| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | Keto-acyl-(ACP) reductase promoter from cuphea lanceolata | US617860 | 1996-05-23 | US6133506A | 2000-10-17 | Reinhard Topfer; Christa Horicke-Grandpierre; Barbara Klein; Jeff Schell |
| Promoters in the 5' non-translated region of genes from Cuphea lanceota that code for .beta.-ketoacyl-(ACP) reductase are disclosed, as well as alleles and derivatives of said promoters. These promoters in the 5' non-translated region may for example be coupled with foreign genes, forming chimeric genes, and be transmitted to plants in appropriate vector systems. | ||||||
| 2 | PRODUCTION OF FATTY ACID DERIVATIVES | US15650285 | 2017-07-14 | US20180010137A1 | 2018-01-11 | Derek L. GREENFIELD; Andreas W. Schirmer; Elizabeth J. CLARKE; Eli S. GROBAN; Bernardo M. Da Costa; Zhihao Hu; Kevin Holden; Noah Helman |
| The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, recombinant host cells and recombinant host cell cultures engineered to produce fatty acid derivative compositions comprising fatty acids, fatty alcohols, fatty aldehydes, fatty esters, alkanes, terminal olefins, internal olefins or ketones. The fatty acid derivative composition is produced extracellularly with a higher titer, yield or productivity than the corresponding wild type or non-engineered host cell. | ||||||
| 3 | PRODUCTION OF FATTY ACID DERIVATIVES | US14390378 | 2013-04-02 | US20150064782A1 | 2015-03-05 | Derek L. Greenfield; Andreas W. Schirmer; Elizabeth J. Clarke; Eli S. Groban; Bernardo M. Da Costa; Zhihao Hu |
| The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, recombinant host cells and recombinant host cell cultures engineered to produce fatty acid derivative compositions comprising fatty acids, fatty alcohols, fatty aldehydes, fatty esters, alkanes, terminal olefins, internal olefins or ketones. The fatty acid derivative composition is produced extracellularly with a higher titer, yield or productivity than the corresponding wild type or non-engineered host cell. | ||||||
| 4 | 改良された脂肪酸誘導体産生方法 | JP2015504687 | 2013-04-02 | JP6381518B2 | 2018-08-29 | グリーンフィールド デレク エル.; シャーマー アンドレアス ダブリュ.; クラーク エリザベス ジェイ.; グローバン イーライ エス.; ダ コスタ バーナード エム.; フ チーハオ; ホールデン ケビン; ヘルマン ノア |
| 5 | PROMOTOREN | EP94926238.0 | 1994-09-05 | EP0716707A1 | 1996-06-19 | TÖPFER, Reinhard; BAUTOR, Jaqueline; BOTHMANN, Hendrick; FILSAK, Elke; HÖRICKE-GRANDPIERRE, Christa; KLEIN, Barbara; MARTINI, Norbert; MÜLLER, Andreas; SCHULTE, Wolfgang; VOETZ, Michael; WALEK, Josef; SCHELL, Jeff |
| Promoters and if required other regulatory elements in the 5', non translated region of genes that code for proteins of the de novo biosynthesis of fatty acids are disclosed, as well as alleles and derivatives of said promoters. These promoters and if required other regulatory elements in the 5' non translated region may for example be coupled with foreign genes, forming chimerical genes, and be transmitted to plants in appropriate vector systems. | ||||||
| 6 | 改良された脂肪酸誘導体産生方法 | JP2018072000 | 2018-04-04 | JP2018134085A | 2018-08-30 | グリーンフィールド デレク エル.; シャーマー アンドレアス ダブリュ.; クラーク エリザベス ジェイ.; グローバン イーライ エス.; ダ コスタ バーナード エム.; フ チーハオ; ホールデン ケビン; ヘルマン ノア |
| 【課題】脂肪酸誘導体の力価、収量、及び/又は、産生能を改良するために有効な系統改変を含む組換え宿主細胞の提供。 【解決手段】3-ヒドロキシデカノイル-[acp]デヒドラターゼ活性を含む、特定の酵素活性からなる群より選択される活性を有する1つ又は複数のポリペプチドをコードする遺伝子操作されたポリヌクレオチド配列を含む組換え宿主細胞であって、炭素源を含有する培地中で、該ポリヌクレオチドを発現するのに有効な条件下で培養された場合に、対応する野生型宿主細胞よりも高い力価、収量、又は、産生能で脂肪酸誘導体組成物を産生する組換え宿主細胞。 【選択図】図2 |
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| 7 | 改良された脂肪酸誘導体産生方法 | JP2015504687 | 2013-04-02 | JP2015512644A | 2015-04-30 | デレク エル． グリーンフィールド; アンドレアス ダブリュ． シャーマー; エリザベス ジェイ． クラーク; イーライ エス． グローバン; コスタ バーナード エム． ダ; チーハオ フ; ケビン ホールデン; ノア ヘルマン |
| 本開示は、脂肪酸誘導体の力価、収量および/または産生能を改良するために有効な系統改変を含む組換え宿主細胞に関する。本開示はさらに、脂肪酸誘導体およびそれらの組成物の発酵産生のための組換え宿主細胞を含む、細胞培養物にも関する。 | ||||||
| 8 | 지방산 유도체들의 개선된 생산 | KR1020147030467 | 2013-04-02 | KR1020150032930A | 2015-03-31 | 그린필드,데렉엘.; 셔머,안드레아스,더블유.; 클라크,엘리자베스,제이.; 그로반,엘리,에스.; 다코스타,베르나르도,엠.; 흐,지하오; 홀덴,케빈; 헬만,노아 |
| 본 발명은 지방산 유도체들의 역가, 수율 및/또는 생산률을 개선시키는데 효과적인 균주 변형을 포함하는 재조합 숙주 세포들에 관한 것이다. 또한, 본 발명은 지방산 유도체들 및 이들의 조성물들의 발효 생산을 위하여 재조합 숙주 세포들을 포함하는 세포 배양들에 관한 것이다. | ||||||
| 9 | IMPROVED PRODUCTION OF FATTY ACID DERIVATIVES | PCT/US2013035037 | 2013-04-02 | WO2013152051A3 | 2013-12-12 | GREENFIELD DEREK L; SCHIRMER ANDREAS W; CLARKE ELIZABETH J; GROBAN ELI S; DA COSTA BERNARDO M; HU ZHIHAO; HOLDEN KEVIN; HELMAN NOAH |
| The disclosure relates to recombinant host cells including strain modifications effective to improve titer, yield and/or productivity of fatty acid derivatives. The disclosure further relates to cell cultures including the recombinant host cells for the fermentative production of fatty acid derivatives and compositions thereof. | ||||||
| 10 | PROMOTERS | PCT/EP9402950 | 1994-09-05 | WO9507357A3 | 1995-07-13 | TOEPFER REINHARD; BAUTOR JAQUELINE; BOTHMANN HENDRICK; FILSAK ELKE; HOERICKE-GRANDPIERRE CHRISTA; KLEIN BARBARA; MARTINI NORBERT; MUELLER ANDREAS; SCHULTE WOLFGANG; VOETZ MICHAEL; WALEK JOSEF; SCHELL JEFF |
| Promoters and if required other regulatory elements in the 5', non translated region of genes that code for proteins of the de novo biosynthesis of fatty acids are disclosed, as well as alleles and derivatives of said promoters. These promoters and if required other regulatory elements in the 5' non translated region may for example be coupled with foreign genes, forming chimerical genes, and be transmitted to plants in appropriate vector systems. | ||||||
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