子分类：
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 盖体阵列及包含该盖体阵列的微型管阵列组 | CN200980160010.9 | 2009-06-25 | CN102481570B | 2014-03-19 | 角田新一郎; 中鼻容子 |
| 本发明提供一种盖体阵列及微型管阵列组，其能够以低价格且在短时间内个别地密封各个微型管的上面开口。盖体阵列(100)具备：按照与微型管(210)的个数和配置对应的方式配置有多个盖体(121)的包含盖体的片(120)、剥离片(140)、涂敷于包含盖体的片(120)的表面的第一粘接层(110)、介于包含盖体的片(120)和剥离片(140)之间的第二粘接层(130)，在包含盖体的片(120)中，各个盖体(121)在以可分离的方式沿其外周切有切缝的状态下保持于剥离片(140)，通过从涂敷有第一粘接层(110)的一侧的面按压在微型管阵列(200)的上面，各个盖体(121)分离并移动，能够使各个微型管(210)的开口密封。 | ||||||
| 2 | 盖体阵列及包含该盖体阵列的微型管阵列组 | CN200980160010.9 | 2009-06-25 | CN102481570A | 2012-05-30 | 角田新一郎; 中鼻容子 |
| 本发明提供一种盖体阵列及微型管阵列组，其能够以低价格且在短时间内个别地密封各个微型管的上面开口。盖体阵列(100)具备：按照与微型管(210)的个数和配置对应的方式配置有多个盖体(121)的包含盖体的片(120)、剥离片(140)、涂敷于包含盖体的片(120)的表面的第一粘接层(110)、介于包含盖体的片(120)和剥离片(140)之间的第二粘接层(130)，在包含盖体的片(120)中，各个盖体(121)在以可分离的方式沿其外周切有切缝的状态下保持于剥离片(140)，通过从涂敷有第一粘接层(110)的一侧的面按压在微型管阵列(200)的上面，各个盖体(121)分离并移动，能够使各个微型管(210)的开口密封。 | ||||||
| 3 | Planar electroporation apparatus and method | US12073167 | 2008-02-29 | US08222014B2 | 2012-07-17 | Kevin L. Firth; Leda Raptis |
| An electroporation apparatus provides for the electroporation of adherent cells attached to an electrode surface or suspended cells in close proximity to an electrode surface. In one embodiment, the electrodes are transparent to allow cell viewing using a microscope or an automated image analysis machine. The geometry of the electrodes and associated electrically non-conductive structures may provide for well-defined regions of electroporated and non-electroporated adherent cells with a clearly defined interface between these regions, facilitating comparison of electroporated cells and non-electroporated cells, and evaluation of transfer of material from cell to cell via intercellular gap junctions. | ||||||
| 4 | LID ELEMENT ARRAY AND A MICRO TUBE ARRAY FOR SAMPLE STORAGE INCLUDING THE SAME | US12745126 | 2009-06-25 | US20120087848A1 | 2012-04-12 | Yoko Nakahana; Shinichiro Kakuda |
| A lid element array and a micro tube array set for sealing the opening of each micro tube in an array quickly at low cost. A lid element array 100 comprises a lid element sheet 120 comprising a plurality of lid element 121 arrayed corresponding to the number and the arrangement of a plurality of said micro tubes 210; a release sheet 140; a first adhesive 110 applied to each said lid element in said lid element sheet 120; a second adhesive 130 applied between said lid element sheet 120 and said release sheet 140; wherein, each said lid element in said lid element sheet is supported by said release sheet with a cut-line cut around the edge of each said lid element for separation from said lid element sheet, each said lid element moves to a corresponding opening of each said micro tube and seals the same by pressing said lid element to the surface of said micro tube array for facing the surface applied with said first adhesive and the surface of said micro tube array. A convex portion is installed on the surface of the lid element 121, and said convex portion works as a positioning guide for the lid element array 100. | ||||||
| 5 | PLANAR LIPID BILAYER ARRAY FORMED BY MICROFLUIDIC TECHNIQUE AND METHOD OF ANALYSIS USING PLANAR LIPID BILAYER | US12744794 | 2008-11-26 | US20100304980A1 | 2010-12-02 | Shoji Takeuchi; Hiroaki Suzuki; Sadao Ota; Wei-Heong Tan |
| There is provided a planar lipid bilayer array formed by microfluidic technique and a method of analysis using the planar lipid bilayers, providing the advantages such as portability, decreased analysis time, a smaller amount of required reagents, and parallel automation with high reproducibility. The planar lipid bilayer array formed by microfluidic technique is a planar lipid bilayer array formed by microfluidic technique (PDMS device) 1 saturated with water by preliminarily immersing in water, comprising microchannels 2 connected to an inlet of a microfluidic channel and arranged in parallel, and microchambers 3 having apertures on both sides of the microchannel 2. | ||||||
| 6 | SYNTHESIS OF CHEMICAL TAGS | US11927826 | 2007-10-30 | US20080108516A1 | 2008-05-08 | Ravi Saraf |
| A method for forming a biological chemical tag. At least one double stranded DNA molecule is provided. At least a portion of the at least one double stranded DNA molecule is denatured. At least one chemical moiety that prohibits recrystallization of the at least one denatured portion to which the at least one chemical moiety is attached is attached to at least one nucleotide in the at least one denatured portion of the at least one double stranded DNA molecule. | ||||||
| 7 | Synthesis of chemical tags | US09916439 | 2001-07-30 | US20010053540A1 | 2001-12-20 | Ravi F. Saraf |
| A method for forming a biological chemical tag. At least one double stranded DNA molecule is provided. At least a portion of the at least one double stranded DNA molecule is denatured. At least one chemical moiety that prohibits recrystallization of the at least one denatured portion to which the at least one chemical moiety is attached is attached to at least one nucleotide in the at least one denatured portion of the at least one double stranded DNA molecule. | ||||||
| 8 | POROUS SURFACE FOR BIOMEDICAL DEVICES | US16230355 | 2018-12-21 | US20190186046A1 | 2019-06-20 | Sangmin JEONG; Hann-Ching CHAO; Ludovic GODET |
| Embodiments described herein generally relate to biomedical devices including a porous layer forming a support structure for a biological probe and methods of making the same. The porous layer can be a porous silicon containing layer. The pore size can be adjusted such that various size biological probes can be incorporated into the pores. Further, the porous silicon containing layer can be used to support a biofunctionalizing layer. | ||||||
| 9 | Magnetic recovery method of magnetically responsive high-aspect ratio photoresist microstructures | US13535296 | 2012-06-27 | US09340417B2 | 2016-05-17 | Mark Bachman; Edward Nelson; Nicholas Gunn |
| Systems and methods that facilitate magnetic collection and/or manipulation of individual micropallets are provided. The embodiments provided herein are directed to a new method for collecting micropallets once released from a substrate. It is accomplished by endowing the micropallets with magnetic properties by incorporating ferromagnetic or superparamagnetic nanoparticles into the photoresist material or otherwise incorporating magnetically responsive material into the micropallet structure. The magnetic particles, which posses magnetic qualities, e.g., ferromagnetism, ferrimagnetism, paramagnetism, and are composed of iron, nickel, and/or other magnetic materials, are mixed into the bulk photoresist prior to its use in the fabrication of microstructures. Also covered are other methods of incorporating magnetically-attractable material into the micropallet structure, such as plating of the micropallets with a material that is magnetically responsive, such as nickel. Additionally, the embodiments provided include a “collection probe” that is used to collect the released magnetic micropallets. | ||||||
| 10 | Planar lipid bilayer array formed by microfluidic technique and method of analysis using planar lipid bilayer | US12744794 | 2008-11-26 | US08513165B2 | 2013-08-20 | Shoji Takeuchi; Hiroaki Suzuki; Sadao Ota; Wei-Heong Tan |
| There is provided a planar lipid bilayer array formed by microfluidic technique and a method of analysis using the planar lipid bilayers, providing the advantages such as portability, decreased analysis time, a smaller amount of required reagents, and parallel automation with high reproducibility. The planar lipid bilayer array formed by microfluidic technique is a planar lipid bilayer array formed by microfluidic technique (PDMS device) 1 saturated with water by preliminarily immersing in water, comprising microchannels 2 connected to an inlet of a microfluidic channel and arranged in parallel, and microchambers 3 having apertures on both sides of the microchannel 2. | ||||||
| 11 | Lid element array and a micro tube array for sample storage including the same | US12745126 | 2009-06-25 | US08202497B2 | 2012-06-19 | Yoko Nakahana; Shinichiro Kakuda |
| A lid element array and a micro tube array set for sealing the opening of each micro tube in an array quickly at low cost. A lid element array 100 comprises a lid element sheet 120 comprising a plurality of lid element 121 arrayed corresponding to the number and the arrangement of a plurality of said micro tubes 210; a release sheet 140; a first adhesive 110 applied to each said lid element in said lid element sheet 120; a second adhesive 130 applied between said lid element sheet 120 and said release sheet 140; wherein, each said lid element in said lid element sheet is supported by said release sheet with a cut-line cut around the edge of each said lid element for separation from said lid element sheet, each said lid element moves to a corresponding opening of each said micro tube and seals the same by pressing said lid element to the surface of said micro tube array for facing the surface applied with said first adhesive and the surface of said micro tube array. A convex portion is installed on the surface of the lid element 121, and said convex portion works as a positioning guide for the lid element array 100. | ||||||
| 12 | Synthesis of chemical tags | US11927826 | 2007-10-30 | US07846714B2 | 2010-12-07 | Ravi F. Saraf |
| A method for forming a biological chemical tag. At least one double stranded DNA molecule is provided. At least a portion of the at least one double stranded DNA molecule is denatured. At least one chemical moiety that prohibits recrystallization of the at least one denatured portion to which the at least one chemical moiety is attached is attached to at least one nucleotide in the at least one denatured portion of the at least one double stranded DNA molecule. | ||||||
| 13 | Synthesis of chemical tags | US09916439 | 2001-07-30 | US06632612B2 | 2003-10-14 | Ravi F. Saraf |
| A method for forming a biological chemical tag. At least one double stranded DNA molecule is provided. At least a portion of the at least one double stranded DNA molecule is denatured. At least one chemical moiety that prohibits recrystallization of the at least one denatured portion to which the at least one chemical moiety is attached is attached to at least one nucleotide in the at least one denatured portion of the at least one double stranded DNA molecule. | ||||||
| 14 | Planar lipid-bilayer membrane array using microfluid and analysis method with use of the planar lipid-bilayer membrane | JP2007304126 | 2007-11-26 | JP2009128206A | 2009-06-11 | TAKEUCHI SHOJI; SUZUKI HIROAKI; OTA SADAO; CHIN HIDEO |
| <P>PROBLEM TO BE SOLVED: To provide a planar lipid-bilayer array that uses a microfluid which has advantages in portability, shortening the analysis periods, reducing the sought reagents sought, enhancing repeatability and realizing parallel automation, and to provide an analysis method tat employs the planar lipid-bilayer. <P>SOLUTION: The planar lipid-bilayer array (PDMS apparatus) 1 is one which has previously been immersed in water and is saturated with water, and the planar lipid-bilayer array 1 is equipped with a microchannel 2 , which is connected to a liquid feeding port and arranged in parallel and a microchamber 3, having apertures at both sides of the microchannel 2. <P>COPYRIGHT: (C)2009,JPO&INPIT | ||||||
| 15 | Chemical labelling | JP26336999 | 1999-09-17 | JP2000093174A | 2000-04-04 | SARAF RAVI F |
| PROBLEM TO BE SOLVED: To provide a method for labelling DNA by providing double-stranded DNA, denaturing a part of the DNA, followed by attaching at least one detectable compound motiety to the denatured part to prevent recrystallization of the part. SOLUTION: This method comprises the steps of providing at least one double-stranded DNA molecule 1, denaturing at least one part of DNA 1, and attaching at least one compound motiety at attaching parts 7, 13, and 15 to the denatured part 3 to prevent recrystallization of the part 3, wherein the compound motiety is bound with inserting compound motiety 5 or 11 which has a detectable part 9 or 17 such as a fluorescent dye. This method is useful for biochemical labelling of DNA molecules. | ||||||
| 16 | A method and apparatus for reading the reporter label bead | JP2002534547 | 2001-10-12 | JP3996056B2 | 2007-10-24 | オルティン ウィリアム; フロスト キース; バシジ デイビッド; ペリー デイビッド; バウアー リチャード; フィンチ ロサリンド |
| 17 | A method and apparatus for reading the reporter label bead | JP2002534547 | 2001-10-12 | JP2004532969A | 2004-10-28 | オルティン ウィリアム; フロスト キース; バシジ デイビッド; ペリー デイビッド; バウアー リチャード; フィンチ ロサリンド |
| 増幅され、ラベルを付けられたゲノムＤＮＡまたはリボ核酸（ＲＮＡ）にハイブリダイズされたエンコードビードに付与された組合合成されたデオキシリボ核酸（ＤＮＡ）オリゴヌクレオチドが、フローイメージングシステムを使用して解析される。 オリゴヌクレオチドおよびそれに対応するレポーターが、複数の小さなビードの表面に結合され、それにより異なるビードが異なるオリゴ配列を担う。 各ビードが、事前定義された数の一意のレポーターを備える一意の光学シグニチャを担い、ここで各レポーターが、異なる蛍光色素の事前定義された組合せを含む。 このとき、組成物スペクトルシグニチャは、それが取り付けられたオリゴ鎖の一意のヌクレオチド配列を同定する。 この光学シグニチャは、ビードでの色および空間位置に関してフロー中の各ビードに取り付けられた異なるレポーターを判別するためにイメージングシステムを使用して迅速にデコードされる（図１５参照）。 | ||||||
| 18 | POROUS SURFACE FOR BIOMEDICAL DEVICES | US14577971 | 2014-12-19 | US20160121292A1 | 2016-05-05 | Sangmin JEONG; Hann-Ching CHAO; Ludovic GODET |
| Embodiments described herein generally relate to biomedical devices including a porous layer forming a support structure for a biological probe and methods of making the same. The porous layer can be a porous silicon containing layer. The pore size can be adjusted such that various size biological probes can be incorporated into the pores. Further, the porous silicon containing layer can be used to support a biofunctionalizing layer. | ||||||
| 19 | Microarray and Method for Forming the Same | US14365881 | 2012-12-19 | US20140357529A1 | 2014-12-04 | Wee Kiong Choi; Heng Phon Too; Raj Rajagopalan; Lihan Zhou; Mohammed Khalid Bin Dawood; Han Zheng; He Cheng |
| There is provided a microarray comprising a plurality of active agents immobilized onto an array of porous nanostructures, wherein each nanostructure has a network of pores that extends throughout the thickness of said nano structure. | ||||||
| 20 | MAGNETIC RECOVERY METHOD OF MAGNETICALLY RESPONSIVE HIGH-ASPECT RATIO PHOTORESIST MICROSTRUCTURES | US13535296 | 2012-06-27 | US20130023438A1 | 2013-01-24 | Mark Bachman; Edward Nelson; Nicholas Gunn |
| Systems and methods that facilitate magnetic collection and/or manipulation of individual micropallets are provided. The embodiments provided herein are directed to a new method for collecting micropallets once released from a substrate. It is accomplished by endowing the micropallets with magnetic properties by incorporating ferromagnetic or superparamagnetic nanoparticles into the photoresist material or otherwise incorporating magnetically responsive material into the micropallet structure. The magnetic particles, which posses magnetic qualities, e.g., ferromagnetism, ferrimagnetism, paramagnetism, and are composed of iron, nickel, and/or other magnetic materials, are mixed into the bulk photoresist prior to its use in the fabrication of microstructures. Also covered are other methods of incorporating magnetically-attractable material into the micropallet structure, such as plating of the micropallets with a material that is magnetically responsive, such as nickel. Additionally, the embodiments provided include a “collection probe” that is used to collect the released magnetic micropallets. | ||||||
QQ群二维码
意见反馈
意见反馈