子分类：
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 61 | INJECTABLE BIOMATERIAL | US13254617 | 2010-03-02 | US20120195826A1 | 2012-08-02 | Minh Tam Baylatry; Anouk Bisdorf-Bresson; Denis Labarre; Alexandre Laurent; Laurence Moine; Jean-Pierre Saint-Maurice; Khelil Slimani; Michel Wassef |
| The invention relates to an injectable biomaterial. The injectable biomaterial of the invention comprises a non aqueous solvent which is compatible for injection to human being and nanoparticles made of a polymer which is insoluble in water and insoluble in said non aqueous solvent, said nanoparticles being loaded with a drug or a biological agent. The injectable biomaterial of the invention is particularly appropriate for occluding normal or malformative blood vessels or non circulating cavities or for necrosing tumors. | ||||||
| 62 | METHOD AND DEVICE FOR FEMALE URINARY INCONTINENCE | US12999114 | 2010-05-03 | US20110162661A1 | 2011-07-07 | Cora St. Anne |
| A method and device for use in stress female urinary incontinence. A small, flexible adhesive patch is applied directly to the clitoris of a person suffering from stress female urinary incontinence. The adhesive is of a type sufficient to stimulate the mechanoreceptors located in the clitoris whereby to inhibit discharge from the bladder. The patch is formed of a backing sheet of an impervious film material containing adhesive on one side. A release liner prevents the adhesive from drying out. | ||||||
| 63 | Devices and methods for treating vascular malformations | US12653821 | 2009-12-21 | US20110137332A1 | 2011-06-09 | Ivan Sepetka; Martin S. Dieck; Ryan Pierce; Maria Aboytes; Son Gia |
| A device for treating vascular malformations includes a primary coil and secondary windings. The primary coil provides resilience and structural integrity while the secondary windings fill interstitial spaces in the primary coil to isolate the vascular malformation. The device may have increased density along a central portion to isolate the malformation. In another aspect, the device may have a central opening through which embolic materials may be delivered. | ||||||
| 64 | BIOACTIVE MATERIAL | US12674236 | 2008-08-19 | US20110059312A1 | 2011-03-10 | Graeme ... Howling; Paul Gunning |
| The present invention relates to a bioactive material and to a method of producing a bioactive material which is suitable for use as an implant or for use as a bone substitute for repairing bone. | ||||||
| 65 | Bioabsorbable Surgical Composition | US12572358 | 2009-10-02 | US20100092533A1 | 2010-04-15 | Joshua Stopek; Ahmad Hadba |
| Bioabsorbable macromer compositions are provided including a polymeric component possessing a hydroxamate segment and a polymer segment. The polymeric component can be used by itself, or in some embodiments, combined with a second component, to form a macromer composition of the present disclosure. The resulting bioabsorbable macromer composition can be employed as an adhesive or sealant for medical/surgical uses. | ||||||
| 66 | HOMOGENEOUS, INTRINSIC RADIOPAQUE EMBOLIC PARTICLES | US12432457 | 2009-04-29 | US20090297612A1 | 2009-12-03 | Levinus Hendrik Koole; Catharina Sibilla Josephine Van Hooy-Corstjens |
| The invention is directed to embolic material comprising spherical, homogeneous and substantially non-porous radiopaque polymer particles based on at least one hydrophilic monomer and at least one radiopaque monomer according to general formula wherein R is H, methyl or ethyl, and R1 is I, Br or wherein R2 is O, NH, O—[CH2—CH2—O]p—C(O)—, O—[CH2]m—O—C(O)—, O—[CH2]p—, NH—[CH2—CH2—O]p—C(O)—, NH—[CH2]m—O—C(O)- or NH—[CH2]p— wherein m>1 and p≧1, R3 is I or Br and n is 1, 2 or 3, the iodine and/or bromine content being at least 5 wt. % based on the dry weight of the particle, the said particles having an average particle diameter of at least 10 μm and being able to imbibe water up to a volume increase of the particle of at least 10%. | ||||||
| 67 | Cyanoacrylate tissue adhesive formulations with multipurpose rheology modifiers | US12386401 | 2009-04-18 | US20090264555A1 | 2009-10-22 | Shalaby W. Shalaby; Michael Aaron Vaughn; James M. Lindsey, III |
| Absorbable and non-absorbable cyanoacrylate tissue adhesive/sealant formulations include at least one multipurpose carboxylic, acid-bearing C-succinylated polymeric rheology modifier capable of increasing the viscosity of the liquid formulation, while controlling the anionic polymerization of the cyanoacrylate monomers and increasing the compliance of the cured solid adhesive. | ||||||
| 68 | DERIVATIZED TERTIARY AMINES AND USES THEREOF | US11942035 | 2007-11-19 | US20090131938A1 | 2009-05-21 | Chetan A. Khatri; Binoy K. Bordoloi |
| The invention relates to a tertiary amine intermediate represented by the following formula, and electrophilic monomers derived therefrom. The invention also relates to adhesives or sealants derived from such electrophilic moieties. where R═CH3, H, CH3CH2 or other alkyl group; and R1═H, C(O)CH2OCH2COOH, C(O)(CH2)nCOOH with n=1-4, or combinations thereof. | ||||||
| 69 | Redox Curing-Type Nonaqueous Curable Composition | US11659805 | 2005-08-08 | US20080081889A1 | 2008-04-03 | Mitsunobu Kawashima; Aki Takase |
| A nonaqueous curable composition including a liquid radical polymeric monomer (a), an organic peroxide (b) and a powdered water-soluble reducing compound (c) with the powdered water-soluble reducing compound (c) dispersed in the liquid radical polymeric monomer (a) is provided.According to the nonaqueous curable composition of this invention, time necessary for adhesion can be secured, and high adhesive strength against a wetting material, and more particularly, a biological hard tissue such as a dentine can be attained, and thus, the present invention is extremely industrially valuable. | ||||||
| 70 | Bone cement composition and method of making the same | US11214151 | 2005-08-29 | US20070048382A1 | 2007-03-01 | Jorg Meyer; Robert Wenz |
| Disclosed herein is a composition suitable for use in spinal surgery. The composition generally includes a reaction product or settable mixture of first and second components, the first component including a spray-dried inorganic filler, a radical donor, and a pre-polymerized vinyl polymer, and the second component including a radical scavenger, a diluent, a polymerization accelerator, and a reactive monomer. Furthermore, disclosed herein is a method of making the composition, which generally includes mixing the first and second components under conditions suitable to form a curable reaction product. | ||||||
| 71 | Bone cement mixture and x-ray contrast medium as well as method for their preparation | US10425337 | 2003-04-29 | US07091260B2 | 2006-08-15 | Klaus-Dieter Kūhn |
| A bone cement mixture comprised of a polymer component containing an x-ray contrast medium and a monomer component, wherein the x-ray contrast medium is a polymer or copolymer having compounds of radio-opaque elements bonded thereto, or is in the form of substantially spherical polymer or copolymer particles with radio-opaque inorganic nano-particles dispersed therein. | ||||||
| 72 | Cell-seeded tissue-engineered polymers for treatment of intracranial aneurysms | US10531544 | 2003-10-16 | US20060099191A1 | 2006-05-11 | Brian Hoh; Christopher Ogilvy; Johnny Pryor; Joseph Vacanti |
| Methods and materials for treating intracranial aneurysms with a tissue-engineered biopolymer are disclosed. A novel technique has been developed which utilizes a tissue-engineering biopolymer (TEBP) with living endothelial cells such that the endothelial cells will produce a neoendothelium across the aneurysm ostium. Alternatively, biocompatible materials can be coated onto aneurysm maintenance devices, and the cells can be seeded onto the biocompatible material. | ||||||
| 73 | Polyurethane based composition for filling or short-circuiting vascular cavities | US10533522 | 2003-10-30 | US20060008499A1 | 2006-01-12 | Istvan Hudak |
| The invention is directed to the use of a polyurethane for preparing a composition or a kit usable for filling or short-circuiting vascular cavities, where the polyurethane used can be dissolved in a solvent or a solvent mixture mingling with body fluids. | ||||||
| 74 | Persistent filmy preparation for topical administration containing prostglandin derivative | US10495160 | 2004-05-11 | US20040258730A1 | 2004-12-23 | Yasuhiko Tabata; Akio Nishiura |
| A sustained release film preparation for local administration to the region of diseases associated with decrease in bone mass, which comprises, as an active ingredient thereof, (11null,13E,15null)-9-oxo-11,15-dihydroxy-16-(3-methoxymethylphenyl)-17,18,19,20-tetranor-5-thiaprost-13-enoic acid methyl ester having the following formula (I) or a non-toxic salt thereof: 1 and a film comprising a biodegradable polymer. The sustained release film preparation which comprises the compound (I) as an active ingredient of the present invention has activity of accelerating bone formation and is useful for treatment of diseases associated with decrease in bone mass. | ||||||
| 75 | Coated combination vaso-occlusive device | US10138781 | 2002-05-06 | US20030004568A1 | 2003-01-02 | Christopher G.M. Ken; Tina J. Patel |
| Methods, compositions and apparatus are disclosed for treating abnormal conditions within a body. The apparatus includes vaso-occlusion devices each comprising a core formed of a metal, metal alloy, or non-metal material. Each core is coated with a polymer material that can include a bioactive agent. The methods include treating patients having abnormal blood flow at a site in their body by implanting such a coated vaso-occlusive device into the body at the site of the abnormal blood flow. The methods also include a method of making the vaso-occlusion devices. The composition includes a coating for the vaso-occlusive devices. | ||||||
| 76 | Dental compositions comprising degradable polymers and methods of manufacture thereof | US09638206 | 2000-08-11 | US06455608B1 | 2002-09-24 | Weitao Jia; Shuhua Jin; Samuel Jien-shek Huang |
| Curable compositions comprising degradable macromonomers having one or more terminal acrylate or methacrylate functionality, a curing composition, and optionally one or more polymerizable acrylate or methacrylate comonomers. Degradable macromonomers are manufactured from cyclic monomers with compounds having acrylate or methacrylate functionality. Depending on their use, the degradable macromonomer compositions further comprise one or more organic or inorganic fillers, including a calcium-based compound and/or a radiopacity-imparting agent. The compositions are particularly suitable for root canal sealants, implants, and pulp capping materials. | ||||||
| 77 | Microstructured dual sided membrane for tissue growth and regeneration | US10081478 | 2002-02-25 | US20020133232A1 | 2002-09-19 | John L. Ricci; Harold Alexander |
| An implantable substantially planar bioabsorbable article for the separation and regeneration of tissue at a tissue defect site includes first surface of the article, which may be circular or elliptical, that is provided with a soft tissue side intended for direction towards soft or subcutaneous tissue and having a microtextured surface optimized for promotion of ingrowth of soft tissue. An opposite side of the article comprises a different microgrooved surface, optionally including osteoconductive chemical properties, and physically oriented against or within the bone defect site toward and against the center of the defect into which any graft material placed. The membrane is flexible and of sufficient density to accommodate sutures or is circumfentially provided with perforations to hold sutures. | ||||||
| 78 | Tissue reactive adhesive compositions | US09530172 | 2000-04-24 | US06326025B1 | 2001-12-04 | Gerry Sigler; Z. David Deng; Dale R. Peterson; Todd P. Glancy; Samuel I. Stupp |
| The present invention is directed to a biocompatible tissue reactive composition comprising a functionalized polymer having tissue reactive substituents that are capable of forming covalent bonds with tissue associated functional groups. | ||||||
| 79 | Vascular embolizing compositions comprising ethyl lactate and methods for their use | US109041 | 1998-07-02 | US6051607A | 2000-04-18 | Richard J. Greff |
| Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery. In one embodiment, the compositions of this invention comprise a biocompatible polymer, ethyl lactate solvent and a biocompatible contrast agent. | ||||||
| 80 | Method for embolizing blood vessels | US594574 | 1996-01-31 | US5702361A | 1997-12-30 | Scott Evans; John Perl, II; Richard Greff |
| Disclosed are methods useful for treating vascular lesions wherein a non-particulate agent such as a metal coil is introduced into a vascular site (e.g., an aneurysm cavity) in conjunction with an embolizing composition comprising a biocompatible polymer and a biocompatible solvent. The biocompatible solvent is miscible or soluble in blood and also solubilizes the polymer during delivery. The biocompatible polymer is selected to be soluble in the biocompatible solvent but insoluble in blood. Upon contact with the blood, the biocompatible solvent dissipates from the embolic composition whereupon the biocompatible polymer precipitates. Precipitation of the polymer in the presence of the non-particulate agent permits the agent to act as a structural lattice for the growing polymer precipitate. In another embodiment, the biocompatible polymer composition can be replaced with a biocompatible prepolymer composition containing a biocompatible prepolymer. | ||||||
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