子分类：
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 81 | Gel compositions prepared from crosslinkable polysaccharides, polycations and/or lipids and uses therefor | US472191 | 1995-06-07 | US5700848A | 1997-12-23 | Patrick Soon-Shiong; Neil P. Desai; Paul A. Sandford; Roswitha A. Heintz; Soebianto Sojomihardjo |
| The present invention relates to a new form of biocompatible materials (e.g., lipids, polycations, polysaccharides) which are capable of undergoing free radical polymerization, e.g., by using certain sources of light; methods of modifying certain synthetic and naturally occurring biocompatible materials to make polymerizable microcapsules containing biological material coated with said polymerizable materials, composites of said polymerizable materials, methods of making microcapsules and encapsulating biological materials therein, and apparatus for making microcapsules containing biological cells (particularly islets of Langerhans) coated with polymerizable alginate or with a composite thereof (e.g., alginate and PEG). The present invention also relates to drug delivery systems relating to the foregoing, as well as bioadhesives and wound dressings made utilizing the foregoing technology. | ||||||
| 82 | CURED BIODEGRADABLE MICROPARTICLES AND SCAFFOLDS AND METHODS OF MAKING AND USING THE SAME | US15941745 | 2018-03-30 | US20180280912A1 | 2018-10-04 | Steven LU; Peter D. GABRIELE; Julia DONNELLY; Brian GINN; Charles Brendan NICHOLSON; Jeremy J. HARRIS; Michael S. FLEMMENS |
| A method of forming cured microparticles includes providing a poly(glycerol sebacate) resin in an uncured state. The method also includes forming the composition into a plurality of uncured microparticles and curing the uncured microparticles to form the plurality of cured microparticles. The uncured microparticles are free of a photo-induced crosslinker. A method of forming a scaffold includes providing microparticles including poly(glycerol sebacate) in a three-dimensional arrangement. The method also includes stimulating the microparticles in the three-dimensional arrangement to sinter the microparticles, thereby forming the scaffold having a plurality of pores. A scaffold is formed of a plurality of microparticles including a poly(glycerol sebacate) thermoset resin in a three-dimensional arrangement. The scaffold has a plurality of pores. | ||||||
| 83 | APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE | US15726928 | 2017-10-06 | US20180028166A1 | 2018-02-01 | Andreas Mylonakis; Jacky Au-Yeung; Florencia Lim |
| A sealant for sealing a puncture through tissue includes a first section, e.g., formed from freeze-dried hydrogel, and a second section extending from the distal end. The second section may be formed from PEG-precursors including PEG-ester and PEG-amine, e.g., in an equivalent ratio of active group sites of PEG-ester/PEG-amine greater than one-to-one, e.g., such that excess esters may provide faster activation upon contact with physiological fluids and enhance adhesion of the sealant within a puncture. At least some of the precursors remain in an unreactive state until exposed to an aqueous physiological environment, e.g., within a puncture, whereupon the precursors undergo in-situ cross-linking to provide adhesion to tissue adjacent the puncture. For example, the PEG-amine precursors may include the free amine form and the salt form. The free amine form at least partially cross-links with the PEG-ester and the salt form remains in the unreactive state in the sealant before introduction into the puncture. | ||||||
| 84 | Cement products and methods of making and using the same | US15149986 | 2016-05-09 | US09757493B2 | 2017-09-12 | Juchui Ray Lin; Edward S. Ahn; Brian M. Schlossberg |
| Disclosed are cement products, methods of forming cement using the cement product, and methods of using the cement product in orthopedic and dental applications. Generally, the disclosed cement product includes a first component and a second component. The first component comprises a polymerizable resin comprising ethylenic unsaturated double bond, a suitable glycidyl group and/or a suitable isocyanate group. The second component includes a compound comprising more than one type of amine selected from the group consisting of primary amine, secondary amines, tertiary amines and quaternary amines. Alternatively, the second component includes a compound comprising a suitable mercapto (SH—) group, a hindered amine or a dimethylthiotoluenediamine (DMTDA). Optionally, the cement product includes a filler and/or a bioactive component to promote bone formation. | ||||||
| 85 | PREPARATION FOR FORMING EMBOLI AND MICROCATHETER | US15514886 | 2015-10-19 | US20170216444A1 | 2017-08-03 | Tsutomu TAMAI; Takayuki TAKEI; Akio IDO; Masahiro YOSHIDA; Shinji SAKAI |
| An object is to provide a preparation for forming emboli highly safe in a living body and capable of retaining and controlled-releasing an anticancer agent, occluding a blood vessel when injected into the blood vessel, unlikely to be washed out and having a controlled decomposition time (i.e., occludes a blood vessel for a while and quickly decomposes to prevent the necrosis of the entire tissues when the function is completed). The preparation for forming emboli according to the present invention comprises a solution comprising a phenolic hydroxyl group-modified polymer represented by the following formula (1): wherein P is a biocompatible polymer, A is a single bond or an —OCO—C2-C4-alkenylene group, a —CONH—C1-C4-alkylene group or an —HNCO—C1-C4-alkylene group, and X is hydrogen or a C1-C3-alkoxy group, a solution comprising at least one selected from a peroxidase, a laccase, a tyrosinase, a catalase and an iron porphyrin complex and a solution comprising hydrogen peroxide. | ||||||
| 86 | METHOD AND DEVICE FOR FEMALE URINARY INCONTINENCE | US15230284 | 2016-08-05 | US20160339142A1 | 2016-11-24 | Cora St. Anne |
| A method and device for use in stress female urinary incontinence. A small, flexible adhesive patch is applied directly to the clitoris of a person suffering from stress female urinary incontinence. The adhesive is of a type sufficient to stimulate the mechanoreceptors located in the clitoris whereby to inhibit discharge from the bladder. The patch is formed of a backing sheet of an impervious material containing adhesive on one side. A release liner prevents the adhesive from drying out. | ||||||
| 87 | FUNCTIONALIZED SURGICAL ADHESIVES | US14619143 | 2015-02-11 | US20150151019A1 | 2015-06-04 | Sebastien Ladet |
| A bioadherent composition includes a first mixture containing a plurality of reactive members of a specific binding pair, said reactive members being bound to a ligand capable of binding a receptor on biological tissue, and a second mixture containing a plurality of complementary reactive members of the specific binding pair, said complementary reactive members being bound to a ligand capable of binding a receptor on biological tissue, said reactive members capable of forming covalent bonds with said complementary reactive members via a reaction selected from Huisgen cycloaddition reactions, Diels-Alder reactions, and/or thiol-alkene reactions. A method for bonding biological tissue involves utilizing the bioadherent composition. | ||||||
| 88 | Bioactive material | US12674236 | 2008-08-19 | US08980425B2 | 2015-03-17 | Graeme Howling; Paul Gunning |
| The present invention relates to a bioactive material and to a method of producing a bioactive material which is suitable for use as an implant or for use as a bone substitute for repairing bone. | ||||||
| 89 | Multi-armed catechol compound blends | US13400333 | 2012-02-20 | US08916652B2 | 2014-12-23 | Jeffrey L. Dalsin; Bruce P. Lee; Laura Vollenweider; Sunil Silvary; John L. Murphy; Fangmin Xu; Amanda Spitz; Arinne Lyman |
| The invention describes families of compounds that utilize multihydroxyl phenyl groups to provide adhesive properties. Selection of the multihydroxy phenyl group along with linkers or linking groups and the linkages between the linkers or linking groups with polyalkylene oxides, provides materials that can be engineered to afford controllable curing time, biodegradation and/or swelling. | ||||||
| 90 | CEMENT PRODUCTS AND METHODS OF MAKING AND USING THE SAME | US14461138 | 2014-08-15 | US20140357754A1 | 2014-12-04 | Juchui Ray Lin; Edward S. Ahn; Brian M. Schlossberg |
| Disclosed are cement products, methods of forming cement using the cement product, and methods of using the cement product in orthopedic and dental applications. Generally, the disclosed cement product includes a first component and a second component. The first component comprises a polymerizable resin comprising ethylenic unsaturated double bond, a suitable glycidyl group and/or a suitable isocyanate group. The second component includes a compound comprising more than one type of amine selected from the group consisting of primary amine, secondary amines, tertiary amines and quaternary amines. Alternatively, the second component includes a compound comprising a suitable mercapto (SH—) group, a hindered amine or a dimethylthiotoluenediamine (DMTDA). Optionally, the cement product includes a filler and/or a bioactive component to promote bone formation. | ||||||
| 91 | INJECTABLE HYDROGELS | US13800013 | 2013-03-13 | US20140277112A1 | 2014-09-18 | Lisa MELLIN; Niklas BORG; Martina KÄLLROT |
| Described herein are methods of forming hydrogels comprising combining (a) a water-soluble polymer comprising thiol groups, and (b) a water-soluble metal salt in an aqueous solution. The hydrogels form rapidly. Hydrogels and related methods, uses, and products also are described. | ||||||
| 92 | In situ formation of an artificial blockage to control bleeding by polymer expansion with hydrogen peroxide | US12073822 | 2008-03-11 | US08828358B2 | 2014-09-09 | Joseph G. Montes; Krishnaswamy Kasthuri Rangan; Ramachandran Radhakrishnan; Tirumalai Srinivas Sudarshan |
| A composition for in situ formation of an artificial blockage to control bleeding includes a suitable amount of a polymer-forming component, a suitable amount of a crosslinking agent, hydrogen peroxide, and a decomposing agent for hydrogen peroxide. The decomposing agent includes exogenous or endogenous catalase, or both. | ||||||
| 93 | Biocompatible surgical compositions | US13732699 | 2013-01-02 | US08790488B2 | 2014-07-29 | Ahmad R. Hadba; Nadya Belcheva |
| Biocompatible macromer compositions are provided including an isocyanate-functional polyalkylene oxide combined with at least one multi-functional isocyanate as a first component, and a multi-amino functional compound possessing multiple primary amines as a second component. The isocyanate-functional polyalkylene oxide has pendant polyalkylene oxide groups. The resulting biocompatible macromer composition can be employed as an adhesive or sealant for medical/surgical uses. | ||||||
| 94 | BIOCOMPATIBLE SURGICAL COMPOSITIONS | US13732699 | 2013-01-02 | US20130138148A1 | 2013-05-30 | Ahmad R. Hadba; Nadya Belcheva |
| Biocompatible macromer compositions are provided including an isocyanate-functional polyalkylene oxide combined with at least one multi-functional isocyanate as a first component, and a multi-amino functional compound possessing multiple primary amines as a second component. The isocyanate-functional polyalkylene oxide has pendant polyalkylene oxide groups. The resulting biocompatible macromer composition can be employed as an adhesive or sealant for medical/surgical uses. | ||||||
| 95 | Biocompatible surgical compositions | US11636159 | 2006-12-08 | US08449714B2 | 2013-05-28 | Ahmad R. Hadba; Nadya Belcheva |
| Biocompatible macromer compositions are provided including an isocyanate-functional polyalkylene oxide combined with at least one multi-functional isocyanate as a first component, and a multi-amino functional compound possessing multiple primary amines as a second component. The isocyanate-functional polyalkylene oxide has pendant polyalkylene oxide groups. The resulting biocompatible macromer composition can be employed as an adhesive or sealant for medical/surgical uses. | ||||||
| 96 | MULTILAYER BACKING FILM FOR ADHESIVE SKIN BARRIER OF OSTOMY APPLIANCE | US13567455 | 2012-08-06 | US20130096523A1 | 2013-04-18 | Moh-Ching Oliver Chang; Joel D. Shutt |
| A one-piece ostomy appliance includes an adhesive skin barrier for attaching an ostomy pouch to a user to receive stomal effluent. The adhesive skin barrier is attached to the ostomy pouch via a multilayer backing film, which includes a layer formed of a material having good resistance to chemical ingredients of the adhesive, and a layer formed of a material having good heat sealability to the pouch. | ||||||
| 97 | Bioabsorbable surgical composition | US12409642 | 2009-03-24 | US08263704B2 | 2012-09-11 | Joshua B. Stopek; Ahmad Robert Hadba |
| Bioabsorbable macromer compositions are provided including a polymeric component possessing a lipid segment which enhances the affinity of the macromer composition to targeted tissue. In some embodiments, the polymeric component can be combined with a second component. The resulting bioabsorbable macromer composition can be employed as an adhesive or sealant for medical/surgical uses. | ||||||
| 98 | Multi-armed catechol compound blends | US12568542 | 2009-09-28 | US08119742B2 | 2012-02-21 | Jeffrey L. Dalsin; Bruce P. Lee; Laura Vollenweider; Sunil Silvary; John L. Murphy; Fangmin Xu; Amanda Spitz; Arinne Lyman |
| The invention describes families of compounds that utilize multihydroxyl phenyl groups to provide adhesive properties. Selection of the multihydroxy phenyl group along with linkers or linking groups and the linkages between the linkers or linking groups with polyalkylene oxides, provides materials that can be engineered to afford controllable curing time, biodegradation and/or swelling. | ||||||
| 99 | DEVICES AND METHODS FOR TREATING VASCULAR MALFORMATIONS | US13114635 | 2011-05-24 | US20110224776A1 | 2011-09-15 | Ivan SEPETKA; Martin S. Dieck; Ryan Pierce; Maria Aboytes; Son Gia |
| A device for treating vascular malformations includes a primary coil and secondary windings. The primary coil provides resilience and structural integrity while the secondary windings fill interstitial spaces in the primary coil to isolate the vascular malformation. The device may have increased density along a central portion to isolate the malformation. In another aspect, the device may have a central opening through which embolic materials may be delivered. | ||||||
| 100 | METHODS AND DEVICES FOR USE WITH SEALANTS | US13000019 | 2009-06-18 | US20110112573A1 | 2011-05-12 | Orahn Preiss Bloom |
| A biocompatible medical sealant for use in a biological system, the sealant comprising a solution of a cross-linkable protein or polypeptide and a solution of a non-toxic cross-linking material which induces cross-linking of said cross-linkable protein, thereby sealing at least a portion of the biological system. | ||||||
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