| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 用于生产聚-4-羟基丁酸酯的遗传工程微生物 | CN201380026228.1 | 2013-03-04 | CN104321427A | 2015-01-28 | W·R·法默; C·W·J·麦克查利彻; T·M·拉姆塞尔; Z·张; D-E·常; J·比克迈耶; J·比利; C·莫泽 |
| 本文描述了用于生产聚-4-羟基丁酸酯和4-碳产物的方法和遗传工程宿主。 | ||||||
| 2 | Fumarate reductases | US15103237 | 2014-12-12 | US09944905B2 | 2018-04-17 | René Marcel De Jong; Zheng Zhao; Ben Den Dulk; Remko Tsjibbe Winter |
| The present invention relates to a variant polypeptide having fumarate reductase activity, which has modified NADP(H)-dependent and/or NAD(H)-dependent activity as compared with a reference polypeptide having fumarate reductase activity. Such a variant may be overexpressed in a host cell in order to improve production of a dicarboxylic acid. | ||||||
| 3 | L-malate production by metabolically engineered escherichia coli | US13819773 | 2011-09-01 | US09187772B2 | 2015-11-17 | Xueli Zhang; Xuan Wang; Keelnatham T. Shanmugam; Lonnie O'Neal Ingram |
| A process for the production of malic acid in commercially significant quantities from the carbon compounds by genetically modified bacterial strains (GMBS; also referred to as biocatalysts or genetically modified microorganisms) is disclosed. Microorganisms suitable for the production of malic acid can be cultured in one or two-step processes as disclosed herein. | ||||||
| 4 | ELECTROCHEMICAL BIOREACTOR MODULE AND ENGINEERED METABOLIC PATHWAYS FOR 1- BUTANOL PRODUCTION WITH HIGH CARBON EFFICIENCY | EP16756175 | 2016-02-23 | EP3262179A4 | 2018-07-11 | DODDS DAVID R; ARMIGER WILLIAM B; KOFFAS MATTHEOS |
| A combination of an electrochemical device for delivering reducing equivalents to a cell, and engineered metabolic pathways within the cell capable of utilizing the electrochemically provided reducing equivalents is disclosed. Such a combination allows the production of commodity chemicals by fermentation to proceed with increased carbon efficiency. | ||||||
| 5 | Compositions and Methods for Succinate Production | US15386506 | 2016-12-21 | US20170107526A1 | 2017-04-20 | Kenneth R. FINLEY; Jeanette M. HURYTA; Beth M. MASTEL; Thomas W. MCMULLIN; Gregory M. POYNTER; Brian J. RUSH; Arlene M. FOSMER; Vernon L. MCINTOSH, JR.; Keith M. BRADY; Kevin T. WATTS |
| The present application provides genetically modified yeast cell comprising an active succinate fermentation pathway, as well as methods of using these cells to produce succinate. | ||||||
| 6 | Compositions and methods for succinate production | US13981517 | 2012-01-25 | US09605285B2 | 2017-03-28 | Kenneth R. Finley; Jeanette M. Huryta; Beth M. Mastel; Thomas W. McMullin; Gregory M. Poynter; Brian J. Rush; Kevin T. Watts; Arlene M. Fosmer; Vernon L. McIntosh, Jr.; Keith M. Brady |
| The present application provides genetically modified yeast cell comprising an active succinate fermentation pathway, as well as methods of using these cells to produce succinate. | ||||||
| 7 | COMPOSITIONS AND METHODS FOR SUCCINATE PRODUCTION | EP12740007 | 2012-01-25 | EP2668281A4 | 2015-08-26 | CARGILL INCORPORATED; BIOAMBER S A S |
| The present application provides genetically modified yeast cell comprising an active succinate fermentation pathway, as well as methods of using these cells to produce succinate. | ||||||
| 8 | Electrochemical Bioreactor Module and Engineered Metabolic Pathways for 1-Butanol Production with High Carbon Efficiency | US15552647 | 2016-02-23 | US20180037914A1 | 2018-02-08 | David R. Dodds; William B. Armiger; Mattheos Koffas |
| A combination of an electrochemical device for delivering reducing equivalents to a cell, and engineered metabolic pathways within the cell capable of utilizing the electrochemically provided reducing equivalents is disclosed. Such a combination allows the production of commodity chemicals by fermentation to proceed with increased carbon efficiency. | ||||||
| 9 | FUMARATE REDUCTASES | US15103237 | 2014-12-12 | US20160319245A1 | 2016-11-03 | René Marcel DE JONG; Zheng ZHAO; Ben DEN DULK; Remko Tsjibbe WINTER |
| The present invention relates to a variant polypeptide having fumarate reductase activity, which has modified NADP(H)-dependent and/or NAD(H)-dependent activity as compared with a reference polypeptide having fumarate reductase activity. Such a variant may be overexpressed in a host cell in order to improve production of a dicarboxylic acid. | ||||||
| 10 | Genetically Engineered Microorganisms for the Production of Poly-4-Hydroxybutyrate | US14386728 | 2013-03-04 | US20150159184A1 | 2015-06-11 | Thomas M. Ramseier; Christopher W.J. McChalicher; William R. Farmer; Zhigang Zhang; Dong-Eun Chang; Jeff Bickmeier; Julie Beaulieu; Catherine Morse |
| Methods and genetically engineered hosts for the production of poly-4-hydroxybutrate and 4-carbon products are described herein. | ||||||
| 11 | COMPOSITIONS AND METHODS FOR SUCCINATE PRODUCTION | US13981517 | 2012-01-25 | US20130302866A1 | 2013-11-14 | Kenneth R. Finley; Jeanette M. Huryta; Beth M. Mastel; Thomas W. McMullin; Gregory M. Poynter; Brian J. Rush; Kevin T. Watts; Arlene M. Fosmer; Vernon L. McIntosh, JR.; Keith M. Brady |
| The present application provides genetically modified yeast cell comprising an active succinate fermentation pathway, as well as methods of using these cells to produce succinate. | ||||||
| 12 | L-MALATE PRODUCTION BY METABOLICALLY ENGINEERED ESCHERICHIA COLI | US13819773 | 2011-09-01 | US20130157330A1 | 2013-06-20 | Xueli Zhang; Xuan Wang; Keelnatham T. Shanmugam; Lonnie O'Neal Ingram |
| A process for the production of malic acid in commercially significant quantities from the carbon compounds by genetically modified bacterial strains (GMBS; also referred to as biocatalysts or genetically modified microorganisms) is disclosed. Microorganisms suitable for the production of malic acid can be cultured in one or two-step processes as disclosed herein. | ||||||
| 13 | ELECTROCHEMICAL BIOREACTOR MODULE AND ENGINEERED METABOLIC PATHWAYS FOR 1- BUTANOL PRODUCTION WITH HIGH CARBON EFFICIENCY | EP16756175.2 | 2016-02-23 | EP3262179A1 | 2018-01-03 | DODDS, David R.; ARMIGER, William B.; KOFFAS, Mattheos |
| A combination of an electrochemical device for delivering reducing equivalents to a cell, and engineered metabolic pathways within the cell capable of utilizing the electrochemically provided reducing equivalents is disclosed. Such a combination allows the production of commodity chemicals by fermentation to proceed with increased carbon efficiency. | ||||||
| 14 | GENETICALLY ENGINEERED MICROORGANISMS FOR THE PRODUCTION OF POLY-4-HYDROXYBUTYRATE | EP13710245.5 | 2013-03-04 | EP2828383A1 | 2015-01-28 | FARMER, William, R.; MCCHALICHER, Christopher, W.J.; RAMSEIER, Thomas, M.; ZHANG, Zhigang; CHANG, Dong-Eun; BICKMEIER, Jeff; BEAULIEU, Julie; MORSE, Catherine |
| Methods and genetically engineered hosts for the production of poly-4-hydroxybutrate and 4-carbon products are described herein. | ||||||
| 15 | COMPOSITIONS AND METHODS FOR SUCCINATE PRODUCTION | EP12740007.5 | 2012-01-25 | EP2668281A2 | 2013-12-04 | Cargill, Incorporated; BioAmber S.A.S. |
| The present application provides genetically modified yeast cell comprising an active succinate fermentation pathway, as well as methods of using these cells to produce succinate. | ||||||
| 16 | COMPOSITIONS AND METHODS FOR SUCCINATE PRODUCTION | PCT/US2012022612 | 2012-01-25 | WO2012103261A3 | 2012-11-22 | FINLEY KENNETH R; HURYTA JEANETTE M; MASTEL BETH M; MCMULLIN THOMAS W; POYNTER GREGORY M; RUSH BRIAN J; WATTS KEVIN T; FOSMER ARLENE M; MCINTOSH VERNON L JR; BRADY KEITH M |
| The present application provides genetically modified yeast cell comprising an active succinate fermentation pathway, as well as methods of using these cells to produce succinate. | ||||||
| 17 | FUMARATE REDUCTASES | PCT/EP2014077638 | 2014-12-12 | WO2015086839A9 | 2016-09-09 | JONG DE RENÉ MARCEL; ZHAO ZHENG; DULK DEN BEN; WINTER REMKO TSJIBBE |
| The present invention relates to a variant polypeptide having fumarate reductase activity, which has modified NADP(H)-dependent and/or NAD(H)-dependent activity as compared with a reference polypeptide having fumarate reductase activity. Such a variant may be overexpressed in a host cell in order to improve production of a dicarboxylic acid. | ||||||
| 18 | L-MALATE PRODUCTION BY METABOLICALLY ENGINEERED ESCHERICHIA COLI | PCT/US2011050146 | 2011-09-01 | WO2012031079A2 | 2012-03-08 | ZHANG XUELI; WANG XUAN; SHANMUGAM KEELNATHAM T; INGRAM LONNIE O'NEAL |
| A process for the production of malic acid in commercially significant quantities from the carbon compounds by genetically modified bacterial strains (GMBS; also referred to as biocatalysts or genetically modified microorganisms) is disclosed. Microorganisms suitable for the production of malic acid can be cultured in one or two-step processes as disclosed herein. | ||||||
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