| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | Methods and Materials for Producing 6-Carbon Monomers | US14941501 | 2015-11-13 | US20160160255A1 | 2016-06-09 | Adriana Leonora Botes; Alex Van Eck Conradie; Nadia Kadi |
| This document describes biochemical pathways for producing 6-hydroxyhexanoic acid using a polypeptide having β-ketothiolase activity to form a 3-oxo-6-hydroxyhexanoyl-CoA intermediate. 6-hydroxyhexanoic acid can be enzymatically converted to adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine or 1,6-hexanediol. This document also describes recombinant hosts producing 6-hydroxyhexanoic acid as well as adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine and 1,6-hexanediol. | ||||||
| 2 | METHOD FOR THE PRODUCTION OF 1-BUTANOL | US13862626 | 2013-04-15 | US20130217060A1 | 2013-08-22 | Michael G. Bramucci; Dennis Flint; Edward S. Miller, JR.; Vasantha Nagarajan; Natalia Sedkova; Manjari Singh; Tina K. Van Dyk |
| A method for the production of 1-butanol by fermentation using a microbial production host is disclosed. The method employs a reduction in temperature during the fermentation process that results in a more robust tolerance of the production host to the butanol product. | ||||||
| 3 | METHOD FOR THE PRODUCTION OF 1-BUTANOL | US12110503 | 2008-04-28 | US20080274524A1 | 2008-11-06 | MICHAEL G. BRAMUCCI; Dennis Flint; Edward S. Miller; Vasantha Nagarajan; Natalia Sedkova; Manjari Singh; Tina K. Van Dyk |
| A method for the production of 1-butanol by fermentation using a microbial production host is disclosed. The method employs a reduction in temperature during the fermentation process that results in a more robust tolerance of the production host to the butanol product. | ||||||
| 4 | ６−炭素モノマーを産生するための方法および材料 | JP2017544854 | 2015-11-13 | JP2017533734A | 2017-11-16 | アドリアナ レオノラ ボーテス; アレックス ヴァン エック コンラディエ; ナディア カジ |
| 本明細書は、3-オキソ-6-ヒドロキシヘキサノイル-CoA中間体を形成するためのβ-ケトチオラーゼ活性を有するポリペプチドを用いて6-ヒドロキシヘキサン酸を産生するための、生化学的経路を記載する。6-ヒドロキシヘキサン酸は、アジピン酸、カプロラクタム、6-アミノヘキサン酸、ヘキサメチレンジアミン、または1,6-ヘキサンジオールに酵素的に変換され得る。本明細書はまた、6-ヒドロキシヘキサン酸、ならびにアジピン酸、カプロラクタム、6-アミノヘキサン酸、ヘキサメチレンジアミン、および1,6-ヘキサンジオールを産生する組換え宿主を記載する。 | ||||||
| 5 | 再生可能資源から化合物を生成するための高収量経路 | JP2016515437 | 2014-09-17 | JP2016533162A | 2016-10-27 | チョカワラ、ハーシャル |
| 本開示は、1−ブタノール、酪酸、コハク酸、1,4−ブタンジオール、1−ペンタノール、ペンタン酸、グルタル酸、1,5−ペンタンジオール、1−ヘキサノール、ヘキサン酸、アジピン酸、1,6−ヘキサンジオール、6−ヒドロキシヘキサン酸、ε−カプロラクトン、6−アミノ−ヘキサン酸、ε−カプロラクタム、ヘキサメチレンジアミン、7〜25炭素長の直鎖脂肪酸および直鎖脂肪アルコール、セバシン酸またはドデカン二酸等の化合物を調製するための方法、組成物、および、天然に存在しない微生物生物であって、前記方法は、a)アルドール付加を介して、CNアルデヒドおよびピルベートをCN+3β−ヒドロキシケトン中間体に変換する工程;およびb)酵素的工程または酵素的工程と化学的工程との組み合わせを介して、該CN+3β−ヒドロキシケトン中間体を該化合物に変換する工程を含む、方法、組成物、および、天然に存在しない微生物生物に関する。【選択図】図1 | ||||||
| 6 | METHODS AND MATERIALS FOR PRODUCING 6-CARBON MONOMERS | EP15804257.2 | 2015-11-13 | EP3218505A1 | 2017-09-20 | BOTES, Adriana Leonora; CONRADIE, Alex Van Eck; KADI, Nadia |
| This document describes biochemical pathways for producing 6-hydroxyhexanoic acid using a polypeptide having ß-ketothiolase activity to form a 3-oxo-6-hydroxyhexanoyl-CoA intermediate. 6-hydroxyhexanoic acid can be enzymatically converted to adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine or 1,6-hexanediol. This document also describes recombinant hosts producing 6-hydroxyhexanoic acid as well as adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine and 1,6-hexanediol. | ||||||
| 7 | MICROORGANISMS AND METHODS FOR PRODUCTION OF SPECIFIC LENGTH FATTY ALCOHOLS AND RELATED COMPOUNDS | US14435723 | 2013-10-14 | US20150275242A1 | 2015-10-01 | Robin E. Osterhout; Anthony P. Burgard |
| The invention provides non-naturally occurring microbial organisms containing a fatty alcohol, fatty aldehyde or fatty acid pathway, wherein the microbial organisms selectively produce a fatty alcohol, fatty aldehyde or fatty acid of a specified length. Also provided are non-naturally occurring microbial organisms having a fatty alcohol, fatty aldehyde or fatty acid pathway, wherein the microbial organisms further include an acetyl-CoA pathway. In some aspects, the microbial organisms of the invention have select gene disruptions or enzyme attenuations that increase production of fatty alcohols, fatty aldehydes or fatty acids. The invention additionally provides methods of using the above microbial organisms to produce a fatty alcohol, a fatty aldehyde or a fatty acid. | ||||||
| 8 | Method for the production of 1-butanol | US12110503 | 2008-04-28 | US08426173B2 | 2013-04-23 | Michael G. Bramucci; Dennis Flint; Edward S. Miller, Jr.; Vasantha Nagarajan; Natalia Sedkova; Manjari Singh; Tina K. Van Dyk |
| A method for the production of 1-butanol by fermentation using a microbial production host is disclosed. The method employs a reduction in temperature during the fermentation process that results in a more robust tolerance of the production host to the butanol product. | ||||||
| 9 | A HIGH YIELD ROUTE FOR THE PRODUCTION OF COMPOUNDS FROM RENEWABLE SOURCES | EP14846017.3 | 2014-09-17 | EP3047030A2 | 2016-07-27 | CHOKHAWALA, Harshal |
| Provided herein are methods, compositions, and non-naturally occurring microbial organism for preparing compounds such as1-butanol, butyric acid, succinic acid, 1,4-butanediol, 1-pentanol, pentanoic acid, glutaric acid, 1,5-pentanediol, 1-hexanol, hexanoic acid, adipic acid, 1,6-hexanediol, 6-hydroxy hexanoic acid, ε-Caprolactone, 6-amino-hexanoic acid, ε-Caprolactam, hexamethylenediamine, linear fatty acids and linear fatty alcohols that are between 7-25 carbons long, linear alkanes and linear -alkenes that are between 6-24 carbons long, sebacic acid and dodecanedioic acid comprising: a) converting a C N aldehyde and pyruvate to a C N+3 -hydroxyketone intermediate through an aldol addition; and b) converting the C N+3 -hydroxyketone intermediate to the compounds through enzymatic steps, or a combination of enzymatic and chemical steps. | ||||||
| 10 | Method for the production of 1-butanol | EP08747082.9 | 2008-04-29 | EP2142656B1 | 2015-04-08 | BRAMUCCI, Michael, G.; FLINT, Dennis; MILLER JR, Edward, S.; NAGARAJAN, Vasantha; SEDKOVA, Natalia; SINGH, Manjari; VAN DYK, Tina, K. |
| 11 | A HIGH YIELD ROUTE FOR THE PRODUCTION OF COMPOUNDS FROM RENEWABLE SOURCES | EP14846017 | 2014-09-17 | EP3047030A4 | 2017-02-22 | CHOKHAWALA HARSHAL |
| Provided herein are methods, compositions, and non-naturally occurring microbial organism for preparing compounds such as 1-butanol, butyric acid, succinic acid, 1,4-butanediol, 1-pentanol, pentanoic acid, glutaric acid, 1,5-pentanediol, 1-hexanol, hexanoic acid, adipic acid, 1,6-hexanediol, 6-hydroxy hexanoic acid, ε-Caprolactone, 6-amino-hexanoic acid, ε-Caprolactam, hexamethylenediamine, linear fatty acids and linear fatty alcohols that are between 7-25 carbons long, linear alkanes and linear α-alkenes that are between 6-24 carbons long, sebacic acid and dodecanedioic acid comprising: a) converting a CN aldehyde and pyruvate to a CN+3 β-hydroxyketone intermediate through an aldol addition; and b) converting the CN+3β-hydroxyketone intermediate to the compounds through enzymatic steps, or a combination of enzymatic and chemical steps. | ||||||
| 12 | MICROORGANISMS AND METHODS FOR PRODUCTION OF SPECIFIC LENGTH FATTY ALCOHOLS AND RELATED COMPOUNDS | EP13846388 | 2013-10-14 | EP2906705A4 | 2016-09-07 | OSTERHOUT ROBIN E; BURGARD ANTHONY P |
| 13 | MICROORGANISMS AND METHODS FOR PRODUCTION OF SPECIFIC LENGTH FATTY ALCOHOLS AND RELATED COMPOUNDS | EP13846388.0 | 2013-10-14 | EP2906705A1 | 2015-08-19 | OSTERHOUT, Robin, E.; BURGARD, Anthony, P. |
| The invention provides non-naturally occurring microbial organisms containing a fatty alcohol, fatty aldehyde or fatty acid pathway, wherein the microbial organisms selectively produce a fatty alcohol, fatty aldehyde or fatty acid of a specified length. Also provided are non-naturally occurring microbial organisms having a fatty alcohol, fatty aldehyde or fatty acid pathway, wherein the microbial organisms further include an acetyl-CoA pathway. In some aspects, the microbial organisms of the invention have select gene disruptions or enzyme attenuations that increase production of fatty alcohols, fatty aldehydes or fatty acids. The invention additionally provides methods of using the above microbial organisms to produce a fatty alcohol, a fatty aldehyde or a fatty acid. | ||||||
| 14 | METHOD FOR THE PRODUCTION OF 1-BUTANOL | EP08747082.9 | 2008-04-29 | EP2142656A1 | 2010-01-13 | BRAMUCCI, Michael, G.; FLINT, Dennis; MILLER JR, Edward, S.; NAGARAJAN, Vasantha; SEDKOVA, Natalia; SINGH, Manjari; VAN DYK, Tina, K. |
| A method for the production of 1-butanol by fermentation using a microbial production host is disclosed. The method employs a reduction in temperature during the fermentation process that results in a more robust tolerance of the production host to the butanol product. | ||||||
| 15 | 특정 길이의 지방 알콜 및 관련 화합물의 생산을 위한 미생물 및 방법 | KR1020157012762 | 2013-10-14 | KR1020150069015A | 2015-06-22 | 오스터하우트로빈이; 버가드앤쏘니피 |
| 본발명은지방알콜, 지방알데하이드또는지방산 경로를함유하는비-천연미생물유기체에관한것으로서, 상기미생물유기체는특정길이의지방알콜, 지방알데하이드또는지방산을선택적으로생산한다. 또한, 지방알콜, 지방알데하이드또는지방산 경로를갖는비-천연미생물유기체가제공되고, 이때상기미생물유기체는아세틸-CoA 경로를추가로포함한다. 일부태양에서, 본발명의미생물유기체는지방알콜, 지방알데하이드또는지방산의생산을증가시키는선택되는유전자파괴또는효소약화를갖는다. 본발명은지방알콜, 지방알데하이드또는지방산을생산하기위해상기미생물유기체를사용하는방법을추가로제공한다. | ||||||
| 16 | A HIGH YIELD ROUTE FOR THE PRODUCTION OF COMPOUNDS FROM RENEWABLE SOURCES | PCT/US2014056175 | 2014-09-17 | WO2015042201A3 | 2015-06-04 | CHOKHAWALA HARSHAL |
| Provided herein are methods, compositions, and non-naturally occurring microbial organism for preparing compounds such as1-butanol, butyric acid, succinic acid, 1,4-butanediol, 1-pentanol, pentanoic acid, glutaric acid, 1,5-pentanediol, 1-hexanol, hexanoic acid, adipic acid, 1,6-hexanediol, 6-hydroxy hexanoic acid, ε-Caprolactone, 6-amino-hexanoic acid, ε-Caprolactam, hexamethylenediamine, linear fatty acids and linear fatty alcohols that are between 7-25 carbons long, linear alkanes and linear -alkenes that are between 6-24 carbons long, sebacic acid and dodecanedioic acid comprising: a) converting a CN aldehyde and pyruvate to a CN+3 -hydroxyketone intermediate through an aldol addition; and b) converting the CN+3 -hydroxyketone intermediate to the compounds through enzymatic steps, or a combination of enzymatic and chemical steps. | ||||||
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