专利检索_ .NAD+或NADP+作为受体专利检索_ .NAD+或NADP+作为受体专利检索查询

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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
1	化学产品的微生物生产以及相关的组合物、方法和系统	CN201280024996.9	2012-03-22	CN103562398A	2014-02-05	迈克尔·D·林奇; 坦尼娅·E·W·利普斯科布; 阿什利·D·塔汉; 埃玛·辛格; 特拉维斯·沃尔特
本文公开了代谢工程化微生物菌株，如细菌菌株，其中存在增加的用于生产化学产品的丙二酰辅酶A利用。这类化学产品包括聚酮化合物、3-羟基丙酸和本文所述的各种其他化学产品。生产方法还可应用于进一步的下游产品，如消费品。在各种实施方案中，对微生物和/或培养系统的修饰至少暂时地将丙二酰辅酶A的应用从脂肪酸生物合成途径转移，从而提供丙二酰辅酶A用于除脂肪酸以外的化学产品的应用。在各种实施方案中，调节脂肪酸生物合成途径以产生特定脂肪酸或脂肪酸的组合。
2	MICROBIAL PRODUCTION OF CHEMICAL PRODUCTS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS	US16030262	2018-07-09	US20180312886A1	2018-11-01	Michael D. Lynch; Tanya Warnecke Lipscomb; Ashley D. Trahan; Amarjeet Singh; Travis Wolter
Metabolically engineered microorganism strains are disclosed, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product. Such chemical products include polyketides, 3-hydroxypropionic acid, and various other chemical products described herein. Methods of production also may be applied to further downstream products, such as consumer products. In various embodiments, modifications to a microorganism and/or culture system divert, at least transiently, usage of malonyl-coA from the fatty acid biosynthesis pathway and thereby provides for usage of the malonyl-coA for a chemical product other than a fatty acid. In various embodiments, the fatty acid biosynthesis pathway is modulated to produce specific fatty acids or combinations of fatty acids.
3	多価不飽和脂肪酸シンターゼの核酸分子およびポリペプチド、組成物、ならびにそれらの作製方法および使用	JP2017179405	2017-09-19	JP2017213008A	2017-12-07	アプトカークイー.; リヒターレスリー; シンプソンデイビッド; ザークレロス
【課題】ドコサヘキサエン酸(DHA)、エイコサペンタエン酸(EPA)、またはそれらの組み合わせに富む多価不飽和脂肪酸(PUFA)を含むPUFAの産生方法の提供。【解決手段】DHA、EPA又はそれらの組み合わせに富むPUFAを含むPUFAの産生に関与する、ヤブレツボカビPUFAシンターゼの単離された核酸分子及びポリペプチド。それらの核酸分子を含むベクター及び宿主細胞、それらの核酸分子によってコードされるポリペプチド、それらの核酸分子またはポリペプチドを含む組成物、並びにそれらの作製方法及び使用。【選択図】なし
4	MICROBIAL PRODUCTION OF CHEMICAL PRODUCTS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS	US16030300	2018-07-09	US20180312887A1	2018-11-01	Michael D. Lynch; Tanya Warnecke Lipscomb; Ashley D. Trahan; Amarjeet Singh; Travis Wolter
Metabolically engineered microorganism strains are disclosed, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product. Such chemical products include polyketides, 3-hydroxypropionic acid, and various other chemical products described herein. Methods of production also may be applied to further downstream products, such as consumer products. In various embodiments, modifications to a microorganism and/or culture system divert, at least transiently, usage of malonyl-coA from the fatty acid biosynthesis pathway and thereby provides for usage of the malonyl-coA for a chemical product other than a fatty acid. In various embodiments, the fatty acid biosynthesis pathway is modulated to produce specific fatty acids or combinations of fatty acids.
5	Pathways to adipate semialdehyde and other organic products	US14418543	2013-09-20	US09809833B2	2017-11-07	Man Kit Lau; Christopher P. Mercogliano
Recombinant microorganisms comprising at least one exogenous nucleic acid sequence and capable of producing adipate semialdehyde are provided. Adipate semialdehyde may be produced in a synthesis pathway utilizing a single thiolase reaction. Adipate semialdehyde may also be produced from intermediates consisting of alpha, omega difunctional aliphatic organic molecules. Methods of using recombinant microorganisms to produce 6-aminocaproic acid, adipic acid, hexamethylenediamine and 1.6-hexanediol are also provided.
6	PRIMER FOR AMPLIFYING ENONE OXIDOREDUCTASE FROM MANGO	US14376404	2013-02-01	US20160002685A1	2016-01-07	Vidya Shrikant Gupta; Ram Shridhar Kulkarni; Ashok Prabhakar Giri; Keshav H. Pujari
The present invention disclosed herein the primers for amplifying enone oxidoreductase, having sequence selected from the group consisting of Seq. ID No. 1 to 13, from mango. Also disclosed herein is a novel nucleotide sequence of Sequence ID No. 14 encoding said amplified enone oxidoreductase, for enzyme production in an artificial system thus generating the desired flavor in food products.
7	CDNA encoding enone oxidoreductase from mango	US14376404	2013-02-01	US09790526B2	2017-10-17	Vidya Shrikant Gupta; Ram Shridhar Kulkarni; Ashok Prabhakar Giri; Keshav H. Pujari
Disclosed herein are primers for amplifying enone oxidoreductase, having a sequence selected from the group consisting of SEQ ID Nos. 1 to 13, from mango. Also disclosed herein is a nucleotide sequence of SEQ ID No. 14 encoding enone oxidoreductase, for enzyme production in an artificial system thus generating the desired flavor in food products.
8	PROCESSES FOR ISOLATING SALICYCLIC ACID RECEPTORS	US14771292	2014-03-03	US20160009769A1	2016-01-14	Hanna Skubatch
The invention provides processes for isolating salicylic acid receptor proteins (SARP) from a diverse origin using organic extraction solutions. The processes comprise the extraction of SARP from the tissue using an oarganic extraction solution, and percipitate the proteins in water, and then purified them to homoginity using reversed phase HPLC. The novel uses of SARP are in control of cellular energy and temperature homehostasis through conformational changes, cellular timekeeping mechanism, gel oscillation, and nanotechnology.
9	PATHWAYS TO ADIPATE SEMIALDEHYDE AND OTHER ORGANIC PRODUCTS	US14418543	2013-09-20	US20150291987A1	2015-10-15	Man Kit Lau
Recombinant microorganisms comprising at least one exogenous nucleic acid sequence and capable of producing adipate semialdehyde are provided. Adipate semialdehyde may be produced in a synthesis pathway utilizing a single thiolase reaction. Adipate semialdehyde may also be produced from intermediates consisting of alpha, omega difunctional aliphatic organic molecules. Methods of using recombinant microorganisms to produce 6-aminocaproic acid, adipic acid, hexamethylenediamine and 1.6-hexanediol are also provided.
10	MICROBIAL PRODUCTION OF CHEMICAL PRODUCTS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS	US14006014	2012-03-22	US20140330032A1	2014-11-06	Michael D. Lynch; Tanya E.W. Lipscomb; Ashley D, Trahan; Amarjeet Singh; Travis Wolter
Metabolically engineered microorganism strains are disclosed, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product. Such chemical products include polyketides, 3-hydroxypropionic acid, and various other chemical products described herein. Methods of production also may be applied to further downstream products, such as consumer products. In various embodiments, modifications to a microorganism and/or culture system divert, at least transiently, usage of malonyl-coA from the fatty acid biosynthesis pathway and thereby provides for usage of the malonyl-coA for a chemical product other than a fatty acid. In various embodiments, the fatty acid biosynthesis pathway is modulated to produce specific fatty acids or combinations of fatty acids.
11	POLYUNSATURATED FATTY ACID SYNTHASE NUCLEIC ACID MOLECULES AND POLYPEPTIDES, COMPOSITIONS, AND METHODS OF MAKING AND USES THEREOF	EP10754185.6	2010-03-19	EP2408797B1	2017-03-15	APT, Kirk, E.; RICHTER, Leslie; SIMPSON, David; ZIRKLE, Ross

12	PRIMER FOR AMPLIFYING ENONE OXIDOREDUCTASE FROM MANGO	EP13708535.3	2013-02-01	EP2809809A2	2014-12-10	GUPTA, Vidya Shrikant; KULKARNI, Ram Shridhar; GIRI, Ashok Prabhakar; PUJARI, Keshav H
The present invention disclosed herein the primers for amplifying enone oxidoreductase, having sequence selected from the group consisting of Seq. ID No. 1 to 13, from mango. Also disclosed herein is a novel nucleotide sequence of Sequence ID No. 14 encoding said amplified enone oxidoreductase, for enzyme production in an artificial system thus generating the desired flavor in food products.
13	POLYUNSATURATED FATTY ACID SYNTHASE NUCLEIC ACID MOLECULES AND POLYPEPTIDES, COMPOSITIONS, AND METHODS OF MAKING AND USES THEREOF	EP10754185.6	2010-03-19	EP2408797A2	2012-01-25	APT, Kirk, E.; RICHTER, Leslie; SIMPSON, David; ZIRKLE, Ross
The present invention is directed to isolated nucleic acid molecules and polypeptides of thraustochytrid polyunsaturated fatty acid (PUFA) synthases involved in the production of PUFAs, including PUFAs enriched in docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), or a combination thereof. The present invention is directed to vectors and host cells comprising the nucleic acid molecules, polypeptides encoded by the nucleic acid molecules, compositions comprising the nucleic acid molecules or polypeptides, and methods of making and uses thereof.
14	多価不飽和脂肪酸シンターゼの核酸分子およびポリペプチド、組成物、ならびにそれらの作製方法および使用	JP2015156630	2015-08-07	JP6432867B2	2018-12-05	アプトカークイー.; リヒターレスリー; シンプソンデイビッド; ザークレロス

15	多価不飽和脂肪酸シンターゼの核酸分子およびポリペプチド、組成物、ならびにそれらの作製方法および使用	JP2015156630	2015-08-07	JP2015231384A	2015-12-24	アプトカークイー.; リヒターレスリー; シンプソンデイビッド; ザークレロス
【課題】ドコサヘキサエン酸(DHA)、エイコサペンタエン酸(EPA)、またはそれらの組み合わせに富む多価不飽和脂肪酸(PUFA)を含むPUFAの産生方法の提供。【解決手段】DHA、EPA又はそれらの組み合わせに富むPUFAを含むPUFAの産生に関与する、ヤブレツボカビPUFAシンターゼの単離された核酸分子及びポリペプチド。それらの核酸分子を含むベクター及び宿主細胞、それらの核酸分子によってコードされるポリペプチド、それらの核酸分子またはポリペプチドを含む組成物、並びにそれらの作製方法及び使用。【選択図】なし
16	Multivalent nucleic acid molecules and polypeptides of the unsaturated fatty acid synthase, compositions and manufacturing methods and uses thereof	JP2012501000	2010-03-19	JP2012521195A	2012-09-13	カークイー．アプト; ロスザークレ; デイビッドシンプソン; レスリーリヒター
本発明は、ドコサヘキサエン酸（DHA）、エイコサペンタエン酸（EPA）、またはそれらの組み合わせに富む多価不飽和脂肪酸（PUFA）を含むPUFAの産生に関与する、ヤブレツボカビ（thraustochytrid）PUFAシンターゼの単離された核酸分子およびポリペプチドを対象とする。本発明は、それらの核酸分子を含むベクターおよび宿主細胞、それらの核酸分子によってコードされるポリペプチド、それらの核酸分子またはポリペプチドを含む組成物、ならびにそれらの作製方法および使用を対象とする。
17	MICROBIAL PRODUCTION OF CHEMICAL PRODUCTS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS	EP18172179.6	2012-03-22	EP3385388A1	2018-10-10	LYNCH, Michael, D.; LIPSCOMB, Tanya, E.w.; TRAHAN, Ashley, D.; SINGH, Amar; WOLTER, Travis
Metabolically engineered microorganism strains are disclosed, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product. Such chemical products include polyketides, 3-hydroxypropionic acid, and various other chemical products described herein. Methods of production also may be applied to further downstream products, such as consumer products. In various embodiments, modifications to a microorganism and/or culture system divert, at least transiently, usage of malonyl-coA from the fatty acid biosynthesis pathway and thereby provides for usage of the malonyl-coA for a chemical product other than a fatty acid. In various embodiments, the fatty acid biosynthesis pathway is modulated to produce specific fatty acids or combinations of fatty acids.
18	MICROBIAL PRODUCTION OF CHEMICAL PRODUCTS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS	EP12759932.2	2012-03-22	EP2689020B1	2018-05-16	LYNCH, Michael, D.; LIPSCOMB, Tanya, E.w.; TRAHAN, Ashley, D.; SINGH, Amar; WOLTER, Travis
Metabolically engineered microorganism strains are disclosed, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product. Such chemical products include polyketides, 3-hydroxypropionic acid, and various other chemical products described herein. Methods of production also may be applied to further downstream products, such as consumer products. In various embodiments, modifications to a microorganism and/or culture system divert, at least transiently, usage of malonyl-coA from the fatty acid biosynthesis pathway and thereby provides for usage of the malonyl-coA for a chemical product other than a fatty acid. In various embodiments, the fatty acid biosynthesis pathway is modulated to produce specific fatty acids or combinations of fatty acids.
19	POLYUNSATURATED FATTY ACID SYNTHASE NUCLEIC ACID MOLECULES AND POLYPEPTIDES, COMPOSITIONS, AND METHODS OF MAKING AND USES THEREOF	EP17153399.5	2010-03-19	EP3192871A1	2017-07-19	APT, Kirk E.; RICHTER, Leslie; SIMPSON, David; ZIRKLE, Ross
The present invention is directed to isolated nucleic acid molecules and polypeptides of thraustochytrid polyunsaturated fatty acid (PUFA) synthases involved in the production of the PUFAs, including PUFAs enriched in docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), or a combination thereof. The present invention is directed to vectors and host cells comprising the nucleic acid molecules, polypeptides encoded by the nucleic acid molecules, compositions comprising the nucleic acid molecules or polypeptides, and methods of making and uses thereof.
20	MICROBIAL PRODUCTION OF CHEMICAL PRODUCTS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS	EP12759932	2012-03-22	EP2689020A4	2014-12-31	LYNCH MICHAEL D; LIPSCOMB TANYA E W; TRAHAN ASHLEY D; SINGH AMAR; WOLTER TRAVIS
Metabolically engineered microorganism strains are disclosed, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product. Such chemical products include polyketides, 3-hydroxypropionic acid, and various other chemical products described herein. Methods of production also may be applied to further downstream products, such as consumer products. In various embodiments, modifications to a microorganism and/or culture system divert, at least transiently, usage of malonyl-coA from the fatty acid biosynthesis pathway and thereby provides for usage of the malonyl-coA for a chemical product other than a fatty acid. In various embodiments, the fatty acid biosynthesis pathway is modulated to produce specific fatty acids or combinations of fatty acids.

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