专利检索_ .二肽基肽酶和三肽基肽酶专利检索_ .二肽基肽酶和三肽基肽酶专利检索查询

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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
1	酶促方法	CN200980122890.0	2009-06-15	CN102065704B	2016-03-02	T·波夫米克; S·I·米亚卡; J·P·范里尔萨姆; R·W·史密斯
提供了水解菠菜植物材料以形成咸味增强性成分的方法、所形成的咸味增强性成分、包含所述咸味增强性成分的食品和增强食品咸味的方法。
2	用于使油酶促脱胶的组合物	CN201580021252.5	2015-02-19	CN106231920A	2016-12-14	U·佐林; K·苏克; P·布本海姆
本发明涉及包含至少一种磷脂裂解酶和至少一种蛋白酶的组合物。本发明进一步涉及通过使用根据本发明的组合物来脱胶含有甘油三酯的组合物的方法，和所述组合物用于脱胶含有甘油三酯的组合物的用途。
3	酶促方法	CN200980122890.0	2009-06-15	CN102065704A	2011-05-18	T·波夫米克; S·I·米亚卡; J·P·范里尔萨姆; R·W·史密斯
提供了水解菠菜植物材料以形成咸味增强性成分的方法、所形成的咸味增强性成分、包含所述咸味增强性成分的食品和增强食品咸味的方法。
4	用于溶酶体贮积症的脑室内酶输注系统	CN200780006925.5	2007-01-22	CN101431960A	2009-05-13	J·道奇; M·帕西尼; L·谢哈布丁; S·郑
采用脑室内输注疾病病因上所缺陷的酶能够成功地治疗溶酶体贮积症。慢速输注可以达到最大的效应。令人惊讶的是，血脑屏障两侧都能观察到效应，这使它成为影响大脑和脏器的溶酶体贮积症的理想的输注方法。
5	Enzymatic process	US14824682	2015-08-12	US09833012B2	2017-12-05	Tarun Bhowmik; Stefka Ivanova Myaka; Johan Peter Van Leersum; Roy Wade Smith
Provided is an enzymatic process that hydrolyzes spinach plant material to form a salt-enhancing ingredient, the formed salt-enhancing ingredient, food products comprising said salt-enhancing ingredient and a method of enhancing the salty taste of food products.
6	Polypeptides Having Protease Activity	US15673594	2017-08-10	US20170342394A1	2017-11-30	Mary Ann Stringer; Tine Hoff; Peter Rahbek Oestergaard; Katrine Fruergaard Pontoppidan
The present invention relates to isolated polypeptides having protease activity and isolated nucleic acid sequences encoding the proteases. The invention also relates to nucleic acid constructs, vectors, and host cells, including plant and animal cells, comprising the nucleic acid sequences, as well as methods for producing and using the proteases, in particular the use of the proteases in animal feed.
7	Polypeptides having protease activity	US14423546	2013-09-05	US09771570B2	2017-09-26	Mary Ann Stringer; Tine Hoff; Peter Rahbek Oestergaard; Katrine Pontoppidan
The present invention relates to isolated polypeptides having protease activity and isolated nucleic acid sequences encoding the proteases. The invention also relates to nucleic acid constructs, vectors, and host cells, including plant and animal cells, comprising the nucleic acid sequences, as well as methods for producing and using the proteases, in particular the use of the proteases in animal feed.
8	POLYPEPTIDES HAVING PROTEASE ACTIVITY	US14423546	2013-09-05	US20150259662A1	2015-09-17	Mary Ann Stringer; Tine Hoff; Peter Rahbek Oestergaard; Katrine Fruergaard Pontoppidan
The present invention relates to isolated polypeptides having protease activity and isolated nucleic acid sequences encoding the proteases. The invention also relates to nucleic acid constructs, vectors, and host cells, including plant and animal cells, comprising the nucleic acid sequences, as well as methods for producing and using the proteases, in particular the use of the proteases in animal feed.
9	METHOD	US15520140	2015-10-23	US20180295858A1	2018-10-18	Svend Haaning; Karsten Matthias Kragh; Stepan Shipovskov; Andrei Miasnikov; Maria Ma; Luis Fernando Romero Millan; Luke Barnard; Shukun Yu; Ernst Meinjohanns; Steffen Bak; Päivi Nurminen; Heli Putaala
A method of preparing a feed additive composition comprising: (a) admixing at least one proline tolerant tripeptidyl peptidase predominantly having exopeptidase activity wherein said proline tolerant tripeptidyl peptidase is capable of cleaving tri-peptides from the N-terminus of peptides having (i) (A) Proline at P1; and (B) An amino acid selected from alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, serine, threonine, tryptophan, tyrosine, valine or synthetic amino acids at P1; or (ii) (a′) Proline at P1′; and (b′) An amino acid selected from alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, serine, threonine, tryptophan, tyrosine, valine or synthetic amino acids or amines at P1′; and one or more ingredients selected from the group consisting of a salt, polyol including sorbitol and glycerol, wheat or a wheat component, sodium acetate, sodium acetate trihydrate, potassium sorbate Talc, polyvinyl alcohol (PVA), benzoate, sorbiate, 1,3-propane diol, glucose, parabens, sodium chloride, citrate, metabisulfite, formate or a combination thereof; and (b) optionally packaging as well as uses of such proline tolerant tripeptidyl peptidases, feed additive compositions, feed additive kits, feeds or feedstuffs and/or premixes.
10	Polypeptides Having Protease Activity	US15954892	2018-04-17	US20180273927A1	2018-09-27	Mary Ann Stringer; Tine Hoff; Peter Rahbek Oestergaard; Katrine Fruergaard Pontoppidan
The present invention relates to isolated polypeptides having protease activity and isolated nucleic acid sequences encoding the proteases. The invention also relates to nucleic acid constructs, vectors, and host cells, including plant and animal cells, comprising the nucleic acid sequences, as well as methods for producing and using the proteases, in particular the use of the proteases in animal feed.
11	METHOD FOR PRODUCING ALCOHOL BY USE OF A TRIPEPTIDYL PEPTIDASE	US15520584	2015-10-23	US20170306360A1	2017-10-26	Andrei MIASNIKOV; Maria MA; Scott D. POWER
The present invention provides a method for producing an alcohol comprising: (a) admixing a tripeptidyl peptidase, predominantly having exopeptidase activity, with a feedstock or a fraction thereof before, during or after fermentation of said feedstock or a fraction thereof; and (b) recovering an alcohol. Also provided are uses of a tripeptidyl peptidase and by-products of alcohol production obtainable by the method of the invention.
12	INTRAVENTRICULAR ENZYME DELIVERY FOR LYSOSOMAL STORAGE DISEASES	US14559851	2014-12-03	US20150313970A1	2015-11-05	James DODGE; Marco A. PASSINI; Lamya SHIHABUDDIN; Seng H. CHENG
Lysosomal storage diseases can be successfully treated using intraventricular delivery of the enzyme which is etiologically deficient in the disease. The administration can be performed slowly to achieve maximum effect. Surprisingly, effects are seen on both sides of the blood-brain barrier, making this an ideal delivery means for lysosomal storage diseases which affect both brain and visceral organs.
13	酵素的プロセス	JP2011513834	2009-06-15	JP5726072B2	2015-05-27	ボウミック,タラン; ミャカ,ステフカ,イワノワ; ヴァンレール−サム,ジョアン,ピーター; スミス,ロイ,ウェイド

14	リソソーム蓄積症のための脳室内酵素の輸送	JP2008551442	2007-01-22	JP5681345B2	2015-03-04	ジェイムズ・ドッジ; マルコ・パッシーニ; ラムヤ・シハブッディン; セン・チェン

15	プロリン耐性トリペプチジルペプチダーゼおよびその使用	JP2017522548	2015-10-23	JP2017534279A	2017-11-24	クラーウ、カーステン・マティーアス; メインヨハンス、エアンスト; ミアスニコフ、アンドレイ; マー、マリア; アイセル、トマス; ホーニン、スヴェン; ダイン、ピーダ・イズヴァト; バク、ステフェン・ユーゼ
(a)少なくとも1つのタンパク質またはその一部を、(A)少なくとも1つのエンドプロテアーゼ;および(B)(a’)少なくとも1つのプロリン耐性トリペプチジルペプチダーゼまたは主としてエキソペプチダーゼ活性を有するプロリン耐性トリペプチジルペプチダーゼを含む発酵物(前記プロリン耐性トリペプチジルペプチダーゼは、P1におけるプロリン;およびP1における合成アミノ酸を有するペプチドのN末端からトリペプチドを開裂し得る);または(b’)エキソペプチダーゼ活性を有する少なくとも1つのプロリン耐性トリペプチジルペプチダーゼ(前記プロリン耐性トリペプチジルペプチダーゼは、PVにおけるプロリン;およびPVにおける合成アミノ酸を有するペプチドのN末端からトリペプチドを開裂し得る)と混合すること;ならびに(b)加水分解物を回収することを含む、加水分解物を生産する方法。本発明はまた、エンドプロテアーゼ、S53ファミリーのエキソトリペプチジルペプチダーゼおよびアミノペプチダーゼの使用を含む加水分解物を生産する方法、プロリン耐性トリペプチジルペプチダーゼの使用、それを含む組成物、食料および/または飼料添加用組成物、ならびに加水分解物ならびにプロリン耐性トリペプチジルペプチダーゼの使用に関する。
16	Preparation of wheat protein hydrolyzate	JP52258896	1996-01-16	JPH11501207A	1999-02-02	ザンダー，アンドレアス; ハイレマン，アンドレア; フォン・クリース，エディト
(57)【要約】タンパク質を含有する基本物質をまずプロテイナーゼにより、次にペプチダーゼにより加水分解する小麦タンパク質加水分解物を製造するための改良法が提案されている。得られる加水分解物は、長期貯蔵期間を有するわずかに着色した脂肪酸との縮合生成物の製造に特に適している。
17	Enzymatic processes	JP2011513834	2009-06-15	JP2011524176A	2011-09-01	レール−サム，ジョアン，ピーターヴァン; スミス，ロイ，ウェイド; ボウミック，タラン; ミャカ，ステフカ，イワノワ
提供するのは、ホウレンソウ植物材料を加水分解して塩味増強成分を生成する酵素的プロセス、生成した塩味増強成分、前記塩味増強成分を含む食品および食品の塩味を増強する方法である。
18	Transport of intraventricular enzymes for lysosomal storage diseases	JP2008551442	2007-01-22	JP2009525963A	2009-07-16	ジェイムズ・ドッジ; セン・チェン; マルコ・パッシーニ; ラムヤ・シハブッディン
リソソーム蓄積症は、病因として欠乏している酵素の脳室内輸送を用いてうまく治療され得る。投与は、ゆっくり行われることにより最大の効果が達成され得る。驚くべきことに、血液脳関門の両側で効果が観察され、これは、脳と内臓の両方に罹患したリソソーム蓄積症に対する理想的な輸送手段として有用である。
19	INCREASING THE EXPRESSION OF A TRANSGENE IN EUKARYOTIC CELLS BY REDUCING RNA INTERFERENCE	EP14756146.8	2014-07-31	EP3030661A1	2016-06-15	MIASNIKOV, Andrei
Described are methods for increasing the expression of a transgene in eukaryotic cells by reducing RNA interference (RNAi), and variant cells produce by the method. The methods and variant cells are useful, for example, for the efficient production of therapeutic and industrial polypeptides in eukaryotic cells.
20	VERFAHREN ZUR HERSTELLUNG VON WEIZENPROTEINHYDROLYSATEN	EP96901272.3	1996-01-16	EP0805631B1	1999-05-06	VON KRIES, Edith; HEILEMANN, Andrea; SANDER, Andreas
The proposal is for an improved process for producing wheat protein hydrolysates in which protein-containing basic substances are first hydrolysed in with proteinases and then with peptidases. The resultant hydrolysates are particularly suitable for producing light-coloured condensation products with fatty acids with a long shelf life.

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