| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | Gene encoding enzyme that reduces position 24 of steroid skeleton and plant in which expression level of the gene is lowered | US14387080 | 2013-03-22 | US09688995B2 | 2017-06-27 | Naoyuki Umemoto; Masako Otsuka |
| This invention provides a plant belonging to the family Solanaceae that does not produce cholesterols, including glycoalkaloids. This invention concerns a protein having activity of an enzyme that reduces position 24 of the steroid skeleton of a plant belonging to the family Solanaceae, a novel plant in which a gene encoding such protein is suppressed, and a method for producing and testing such plant. | ||||||
| 2 | GENE ENCODING ENZYME THAT REDUCES POSITION 24 OF STEROID SKELETON AND PLANT IN WHICH EXPRESSION LEVEL OF THE GENE IS LOWERED | US14387080 | 2013-03-22 | US20150052635A1 | 2015-02-19 | Naoyuki Umemoto; Masako Otsuka |
| This invention provides a plant belonging to the family Solanaceae that does not produce cholesterols, including glycoalkaloids. This invention concerns a protein having activity of an enzyme that reduces position 24 of the steroid skeleton of a plant belonging to the family Solanaceae, a novel plant in which a gene encoding such protein is suppressed, and a method for producing and testing such plant. | ||||||
| 3 | PREPARATION OF 7-DEHYDROCHOLESTEROL AND/OR THE BIOSYNTHETIC INTERMEDIATES AND/OR SECONDARY PRODUCTS THEREOF IN TRANSGENIC ORGANISMS | US13548898 | 2012-07-13 | US20130210072A1 | 2013-08-15 | Christine Lang; Markus Veen |
| The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves. | ||||||
| 4 | Method for the production of 7-dehydrocholesterol and/or the biosynthetic intermediate or subsequent products thereof in transgenic organisms | US10503044 | 2003-01-22 | US07608421B2 | 2009-10-27 | Christine Lang; Markus Veen |
| The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves. | ||||||
| 5 | Preparation of 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof in transgenic organisms | US10503044 | 2003-01-22 | US20060240508A1 | 2006-10-26 | Christine Lang; Markus Veen |
| The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves. | ||||||
| 6 | ステロイド骨格の24位を還元する酵素をコードする遺伝子および該遺伝子の発現が低下した植物体 | JP2014506305 | 2013-03-22 | JP5902801B2 | 2016-04-13 | 梅基 直行; 大塚 雅子 |
| 7 | VERFAHREN ZUR HERSTELLUNG VON 7-DEHYDROCHOLESTEROL IN TRANSGENEN ORGANISMEN | EP03701537.7 | 2003-01-22 | EP1472354B1 | 2012-09-19 | LANG, Christine; VEEN, Markus |
| 8 | VERFAHREN ZUR HERSTELLUNG VON 7-DEHYDROCHOLESTEROL UND/ODER DESSEN BIOSYNTHETISCHEN ZWISCHEN- UND/ODER FOLGEPRODUKTEN IN TRANSGENEN ORGANISMEN | EP03701537.7 | 2003-01-22 | EP1472354A1 | 2004-11-03 | LANG, Christine; VEEN, Markus |
| The invention relates to a method for the production of 7-dehydrocholesterol and/or the biosynthetic intermediate or subsequent products thereof by the cultivation of organisms, in particular, yeasts which show an increased activity of at least one activity, selected from delta-8/delta-7 isomerisation activity, delta-5 desaturase activity or delta-24 reductase activity. The invention further relates to the nucleic acid constructs necessary for production of the genetically-modified organisms and the genetically-modified organisms, in particular, the yeasts themselves. | ||||||
| 9 | PREPARATION OF 7-DEHYDROCHOLESTEROL AND/OR THE BIOSYNTHETIC INTERMEDIATES AND/OR SECONDARY PRODUCTS THEREOF IN TRANSGENIC ORGANISMS | US15412724 | 2017-01-23 | US20170198328A1 | 2017-07-13 | Christine Lang; Markus Veen |
| The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves. | ||||||
| 10 | PREPARATION OF 7-DEHYDROCHOLESTEROL AND/OR THE BIOSYNTHETIC INTERMEDIATES AND/OR SECONDARY PRODUCTS THEREOF IN TRANSGENIC ORGANISMS | US14583418 | 2014-12-26 | US20150353980A1 | 2015-12-10 | Christine Lang; Markus Veen |
| The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves. | ||||||
| 11 | PREPARATION OF 7-DEHYDROCHOLESTEROL AND/OR THE BIOSYNTHETIC INTERMEDIATES AND/OR SECONDARY PRODUCTS THEREOF IN TRANSGENIC ORGANISMS | US12607017 | 2009-10-27 | US20110151509A1 | 2011-06-23 | Christine Lang; Markus Veen |
| The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves. | ||||||
| 12 | ステロイド骨格の２４位を還元する酵素をコードする遺伝子および該遺伝子の発現が低下した植物体 | JP2014506305 | 2013-03-22 | JPWO2013141383A1 | 2015-08-03 | 直行 梅基; 雅子 大塚 |
| 本発明はグリコアルカロイドを含むコレステロール類を産生しないナス科植物(Solanaceae)の提供を目的とし、本発明はナス科植物におけるステロイド骨格の24位を還元する酵素活性を有するタンパク質、及び該タンパク質をコードする遺伝子を抑制した新規の植物、及び該植物を作成・検定する方法である。 | ||||||
| 13 | Gene for coding enzyme that reduce position 24 of steroid skeleton | JP2011111888 | 2011-05-18 | JP2012239412A | 2012-12-10 | UMEKI NAOYUKI; OYAMA KIYOSHI |
| PROBLEM TO BE SOLVED: To provide a gene for coding an enzyme that reduces the position 24 of a steroid skeleton, and a method for producing steroids and vitamin D3.SOLUTION: Disclosed are an enzymatic conversion method for reducing the double bond at the 24 position of a steroid skeleton in the presence of a protein having enzymatic activity for reducing the double bond at the 24 position of an exogenous steroid skeleton, or under expression of DNA coding for the protein, in a cell-free system, using cells, or a plant; and a method for producing a compound in which the double bond at the 24 position of the steroid skeleton is reduced, using the method. | ||||||
| 14 | GENE ENCODING OF ENZYME FOR REDUCING POSITION 24 OF STEROID SKELETON AND PLANT HAVING REDUCED EXPRESSION OF SAME GENE | EP13764240 | 2013-03-22 | EP2829607A4 | 2015-12-02 | UMEMOTO NAOYUKI; OTSUKA MASAKO |
| This invention provides a plant belonging to the family Solanaceae that does not produce cholesterols, including glycoalkaloids. This invention concerns a protein having activity of an enzyme that reduces position 24 of the steroid skeleton of a plant belonging to the family Solanaceae, a novel plant in which a gene encoding such protein is suppressed, and a method for producing and testing such plant. | ||||||
| 15 | GENE ENCODING OF ENZYME FOR REDUCING POSITION 24 OF STEROID SKELETON AND PLANT HAVING REDUCED EXPRESSION OF SAME GENE | EP13764240.1 | 2013-03-22 | EP2829607A1 | 2015-01-28 | UMEMOTO Naoyuki; OTSUKA Masako |
This invention provides a plant belonging to the family Solanaceae that does not produce cholesterols, including glycoalkaloids. This invention concerns a protein having activity of an enzyme that reduces position 24 of the steroid skeleton of a plant belonging to the family Solanaceae, a novel plant in which a gene encoding such protein is suppressed, and a method for producing and testing such plant. |
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| 16 | 머리카락 절편을 활용한 계절별 콜레스테롤류 변화 평가 기술 | KR1020120121162 | 2012-10-30 | KR1020140054985A | 2014-05-09 | 최만호; 정봉철; 손현화; 서홍석 |
| The present invention relates to a method for measuring seasonal changes in the concentration of a cholesterol compound in hair or the metabolic enzyme activity of a cholesterol compound and to a method for predicting the occurrence of cholesterol-related diseases, the possibilities of occurrence, or the degree of alleviation. According to the present invention, a seasonal change in the concentration of a cholesterol compound in the human body with just one strand of hair can be very accurately measured so that measurement can be performed more stably and easily than in existing periodical blood tests. Moreover, the method of the present invention reinforces existing difficulties in obtaining blood samples and is effectively applied to checkups so that disease related to cholesterol metabolism can be easily predicted. | ||||||
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