| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 2‑芳基（烯基）‑乙烯基磺酰氟化合物的制备方法 | CN201710240070.8 | 2017-04-13 | CN106957207A | 2017-07-18 | 秦华利; 查高峰; 冷静 |
| 本发明公开了一种2‑芳基(烯基)‑乙烯基磺酰氟化合物的制备方法。以有机碘化合物为原料，与乙烯基磺酰氟、钯催化剂、银盐和溶剂混合，20℃至120℃反应2h以上，分离纯化，得乙烯基磺酰氟化产物。有机碘化合物为芳基碘化合物时，产物为2‑芳基‑乙烯基磺酰氟。有机碘化合物为烯基碘化合物时，产物为2‑烯基‑乙烯基磺酰氟。本发明所提供的制备方法不需要无水无氧，在空气条件下即可进行，钯催化剂负载低(正常为2％)，不需要外加膦配体，且反应产率高。对绝大部分的官能团均能耐受，反应选择性好，具备实验室大量制备和工业放大生产的技术潜力。 | ||||||
| 2 | 一种含无机卤化物的醚溶液 | CN201510972712.4 | 2015-12-23 | CN105503489A | 2016-04-20 | 武卫明; 顾朝蟠 |
| 本发明公开了一种含无机卤化物的醚溶液，该溶液主要用于有机合成，可以作为环化加成反应的催化剂，也可以用于制备碳-碳偶联反应的锌试剂，或用于制备锌的烯醇化物以及选择性还原性试剂。 | ||||||
| 3 | 顺式共轭烯炔的制备方法 | CN201610214215.2 | 2016-04-08 | CN105859494A | 2016-08-17 | 张武; 李佳; 武超婷 |
| 本发明公开了一种如式(I)所示结构的顺式共轭烯炔的制备方法，包括：在保护气和有机溶剂的存在下，将如式(II)所示结构的顺式烯溴、如式(III)所示结构的端基炔、催化剂、弱碱性化合物和邻菲罗啉进行接触反应以制得如式(I)所示结构的顺式共轭烯炔，其中，R1为H、烷基、烷氧基、卤素或三氟甲基，R2为H、烷基、烷氧基或卤素；催化剂选自纳米氧化铜、纳米氧化亚铜和纳米碘化亚铜中的一种。本制备方法成本低，原料易得，效率高，立体选择性高，使用范围广，适合多种底物反应，且催化剂能够回收再利用， | ||||||
| 4 | 一种合成非对称三联苯类化合物的方法 | CN201410460478.2 | 2014-09-05 | CN104262119A | 2015-01-07 | 刘平; 代斌; 马晓伟; 刘岩; 谢建伟; 谷宁宁 |
| 本发明公开了一种合成非对称三联苯类化合物的方法，其特征在于，包括以下具体步骤：将反应底物溴代氯苯和芳基硼酸与催化剂Pd(OAc)2，PCy3和Cs2CO3加入到反应容器，抽真空充氮气置换后，加入溶剂，加热(25-100℃)搅拌反应，反应完成转化；待溴代氯苯反应完成后，加入反应底物多氟芳烃升温(60-140℃)，继续反应，反应完成后；冷却到室温，向所述反应容器中加入水，用萃取剂萃取，合并溶剂层，用无水Na2SO4干燥，滤液浓缩，柱层析分离提纯得到产物。 | ||||||
| 5 | 二草酸根合硼酸的应用 | CN97102008.6 | 1997-01-08 | CN1161251A | 1997-10-08 | C·福勒比林格 |
| 式I的二草酸根合硼酸用作缩合反应如Friedel-Crafts缩合、乙缩醛与乙烯基醚或丙烯基醚的乙烯基醚缩合及酚的酰化反应的质子酸催化剂。这类反应产物是如二氢维生素K1单苯甲酸酯、d，1-α-生育酚、各种合成类胡萝卜素的中间体以及d，1-α-生育酚乙酸酯。由于采用本发明的二草酸根合硼酸，可避免因使用其它质子酸催化剂产生的缺点如腐蚀、毒性和环境污染问题。新型催化剂在选择性、得率、用量及在相应缩合反应完成后处理方面具有优势。 | ||||||
| 6 | 一种PNN配体-钴络合物催化剂及其制备方法和应用 | CN201610005350.6 | 2014-01-07 | CN105665025A | 2016-06-15 | 黄正; 张雷; 彭东杰; 左自青 |
| 本发明公开了一种PNN配体-钴络合物催化剂及其制备方法和应用。所述催化剂是具有如下通式的化合物：其中：M为钴，R为C1～C30的烷烃基或C6～C30的芳基；R1、R2、R3、R4、R5、R6、R7独立选自氢原子、卤素原子、C1-C30的烃基、C1-C30的含氧基团、C1-C30的含硫基团、C1-C30的含氮基团、C1-C30的含磷基团、C1-C30的含硅基团或其它惰性功能性基团；X为卤原子或C1～C30的烷烃基。该催化剂的制备是将PNN配体与MX2或Py2MX2进行配位反应。本发明提供的PNN配体-钴络合物对单烯烃的硼氢化反应具有非常好的催化活性。 | ||||||
| 7 | 一种微波合成反式二苯乙烯类化合物的方法 | CN201410643161.2 | 2014-11-13 | CN104447228A | 2015-03-25 | 张恩生; 邹永; 徐田龙; 王德建; 魏文 |
| 本发明公开了一种微波合成反式二苯乙烯类化合物的方法，该方法包括以下步骤：冰浴下向锌粉和有机溶剂的混合物中滴加四氯化钛，滴加完毕后，将苯甲醛类化合物(式2)加入到上述反应体系中，室温下搅拌1小时；将上述反应体系于微波反应器中回流反应，生成反式二苯乙烯类化合物(式1)。本发明提供了一种微波合成反式二苯乙烯类化合物的方法，该方法反应时间短、后处理方便、收率高。本发明的方法无需贵金属催化及严格无水操作，操作简便易于放大生产。。 | ||||||
| 8 | 组合物及制备α-(1,2)-支化的α-(1,6)葡聚寡糖的方法 | CN201080020234.2 | 2010-05-07 | CN102439048B | 2015-03-25 | T·纳艾; A·艾纳汉德; M·洛佩; S·M·波特; M·勒莫-西梅翁; P·F·E·蒙桑 |
| 本发明提供用于改善个体健康的组合物，其包含α-(1，2)-支化的α-(1，6)葡聚寡糖，所述葡聚寡糖的平均分子量优选为约10kDa至70kDa，具有约10％至50％的α-(1，2)-糖苷侧链，并且在所述个体中至少部分地不可消化。本发明还提供用于改善个体健康的方法，其包括向个体给药有效量的所述组合物以改善肠健康，或者预防或治疗胃肠道病症、胆固醇相关的病症、糖尿病或者肥胖。本发明还提供制备具有受控的大小和受控的支化度的葡聚寡糖的方法，其包括：提供平均分子量为0.5-100kDa的α-(1，6)葡聚寡糖，并将至少10％的α-(1，2)-糖苷侧链引入所述α-(1，6)葡聚寡糖上。 | ||||||
| 9 | 组合物及制备α-(1,2)-支化的α-(1,6)葡聚寡糖的方法 | CN201080020234.2 | 2010-05-07 | CN102439048A | 2012-05-02 | T·纳艾; A·艾纳汉德; M·洛佩; S·M·波特; M·勒莫-西梅翁; P·F·E·蒙桑 |
| 本发明提供用于改善个体健康的组合物，其包含α-(1，2)-支化的α-(1，6)葡聚寡糖，所述葡聚寡糖的平均分子量优选为约10kDa至70kDa，具有约10％至50％的α-(1，2)-糖苷侧链，并且在所述个体中至少部分地不可消化。本发明还提供用于改善个体健康的方法，其包括向个体给药有效量的所述组合物以改善肠健康，或者预防或治疗胃肠道病症、胆固醇相关的病症、糖尿病或者肥胖。本发明还提供制备具有受控的大小和受控的支化度的葡聚寡糖的方法，其包括：提供平均分子量为0.5-100kDa的α-(1，6)葡聚寡糖，并将至少10％的α-(1，2)-糖苷侧链引入所述α-(1，6)葡聚寡糖上。 | ||||||
| 10 | 取代烯烃的制备 | CN00102296.2 | 2000-02-22 | CN1183061C | 2005-01-05 | P·施瓦布; M·舒尔兹 |
| 通式E-CH2-CH＝CH-CH2-E1(I)所示的C6化合物的制备方法，该方法包括：在含有钌化合物或钌配合物的均相催化剂存在下使通式R-CH＝CH-CH2-E(II)和/或R1-CH＝CH-CH2-E1(III)的化合物进行自复分解反应或交叉复分解反应，式中：E，E1独立地是-CHO、-COOH、-COOR2、-C(O)NR3R4、-CN，R、R1独立地是H、C1-12-烷基、C6-12-芳基或C7-13烷芳基，以及R2，R3，R4独立地是H、C1-12-烷基、C7-13-芳烷基。 | ||||||
| 11 | 二草酸根合硼酸的应用 | CN97102008.6 | 1997-01-08 | CN1099911C | 2003-01-29 | C·福勒比林格 |
| 式I的二草酸根合硼酸用作缩合反应如Friedel-Crafts缩合、乙缩醛与乙烯基醚或丙烯基醚的乙烯基醚缩合及酚的酰化反应的质子酸催化剂。这类反应产物是如二氢维生素K1单苯甲酸酯、d，1-α-生育酚、各种合成类胡萝卜素的中间体以及d，1-α-生育酚乙酸酯。由于采用本发明的二草酸根合硼酸，可避免因使用其它质子酸催化剂产生的缺点如腐蚀、毒性和环境污染问题。新型催化剂在选择性、得率、用量及在相应缩合反应完成后处理方面具有优势。 | ||||||
| 12 | 取代烯烃的制备 | CN00102296.2 | 2000-02-22 | CN1270946A | 2000-10-25 | P·施瓦布; M·舒尔兹 |
| 通式E－CH2－CH=CH－CH2－E1(Ⅰ)所示的C6化合物的制备方法,该方法包括:在含有钌化合物或钌配合物的均相催化剂存在下使通式R－CH=CH－CH2－E(Ⅱ)和/或R1－CH=CH－CH2－E1(Ⅲ)的化合物进行自复分解反应或交叉复分解反应,式中:E,E1独立地是－CHO、－COOH、－COOR2、－C(O)NR3R4、－CN,R、R1独立地是H、C1－12－烷基、C6－12－芳基或C7－13烷芳基,以及R2,R3,R4独立地是H、C1－12－烷基、C7－13－芳烷基。 | ||||||
| 13 | 环戊烯醇衍生物的制备方法 | CN94106209.0 | 1994-06-02 | CN1100406A | 1995-03-22 | 对岛和礼; 岩崎智则; 铃木雅也; 松尾宪忠 |
| 本发明涉及环戊烯醇化合物I的制备方法，它包括：(i)保护环戊烯醇酮化合物II的羟基，得到环戊烯醇酮衍生物III；(ii)使锌和二溴甲烷或二碘甲烷的混合物在惰性有机溶剂中与四氯化钛反应；(iii)使(ii)所得反应混合物与环戊烯醇酮衍生物III反应，得到环戊烯醇衍生物IV；(iv)去除环戊烯醇衍生物IV的保护基A。式中R1表示2-丙烯基或2-丙炔基，A表示保护基。 | ||||||
| 14 | Method of manufacturing a styrene derivative | JP30049394 | 1994-12-05 | JP3585277B2 | 2004-11-04 | 藤尚 松永; 義夫 石野; 義治 綾部; 郁三 西口; 研三 辻本 |
| 15 | Oxidation coupling method of olefin and aromatic compound using rhodium catalyst and copper (ii) redox reagent | JP2000088594 | 2000-03-24 | JP2000302700A | 2000-10-31 | MATSUMOTO TAKANARI; DOUGLAS J TAUBI; ROY A PERIANA |
| PROBLEM TO BE SOLVED: To provide a method for coupling in high selectivity by reacting a specific olefin compound with a specific aromatic compound in the presence of rhodium (III) acetylacetonato catalyst, or the like, and simultaneously obtaining a sufficient catalyst turnover frequency. SOLUTION: In coupling an olefin compound having one or more C-C double bonds and one or more hydrogen atoms bonding to one carbon atom of the C-C double bond such as ethylene with an aromatic compound having an atom of an aromatic ring and a hydrogen atom bonding to one or more atoms of the aromatic ring through a covalent bond such as benzene, the olefin compound and the aromatic compound are reacted in a reaction medium free from a carboxylic acid in the presence of Rh (III) acetylacetonato catalyst such as Rh(acac)2Cl(H2O) and a Cu (II) redox reagent such as Cu(CH3COO)2 at 150-225 deg.C to perform the coupling reaction. | ||||||
| 16 | Production of substituted olefin | JP2000038987 | 2000-02-17 | JP2000297063A | 2000-10-24 | SCHWAB PETER DR; SCHULTZ MICHAEL |
| PROBLEM TO BE SOLVED: To obtain a difunctionalized 6C-hydrocarbon by an economically excellent reaction path by subjecting one or more two kinds of specific olefins to self double decomposition or cross double decomposition in the presence of a homogeneous catalyst containing a specific ruthenium catalyst, etc. SOLUTION: A compound of the formula R-CH=CH-CH2-E and/or R1-CH= CH-CH2-E1 (E and E1 are each COOH or the like; R and R1 are each H, a 1-12C alkyl or the like) (e.g. 3-methyl pentenoate) is subjected to self double decomposition or cross double decomposition in the presence of a homogenous catalyst containing a ruthenium compound or a ruthenium complex to give a 6C compound of the formula E-CH2-CH=CH-CH2-E1 (e.g. methyl dehydroadipate). The catalyst used is preferably a ruthenium-alkylidene complex of the formula RuX'Y' (=CH-CH2R")L1L2 (X' and Y' are each an anionic ligand; R" is H, a 1-20C alkyl or the like; L1 and L2 are each an uncharged electron donor ligand). COPYRIGHT: (C)2000,JPO | ||||||
| 17 | Improved production of biaryl derivative | JP12902492 | 1992-05-21 | JPH05178790A | 1993-07-20 | EIBURAMU BETSUKAA; ARIERU ADAMU EUINSON; BAASA KUROITORU |
| PURPOSE: To provide an improved process for producing a biaryl deriv. by reduction coupling of an aryl halide compd. CONSTITUTION: The aryl halide (for example, 4-bromophthalic acid) is coupled by using hydrazide formate as a reducing agent in the presence of a palladium catalyst in an aq. alkaline soln., by which the biaryl deriv. 3,3',4,4'- biphenyltetracarboxylic acid is produced. COPYRIGHT: (C)1993,JPO | ||||||
| 18 | Build sequences for mechanosynthesis | US14712506 | 2015-05-14 | US09676677B2 | 2017-06-13 | Robert A. Freitas, Jr.; Ralph C. Merkle |
| Processes for creating build sequences are described which use computational chemistry algorithms to simulate mechanosynthetic reactions, and which may use the mechanosynthesis process conditions or equipment limitations in these simulations, and which facilitate determining a set of mechanosynthetic reactions that will build an atomically-precise workpiece with a desired degree of reliability. Included are methods for error correction of pathological reactions or avoidance of pathological reactions. Libraries of reactions may be used to reduce simulation requirements. | ||||||
| 19 | Compositions and methods for making alpha-(1,2)-branched alpha-(1,6) oligodextrans | US14329549 | 2014-07-11 | US09512239B2 | 2016-12-06 | Thierry Naeye; Alexandra Einerhand; Michel Lopez; Susan M. Potter; Magali Remaud-Siméon; Pierre Frédéric Emmanuel Monsan |
| Compositions for improving the health of a subject comprise alpha-(1,2)-branched alpha-(1,6) oligodextrans, preferably with an average molecular weight between about 10 kDa and 70 kDa, between about 10% and 50% alpha-(1,2)-osidic side chains, and having at least partial indigestibility in the subject. Methods for improving the health of a subject comprise administering the composition to a subject in an amount effective to improve gut health, or to prevent or treat a gastrointestinal disorder, a cholesterol-related disorder, diabetes, or obesity. Methods for making oligodextrans having controlled size and controlled degree of branching comprise providing alpha-(1,6) oligodextrans having an average molecular weight between 0.5 and 100 kDa and introducing at least 10% alpha-(1,2)-osidic side chains onto the alpha-(1,6) oligodextrans. | ||||||
| 20 | HIGHLY ACTIVE MULTIDENTATE CATALYSTS FOR EFFICIENT ALKYNE METATHESIS | US14674754 | 2015-03-31 | US20150273457A1 | 2015-10-01 | WEI ZHANG; JYOTHISH KUTHANAPILLIL; QI WANG |
| The invention relates to highly active and selective catalysts for alkyne metathesis. In one aspect, the invention includes a multidentate organic ligand wherein one substrate-binding site of the metal center is blocked. In another aspect, the invention includes N-quaternized or silane-based multidentate organic ligands, capable of binding to metals. In yet another aspect, the invention includes N-quaternized or silane-based multidentate catalysts. The catalysts of the invention show high robustness, strong resistance to small alkyne polymerization and significantly enhanced catalytic activity compared to their corresponding non-quaternized or non-silane-based multidentate catalyst analogues. | ||||||
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