| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 141 | 抗ウィルス化合物 | JP2013533986 | 2011-10-12 | JP5834085B2 | 2015-12-16 | デイゴーイ,デイビツド・エイ; ケイテイ,ウオーレン・エム; ハツチンス,チヤールズ・ダブリユ; ドナー,パメラ・エル; クリユーガー,アラン・シー; ランドルフ,ジヨン・テイー; モツター,クリストフアー・イー; ネルソン,リサ・テイー; パテル,サツチエル・ブイ; マツレンコ,マーク・エイ; ケデイー,ライアン・ジー; ジンカーソン,タミー・ケイ; ガオ,イー; リウ,ダーチユン; プラツト,ジヨン・ケイ; ロツクウエイ,トツド・ダブリユ; マーリング,クラレンス・ジエイ; ハツチンソン,ダグラス・ケイ; フレンテ,チヤールズ・エイ; ワグナー,ロルフ; テユフアノ,マイケル・デイー; ベテベナー,デイビツド・エイ; サリス,キヤシー; ウオーラー,ケビン・アール; ワゴー,シーブル・エイチ; カリフアノ,ジーン・シー; リー,ウエンケ; カスピ,ダニエル・デイー; ベリツツイ,メアリー・イー; キヤロル,ウイリアム・エイ |
| 142 | Glucosylceramide synthase inhibitors | JP2013558205 | 2012-03-16 | JP2014517808A | 2014-07-24 | エリゼ・ボーク; カッサンドラ・セラツカ; ブラッドフォード・ハース; マルクス・メッツ; ジョーン・ジャオ; レナート・スケルリ; イービン・シアーン; キャサリン・ジャンシシックス; ジョン・マーシャル; スオン・チュヨン; ロナルド・シュール; マリオ・カブレラ−サラザール; アンドリュー・グッド |
| 本発明は、単独で、または酵素補充療法と組み合わせて、リソソーム蓄積症などの代謝性疾患の治療に有用な、および癌の治療に有用なグルコシルセラミド合成酵素（ＧＣＳ）の阻害剤に関する。 | ||||||
| 143 | Antibacterial agent | JP2010167639 | 2010-07-26 | JP5277213B2 | 2013-08-28 | エイチ． アンダーセン ネイルズ; ボウマン ジェイソン; アーウィン アリス; ハーウッド エリック; クライン トニ; ムドゥルリ ヒシムジ; ング シモン; ビー． フィスター キース; ショーアー リビー; ワグマン アラン; ヤバンナバー アシャ |
| Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds. | ||||||
| 144 | Antibacterial agent | JP2006500858 | 2004-01-08 | JP5086635B2 | 2012-11-28 | ネイルズ エイチ． アンダーセン，; ジェイソン ボウマン，; アリス アーウィン，; エリック ハーウッド，; トニ クライン，; ヒシムジ ムドゥルリ，; シモン ング，; キース ビー． フィスター，; リビー ショーアー，; アラン ワグマン，; アシャ ヤバンナバー， |
| 145 | Compounds for the treatment of hepatitis C | JP2011526931 | 2009-09-08 | JP2012502101A | 2012-01-26 | アンドリュー・ニッケル; イン・ハン; カイル・イー・パーセラ; カプ−スン・イェウン; キャサリン・エイ・グラント−ヤング; ジョン・エイ・ベンダー; ジョン・エフ・カドウ; ピヤセナ・ヘワワサム; ブレット・アール・ベノ |
| 本発明は、式Iの化合物、およびそれらの塩、ならびに該化合物を用いた組成物および方法を提供する。 該化合物はC型肝炎ウイルス(HCV)に対する活性を有し、HCVに感染した患者の治療に有用でありうる。 | ||||||
| 146 | Antimicrobial agents | JP2010167639 | 2010-07-26 | JP2010280684A | 2010-12-16 | ANDERSEN NEILS H; BOWMAN JASON; ERWIN ALICE; HARWOOD ERIC; KLINE TONI; MDLULI KHISIMUZI; NG SIMON; PFISTER KEITH B; SHAWAR RIBHI; WAGMAN ALLAN; YABANNAVAR ASHA |
| <P>PROBLEM TO BE SOLVED: To provide antimicrobial compounds. <P>SOLUTION: The antimicrobial compounds of formula (I) are provided. Similarly, stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof are also provided. Further, pharmaceutical compositions containing such compounds, methods for treating bacterial infections by administering such compounds, and processes for preparing the compounds, are provided. Besides, such new compounds, pharmaceutical compositions containing the same, methods of inhibiting UDP-3-O-(R-3-hydroxydecanoyl)-N-acetylglucosamine deacetylase(LpxC), and methods for treating Gram-negative bacterial infections, are also provided. <P>COPYRIGHT: (C)2011,JPO&INPIT | ||||||
| 147 | Process for producing an optically active 3-quinuclidinol | JP562797 | 1997-01-16 | JP4122536B2 | 2008-07-23 | ブリーデン ヴァルター |
| 148 | Production of optically active 3-quinuclidinol | JP562797 | 1997-01-16 | JPH09194480A | 1997-07-29 | BUARUTAA BURIIDEN |
| PROBLEM TO BE SOLVED: To produce an optically active 3-quinuclidinol useful as a raw material, etc., for synthesizing a pharmacologically active substance by asymmetrically hydrogenating a quinuclidine derivative such as an optically active 3- quinuclidinone in the presence of a transition metallic complex catalyst containing a chiral diphosphine as a ligand and then removing a substituent group. SOLUTION: A quinuclidine derivative selected from a 3-quinuclidinone represented by formula I, its adduct to a Lewis acid and a tertiary and a quaternary salts, etc., corresponding thereto and represented by formula II (R 1 is H, a mono-, a di- or a tri-arylmethyl; A - is an anion of an inorganic or an organic acid) is asymmetrically hydrogenated in the presence of an optically active complex compound of rhodium, iridium or ruthenium having a chiral diphosphine, acting as a catalyst and having a metallocene structure represented by formula III [R 2a, R 2b, R 3a and R 3b are each a 1-12C alkyl, a 5-7C cycloalkyl, a (substituted)phenyl or its enantiomer] and the substituent group R 1, as necessary, is then eliminated to afford the objective optically active 3-quinuclidinol represented by formula IV. COPYRIGHT: (C)1997,JPO | ||||||
| 149 | GEMINAL SUBSTITUTED QUINUCLIDINE AMIDE COMPOUNDS AS AGONISTS OF ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTORS | EP15870786 | 2015-12-14 | EP3233087A4 | 2018-05-30 | ACHARYA RAKSHA; BURNETT DUANE A; BURSAVICH MATTHEW GREGORY; COOK ANDREW SIMON; HARRISON BRYCE ALDEN; KOENIG GERHARD; MCRINER ANDREW J |
| The present invention relates to novel geminal substituted quinuclidine amide compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of α7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom. | ||||||
| 150 | 3,5-DICHLORO,4-(3,4-(CYCLO-)ALKOXYPHENYL)--2-CARBONYLOXY)ETHYL)PYRIDINE DERIVATIVES AS PDE-4 INHIBITORS | EP14730808.4 | 2014-06-04 | EP3152202A1 | 2017-04-12 | AMARI, Gabriele; ARMANI, Elisabetta; RICCABONI, Mauro; RIZZI, Andrea; BAKER-GLENN, Charles; BLACKABY, Wesley; VAN DE POËL, Hervé; WHITTAKER, Ben |
| The invention relates to novel 3,5-dichloro,4-(3,4-(cyclo-) alkoxyphenyl)--2-carbonyloxy)ethyl)pyridine compounds which are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof. | ||||||
| 151 | PHENYLETHYLPYRIDINE DERIVATIVES AS PDE4-INHIBITORS | EP13811823.7 | 2013-12-04 | EP2928883A1 | 2015-10-14 | AMARI, Gabriele; ARMANI, Elisabetta; RICCABONI, Mauro; BAKER-GLENN, Charles |
| Compounds of formula (I) described herein are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction. | ||||||
| 152 | PHENYLETHYLPYRIDINE DERIVATIVES AS PDE4-INHIBITORS | EP13811821.1 | 2013-12-04 | EP2928879A1 | 2015-10-14 | AMARI, Gabriele; ARMANI, Elisabetta; RICCABONI, Mauro; BAKER-GLENN, Charles |
| Compounds of formula (I) defined herein are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of a disease of the respiratory tract characterized by airway obstruction. | ||||||
| 153 | Heterocyclic compounds as inhibitors of hepatitis C virus (HCV) | EP12155991.8 | 2010-06-10 | EP2455376B1 | 2014-11-26 | Randolph, John T.; Matulenko, Mark A.; Keddy, Ryan G.; Jinkerson, Tammie K.; Hutchinson, Douglas K.; Flentge, Charles A.; Wagner, Rolf; Maring, Clarence J.; Tufano, Michael D.; Betebenner, David A.; Rockway, Todd W.; Degoey, David A.; Liu, Dachun; Pratt, John K.; Sarris, Kathy; Woller, Kevin R.; Wagaw, Seble H.; Califano, Jean C.; Li, Wenke; Caspi, Daniel D.; Bellizzi, Mary, E.; Gao, Yi; Kati, Warren M.; Hutchins, Charles W.; Donner, Pamela L.; Krueger, Allan C.; Motter, Christopher E; Nelson, Lissa T.; Patel, Sachin V. |
| 154 | AMINOPYRAZINE COMPOUNDS USEFUL AS INHIBITORS OF TRA KINASE | EP12716870.6 | 2012-04-05 | EP2694498A1 | 2014-02-12 | CHARRIER, Jean-Damien; MACCORMICK, Somhairle; STORCK, Pierre-Henri; PINDER, Joanne; O'DONNELL, Michael, Edward; KNEGTEL, Ronald Marcellus, Alphonsus; YOUNG, Stephen, Clinton Young; KAY, David; REAPER, Philip, Michael; DURRANT, Steven, John; TWIN, Heather, Clare; DAVIS, Christopher, John |
| The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (I): wherein the variables are as defined herein. | ||||||
| 155 | 2,5-METHANO-AND 2,5-ETHANO-TETRAHYDROBENZAZEPINE DERIVATIVES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN | EP11818722 | 2011-08-17 | EP2606049A4 | 2014-01-08 | GUZZO PETER ROBERT; LIU SHUANG; RYAN KRISTEN N |
| 156 | ANTI-VIRAL COMPOUNDS | EP11773371.7 | 2011-10-12 | EP2627651A1 | 2013-08-21 | DEGOEY, David A.; KATI, Warren M.; HUTCHINS, Charles W.; DONNER, Pamela L.; KRUEGER, Allan C.; RANDOLPH, John T.; MOTTER, Christopher E.; NELSON, Lissa T.; PATEL, Sachel V.; MATULENKO, Mark A.; KEDDY, Ryan G.; JINKERSON, Tammie K.; GAO, Yi; LIU, Dachun; PRATT, John K.; ROCKWAY, Todd W.; MARING, Clarence J.; HUTCHINSON, Douglas K.; FLENTGE, Charles A.; WAGNER, Rolf; TUFANO, Michael D.; BETEBENNER, David A.; SARRIS, Kathy; WOLLER, Kevin R.; WAGAW, Sebel H.; CALIFANO, Jean C.; LI, Wenke; CASPI, Daniel D.; BELLIZZI, Mary E.; CARROLL, William A. |
| Compounds effective in inhibiting replication of Hepatitis C virus (HCV) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection. | ||||||
| 157 | 2,5-METHANO-AND 2,5-ETHANO-TETRAHYDROBENZAZEPINE DERIVATIVES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN | EP11818722.8 | 2011-08-17 | EP2606049A2 | 2013-06-26 | GUZZO, Peter, Robert; LIU, Shuang; RYAN, Kristen, N. |
| The compounds of the present invention are represented by the following 2,5-methano- and 2,5-ethano-tetrahydrobenzazepine derivatives having formula (I): where the carbon atom designated * is in the R or S configuration when n is 1 and the substituents X and R1-R7 are as defined herein. | ||||||
| 158 | Hepatitis C virus inhibitors | EP11160830.3 | 2010-06-10 | EP2368890B1 | 2013-04-17 | Randolph, John T.; Degoey, David A.; Kati, Warren M.; Hutchins, Charles W.; Donner, Pamela L.; Krueger, Allan C.; Motter, Christopher E.; Nelson, Lissa T.; Patel, Sachin V.; Matulenko, Mark A.; Keddy, Ryan G.; Jinkerson, Tammie K.; Hutchinson, Douglas K.; Flentge, Charles A.; Wagner, Charles A.; Maring, Clarence J.; Tufano, Michael D.; Betebenner, David A.; Rockway, Todd W.; Liu, Dachun; Pratt, John K.; Sarris, Kathy; Woller, Kevin R.; Wagaw, Seble H.; Califano, Jean C.; Li, Wenke; Caspi, Daniel D.; Bellizzi, Mary E.; YI, Gao |
| 159 | Heterocyclic compounds as inhibitors of hepatitis C virus (HCV) | EP12155991.8 | 2010-06-10 | EP2455376A1 | 2012-05-23 | Randolph, John T.; Matulenko, Mark A.; Keddy, Ryan G.; Jinkerson, Tammie K.; Hutchinson, Douglas K.; Flentge, Charles A.; Wagner, Rolf; Maring, Clarence J.; Tufano, Michael D.; Betebenner, David A.; Rockway, Todd W.; Degoey, David A.; Liu, Dachun; Pratt, John K.; Sarris, Kathy; Woller, Kevin R.; Wagaw, Seble H.; Califano, Jean C.; Li, Wenke; Caspi, Daniel D.; Bellizzi, Mary, E.; Gao, Yi; Kati, Warren M.; Hutchins, Charles W.; Donner, Pamela L.; Krueger, Allan C.; Motter, Christopher E; Nelson, Lissa T.; Patel, Sachin V. |
Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection. |
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| 160 | Hepatitis C virus inhibitors | EP11160830.3 | 2010-06-10 | EP2368890A1 | 2011-09-28 | Randolph, John T.; Degoey, David A.; Kati, Warren M.; Hutchins, Charles W.; Donner, Pamela L.; Krueger, Allan C.; Motter, Christopher E.; Nelson, Lissa T.; Patel, Sachin V.; Matulenko, Mark A.; Keddy, Ryan G.; Jinkerson, Tammie K.; Soltwedel, Todd N.; Hutchinson, Douglas K.; Flentge, Charles A.; Wagner, Charles A.; Maring, Clarence J.; Tufano, Michael D.; Betebenner, David A.; Rockway, Todd W.; Liu, Dachun; Pratt, John K.; Lavin, Michael J.; Sarris, Kathy; Woller, Kevin R.; Wagaw, Seble H.; Califano, Jean C.; Li, Wenke; Caspi, Daniel D.; Bellizzi, Mary E. |
Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection. |
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