| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 空间编码的生物学测定 | CN201180017696.3 | 2011-04-05 | CN102834526B | 2015-12-02 | 马克·S·奇 |
| 本发明提供了用于空间编码的生物学测定的测定及测定系统。本发明提供了包含如下的测定系统：能够高水平地多重检测的测定，其中以特定的空间模式给生物样品提供试剂；能够根据该空间模式控制递送试剂的设备；和提供本质上是数字的读出的解码方案。 | ||||||
| 2 | 空间编码的生物学测定 | CN201180017696.3 | 2011-04-05 | CN102834526A | 2012-12-19 | 马克·S·奇 |
| 本发明提供了用于空间编码的生物学测定的测定及测定系统。本发明提供了包含如下的测定系统：能够高水平地多重检测的测定，其中以特定的空间模式给生物样品提供试剂；能够根据该空间模式控制递送试剂的设备；和提供本质上是数字的读出的解码方案。 | ||||||
| 3 | 空間コード化生物学的アッセイ | JP2013503861 | 2011-04-05 | JP5893607B2 | 2016-03-23 | チー、マーク エス. |
| 4 | SPATIALLY ENCODED BIOLOGICAL ASSAYS | EP11766613.1 | 2011-04-05 | EP2556171B1 | 2015-09-02 | CHEE, Mark, S. |
| 5 | SPATIALLY ENCODED BIOLOGICAL ASSAYS | EP11766613.1 | 2011-04-05 | EP2556171A1 | 2013-02-13 | CHEE, Mark, S. |
| The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature. | ||||||
| 6 | Spatial encoding biological assays | JP2013503861 | 2011-04-05 | JP2013523151A | 2013-06-17 | エス． チー、マーク |
| 本発明は、空間コード化生物学的アッセイで使用するためのアッセイおよびアッセイ系を提供する。 本発明は、試薬が規定の空間パターンで生物学的サンプルに提供される高レベルの多重化が可能なアッセイと、空間パターンに従って試薬の制御送達が可能な機器と、本質的にデジタル読取情報を提供するデコード化スキームとを含むアッセイ系を提供する。 | ||||||
| 7 | Integrated system and method for diversity generation and screening | JP2001551237 | 2001-01-10 | JP2003519495A | 2003-06-24 | ジョセフ エイ． アフォールター，; マーク ウェルチ，; ロビン エミグ，; ブライアン カー，; ロレイン ジェイ． ギバー，; クライス グスタフソン，; アンドレアス クラメーリ，; スタンリー ゴールドマン，; ステファン ジェン，; ウィレム ペー．セー． ステマー，; エス． クリストファー デイビス，; マシュー トビン，; スティーブン エイチ． バス，; フィリップ エイ． パテン，; ジェレミー ミンシャル，; サン アイ ライラード，; パスカル ロンシャン， |
| (57)【要約】 多様性生成およびスクリーニングのための一体化されたシステムおよび方法が、提供される。 このシステムは、一般的な流体およびアレイ取り扱い成分を使用して、核酸多様性、転写、翻訳、産物スクリーニングおよびその後の多様性反応を提供する。 本発明はまた、反応混合物の物理的アレイまたは論理的アレイを備え、各反応混合物が１つ以上のシャッフリングされた核酸もしくは変異誘発された核酸、または１つ以上の転写されたシャッフリングされた核酸もしくは変異誘発された核酸、および１つ以上のインビトロ翻訳試薬を含む、デバイスまたは一体化されたシステムを提供する。 | ||||||
| 8 | SPATIALLY ENCODED BIOLOGICAL ASSAYS | EP11766613 | 2011-04-05 | EP2556171A4 | 2014-02-12 | CHEE MARK S |
| 9 | INTEGRATED SYSTEMS AND METHODS FOR DIVERSITY GENERATION AND SCREENING | EP01902036.1 | 2001-01-10 | EP1276900A2 | 2003-01-22 | BASS, Steven, H.; DAVIS, S., Christopher; PATTEN, Phillip, A.; TOBIN, Matthew; MINSHULL, Jeremy; WELCH, Mark; GUSTAFSSON, Claes; CARR, Brian; JENNE, Stephane; RAILLARD, Sun, Ai; CRAMERI, Andreas; STEMMER, Willem, P. C.; EMIG, Robin; LONGCHAMP, Pascal; GOLDMAN, Stanley; GIVER, Lorraine, J.; AFFHOLTER, Joseph A. |
| Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions. | ||||||
| 10 | POROUS SURFACE FOR BIOMEDICAL DEVICES | US14577971 | 2014-12-19 | US20160121292A1 | 2016-05-05 | Sangmin JEONG; Hann-Ching CHAO; Ludovic GODET |
| Embodiments described herein generally relate to biomedical devices including a porous layer forming a support structure for a biological probe and methods of making the same. The porous layer can be a porous silicon containing layer. The pore size can be adjusted such that various size biological probes can be incorporated into the pores. Further, the porous silicon containing layer can be used to support a biofunctionalizing layer. | ||||||
| 11 | Method for mass production of high-purity oligonucleotides | US13524029 | 2012-06-15 | US09328366B2 | 2016-05-03 | Sunghoon Kwon; Hyoki Kim; Howon Lee; Sungsik Kim; Taehoon Ryu |
| Provided is a method of mass-producing high-purity nucleotides including providing a sequencing substrate having a clonal library of oligonucleotides on a solid support, sequencing the clonal library, obtaining measured location data of the solid support on the sequencing substrate, mapping pixel data of a signal generated from the solid support given as a result of the sequencing with the measured location data, extracting the solid support having a desired base sequence from the sequencing substrate using the mapping result, and amplifying an oligonucleotide on the extracted solid support to replicate on a large scale. | ||||||
| 12 | Detection apparatus for biological materials and methods of making and using the same | US13284868 | 2011-10-28 | US08425844B2 | 2013-04-23 | Robert L. Willett; Kirk W. Baldwin; Loren N. Pfeiffer |
| Apparatus comprising surface site comprising substantially inorganic surface having chemical composition selected from group consisting of metals, semiconductors, insulators, and mixtures thereof, the surface positioned within polypeptide bonding region and having selective bonding affinity for polypeptide; plurality of interlayers between which surface site is interposed; distal site end on surface site and distanced from interlayers, the surface being provided on distal site end; surface site and interlayers being interposed between first and second supports; first and second conductors provided on first and second supports and having respective first and second distal conductor ends positioned within polypeptide bonding region; conductors being capable of applying external voltage potential across polypeptide bonding region. Apparatus, optionally comprising such first and second supports and conductors; and comprising third conductor in electrical communication with surface site, the third conductor positioned for electrical communication with source of an external bias voltage. Techniques for making apparatus. | ||||||
| 13 | Detection apparatus for biological materials and methods of making and using the same | US13252169 | 2011-10-03 | US08377702B2 | 2013-02-19 | Robert L. Willett; Kirk W. Baldwin; Loren N. Pfeiffer |
| Method that includes providing plurality of test sites each having first and second layers respectively including inorganic first and second surface sites forming parts of interior of a well, the surface sites having positions and thicknesses being configured for locating thereon portions of unidentified amino acid-containing molecules; exposing each of a first plurality of the test sites to a fluid containing a different one of plurality of pre-identified amino acid-containing molecules and determining bonding signatures onto each of first plurality of test sites; exposing each of second plurality of test sites to another fluid containing unidentified amino acid-containing molecule and determining bonding signatures onto second plurality of test sites; and comparing bonding signatures to determine or exclude identity of unidentified amino acid-containing molecule. | ||||||
| 14 | ARRAYS AND METHODS FOR GUIDED CELL PATTERNING | US12496730 | 2009-07-02 | US20100041566A1 | 2010-02-18 | Miqin Zhang; Mandana Veiseh |
| Guided cell patterning arrays for single cell patterning, methods for making the arrays, and methods for using the arrays. | ||||||
| 15 | BIOASSAY SYSTEM INCLUDING OPTICAL DETECTION APPARATUSES, AND METHOD FOR DETECTING BIOMOLECULES | US12500567 | 2009-07-09 | US20090311774A1 | 2009-12-17 | CHUNG-FAN CHIOU; Cheng-Wei Chu; Yu-Tang Li; Chang-Sheng Chu; Shuang-Chao Chung; Chih-Hsun Fan |
| A bioassay system is disclosed. The bioassay system may include a plurality of optical detection apparatuses, each of which includes a substrate having a light detector, and a linker site formed over the light detector, the linker site being treated to affix the biomolecule to the linker site. The linker site is proximate to the light detector and is spaced apart from the light detector by a distance of less than or equal to 100 micrometers. The light detector collects light emitted from the biomolecule within a solid angle of greater than or equal to 0.8 SI steridian. The optical detection apparatus may further include an excitation light source formed over the substrate so as to provide a light source for exciting a fluorophore attached to the biomolecule. | ||||||
| 16 | Integrated system for diversity generation and screening | US10154936 | 2002-05-23 | US07462469B2 | 2008-12-09 | Steven H. Bass; S. Christopher Davis; Phillip A. Patten; Matthew Tobin; Jeremy Minshull; Mark Welch; Claes Gustafsson; Brian Carr; Stephane Jenne; Sun Ai Raillard; Andreas Crameri; Willem P. C. Stemmer; Robin Emig; Pascal Longchamp; Stanley Goldman; Lorraine J. Giver; Joseph A. Affholter |
| Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions. | ||||||
| 17 | Integrated Systems and Methods for Diversity Generation and Screening | US11677505 | 2007-02-21 | US20080015116A1 | 2008-01-17 | Steven Bass; S. Davis; Phillip Patten; Matthew Tobin; Jeremy Minshull; Mark Welch; Claus Gustafsson; Brian Carr; Stephane Jenne; Sun Raillard; Andreas Crameri; Willem Stemmer; Robin Emig; Pascal Longschamp; Stanley Goldman; Lorraine Giver; Joseph Affholter |
| Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions. | ||||||
| 18 | Integrated systems and methods for diversity generation and screening | US10154936 | 2002-05-23 | US20030054383A1 | 2003-03-20 | Steven H. Bass; S. Christopher Davis; Phillip A. Patten; Matthew Tobin; Jeremy Minshull; Mark Welch; Claes Gustafsson; Brian Carr; Stephane Jenne; Sun Ai Raillard; Andreas Crameri; Willem P.C. Stemmer; Robin Emig; Pascal Longschamp; Stanley Goldman; Lorraine J. Giver; Joseph A. Affholter |
| Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions. | ||||||
| 19 | Integrated systems and methods for diversity generation and screening | US09760010 | 2001-01-10 | US20010039014A1 | 2001-11-08 | Steven H. Bass; S. Christopher Davis; Phillip A. Patten; Matthew Tobin; Jeremy Minshull; Mark Welch; Claes Gustafsson; Brian Carr; Stephane Jenne; Sun Ai Raillard; Andreas Crameri; Willem P.C. Stemmer; Robin Emig; Pascal Longchamp; Stanley Goldman; Lorraine J. Giver; Joseph A. Affholter |
| Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions. | ||||||
| 20 | ARRAYS AND METHODS FOR GUIDED CELL PATTERNING | US14835224 | 2015-08-25 | US20160054302A1 | 2016-02-25 | Miqin Zhang; Mandana Veiseh |
| Guided cell patterning arrays for single cell patterning are disclosed. The arrays include a plurality of cell adhesion sites that are individually isolated on an inert surface. Each cell adhesion site has one or more cell adhesion peptides having affinity to a cell surface receptor. The inert surface is resistant to cell adhesion. | ||||||
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