MICROBIAL PRODUCTION OF CHEMICAL PRODUCTS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS |
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| 申请号 | EP12759932 | 申请日 | 2012-03-22 | 公开(公告)号 | EP2689020A4 | 公开(公告)日 | 2014-12-31 |
| 申请人 | OPX BIOTECHNOLOGIES INC; | 发明人 | LYNCH MICHAEL D; LIPSCOMB TANYA E W; TRAHAN ASHLEY D; SINGH AMAR; WOLTER TRAVIS; | ||||
| 摘要 | Metabolically engineered microorganism strains are disclosed, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product. Such chemical products include polyketides, 3-hydroxypropionic acid, and various other chemical products described herein. Methods of production also may be applied to further downstream products, such as consumer products. In various embodiments, modifications to a microorganism and/or culture system divert, at least transiently, usage of malonyl-coA from the fatty acid biosynthesis pathway and thereby provides for usage of the malonyl-coA for a chemical product other than a fatty acid. In various embodiments, the fatty acid biosynthesis pathway is modulated to produce specific fatty acids or combinations of fatty acids. | ||||||
| 权利要求 | |||||||
| 说明书全文 | |||||||
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