| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 对多个试样进行化学反应的方法和装置 | CN03824872.7 | 2003-09-03 | CN1695061A | 2005-11-09 | S·R·卢斯蒂格; G·W·福金; R·阿格林 |
| 用于同时对多个诸如薄膜试样的试样进行化学反应并确定分子运动动态的方法和装置。本发明的装置可以在外壳内的试样保持器的单个试样保持位置容纳多个试样，并使这些保持位置之间保持相互化学隔离。在计算机控制器的控制下，装置对试样保持器定位，以使每一试样保持位置被定位在与分配歧管连接的一个或多个口相邻的位置上。该装置可使每一试样暴露于一种或多种呈液相或气相的流体，并因而在温度和压力条件受控的情况下发生化学反应和/或确定分子运动动态。试样保持位置可以被定位在外壳内的分析测量台上，以便对生成的化合物或混合物定性。 | ||||||
| 2 | Investigating different physical and/or chemical forms of materials | US11280980 | 2005-11-15 | US20060129329A1 | 2006-06-15 | Ryszard Kobylecki; Daniel Cowell; Vassilis Stylianopoulos |
| A method is provided for investigating different physical and/or chemical forms of a material. The material is placed in an array of receptacles. The material in different receptacles is subjected to different treatments under the control of a computer. Any material resulting from the different treatments is then analyzed. The treatments and the resultant material may be suitably associated. An apparatus used in this method provides an array of receptacles into which the material may be placed. The apparatus includes means for treating the material in the receptacles, for example by heating with a heater block, cooling with a cooling coil, and agitation by a stirrer block. The apparatus includes a computer to control the respective different treatments to the material in the different receptacles. The receptacles may optionally include a porous member that is porous to fluids but not the initial material. | ||||||
| 3 | Improved spherical coded beads | JP2008549760 | 2007-01-11 | JP2009523237A | 2009-06-18 | セレン・フリゲンリング・クリステンセン |
| 本願は、周波数２．２〜２．７ＧＨｚにおいて作動する無線チップがそれぞれに埋め込まれ、かつ本質的にそれぞれ、無線識別に基づいて個々に識別性である、複数の球状ビーズを含有する組成物を開示する。 超音波識別チップを利用する代替物も更に開示する。 ビーズは、好ましくは、高分子材料でできており、例えば、固相ケミカルライブラリーの合成に使用され得る。 好ましい材料としては、生化学アッセイにおける妨害（ファウリング）を最小化する材料が挙げられる。 本発明は、更に、そのような組成物を製造する、エマルジョン重合法を含む、バッチ法および連続法にも関する。 更なる形態において、本発明は、無線コード化ビーズ分析装置に関する。 更に、ビーズ検出および／または分析および／または分類方法、並びに、一旦分析および／または分類されたビーズの加工方法も提供する。 | ||||||
| 4 | IMPROVED SPHERICAL ENCODED BEADS | EP07700154.3 | 2007-01-11 | EP1976626A2 | 2008-10-08 | CHRISTENSEN, Søren, Flygenring |
| The present application discloses a composition comprising a plurality of spherical beads, wherein a radiofrequency chip operating at a frequency of in the range of 2.2-2.7 GHz is embedded within each of said beads and wherein essentially each of said beads is individually identifiable on the basis of radiofrequency identification. Alternatives utilizing a ultrasonic identification chip are also disclosed. The beads are preferably made of polymeric material and can for example be used for the synthesis of e.g. solid-phase chemical libraries. Preferred materials include some that minimise interference in biochemical assays (fouling). The invention also relates to batch and continuous methods of producing such compositions, including emulsion-polymerisation methods. In a further aspect, the present invention relates to an apparatus for analysing radiofrequency-encoded beads. Also provided are methods for detecting and/or analysing and/or sorting beads, as well as methods for processing beads once they have been analysed and/or sorted. | ||||||
| 5 | Methods and devices for multiplexed microarray microfluidic analysis of biomolecules | US13597362 | 2012-08-29 | US09481945B2 | 2016-11-01 | David Juncker; Huiyan Li |
| Rapid and specific detection of biological cells and biomolecules is important to biological assays across diverse fields including genomics, proteomics, diagnoses, and pathological studies. Microarrays and microfluidics increasingly dominate such detection techniques due to the ability to perform significant numbers of tests with limited sample volumes. A snap chip assembly is provided for the transfer of a microarray of reagents within semi-spherical liquid droplets on a transfer chip to a target assay microarray on an assay chip following assembly of the two chips and physical contact of the droplets with the target array. Reagents in nanoliter quantities are spotted on both chips and selectively transferred as liquid droplets between transfer chip and assay chip within the contact areas. Using the snap chip structure the inventors performed immunoassays with colocalization of capture and detection antibodies with 10 targets and bead-in-gel droplet microarrays with 9 targets in the low pg/ml regime. | ||||||
| 6 | METHODS AND DEVICES FOR MULTIPLEXED MICROARRAY MICROFLUIDIC ANALYSIS OF BIOMOLECULES | US13597362 | 2012-08-29 | US20130053273A1 | 2013-02-28 | David Juncker; Huiyan Li |
| Rapid and specific detection of biological cells and biomolecules is important to biological assays across diverse fields including genomics, proteomics, diagnoses, and pathological studies. Microarrays and microfluidics increasingly dominate such detection techniques due to the ability to perform significant numbers of tests with limited sample volumes. A snap chip assembly is provided for the transfer of a microarray of reagents within semi-spherical liquid droplets on a transfer chip to a target assay microarray on an assay chip following assembly of the two chips and physical contact of the droplets with the target array. Reagents in nanolitre quantities are spotted on both chips and selectively transferred as liquid droplets between transfer chip and assay chip within the contact areas. Using the snap chip structure the inventors performed immunoassays with colocalization of capture and detection antibodies with 10 targets and bead-in-gel droplet microarrays with 9 targets in the low pg/ml regime. | ||||||
| 7 | SYSTEM AND METHOD FOR SURFACE PLASMON RESONANCE BASED DETECTION OF MOLECULES | US12527961 | 2008-02-21 | US20100045995A1 | 2010-02-25 | Lidija Malic; Maryam Tabrizian; Teodor Veres; Bo Cui; Francois Normandin |
| A system and method for molecule detection uses a surface plasmon resonance (SPR) system with detection spots having fixed nanostructures. An SPR assembly may be combined with a digital microfluidic control system such as an electrowetting-on-dielectric (EWOD) chip. The microfluidic system individually directs sample droplets to different detection spots of the SPR assembly, thus allowing the SPR examination of different samples or sample reactions on the same surface. The nanostructures at the detection spots enhance the sensitivity of the SPR signals. | ||||||
| 8 | SPHERICAL ENCODED BEADS | US12160306 | 2007-01-11 | US20090032592A1 | 2009-02-05 | Soren Flygenring Christensen |
| The present application discloses a composition comprising a plurality of spherical beads, wherein a radiofrequency chip operating at a frequency of in the range of 2.2-2.7 GHz is embedded within each of said beads and wherein essentially each of said beads is individually identifiable on the basis of radiofrequency identification. Alternatives utilizing a ultrasonic identification chip are also disclosed. The beads are preferably made of polymeric material and can for example be used for the synthesis of e.g. solid-phase chemical libraries. Preferred materials include some that minimise interference in biochemical assays (fouling). The invention also relates to batch and continuous methods of producing such compositions, including emulsion-polymerisation methods. In a further aspect, the present invention relates to an apparatus for analysing radiofrequency-encoded beads. Also provided are methods for detecting and/or analysing and/or sorting beads, as well as methods for processing beads once they have been analysed and/or sorted. | ||||||
| 9 | Method and apparatus for performing chemical reactions in a plurality of samples | US10653757 | 2003-09-03 | US20040156757A1 | 2004-08-12 | Steven Raymond Lustig; Gary W. Foggin; Robert C. Agreen |
| A method and apparatus for simultaneously performing chemical reactions and determining molecular transport dynamics on a plurality of samples such as thin film samples. The apparatus of the present invention is capable of containing multiple samples in individual sample holding positions in a sample holder within a housing and maintaining those holding positions in chemical isolation from each other. Under control of a computerized controller, the apparatus positions the sample holder so that each sample holding position may be positioned adjacent to one or more ports connected to a distribution manifold. The apparatus exposes each sample to one or more fluids in liquid or gas phase, thereby carrying out a chemical reaction and/or determining molecular transport dynamics under controlled temperature and pressure conditions. The sample holding positions may be positioned in an analytical measurement station within the housing so that the resulting chemical compound or mixture may be characterized. | ||||||
| 10 | MULTI-STAGE SAMPLE RECOVERY SYSTEM | US15853332 | 2017-12-22 | US20180188276A1 | 2018-07-05 | Bob CHEN |
| Multi-stage sample-recovery systems, including automated 2-stage and 3-stage sample-recovery systems, are provided. Such systems enable the rapid screening and recovery of samples, including viable cell-based samples, from high-throughput screening systems, including systems utilizing large-scale arrays of microcapillaries. In specific screening systems, each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element. Immobilized target molecules may include any molecule of interest, including proteins, nucleic acids, carbohydrates, and other biomolecules. The association of a variant protein with a molecular target is assessed by measuring a signal from the reporter element. The contents of microcapillaries identified in the assays as containing variant proteins of interest can be identified and recovered using the multi-stage systems disclosed herein. | ||||||
| 11 | System and method for surface plasmon resonance based detection of molecules | US12527961 | 2008-02-21 | US08345253B2 | 2013-01-01 | Lidija Malic; Maryam Tabrizian; Teodor Veres; Bo Cui; Francois Normandin |
| A system and method for molecule detection uses a surface plasmon resonance (SPR) system with detection spots having fixed nanostructures. An SPR assembly may be combined with a digital microfluidic control system such as an electrowetting-on-dielectric (EWOD) chip. The microfluidic system individually directs sample droplets to different detection spots of the SPR assembly, thus allowing the SPR examination of different samples or sample reactions on the same surface. The nanostructures at the detection spots enhance the sensitivity of the SPR signals. | ||||||
| 12 | SPHERICAL ENCODED BEADS | US13353141 | 2012-01-18 | US20120132572A1 | 2012-05-31 | Soren Flygenring CHRISTENSEN |
| The present application discloses spherical polymer bead comprising embedded therein an ultrasonic identification chip, said chip comprising one or more resonator cavities, the dimensions of each of the one or more resonator cavities giving rise to an ultrasonic resonance frequency of 20 kHz or more. The application also discloses a bead sorting apparatus equipped with at least one ultrasonic transmitter and at least one ultrasonic receiver, and a method of measuring the ultrasonic code of an ultrasonic encoded bead using the bead sorting apparatus. | ||||||
| 13 | Method and apparatus for performing chemical reactions in a plurality of samples | US10653757 | 2003-09-03 | US07373259B2 | 2008-05-13 | Steve R. Lustig; Gary W. Foggin; Robert Agreen |
| A method and apparatus for simultaneously performing chemical reactions and determining molecular transport dynamics on a plurality of samples such as thin film samples. The apparatus of the present invention is capable of containing multiple samples in individual sample holding positions in a sample holder within a housing and maintaining those holding positions in chemical isolation from each other. Under control of a computerized controller, the apparatus positions the sample holder so that each sample holding position may be positioned adjacent to one or more ports connected to a distribution manifold. The apparatus exposes each sample to one or more fluids in liquid or gas phase, thereby carrying out a chemical reaction and/or determining molecular transport dynamics under controlled temperature and pressure conditions. The sample holding positions may be positioned in an analytical measurement station within the housing so that the resulting chemical compound or mixture may be characterized. | ||||||
| 14 | Methods and computer system for combinatorial analysis of lighting phosphors | US09704475 | 2000-11-03 | US06567751B1 | 2003-05-20 | Xiao-Dong Sun |
| There is disclosed a method and a computer system enabling high-throughput combinatorial synthesis and screening of lighting phosphors. The system links hardware instrumentation for synthesis and screening. It records, sorts, and analyzes photo-metric data gathered from the combinatorial studies, along with the characteristics of the combinatory processes. The system provides a database as the data storage and query engine, an analysis module as the processor for analytical operations, and an interface for accepting the user's input and displaying the analysis results and other information requested by the user. | ||||||
| 15 | A spherical encoded bead with an ultrasonic identification chip | EP11173879.5 | 2007-01-11 | EP2384811A1 | 2011-11-09 | Christensen, Søren Flygenring |
The present application discloses spherical polymer bead comprising embedded therein an ultrasonic identification chip, said chip comprising one or more resonator cavities, the dimensions of each of the one or more resonator cavities giving rise to an ultrasonic resonance frequency of 20 kHz or more. The application also discloses a bead sorting apparatus equipped with at least one ultrasonic transmitter and at least one ultrasonic receiver, and a method of measuring the ultrasonic code of an ultrasonic encoded bead using the bead sorting apparatus.
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| 16 | SYSTEM AND METHOD FOR SURFACE PLASMON RESONANCE BASED DETECTION OF MOLECULES | EP08714664.3 | 2008-02-21 | EP2122333A1 | 2009-11-25 | MALIC, Lidija; TABRIZIAN, Maryam; VERES, Teodor; CUI, Bo; NORMANDIN, François |
| A system and method for molecule detection uses a surface plasmon resonance (SPR) system with detection spots having fixed nanostructures. An SPR assembly may be combined with a digital microfluidic control system such as an electrowetting-on-dielectric (EWOD) chip. The microfluidic system individually directs sample droplets to different detection spots of the SPR assembly, thus allowing the SPR examination of different samples or sample reactions on the same surface. The nanostructures at the detection spots enhance the sensitivity of the SPR signals. | ||||||
| 17 | Coating platform and process for the preparation of thin coatings | EP07009227.5 | 2007-05-08 | EP2002886A1 | 2008-12-17 | Zech, Torsten, Dr.; Hoffmann, Heiko; Matthes, Volker, Dipl.-Ing.; Güllich, Frank; Vietze, Uwe, Dr.; Födisch, Ringo, Dr.; Schrapel, Thomas, Dr.; Sundermann, Andreas, Dr.; Reichardt, Jan; Desie, Guido, Dr.; Hörzenberger, Franz; Paul, Johan, Dr. |
The application of coatings on the surface of a substrate is of high commercial interest. The present invention relates to a platform for rendering the development of surface coatings more efficient and bringing the development and testing cycle closer to industrial manufacturing reality. |
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| 18 | IMPROVED SPHERICAL ENCODED BEADS | PCT/DK2007000015 | 2007-01-11 | WO2007079752A3 | 2008-02-21 | CHRISTENSEN SOEREN FLYGENRING |
| The present application discloses a composition comprising a plurality of spherical beads, wherein a radiofrequency chip operating at a frequency of in the range of 2.2-2.7 GHz is embedded within each of said beads and wherein essentially each of said beads is individually identifiable on the basis of radiofrequency identification. Alternatives utilizing a ultrasonic identification chip are also disclosed. The beads are preferably made of polymeric material and can for example be used for the synthesis of e.g. solid-phase chemical libraries. Preferred materials include some that minimise interference in biochemical assays (fouling). The invention also relates to batch and continuous methods of producing such compositions, including emulsion-polymerisation methods. In a further aspect, the present invention relates to an apparatus for analysing radiofrequency-encoded beads. Also provided are methods for detecting and/or analysing and/or sorting beads, as well as methods for processing beads once they have been analysed and/or sorted. | ||||||
| 19 | METHOD AND APPARATUS FOR PERFORMING CHEMICAL REACTIONS IN A PLURALITY OF SAMPLES | PCT/US0327406 | 2003-09-03 | WO2005033712A8 | 2005-11-17 | LUSTIG STEVE R; FOGGIN GARY W; AGREEN ROBERT |
| A method and apparatus for simultaneously performing chemical reactions and determining molecular transport dynamics on a plurality of samples such as thin film samples. The apparatus of the present invention is capable of containing multiple samples in individual sample holding positions in a sample holder within a housing and maintaining those holding positions in chemical isolation from each other. Under control of a computerized controller, the apparatus positions the sample holder so that each sample holding position may be positioned adjacent to one or more ports connected to a distribution manifold. The apparatus exposes each sample to one or more fluids in liquid or gas phase, thereby carrying out a chemical reaction and/or determining molecular transport dynamics under controlled temperature and pressure conditions. The sample holding positions may be positioned in an analytical measurement station within the housing so that the resulting chemical compound or mixture may be characterized. | ||||||
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