| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 41 | Design and construction of a variety of synthetic peptides and polypeptides library | JP2009531542 | 2007-09-28 | JP5473603B2 | 2014-04-16 | ローレンス ホロウィッツ，; ラメッシュ アール． バート，; アロン エル． カーツマン， |
| 42 | Design and construction of diverse synthetic peptide and polypeptide libraries | JP2013151434 | 2013-07-22 | JP2013235610A | 2013-11-21 | LAWRENCE HOROWITZ; RAMESH R BHATT; AARON L KURTZMAN |
| PROBLEM TO BE SOLVED: To provide design and construction of diverse synthetic peptide and polypeptide libraries.SOLUTION: The present invention concerns design and construction of diverse peptide and polypeptide libraries. Specifically, the invention concerns methods of analytical database design for creating datasets using multiple relevant parameters as filters, and methods for generating sequence diversity by directed multisyntheses oligonucleotide synthesis. The present methods enable reduction of large complex annotated databases to simpler datasets of related sequences, on the basis of relevant single or multiple key parameters that can be individually directly defined. The methods further enable creation of diverse libraries on the basis of this approach, using multisynthetic collections of discrete and degenerate oligonucleotides to capture the diverse collection of sequences, or portions thereof. | ||||||
| 43 | Optimization of crossover point for directed evolution | JP2011112828 | 2011-05-19 | JP2011217751A | 2011-11-04 | GOVINDARAJAN SRIDAR; GUSTAFSSON CLAES; MINSHULL JEREMY S |
| PROBLEM TO BE SOLVED: To provide a method for producing libraries of biomolecules that are enriched for functional biomolecules.SOLUTION: Methods and devices for more efficiently engineering diversity into recombinant polypeptides and/or nucleic acids includes: for example, a variety of methods for selecting and/or assessing potential crossover sites in an amino acid sequence or a nucleotide sequence; and the resulting chimeric product sequences. The methods include, e.g. consideration of structural, functional and/or statistical data in the selection and assessment of sequences and crossover sites for use in recombination. | ||||||
| 44 | And use thereof for producing a peptide library | JP2009553040 | 2008-03-04 | JP2010522368A | 2010-07-01 | エーファ・ユンク; マンフレート・ヘントリッヒ |
| 種々のアッセイにおけるペプチドライブラリのスクリーニングは、細胞内シグナル伝達経路の同時調査、経路をより理解するための試薬の製造、および治療の新規な形態の作製の可能性を示す。 全部ではないが多くの生物活性ペプチド（例えば、ペプチドホルモン）は、増殖促進的役割、増殖抑制的役割、または非常に重要な代謝経路の制御のいずれかにおいて、健康および疾病に大きな影響を与える。 本発明は、新規な生物活性ペプチド、コンピュータ内で前記ペプチドを同定するための方法および前記ペプチドを含むペプチドライブラリに関する。 | ||||||
| 45 | Method, system, and software for identifying functional bio-molecule | JP2009123638 | 2009-05-21 | JP2009277235A | 2009-11-26 | GUSTAFSSON CLAES; GOVINDARAJAN SRIDAR; EMIG ROBIN; FOX RICHARD JOHN; ROY AJOY; MINSHULL JEREMY; DAVIS S CHRISTOPHER; COX ANTHONY; PATTEN PHIL; CASTLE LINDA A; SIEHL DANIEL L; GORTON REBECCA LYNNE; CHEN TEDDY |
| <P>PROBLEM TO BE SOLVED: To provide new methods of efficiently searching sequence space for identifying functional protein. <P>SOLUTION: The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods. <P>COPYRIGHT: (C)2010,JPO&INPIT | ||||||
| 46 | Methods for identifying functional biomolecules, systems and software | JP2007518248 | 2005-06-21 | JP2008503589A | 2008-02-07 | リチャード ジョン フォックス， |
| 本発明は一般的に、生物学的に関連するデータスペースを迅速かつ効率的に検索する方法に関する。 さらに詳細には、本発明は、所望の特性を有する生体分子を同定する方法、または、複雑な生体分子ライブラリもしくはこのようなライブラリのセットから、このような特性を獲得するために最も適切である方法を包含する。 本発明はまた、配列活性関係をモデリングする方法を提供する。 この方法の多くはコンピューターで実行されるので、本発明はさらに、これらの方法を行うためのデジタルシステムおよびソフトウェアを提供する。 | ||||||
| 47 | Method of identifying a functional biomolecule, systems, and software | JP2003573522 | 2003-03-03 | JP2005519384A | 2005-06-30 | ロビン エミグ，; クラエス ガスタフソン，; リンダ エー． キャッスル，; レベッカ リーン ゴートン，; アンソニー コックス，; スリダー ゴビンダラジャン，; ダニエル エル． シエル，; テディー チェン，; エス． クリストファー デイビス，; フィル パッテン，; リチャード ジョン フォックス，; ジェレミー ミンシャル，; アジョイ ロイ， |
| The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods. | ||||||
| 48 | How to order the orders for products and services, and acceptance, and to satisfy | JP2003564674 | 2003-01-02 | JP2005516300A | 2005-06-02 | ハダー アイ． アヴィ−イットザーク，; ジュリー ウィリアムス，; エミリー ウィン−ディーン，; リン ウー，; マリオン エヌ． ウェブスター，; スーザン エディンズ，; ジョアンナ カーリー，; キャリー ギアー，; デニス エー． ギルバート，; ステファン グラノウスキー，; ライアン ティー． コーラー，; ジャネット ジーグル，; リリー シュー，; チャールズ アール． スカフェ，; ジョン スコット，; ジュンコ スティーブンズ，; ユージーン ジー． スパイアー，; アリアン スプラギュー，; ラ ヴェガ， フランシスコ エム． デ; アニー ティタス，; デービッド デイリー，; ジェレミー ヘイル，; へインズ ヘムケン，; ローレント アール． ベロン，; アイビー マククレン，; ダウン マドゥン，; シャオチン ユー，; ケネス ジェイ． リバック，; マイケル ローデス、; ユー エヌ． ワン， |
| ＳＮＰまたは遺伝子発現を検出するアッセイを、注文する方法およびシステムを提供する。 本方法は、ＰＣＲおよびＲＴ‐ＰＣＲ法を使用する。 製造前および製造後の品質管理手順を用いて、ストックアッセイの集団を構築して、消費者がインターネット経由で入手できるようにする。 さらに、消費者からの注文に応じてカスタムアッセイを調製し、これらのアッセイもやはり製造前および製造後品質管理手順を用いて調製する。 アッセイは、次いで、消費者に配達される。 | ||||||
| 49 | Screening and method of generating a compound library | JP2000570698 | 1999-09-14 | JP2003521673A | 2003-07-15 | イー． ウェルリ，ジョン; エム． グラス，ジョージ; ジェイ． シンコ，パトリック; エー． ノリス，ダニエル; ディー． リースマン，グレン |
| The present invention relates to a pharmacokinetic-based design and selection tool (PK tool) and methods for predicting absorption of an administered compound of interest. The methods utilize the tool, and optionally a separately operable component or subsystem thereof. The PK tool includes as computer-readable components: (1) input/output system; (2) physiologic-based simulation model of one or more segments of a mammalian system of interest having one or more physiological barriers to absorption that is based on the selected route of administration; and (3) simulation engine having a differential equation solver. The invention also provides methods for optimizing as well as enabling minimal input requirements a physiologic-based simulation model for predicting in vivo absorption, and optionally one or more additional properties, from either in vitro or in vivo data. The PK tool of the invention may be provided as a computer system, as an article of manufacture in the form of a computer-readable medium, or a computer program product and the like. Subsystems and individual components of the PK tool also can be utilized and adapted in a variety of disparate applications for predicting the fate of an administered compound. The PK tool and methods of the invention can be used to screen and design compound libraries, select and design drugs, as well as predict drug efficacy in mammals from in vitro and/or in vivo data of one or more compounds of interest. The PK tool and methods of the invention also finds use in selecting, designing, and preparing drug compounds, and multi-compound drugs and drug formulations (i.e., drug delivery system) for preparation of medicaments for use in treating mammalian disorders. | ||||||
| 50 | Construction of pharmacophore fingerprint, as well as the primary library in quantitative structure-activity relationship | JP2000578631 | 1999-10-27 | JP2002530727A | 2002-09-17 | マクレガー・マルコム・ジェイ．; ムスカル・スティーブン・エム． |
| (57)【要約】 【課題】 本発明は、改良されたファーマコフォア・フィンガープリントと、フィンガープリントを形成してこれを利用する改良された方法とを提供する。 また、本発明の一態様として、ファーマコフォア・フィンガープリントを利用した構造活性相関解析を行う。 【解決手段】 所定の化合物に関するファーマコフォア・フィンガープリントにより、その化合物の構造にマッチングするファーマコフォア群を特定することができる。 フィンガープリントが、エネルギ的に望ましい種々のコンホメーションにマッチングする様々なファーマコフォアを含むと考えられる。 第一のコンホメーションにマッチングし、第二のコンホメーションにはマッチングしないファーマコフォアが存在する一方で、第二のコンホメーションにマッチングし、第一のコンホメーションにはマッチングしないファーマコフォアが存在する。 この場合、２つのコンホメーションは、それぞれ、化合物の活性に大きく寄与する。 すなわち、フィンガープリントは、任意の適当なコンホメーションにマッチングするファーマコフォアを特定する。 本発明は、さらに、ケミカルスペースの高活性領域を特定し、表現し、生産的に利用する装置並びに方法を提供する。 ケミカルスペースを表すものとしては、様々な表現が用いられており、さらに別のものを想定することも可能である。 本発明の好適な態様では、少なくとも二種類の表現で、有用な情報が得られる。 第一の表現は、ファーマコフォアの基本セットにより定義される多数の次元と、さらに、（薬理活性等の）所定の化学活性を表す１つあるいは複数の追加次元を用いるものである。 第二の表現は、次元数を削減したものであり、適当な数学的手法を用いて、第一の表現から第二の表現の座標値を誘導する。 第二の表現の例としては、例えば、化合物群に関するファーマコフォア・フィンガープリント/活性データを用いて、主要コンポーネント解析により得られる主要コンポーネントが挙げられる。 | ||||||
| 51 | Apparatus and method for automatically generating a compound having the desired properties | JP51024795 | 1995-09-11 | JPH10505832A | 1998-06-09 | アグラフィオティス，ディミトリス，ケイ．; サレンム，フランシス，アール．; ソル，リチャード，エム．; ボーン，ロジャー，エフ． |
| A computer based, iterative process for generating chemical entities with defined physical, chemical and/or bioactive properties. During each iteration of the process, (1) a directed diversity chemical library is robotically generated in accordance with robotic synthesis instructions; (2) the compounds in the directed diversity chemical library are analyzed to identify compounds with the desired properties; (3) structure-property data are used to select compounds to be synthesized in the next iteration; and (4) new robotic synthesis instructions are automatically generated to control the synthesis of the directed diversity chemical library for the next iteration. | ||||||
| 52 | 다수의 목표 유전자를 검출할 수 있는 특이성 조건을 만족하는 유효한 프라이머 세트와 프루브 세트를 동시에 디자인하는 방법 | KR1020160080872 | 2016-06-28 | KR101889146B1 | 2018-08-17 | |
| 본발명은다수의목표유전자를검출할수 있는특이성조건을만족하는유효한프라이머세트와프루브세트를한꺼번에빠르게설계할수 있도록한 방법에관한것으로서, 상기방법은, 대규모 DNA 서열데이터베이스에대한하둡기반의오프라인연산을통해가능한모든유전자쌍에대해특이성조건을만족하는후보프라이머집합과프루브집합을추출하는제 1 단계; 상기제 1단계에서추출한후보프라이머집합과프루브집합을이용하여특이성검사를할 수있는색인구조를메인메모리상에서구성하는제 2 단계; 상기제 2 단계에서구성된색인구조를이용하여사용자에의해주어진다수의목표유전자들의각각을검출할수 있는싱글/페어필터링제약조건들을만족하는유효한프라이머집합과프루브집합을온라인연산을통해빠르게검색한후, 각표적유전자를위한최적의프라이머쌍과프루브만을선별하여웹 페이지로출력하는제3 단계를포함한다. | ||||||
| 53 | 신규 항체 라이브러리 제조방법 및 이로부터 제조된 라이브러리 | KR1020180075824 | 2018-06-29 | KR1020180077144A | 2018-07-06 | |
| 본발명은신규항체라이브러리제조방법및 이로부터제조된라이브러리에관한것이다. 본발명에의해제조된항체라이브러리는다수의항원에대해우수한물성을가지는항체들을포함하여, 기능적다양성을가질뿐 아니라고유서열을다수포함하는등 항체라이브러리로써유용하게사용될수 있다. | ||||||
| 54 | 항체 라이브러리 | KR1020177033563 | 2011-07-14 | KR1020170131711A | 2017-11-29 | 바스케스,막시밀리아노; 시바수브라마니안,아르빈드; 펠드하우스,마이클 |
| 본발명은유도된 (directed) 서열및 길이다양성을가진라이브러리들을특이적으로설계하여항체-인코딩폴리뉴클레오타이드들의라이브러리들을생산하는기지의방법들에서본질적인부적당한점들을극복하고있다. | ||||||
| 55 | 신규 항체 라이브러리 제조방법 및 이로부터 제조된 라이브러리 | KR1020160004232 | 2016-01-13 | KR1020160087766A | 2016-07-22 | 심현보; 김지혜; 백설련 |
| 본발명은신규항체라이브러리제조방법및 이로부터제조된라이브러리에관한것이다. 본발명에의해제조된항체라이브러리는다수의항원에대해우수한물성을가지는항체들을포함하여, 기능적다양성을가질뿐 아니라고유서열을다수포함하는등 항체라이브러리로써유용하게사용될수 있다. | ||||||
| 56 | 인-실리코 분석 방법을 통한 인트론 기반 다형성 프라이머세트의 제조방법 | KR1020080023266 | 2008-03-13 | KR1020090098087A | 2009-09-17 | 설영주; 문정환; 김정선; 진민아; 임명호; 권수진; 김진아; 이수인; 강만정; 김창국; 박동석; 박범석; 한장호 |
| A method for manufacturing intron based polymorphism primer set through in-silico analysis is provided to quickly and massively produce molecular marker and develop novel species. A method for manufacturing an intro based polymorphism primer set comprises: a step of comparing gene of Brassicaceae plant with expressed gene sequence tag to distinguish exon and intron in the plant gene; a step of determining common axon; and a step of performing in-silico simulation using intron between the axons to produce the intron based polymorphism primer. The Brassicaceae plant is Chinese cabbage, Brassica oleracea var. or broccoli. | ||||||
| 57 | 다수의 목표 유전자를 검출할 수 있는 특이성 조건을 만족하는 유효한 프라이머 세트와 프루브 세트를 동시에 디자인하는 방법 | KR20160080872 | 2016-06-28 | KR20180002109A | 2018-01-08 | |
| 본발명은다수의목표유전자를검출할수 있는특이성조건을만족하는유효한프라이머세트와프루브세트를한꺼번에빠르게설계할수 있도록한 방법에관한것으로서, 상기방법은, 대규모 DNA 서열데이터베이스에대한하둡기반의오프라인연산을통해가능한모든유전자쌍에대해특이성조건을만족하는후보프라이머집합과프루브집합을추출하는제 1 단계; 상기제 1단계에서추출한후보프라이머집합과프루브집합을이용하여특이성검사를할 수있는색인구조를메인메모리상에서구성하는제 2 단계; 상기제 2 단계에서구성된색인구조를이용하여사용자에의해주어진다수의목표유전자들의각각을검출할수 있는싱글/페어필터링제약조건들을만족하는유효한프라이머집합과프루브집합을온라인연산을통해빠르게검색한후, 각표적유전자를위한최적의프라이머쌍과프루브만을선별하여웹 페이지로출력하는제3 단계를포함한다. | ||||||
| 58 | 승법형 모델을 이용하여 생체분자를 확인하기 위한 방법, 시스템, 및 소프트웨어 | KR1020157023739 | 2014-01-29 | KR1020150113167A | 2015-10-07 | 코프그레고리앨런; 아가드니콜라스존 |
| 본발명은복합생체분자라이브러리, 또는상기라이브러리세트로부터원하는특성을가지거나, 상기특성을획득하는데 가장적합한생체분자를확인하는방법을제공한다. 더욱구체적으로, 본발명의일부실시양태는곱셈항의곱을포함하는서열-활성모델을구축하고, 상기모델을이용하여유도진화를유도하는방법을제공한다. 일부실시양태에서, 서열-활성모델은하나이상의상호작용항을포함하며, 이들은각각 2개이상의정의된잔기의활성에대한기여도를나타내는상호작용계수를포함한다. 일부실시양태에서, 모델은단백질또는핵산서열과단백질활성사이의관계를기술한다. 일부실시양태에서, 본발명은또한단계적가산또는감산기법, 베이지안회귀, 앙상블회귀및 다른방법을포함하나, 이에한정되지않는, 서열-활성모델을제조하는방법을제공한다. 본발명은본원에서제공하는방법을수행하기위한디지털시스템및 소프트웨어를추가로제공한다. | ||||||
| 59 | 상호작용 성분을 이용하여 생체분자를 확인하기 위한 방법, 시스템, 및 소프트웨어 | KR1020157023727 | 2014-01-29 | KR1020150113166A | 2015-10-07 | 코프그레고리앨런 |
| 본발명은생물학적으로관련된데이터공간을빠르고효율적으로검색하는방법을제공한다. 더욱구체적으로, 본발명은복합생체분자라이브러리, 또는상기라이브러리세트로부터원하는특성을가지거나, 상기특성을획득하는데 가장적합한생체분자를확인하는방법을제공한다. 본발명은또한단계적가산또는감산기법, 베이지안회귀, 앙상블회귀및 다른방법을포함하나, 이에한정되지않는, 서열활성관계를모델링하는방법을제공한다. 본발명은본원에서제공하는방법을수행하기위한디지털시스템및 소프트웨어를추가로제공한다. | ||||||
| 60 | 셀룰로오스를 용해시킬 수 있는 이온성 액체를 탐색하는 방법 | KR1020120081165 | 2012-07-25 | KR1020140014641A | 2014-02-06 | 구윤모; 김찬경; 박헌진 |
| The present invention relates to a method for screening an ionic liquid capable of dissolving cellulose, and more particularly, to a method for screening an ionic liquid capable of dissolving cellulose, wherein the method comprises: a step of collecting solubility data of ionic liquids capable of dissolving cellulose (Step 1); a step of optimizing geometric structures of the ionic liquids applied to the collection of solubility data of Step 1 to deduce a geometric structure with the minimum energy state (global minimum) (Step 2); a step of deducing molecular descriptors of the ionic liquid capable of dissolving cellulose from the geometric structure deduced from Step 2 (Step 3); and deducing an objective function consisting of molecular descriptors from the molecular descriptors deduced in Step 3 and the solubility data collected in Step 1 (Step 4). According to the method for screening an ionic liquid capable of dissolving cellulose of the present invention, the descriptors are deduced from the ionic liquids known as solvents capable of dissolving cellulose, and then the objective function capable of expressing the ionic liquids by using the deduced descriptor values, thereby screening the ionic liquid capable of dissolving cellulose, which meets to the objective function. Further, the ionic liquid screened according to the present invention can exhibit excellent solubility as compared with the conventional ionic liquids used as solvents of cellulose. | ||||||
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