| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 81 | 磁性ナノ粒子、磁性検出器アレイ、および生物学的分子の検出におけるそれらの使用方法 | JP2015075418 | 2015-04-01 | JP2015163882A | 2015-09-10 | シャン・エックス・ワン; ロバート・エル・ホワイト; クリス・ディ・ウェブ; リ・グアンション |
| 【課題】生物学的分子の検出における磁性ナノ粒子およびそれらの好感度な使用方法を提供する。 【解決手段】少なくとも1つの磁化可能ナノ粒子に共有結合している第1の分子を提供する工程;基体に共有結合している第2の分子を提供する工程;該第1の分子の該第2の分子への選択的結合に適する条件下において、該第1の分子を該第2の分子と接触させ、複合体を形成させる工程;および該複合体を検出する工程を含む。磁性ナノ粒子は核酸分子に連結することができ、続いてスピンバルブ検出器または磁気トンネルジャンクション検出器のような検出器に連結している相補的配列により捕捉される。結合した磁性ナノ粒子の検出は、高い特異性および感度で達成できる。 【選択図】図2A |
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| 82 | DNAコード化ライブラリを作製およびスクリーニングする方法 | JP2011550313 | 2010-02-16 | JP5770641B2 | 2015-08-26 | ワグナー リチャード ダブリュ. |
| 83 | Production method and quantification method using the fluorescent dye compound containing colloidal silica particles | JP2009284588 | 2009-12-15 | JP5356204B2 | 2013-12-04 | 英樹 會澤; 典雄 大久保; 教泰 中村; 弘一 三好 |
| Colloidal silica particles containing a fluorescent dye compound, composed of a silica particle containing a silica component and a fluorescent dye compound chemically bound or adsorbed thereto, wherein the colloidal silica particles containing a fluorescent dye compound have an average diameter of 30 nm or less, and wherein said silica particles are used simultaneously as fluorescent-labelling nanobeads; a fluorescent nano-material comprising said colloidal silica particles; and a biochip and an assay method using the same. | ||||||
| 84 | Methods for their use in the magnetic detector array, and detection of biological molecules | JP2006540017 | 2004-11-12 | JP5161459B2 | 2013-03-13 | シャン・エックス・ワン; ロバート・エル・ホワイト; クリス・ディ・ウェブ; リ・グアンション |
| 85 | Methods for making and screening Dna encoding library | JP2011550313 | 2010-02-16 | JP2012517812A | 2012-08-09 | リチャード ダブリュ． ワグナー |
| 本発明は、生物学的標的に結合する1つまたは複数の化合物を同定するための多数の方法を特徴とする。 本方法には、1つまたは複数の多様性位置を有する機能的成分を含有する化合物のライブラリを合成する段階が含まれる。 化合物の機能的成分は、該機能的成分の構造を識別するイニシエーターオリゴヌクレオチドに機能的に連結される。 | ||||||
| 86 | Surface adhesion products | JP2010550180 | 2009-03-10 | JP2011514972A | 2011-05-12 | コリン・キャンベル; ティル・バックマン; ホルガー・シュルツェ |
| Provided is a method of attaching a substance to a surface, which method comprises contacting a surface comprising amine reactive groups with a substance labelled with a peptide tag such that the substance is covalently attached to the surface via the peptide tag, wherein the peptide tag comprises one or more histidine residues, one of which is a terminal histidine residue having a free N-terminal amino group. Also provided is a method of processing or analysis which comprises a method of attaching a substance to a surface as detailed above and comprises one or more further steps of processing or analysing the substance. The present invention further provides a method of processing or analysis comprising the steps of: a) attaching a substance to a surface by a method as defined above b) contacting the surface with a sample comprising an analyte in order that the analyte in the sample binds to the substance attached to the surface; and c) processing and/or analysing the analyte | ||||||
| 87 | The method for making complementary oligonucleotide tag set | JP2000579783 | 1999-11-01 | JP4651196B2 | 2011-03-16 | スティーブン アール． ウィリアム，; ジェームス ジェイ． カーチナー，; ロバート ビー． ダブリッジ， |
| 88 | Method of screen ring of material of micro-well in the array | JP2008103292 | 2008-04-11 | JP4607202B2 | 2011-01-05 | カニガン、ターニャ・エス; ハンター、イアン・ダブリュー; ブレナン、コリン・ジェイ・エイチ |
| 89 | Microarray and a method for performing hybridization reaction of a large number of samples on a single microarray | JP2004508254 | 2003-05-23 | JP4544989B2 | 2010-09-15 | トーマス アルバート; マーク マコーミック |
| 90 | Molecular tag system | JP2003350142 | 2003-10-08 | JP4480380B2 | 2010-06-16 | ブレンナー シドニー |
| The invention provides a method of tracking, identifying, and/or sorting classes or subpopulations of molecules by the use of oligonucleotide tags. Oligonucleotide tags of the invention each consist of a plurality of subunits 3 to 6 nucleotides in length selected from a minimally cross-hybridizing set. A subunit of a minimally cross-hybridizing set forms a duplex or triplex having two or more mismatches with the complement of any other subunit of the same set. The number of oligonucleolicle tags available in a particular embodiment depends on the number of subunits per tag and on the length of the subunit. An important aspect of the invention is the use of the oligonucleotide tags for sorting polynucleotides by specifically hybridizing tags attached to the polynucleotides to their complements on solid phase supports. This embodiment provides a readily automated system for manipulating and sorting polynucleotides, particularly useful in large-scale parallel operations, such as large-scale DNA sequencing, mRNA fingerprinting, and the like, wherein many target polynucleotides or many segments of a single target polynucleotide are sequenced simultaneously. | ||||||
| 91 | Beads distributed system | JP2005121751 | 2005-04-19 | JP4451809B2 | 2010-04-14 | エス． バン チャールズ; レートー デニス |
| 92 | Raw inspection technology | JP2000573846 | 1999-09-17 | JP4377069B2 | 2009-12-02 | イングランド，ジェイムズ; コルビー，エドワード; デイムス，アンドリュー |
| 93 | Method and compound for analyzing nucleic acid by mass spectrometry | JP2009098483 | 2009-04-14 | JP2009159985A | 2009-07-23 | VAN NESS JEFFREY; TABONE JOHN C; HOWBERT JEFFRY; MULLIGAN JOHN T |
| <P>PROBLEM TO BE SOLVED: To provide a composition and a method which can be utilized for wide variety of ligand pair reactions in which separation of target molecules based on size is required. <P>SOLUTION: A compound is represented by the formula: T<SP>ms</SP>-L-X, wherein T<SP>ms</SP>is an organic group which is detectable by mass spectrometry and contains carbon, at least one of hydrogen and fluoride and optional atoms selected from oxygen, nitrogen, sulfur, phosphorus and iodine; L is an organic group which allows a unique T<SP>ms</SP>-containing moiety to be cleaved from the remainder of the compound, wherein the T<SP>ms</SP>-containing moiety comprises a functional group which supports a single ionized charge state when the compound is subjected to mass spectrometry and is tertiary amine, quaternary amine or organic acid; and X is a functional group selected from phosphoramidite and H-phosphonate. <P>COPYRIGHT: (C)2009,JPO&INPIT | ||||||
| 94 | Combinatorial synthesis of novel material | JP2008278793 | 2008-10-29 | JP2009155319A | 2009-07-16 | SCHULTZ PETER G; XIANG XIAO-DONG; GOLDWASSER ISY; BRICENO GABRIEL; SUN XIAO-DONG; WANG KAI-AN |
| <P>PROBLEM TO BE SOLVED: To provide a device for preparing giant magnetoresistive cobalt oxide compounds by combinatorial synthesis. <P>SOLUTION: Combinatorial synthesis is done by using a substrate having an array of diverse materials thereon prepared by delivering components to predefined regions on the substrate and simultaneously reacting the components to form at least two materials. Other materials that can be prepared using these methods are covalent network solids, ionic solids and molecular solids. Examples are inorganic, organometallic, intermetallic, ceramic organic polymeric and composite materials. Once prepared, these materials can be screened for useful properties such as magnetoresistance. Thus, the materials parallel synthesize and decompose of novel material having useful properties. <P>COPYRIGHT: (C)2009,JPO&INPIT | ||||||
| 95 | Method for screening substance in microwell array | JP2008237574 | 2008-09-17 | JP2009096992A | 2009-05-07 | HUNTER IAN W; BRENAN COLIN J H; KANIGAN TANYA S |
| <P>PROBLEM TO BE SOLVED: To provide a method for hydrophobizing treatment of a platen surface by which, when contents are filled in array-like through-holes formed in the platen, the contents are prevented from flowing into an adjacent hole, in an apparatus which manipulates and analyzes materials including cells present in a liquid or suspension as a large number of microscopic samples. <P>SOLUTION: This method is for providing hydrophobic coating to a silicon platen having first and second surfaces, which are substantially parallel to each other, and a plurality of through-holes disposed substantially orthogonal to the surface. The method comprises a step (a) of oxidizing the first surface, a step (b) of cleaning the oxidized first surface, a step (c) of applying a positive pressure of an inert gas to the plurality of through-holes from the direction of the second surface, and a step (d) of exposing the first surface to a vapor of a silane coupling agent. <P>COPYRIGHT: (C)2009,JPO&INPIT | ||||||
| 96 | Biomolecules board as well as the inspection using the same and diagnostic method and apparatus | JP2002589680 | 2002-05-10 | JP4220251B2 | 2009-02-04 | 光昭 大嶋 |
| 97 | Clinically intelligent diagnostic apparatus and method | JP2002544663 | 2001-11-27 | JP4179876B2 | 2008-11-12 | ビニート グプタ; アリス アン ジャコブス; ボリス ニコリック |
| The present invention is related to a method of determining a cause of one or more medical symptoms exhibited by a subject, the method comprising: (a) obtaining a biological sample from the subject; (b) obtaining an array of different probes or different sets of probes, wherein each probe or set of probes selectively interacts with a target associated with a different known cause of the one or more medical symptoms; (c) applying the biological sample to the probes in the array under conditions that enable all of the probes to selectively interact with any targets in the biological sample; (d) detecting interactions; and (e) analyzing interactions to determine a cause of the one or more medical symptoms. | ||||||
| 98 | Method for screening substance in microwell array | JP2008103292 | 2008-04-11 | JP2008268202A | 2008-11-06 | HUNTER IAN W; BRENAN COLIN J H; KANIGAN TANYA S |
| <P>PROBLEM TO BE SOLVED: To provide a method for manufacturing and using an apparatus for manipulating and analyzing a material, including cells existing in a liquid and suspension as a large quantity of microscopic samples. <P>SOLUTION: Parallel through-holes are formed in a platen, and loaded with liquid. Loading may be performed in such a way as to create a gradient, with respect to the position of the through-holes, of the concentration of a specified substance or of other physical quantity. By bringing filled microwell arrays into contact with each other, with the registration of the individual through-holes, mixing of the contents of the through-holes may be obtained. <P>COPYRIGHT: (C)2009,JPO&INPIT | ||||||
| 99 | Bio-molecular substrate and method and apparatus for examination and diagnosis using the same | JP2008101151 | 2008-04-09 | JP2008249711A | 2008-10-16 | OSHIMA MITSUAKI |
| <P>PROBLEM TO BE SOLVED: To provide a method capable of creating a substrate with an inaccurate device and inspecting it with an inaccurate inspection device. <P>SOLUTION: A substrate is used on which a plurality of bio-molecular spots containing a group of bio-molecules (e.g., DNA, etc.) of a specific type are formed. The pattern or position of the biomolecule spot is changed depending on specific data so that information of the specific data is recorded on the substrate. <P>COPYRIGHT: (C)2009,JPO&INPIT | ||||||
| 100 | Encoded combinatorial chemical library | JP2007280398 | 2007-10-29 | JP2008136483A | 2008-06-19 | LERNER RICHARD; JANDA KIM; BRENNER SYDNEY; NIELSEN JOHN |
| <P>PROBLEM TO BE SOLVED: To provide an encoded chemical library composed of accumulation of chemical structures defining diversity of biological structures. <P>SOLUTION: An encoded combinatorial chemical library composed of a plurality of bifunctional molecules having both a chemical polymer and an identifier oligonucleotide sequence defining the structure of the chemical polymer, is provided. Further, bifunctional molecules in the library and methods of using the library to identify chemical structures within the library that bind to biologically active molecules in preselected binding interactions, are also provided. <P>COPYRIGHT: (C)2008,JPO&INPIT | ||||||
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