | JP2010029198A | 2010-02-12 | KNAPPIK ACHIM; PACK PETER; GE LIMING; MORONEY SIMON; PLUECKTHUN ANDREAS |
| <P>PROBLEM TO BE SOLVED: To provide synthetic DNA sequences encoding one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. <P>SOLUTION: A library of human-derived antibody genes is prepared by using synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, a single consensus antibody gene is used as a universal framework for highly diverse antibody libraries. <P>COPYRIGHT: (C)2010,JPO&INPIT | ||||||
| 137 | Protein, how to use the nucleic acid and associated encoding it | JP2009519512 | 2007-07-11 | JP2009543551A | 2009-12-10 | ヴァイスレーダー，ノア; チャイ，チュアンシー; マー，ジャンジエ |
| 新規ポリペプチドをコードする核酸配列が本明細書に開示される。 これらの核酸配列によってコードされるポリペプチド、該ポリペプチドに免疫特異的に結合する抗体、および上記ポリペプチド、ポリヌクレオチド、または抗体の誘導体、変異形、突然変異体、またはフラグメントも開示される。 本発明はさらに、これらの新規ヒト核酸およびタンパク質のいずれか１つが関与する障害の診断、処置、および予防のための治療、診断および研究の方法を開示する。 | ||||||
| 138 | Method for screening a peptide display library using a mini-cell display | JP2002571815 | 2002-03-06 | JP4295513B2 | 2009-07-15 | サミー アシュカー， |
| 139 | Nucleic-acid-bonded polypeptide library | JP2008278701 | 2008-10-29 | JP2009079063A | 2009-04-16 | CHOO YEN; KLUG AARON; ISALAN MARK |
| <P>PROBLEM TO BE SOLVED: To provide a zinc finger polypeptide library containing one or more zinc fingers where each polypeptide is at least partially randomized. <P>SOLUTION: The zinc finger polypeptide library containing one or more zinc fingers where each polypeptide is at least partially randomized and a zinc finger polypeptide library set that cords overlapping zinc finger polypeptide are provided. The selected polypeptide can be assembled into a zinc finger polypeptide having a multiple finger. <P>COPYRIGHT: (C)2009,JPO&INPIT | ||||||
| 140 | Method for identification, isolation and production of antigen to specific pathogen | JP2008152742 | 2008-06-11 | JP2008291035A | 2008-12-04 | MEINKE ANDREAS; NAGY ESZTER; VON AHSEN UWE; KLADE CHRISTOPH; HENICS TAMAS; ZAUNER WOLFGANG; MINH DUC BUI; VYTVYTSKA ORESTA; ETZ HILDEGARD; DRYLA AGNIESZKA; WEICHHART THOMAS; HAFNER MARTIN; TEMPELMAIER BRIGITTE; FRASER CLAIRE M; GILL STEVEN |
| <P>PROBLEM TO BE SOLVED: To provide a method for identifying antigens effective to a given pathogen or preferably practically (clinically) relating almost complete set of all antigens of given pathogen. <P>SOLUTION: Disclosed are hyperimmune serum-reactive antigens selected from a group comprising Staphylococcus aureus-originating specific sequences; the use of the antigens for production of pharmaceutical preparation; hyperimmune fragments of the antigens reactive to the hyperimmune serum; vaccines containing the antigens or the fragments; the preparation containing antibodies to the antigens or the fragments; a method for production of the preparation; and the use of the preparation for production of a pharmaceutical. <P>COPYRIGHT: (C)2009,JPO&INPIT | ||||||
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