| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 161 | Antibacterial agents | EP10179798.3 | 2004-01-08 | EP2295402A3 | 2011-08-03 | Andersen, Neils H.; Bowman, Jason; Erwin, Alice; Harwood, Eric; Kline, Toni; Mdluli, Khisimuzi; Ng, Simon; Pfister, Keith B.; Shawar, Ribhi; Wagman, Allan; Yabannavar, Asha |
Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds. |
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| 162 | ANTI-VIRAL COMPOUNDS TO TREAT HCV INFECTION | EP10724656.3 | 2010-06-10 | EP2337781A2 | 2011-06-29 | RANDOLPH, John T.; DEGOEY, David A.; KATI, Warren M.; HUTCHINS, Charles W.; DONNER, Pamela L.; KRUEGER, Allan C.; MOTTER, Christopher E.; NELSON, Lissa T.; PATEL, Sachin V.; MATULENKO, Mark A.; KEDDY, Ryan G.; JINKERSON, Tammie K.; SOLTWEDEL, Todd N.; HUTCHINSON, Douglas K.; FLENTGE, Charles A.; WAGNER, Rolf; MARING, Clarence J.; TUFANO, Michael D.; BETEBENNER, David A.; ROCKWAY, Todd W.; LIU, Dachun; PRATT, John K.; LAVIN, Michael J.; SARRIS, Kathy; WOLLER, Kevin R.; WAGAW, Seble H.; CALIFANO, Jean C.; LI, Wenke; CASPI, Daniel.D.; BELLIZZI, Mary, E. |
| Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection. | ||||||
| 163 | ANTIBACTERIAL AGENTS | EP04700887 | 2004-01-08 | EP1618087A4 | 2007-01-31 | ANDERSON NIELS H; BOWMAN JASON; ERWIN ALICE; HARWOOD ERIC; KLINE TONI; MDLULI KHISIMUZI; NG SIMON; PFISTER KEITH B; SHAWAR RIBHI; WAGMAN ALLAN; YABANNAVAR ASHA |
| 164 | Verfahren zur Herstellung von optisch aktivem 3-Chinuclidinol | EP96120280.1 | 1996-12-17 | EP0785198A1 | 1997-07-23 | Brieden, Walter Dr. |
Optisch aktives 3-Chinuclidinol wird durch asymmetrische Hydrierung von 3-Chinuclidinon, dessen Lewis-Säure-Addukten oder dessen tertiären oder quartären Salzen wie beispielsweise 1-(Diphenylmethyl)-3-oxochinuclidiniumbromid erhalten. Als Katalysatoren werden vorzugsweise Rhodiumkomplexe mit chiralen Diphosphinen mit Metallocenstruktur eingesetzt. Das optisch aktive 3-Chinuclidinol ist ein Synthesebaustein für pharmazeutische Wirkstoffe (M1-Rezeptor-Agonisten). |
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| 165 | PHENYLETHYLPYRIDINE DERIVATIVES AS PDE4-INHIBITORS AND MUSCARINIC RECEPTOR ANTAGONISTS | EP13811821.1 | 2013-12-04 | EP2928879B1 | 2018-02-28 | AMARI, Gabriele; ARMANI, Elisabetta; RICCABONI, Mauro; BAKER-GLENN, Charles |
| Compounds of formula (I) defined herein are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of a disease of the respiratory tract characterized by airway obstruction. | ||||||
| 166 | PHENYLETHYLPYRIDINE DERIVATIVES AS PDE4-INHIBITORS AND MUSCARINIC RECEPTOR ANTAGONISTS | EP13811823.7 | 2013-12-04 | EP2928883B1 | 2018-02-14 | AMARI, Gabriele; ARMANI, Elisabetta; RICCABONI, Mauro; BAKER-GLENN, Charles |
| Compounds of formula (I) described herein are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction. | ||||||
| 167 | PHENYLETHYLPYRIDINE DERIVATIVES AS PDE4-INHIBITORS AND MUSCARINIC RECEPTOR ANTAGONISTS | EP13811822.9 | 2013-12-04 | EP2928880B1 | 2018-02-14 | AMARI, Gabriele; ARMANI, Elisabetta; RICCABONI, Mauro; RIZZI, Andrea; BAKER-GLENN, Charles; BLACKABY, Wesley; VAN DE PÖEL, Hervé; WHITTAKER, Ben |
| Compounds of formula (I) described herein are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction. | ||||||
| 168 | 3,5-DICHLORO,4-(3,4-(CYCLO-)ALKOXYPHENYL)- 2-CARBONYLOXY)ETHYL)PYRIDINE DERIVATIVES AS PDE-4 INHIBITORS | EP14731175.7 | 2014-06-04 | EP3152203A1 | 2017-04-12 | AMARI, Gabriele; ARMANI, Elisabetta; RICCABONI, Mauro; BAKER-GLENN, Charles |
| The invention relates to novel 3,5-dichloro,4-(3,4-(cyclo-) alkoxyphenyl)-2-carbonyloxy)ethyl)pyridine compounds which are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof. | ||||||
| 169 | BENZOPYRROLIDONE DERIVATIVES POSSESSING ANTIVIRAL AND ANTICANCER PROPERTIES | EP15155298.1 | 2015-02-16 | EP3056202A1 | 2016-08-17 | Kéri, György; Örfi, László; Horváth, Zoltán; Szokol, Bálint; Dobos, Judit; Nemes, Zoltán; Szàntay Kis, Csaba; Erös, Dánilel; Breza, Nóra; Baska, Ferenc; Karlas, Alexander; Gödert, Sigrid; Meyer, Thomas F. |
The present invention relates to benzopyrrolidone derivatives and/or pharmaceutically acceptable salts thereof for the use in the treatment of infectious diseases or cancer, and pharmaceutical compositions containing at least one of said benzopyrrolidone derivatives and/or pharmaceutically acceptable salts thereof for the use in the treatment of infectious diseases or cancer.
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| 170 | Antibacterial agents | EP10179798.3 | 2004-01-08 | EP2295402B1 | 2015-08-12 | Andersen, Niels H.; Bowman, Jason; Erwin, Alice; Harwood, Eric; Kline, Toni; Mdluli, Khisimuzi; Ng, Simon; Pfister, Keith B.; Shawar, Ribhi; Wagman, Allan; Yabannavar, Asha |
| 171 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | EP12760259 | 2012-03-16 | EP2685986A4 | 2015-03-04 | BOURQUE ELYSE; CELATKA CASSANDRA; HIRTH BRADFORD; METZ MARKUS; ZHAO ZHONG; SKERLJ RENATO; XIANG YIBIN; JANCISICS KATHERINE; MARSHALL JOHN; CHENG SENG; SCHEULE RONALD; CABRERA-SALAZAR MARIO; GOOD ANDREW |
| The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer. | ||||||
| 172 | COMPOUNDS USEFUL AS INHIBITORS OF CHOLINE KINASE | EP12772843.4 | 2012-09-21 | EP2758395A1 | 2014-07-30 | EVERITT, Simon; KNEGTEL, Ronald; MORTIMORE, Michael; Rutherford, Alistair |
| The present invention relates to compounds useful as inhibitors of choline kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions. | ||||||
| 173 | Anti-viral compounds | EP13191049.9 | 2011-10-12 | EP2692726A1 | 2014-02-05 | Degoey, David A.; Kati, Warren M.; Hutchins, Charles W.; Donner, Pamela L; Krueger, Allan C.; Randolph, John T.; Motter, Christopher E.; Nelson, Lissa T.; Patel, Sachel V.; Matulenko, Mark A.; Keddy, Ryan G.; Jinkerson, Tammie K.; Gao, Yi; Liu, Dachun; Pratt, John K.; Rockway, Todd W.; Maring, Clarence J.; Hutchinson, Douglas K.; Flentge, Charles A.; Wagner, Rolf; Tufano, Michael D.; Betebenner, David A.; Sarris, Kathy; Woller, Kevin R.; Wagaw, Sebel H.; Califano, Jean C.; Li, Wenke; Caspi, Daniel D.; Bellizzi, Mary E.; Carroll, William A. |
Compounds effective in inhibiting replication of Hepatitis C virus (HCV) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection. |
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| 174 | Trisubstituted heterocycles as replication inhibitors of hepatitis C virus HCV | EP13167828.6 | 2010-06-10 | EP2628481A1 | 2013-08-21 | Randolph, John T.; Degoey, David A.; Kati, Warren M.; Hutchins, Charles W.; Donner, Pamela L.; Krueger Allan C.; Motter, Christopher E.; Nelson, Lissa T.; Patel, Sachin V.; Matulenko, Mark A.; Keddy, Ryan G.; Jinkerson, Tammie K.; Hutchinson Douglas K.; Flentge, Charles A.; Wagner, Rolf; Maring, Clarence J.; Tufano, Michael D.; Betebenner, David A.; Rockway, Todd W.; Liu, Dachun; Pratt, John K.; Sarris, Kathy; Woller, Kevin R.; Wagaw, Seble H.; Califano, Jean C.; Li, Wenke; Caspi, Daniel.D.; Bellizzi, Mary, E.; Gao, Yi |
Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection. |
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| 175 | ANTIBACTERIAL AGENTS | EP04700887.5 | 2004-01-08 | EP1618087B1 | 2012-06-13 | ANDERSON, Niels H.; BOWMAN, Jason; ERWIN, Alice; HARWOOD, Eric; KLINE, Toni; MDLULI, Khisimuzi; NG, Simon; PFISTER, Keith B.; SHAWAR, Ribhi; WAGMAN, Allan; YABANNAVAR, Asha |
| Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds. | ||||||
| 176 | Antibacterial agents | EP10179798.3 | 2004-01-08 | EP2295402A2 | 2011-03-16 | Andersen, Neils H.; Bowman, Jason; Erwin, Alice; Harwood, Eric; Kline, Toni; Mdluli, Khisimuzi; Ng, Simon; Pfister, Keith B.; Shawar, Ribhi; Wagman, Allan; Yabannavar, Asha |
Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds. |
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| 177 | NOUVEAUX DERIVES DE CARBAZOLE INHIBITEURS D' HSP90, COMPOSITIONS LES CONTENANT ET UTILISATION | EP09728587.8 | 2009-03-13 | EP2265598A2 | 2010-12-29 | ALASIA, Marcel; BERTIN, Luc; CERTAL, Victor; HALLEY, Frank; MAILLIET, Patrick; MENDEZ PEREZ, Maria; MINOUX, Hervé; RUXER, Jean-Marie |
| The invention relates to the novel substances in Formula (I): wherein Het is a heterocycle optionally substituted by one or a plurality of radicals R1 or R'1; R is selected from the group comprising Formula (II) with R1 and/or R'1 selected from H, halogen, CF3, nitro, cyano, alkyl, hydroxyl, mercapto, amino, alkylamino, dialkylamino, alkoxy, phenylalcoxy, alkythio, or carboxy that is free or esterified by an alkyl, carboxamide, CO-NH(alkyl), CON(alkyl)2, NH-CO-alkyl, sulfonamide, NH-SO2-alkyl, S(O)2-NHalkyl, or S(O2)-N(alkyl)2 radical; all these radicals are optionally substituted; W1, W2, and W3 independently are CH or N; X is O, S, NR2, C(O), S(O), or S(O)2; Z is optionally substituted H, HaI, -O-R2 or –NH-R2 with R2 being H, alkyl, cycloalkyl, or heterocycloalkyl; and these substances are all isomeric forms and salts thereof, used as drugs. | ||||||
| 178 | A METHOD FOR THE PREPARATION OF SOLIFENACIN | EP07855994.5 | 2007-12-21 | EP2094693A2 | 2009-09-02 | JIRMAN, Josef; JUNEK, Richard |
| A method of preparing (lS)-(3R)-l-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-l-phenyl-2(lH)- isoquinoline carboxylate (solifenacin) or its pharmaceutically acceptable salts with high optic purity, wherein the crude solifenacin base is transformed to the hydrogen tartrate, which is then optionally transformed to another pharmaceutically acceptable salt or the base of solifenacin. A crystalline salt of solifenacin hydrogen tartrate. | ||||||
| 179 | PYRIDONE/HYDROXYPYRIDINE 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS | EP07812540.8 | 2007-07-02 | EP2046753A2 | 2009-04-15 | ROBL, Jeffrey A.; WU, Shung C.; YOON, David S. |
| Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds have the structure formula (I) enantiomers, diastereomers, solvates, salts, tautomers or prodrugs thereof wherein, A, W, X, Y and R1 are defined herein. | ||||||
| 180 | Nouveaux dérivés peptidiques, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent | EP90401877.7 | 1990-06-29 | EP0406119B1 | 1994-01-19 | Vincent, Michel; Remond, Georges; Portevin, Bernard; Hervé, Yolande; Lepagnol, Jean; Biton, Catherine |
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