| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | MONOFUNCTIONAL ALDEHYDE AND ALCOHOL DEHYDROGENASES FOR PRODUCTION OF FUELS AND COMMODITY CHEMICALS | US15575709 | 2016-05-27 | US20180291353A1 | 2018-10-11 | Michelle C.Y. CHANG; Matthew DAVIS; Josh SILVERMAN; Drew REGITSKY |
| The present disclosure relates generally to the production of alcohols, and more specifically to biological platforms for the production of alcohols using monofunctional aldehyde dehydrogenases and monofunctional alcohol dehydrogenases. | ||||||
| 2 | METHOD FOR THE PRODUCTION OF 1-BUTANOL | US13862626 | 2013-04-15 | US20130217060A1 | 2013-08-22 | Michael G. Bramucci; Dennis Flint; Edward S. Miller, JR.; Vasantha Nagarajan; Natalia Sedkova; Manjari Singh; Tina K. Van Dyk |
| A method for the production of 1-butanol by fermentation using a microbial production host is disclosed. The method employs a reduction in temperature during the fermentation process that results in a more robust tolerance of the production host to the butanol product. | ||||||
| 3 | METHOD FOR THE PRODUCTION OF 1-BUTANOL | US12110503 | 2008-04-28 | US20080274524A1 | 2008-11-06 | MICHAEL G. BRAMUCCI; Dennis Flint; Edward S. Miller; Vasantha Nagarajan; Natalia Sedkova; Manjari Singh; Tina K. Van Dyk |
| A method for the production of 1-butanol by fermentation using a microbial production host is disclosed. The method employs a reduction in temperature during the fermentation process that results in a more robust tolerance of the production host to the butanol product. | ||||||
| 4 | ６−炭素モノマーを産生するための方法および材料 | JP2017544854 | 2015-11-13 | JP2017533734A | 2017-11-16 | アドリアナ レオノラ ボーテス; アレックス ヴァン エック コンラディエ; ナディア カジ |
| 本明細書は、3-オキソ-6-ヒドロキシヘキサノイル-CoA中間体を形成するためのβ-ケトチオラーゼ活性を有するポリペプチドを用いて6-ヒドロキシヘキサン酸を産生するための、生化学的経路を記載する。6-ヒドロキシヘキサン酸は、アジピン酸、カプロラクタム、6-アミノヘキサン酸、ヘキサメチレンジアミン、または1,6-ヘキサンジオールに酵素的に変換され得る。本明細書はまた、6-ヒドロキシヘキサン酸、ならびにアジピン酸、カプロラクタム、6-アミノヘキサン酸、ヘキサメチレンジアミン、および1,6-ヘキサンジオールを産生する組換え宿主を記載する。 | ||||||
| 5 | フェニルプロパノイドおよびジヒドロフェニルプロパノイド誘導体の生合成 | JP2017563056 | 2016-06-06 | JP2018520661A | 2018-08-02 | ナエスビー,ミヒャエル; シモン ヴェシリア,エルネスト; アイヒェンベルガー,ミヒャエル; レーカ,ベアタ ジョアンナ; ビョルン−ヨシモト,ワルデン エミール; イェンセン,ニールス ベルグ; ディエクイェル,ジェーン ダノウ |
| 本明細書では、カルコンおよびスチルベンなどのフェニルプロパノイド誘導体、ならびにジヒドロカルコンおよびジヒドロスチルベンなどのジヒドロフェニルプロパノイド誘導体を、微生物中で生産するための方法および組成物が提供される。特に本開示は、フェニルプロパノイド誘導体化合物およびジヒドロフェニルプロパノイド誘導体化合物を生産するための、組換え微生物およびその使用方法を提供する。 | ||||||
| 6 | Electrochemical Bioreactor Module and Engineered Metabolic Pathways for 1-Butanol Production with High Carbon Efficiency | US15552647 | 2016-02-23 | US20180037914A1 | 2018-02-08 | David R. Dodds; William B. Armiger; Mattheos Koffas |
| A combination of an electrochemical device for delivering reducing equivalents to a cell, and engineered metabolic pathways within the cell capable of utilizing the electrochemically provided reducing equivalents is disclosed. Such a combination allows the production of commodity chemicals by fermentation to proceed with increased carbon efficiency. | ||||||
| 7 | BACTERIA ENGINEERED FOR CONVERSION OF ETHYLENE TO N-BUTANOL | US15317656 | 2015-06-09 | US20170137846A1 | 2017-05-18 | Shota ATSUMI; Michael D. TONEY; Gabriel M. RODRIGUEZ; Yohei TASHIRO; Justin B. SIEGEL; D. Alexander CARLIN; Irina KORYAKINA; Shuchi H. DESAI |
| The present disclosure provides recombinant bacteria with elevated production of ethanol and/or n-butanol from ethylene. Methods for the production of the recombinant bacteria, as well as for use thereof for production of ethanol and/or n-butanol are also provided. | ||||||
| 8 | Method for the production of 1-butanol | US12110503 | 2008-04-28 | US08426173B2 | 2013-04-23 | Michael G. Bramucci; Dennis Flint; Edward S. Miller, Jr.; Vasantha Nagarajan; Natalia Sedkova; Manjari Singh; Tina K. Van Dyk |
| A method for the production of 1-butanol by fermentation using a microbial production host is disclosed. The method employs a reduction in temperature during the fermentation process that results in a more robust tolerance of the production host to the butanol product. | ||||||
| 9 | ITERATIVE PLATFORM FOR THE SYNTHESIS OF ALPHA FUNCTIONALIZED PRODUCTS | US15566704 | 2016-04-15 | US20180142273A1 | 2018-05-24 | Ramon GONZALEZ; James M. CLOMBURG; Seokjung CHEONG |
| The use of microorganisms to make alpha-functionalized chemicals and fuels, (e.g. alpha-functionalized carboxylic acids, alcohols, hydrocarbons, amines, and their beta-, and omega-functionalized derivatives), by utilizing an iterative carbon chain elongation pathway that uses functionalized extender units. The core enzymes in the pathway include thiolase, dehydrogenase, dehydratase and reductase. Native or engineered thiolases catalyze the condensation of either unsubstituted or functionalized acyl-CoA primers with an alpha-functionalized acetyl-CoA as the extender unit to generate alpha-functionalized β-keto acyl-CoA. Dehydrogenase converts alpha-functionalized β-keto acyl-CoA to alpha-functionalized β-hydroxy acyl-CoA. Dehydratase converts alpha-functionalized β-hydroxy acyl-CoA to alpha-functionalized enoyl-CoA. Reductase converts alpha-functionalized enoyl-CoA to alpha-functionalized acyl-CoA. The platform can be operated in an iterative manner (i.e. multiple turns) by using the resulting alpha-functionalized acyl-CoA as primer and the aforementioned alpha-functionalized extender unit in subsequent turns of the cycle. Termination pathways acting on any of the four alpha-functionalized CoA thioester intermediates terminate the platform and generate various alpha-functionalized carboxylic acids, alcohols and amines with different β-reduction degree. | ||||||
| 10 | Biosynthesis of Phenylpropanoid and Dihydrophenylpropanoid Derivatives | US15579415 | 2016-06-06 | US20180142216A1 | 2018-05-24 | Michael NAESBY; Ernesto SIMÓN VECILLA; Michael EICHENBERGER; Beata Joanna LEHKA; Walden Emil BJØRN-YOSHIMOTO; Niels Bjerg JENSEN; Jane Dannow DYEKJÆR |
| Provided herein are methods and compositions for producing phenylpropanoid derivatives, such as chalcones and stilbenes, and dihydrophenylpropanoid derivatives, such as dihydrochalcones and dihydrostilbenes, in microorganisms. In particular, the disclosure provides recombinant microorganisms and methods of use thereof for producing phenylpropanoid derivative compounds and dihydrophenylpropanoid derivative compounds. | ||||||
| 11 | COMPOSTITIONS AND METHODS FOR RECOMBINANT BIOSYNTHESIS OF PROPANE | US15421861 | 2017-02-01 | US20170218401A1 | 2017-08-03 | Nigel Scrutton; Patrik Jones; Navya Menon |
| Provided are genetically engineered microorganism that catalyze the synthesis of propane and/or butanol from a suitable substrate such as glucose. Also provided are methods of engineering said genetically engineered microorganism and methods of producing propane and/or butanol using the genetically engineered microorganism. | ||||||
| 12 | Materials and Methods of Producing 7-Carbon Monomers | US14977026 | 2015-12-21 | US20160201097A1 | 2016-07-14 | Adriana Leonora Botes; Alex Van Eck Conradie |
| This document describes materials and methods for producing 7-hydroxyheptanoic acid using a β-ketothiolase or a synthase and an alcohol O-acetyltransferase to form a 7-acetyloxy-3-oxoheptanoyl-CoA intermediate. This document describes biochemical pathways for producing 7-hydroxyheptanoic acid using a β-ketothiolase or a synthase and an alcohol O-acetyltransferase to form a 7-acetyloxy-3-oxoheptanoyl-CoA intermediate. 7-hydroxyheptanoic acid can be enzymatically converted to pimelic acid, 7-aminoheptanoic acid, heptamethylenediamine or 1,7 heptanediol. This document also describes recombinant hosts producing 7-hydroxyheptanoic acid as well as pimelic acid, 7-aminoheptanoic acid, heptamethylenediamine and 1,7 heptanediol. | ||||||
| 13 | Methods and Materials for Producing 6-Carbon Monomers | US14941501 | 2015-11-13 | US20160160255A1 | 2016-06-09 | Adriana Leonora Botes; Alex Van Eck Conradie; Nadia Kadi |
| This document describes biochemical pathways for producing 6-hydroxyhexanoic acid using a polypeptide having β-ketothiolase activity to form a 3-oxo-6-hydroxyhexanoyl-CoA intermediate. 6-hydroxyhexanoic acid can be enzymatically converted to adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine or 1,6-hexanediol. This document also describes recombinant hosts producing 6-hydroxyhexanoic acid as well as adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine and 1,6-hexanediol. | ||||||
| 14 | BIOSYNTHESIS OF PHENYLPROPANOID AND DIHYDROPHENYLPROPANOID DERIVATIVES | EP16729515.3 | 2016-06-06 | EP3303573A1 | 2018-04-11 | NAESBY, Michael; SIMÓN VECILLA, Ernesto; EICHENBERGER, Michael; LEHKA, Beata Joanna; BJØRN-YOSHIMOTO, Walden Emil; JENSEN, Niels Bjerg; DYEKJÆR, Jane Dannow |
| Provided herein are methods and compositions for producing phenylpropanoid derivatives, such as chalcones and stilbenes, and dihydrophenylpropanoid derivatives, such as dihydrochalcones and dihydrostilbenes, in microorganisms. In particular, the disclosure provides recombinant microorganisms and methods of use thereof for producing phenylpropanoid derivative compounds and dihydrophenylpropanoid derivative compounds. | ||||||
| 15 | Method for the production of 1-butanol | EP08747082.9 | 2008-04-29 | EP2142656B1 | 2015-04-08 | BRAMUCCI, Michael, G.; FLINT, Dennis; MILLER JR, Edward, S.; NAGARAJAN, Vasantha; SEDKOVA, Natalia; SINGH, Manjari; VAN DYK, Tina, K. |
| 16 | ELECTROCHEMICAL BIOREACTOR MODULE AND ENGINEERED METABOLIC PATHWAYS FOR 1- BUTANOL PRODUCTION WITH HIGH CARBON EFFICIENCY | EP16756175.2 | 2016-02-23 | EP3262179A1 | 2018-01-03 | DODDS, David R.; ARMIGER, William B.; KOFFAS, Mattheos |
| A combination of an electrochemical device for delivering reducing equivalents to a cell, and engineered metabolic pathways within the cell capable of utilizing the electrochemically provided reducing equivalents is disclosed. Such a combination allows the production of commodity chemicals by fermentation to proceed with increased carbon efficiency. | ||||||
| 17 | METHOD FOR THE PRODUCTION OF 1-BUTANOL | EP08747082.9 | 2008-04-29 | EP2142656A1 | 2010-01-13 | BRAMUCCI, Michael, G.; FLINT, Dennis; MILLER JR, Edward, S.; NAGARAJAN, Vasantha; SEDKOVA, Natalia; SINGH, Manjari; VAN DYK, Tina, K. |
| A method for the production of 1-butanol by fermentation using a microbial production host is disclosed. The method employs a reduction in temperature during the fermentation process that results in a more robust tolerance of the production host to the butanol product. | ||||||
| 18 | ELECTROCHEMICAL BIOREACTOR MODULE AND ENGINEERED METABOLIC PATHWAYS FOR 1- BUTANOL PRODUCTION WITH HIGH CARBON EFFICIENCY | EP16756175 | 2016-02-23 | EP3262179A4 | 2018-07-11 | DODDS DAVID R; ARMIGER WILLIAM B; KOFFAS MATTHEOS |
| A combination of an electrochemical device for delivering reducing equivalents to a cell, and engineered metabolic pathways within the cell capable of utilizing the electrochemically provided reducing equivalents is disclosed. Such a combination allows the production of commodity chemicals by fermentation to proceed with increased carbon efficiency. | ||||||
| 19 | ITERATIVE PLATFORM FOR THE SYNTHESIS OF ALPHA FUNCTIONALIZED PRODUCTS | EP16780890.6 | 2016-04-15 | EP3283615A1 | 2018-02-21 | GONZALEZ, Ramon; CLOMBURG, James, M.; CHEONG, Seokjung |
| The use of microorganisms to make alpha-functionalized chemicals and fuels, (e.g. alpha-functionalized carboxylic acids, alcohols, hydrocarbons, amines, and their beta-, and omega-functionalized derivatives), by utilizing an iterative carbon chain elongation pathway that uses functionalized extender units. The core enzymes in the pathway include thiolase, dehydrogenase, dehydratase and reductase. Native or engineered thiolases catalyze the condensation of either unsubstituted or functionalized acyl-CoA primers with an alpha-functionalized acetyl-CoA as the extender unit to generate alpha-functionalized β-keto acyl-CoA. Dehydrogenase converts alpha-functionalized β-keto acyl-CoA to alpha-functionalized β-hydroxy acyl-CoA. Dehydratase converts alpha-functionalized β-hydroxy acyl-CoA to alpha-functionalized enoyl-CoA. Reductase converts alpha-functionalized enoyl-CoA to alpha-functionalized acyl-CoA. The platform can be operated in an iterative manner (i.e. multiple turns) by using the resulting alpha-functionalized acyl-CoA as primer and the aforementioned alpha-functionalized extender unit in subsequent turns of the cycle. Termination pathways acting on any of the four alpha-functionalized CoA thioester intermediates terminate the platform and generate various alpha-functionalized carboxylic acids, alcohols and amines with different β-reduction degree. | ||||||
| 20 | MATERIALS AND METHODS OF PRODUCING 7-CARBON MONOMERS | EP15831024.3 | 2015-12-21 | EP3237634A1 | 2017-11-01 | BOTES, Adriana Leonora; CONRADIE, Alex Van Eck |
| This document describes materials and methods for producing 7-hydroxyheptanoic acid using a β-ketothiolase or a synthase and an alcohol O-acetyltransferase to form a 7-acetyloxy-3-oxoheptanoyl-CoA intermediate. This document describes biochemical pathways for producing 7-hydroxyheptanoic acid using a β-ketothiolase or a synthase and an alcohol O-acetyltransferase to form a 7-acetyloxy-3-oxoheptanoyl-CoA intermediate. 7-hydroxyheptanoic acid can be enzymatically converted to pimelic acid, 7-aminoheptanoic acid, heptamethylenediamine or 1,7 heptanediol. This document also describes recombinant hosts producing 7-hydroxyheptanoic acid as well as pimelic acid, 7-aminoheptanoic acid, heptamethylenediamine and 1,7 heptanediol. | ||||||
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