| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | Oligonucleotide—containing pharmacological compositions and their use | US14534901 | 2014-11-06 | US09567584B2 | 2017-02-14 | Roderic M.K. Dale; Amy Arrow; Teresa Thompson |
| The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals. | ||||||
| 2 | Oligonucleotide-containing pharmacological compositions and their use | US10191997 | 2002-07-10 | US20030207834A1 | 2003-11-06 | Roderic M.K. Dale; Amy Arrow; Terry Thompson |
| The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals. | ||||||
| 3 | OLIGONUCLEOTIDE-CONTAINING PHARMACOLOGICAL COMPOSITIONS AND THEIR USE | US14534901 | 2014-11-06 | US20150232857A1 | 2015-08-20 | RODERIC M.K. DALE; AMY ARROW; Teresa Thompson |
| The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals. | ||||||
| 4 | Oligonucleotide-containing pharmacological compositions and their use | US11673486 | 2007-02-09 | US08916529B2 | 2014-12-23 | Roderic M. K. Dale; Amy Arrow; Terry Thompson |
| The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals. | ||||||
| 5 | Oligonucleotide-containing pharmacological compositions and their use | US11673508 | 2007-02-09 | US08188259B2 | 2012-05-29 | Roderic M. K. Dale; Amy Arrow; Terry Thompson |
| The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals. | ||||||
| 6 | Oligonucleotide-containing pharmacological compositions and their use | US11673509 | 2007-02-09 | US08183361B2 | 2012-05-22 | Roderic M. K. Dale; Amy Arrow; Terry Thompson |
| The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals. | ||||||
| 7 | オリゴヌクレオチド含有薬理学的組成物およびその使用 | JP2015207011 | 2015-10-21 | JP2016074669A | 2016-05-12 | デール,ロデリック,エム.,ケー.; アーロウ,エミィ; トンプソン,テリー |
| 【課題】選択されたメッセンジャーRNAの翻訳を阻害するためのアンチセンスオリゴヌクレオチド含有薬理学的組成物の提供。 【解決手段】第1及び第2の修飾オリゴヌクレオチドのそれぞれがアキラルな5’から3’へのヌクレオチド間ホスフェート結合によって結合された7個以上の連続するリボース基を含んだ7〜75個のヌクレオチドを含み、少なくとも一つの前記修飾オリゴヌクレオチドの少なくとも一つの修飾されたリボース基を有する、オリゴヌクレオチド、及びヌクレオチド間にホスフェート結合を有する、オリゴヌクレオチドを含有する、薬理学的組成物。食欲異常、高血圧、高コレステロール血症、高脂血症、勃起機能不全、湿疹、うつ病、不安、ストレス、炎症性腸症候群、潰瘍性大腸炎、クローン病等の病理学的障害又は疾患に関連す遺伝子の領域に相補的なアンチセンスオリゴヌクレオチド、及びこれを含む治療又は予防用組成物。 【選択図】なし |
||||||
| 8 | METHOD FOR PRODUCING ALCOHOL BY USE OF A TRIPEPTIDYL PEPTIDASE | EP15794686.4 | 2015-10-23 | EP3172329A1 | 2017-05-31 | MIASNIKOV, Andrei; MA, Maria; POWER, Scott D. |
| The present invention provides a method for producing an alcohol comprising: (a) admixing a tripeptidyl peptidase, predominantly having exopeptidase activity, with a feedstock or a fraction thereof before, during or after fermentation of said feedstock or a fraction thereof; and (b) recovering an alcohol. Also provided are uses of a tripeptidyl peptidase and by-products of alcohol production obtainable by the method of the invention. | ||||||
| 9 | METHOD FOR PRODUCING ALCOHOL BY USE OF A TRIPEPTIDYL PEPTIDASE | US15520584 | 2015-10-23 | US20170306360A1 | 2017-10-26 | Andrei MIASNIKOV; Maria MA; Scott D. POWER |
| The present invention provides a method for producing an alcohol comprising: (a) admixing a tripeptidyl peptidase, predominantly having exopeptidase activity, with a feedstock or a fraction thereof before, during or after fermentation of said feedstock or a fraction thereof; and (b) recovering an alcohol. Also provided are uses of a tripeptidyl peptidase and by-products of alcohol production obtainable by the method of the invention. | ||||||
| 10 | MEANS AND METHODS FOR COUNTERACTING POLYQ EXPANSION DISORDERS | US13321539 | 2010-05-20 | US20120164128A1 | 2012-06-28 | Eric Albert Julius Reits |
| The present invention provides means and methods for counteracting and/or preventing aggregation of a polyQ protein. Further provided are improved poly constructs which are, amongst other things, useful for testing assays. According to the invention, several peptidases like, e.g. tripeptidyl peptidase II (TPPII), appear to be capable of cleaving long polyQ peptides comprising at least 45 glutamine residues. Hence, according to the invention, administration of such peptidases to an individual suffering from a polyQ expansion disorder results in degradation of long polyQ peptides. | ||||||
| 11 | Oligonucleotide-Containing Pharmacological Compositions and Their Use | US11673508 | 2007-02-09 | US20080234214A1 | 2008-09-25 | Roderic M.K. Dale; Amy Arrow; Terry Thompson |
| The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals. | ||||||
| 12 | Oligonucleotide-Containing Pharmacological Compositions And Their Use | US11673509 | 2007-02-09 | US20080167257A1 | 2008-07-10 | Roderic M.K. Dale; Amy Arrow; Terry Thompson |
| The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals. | ||||||
| 13 | Oligonucleotide-Containing Pharmacological Compositions And Their Use | US11673486 | 2007-02-09 | US20080161257A1 | 2008-07-03 | Roderic M.K. Dale; Amy Arrow; Terry Thompson |
| The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals. | ||||||
| 14 | Oligonucleotide-containing pharmacological compositions and their use | JP2013268225 | 2013-12-26 | JP2014088412A | 2014-05-15 | DALE RODERIC M K; ARROW AMY; THOMPSON TERRY |
| PROBLEM TO BE SOLVED: To provide therapeutic methods and compositions containing oligonucleotides suitable for administration to humans and other mammals.SOLUTION: Provided is a modified oligonucleotide of about 7 to 75 nucleotides including seven or more contiguous ribose groups linked by achiral 5' to 3' internucleoside phosphate linkages, where the modified oligonucleotide complementary to a region of a gene associated with a pathological disorder is selected from the group consisting of the 5' UTR region, the translational start site, the 3' UTR, and the translational termination site. Also provided is a therapeutic method including oral administration of the oligonucleotide. | ||||||
| 15 | Oligonucleotides containing pharmacologically compositions and the use thereof | JP2003512248 | 2002-07-10 | JP4999255B2 | 2012-08-15 | アーロウ，エミィ; デール，ロデリック，エム．，ケー．; トンプソン，テリー |
| 16 | Oligonucleotide-containing pharmacological composition and use of the same | JP2010125456 | 2010-06-01 | JP2010229143A | 2010-10-14 | DALE RODERIC M K; ARROW AMY; THOMPSON TERRY |
| <P>PROBLEM TO BE SOLVED: To provide a method of containing an antisense oligonucleotide to facilitate oral and local administration to human and other mammals, and a composition. <P>SOLUTION: This pharmacological composition includes a first and a second modified oligonucleotides of 10-75 nucleotides containing not less than 7 continuous ribose groups which are bonded by an achiral phosphate bond from 5' to 3' nucleotides, at least a ribose group of the oligonucleotide has a modified 2' substituent, 5' and 3' ends of the modified oligonucleotide are blocked, the first modified oligonucleotide is complementary to the region of phosphodiesterase 4 gene, the second modified oligonucleotide is complementary to the region of cyclooxygenase 2 gene and every modified oligonucleotide is, when administered, existent at effective concentration to decrease the expression of each gene. <P>COPYRIGHT: (C)2011,JPO&INPIT | ||||||
| 17 | Oligonucleotides containing pharmacologically compositions and the use thereof | JP2003512248 | 2002-07-10 | JP2005504739A | 2005-02-17 | アーロウ，エミィ; デール，ロデリック，エム．，ケー．; トンプソン，テリー |
| 本発明は、ヒトおよび他の哺乳動物に投与するのに好適なオリゴヌクレオチドを含む、方法および組成物に関する。 | ||||||
| 18 | OLIGONUCLEOTIDE-CONTAINING PHARMACOLOGICAL COMPOSITIONS AND THEIR USE | EP02749875.7 | 2002-07-10 | EP1414841B1 | 2012-11-14 | DALE, Roderic, M., K., Oligos Etc. Inc.; ARROW, Amy c/o Oligos Etc. Inc.; THOMPSON, Terry c/o Oligos Etc. Inc. |
| 19 | MEANS AND METHODS FOR COUNTERACTING POLYQ EXPANSION DISORDERS | EP10732470.9 | 2010-05-20 | EP2432491A2 | 2012-03-28 | REITS, Eric, Albert, Julius |
| The present invention provides means and methods for counteracting and/or preventing aggregation of a polyQ protein. Further provided are improved poly constructs which are, amongst other things, useful for testing assays. According to the invention, several peptidases like, e.g. tripeptidyl peptidase II (TPPII), appear to be capable of cleaving long polyQ peptides comprising at least 45 glutamine residues. Hence, according to the invention, administration of such peptidases to an individual suffering from a polyQ expansion disorder results in degradation of long polyQ peptides. | ||||||
| 20 | Oligonucleotide-containing pharmacological compositions and their use | EP10185703.5 | 2002-07-10 | EP2351765A3 | 2012-02-22 | Dale, Roderic; Arrow, Amy; Thompson, Terry |
The present invention related to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals. |
||||||
QQ群二维码
意见反馈
意见反馈