| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 自動化された再使用可能な並行生物反応のための系および方法 | JP2013532882 | 2011-10-04 | JP6114694B2 | 2017-04-12 | エスファンディヤープール,ヘサーム; コーザー ビー,パリジ; マーク エフ.オールダム; エリック エス.ノードマン |
| 2 | High-throughput platform of vertebrate organisms juveniles (larvae) sub-cell resolution in vivo targeting the (Inbibo) for screening | JP2012555009 | 2011-01-25 | JP2013520198A | 2013-06-06 | モハメト エフ ヤニク; スティーブン シー ワサーマン; カルロス パード; ツンヤオ チェン; コディ エル ギレランド |
| 脊椎動物の幼体に関する高スループットなインビーボスクリーニングシステムを提供する。 本システムは、液質媒体に入った脊椎動物幼体の供給源、並びにその幼体を吸入する管内装荷手段を備える。 通過していく幼体を泡やデブリから弁別する検知器アセンブリを設ける。 その幼体の共焦点撮像，広視野蛍光撮像双方を行える撮像手段を設ける。 その幼体を光操作できるレーザを設ける。 | ||||||
| 3 | Device and method and system therefor for making and testing the pre-formulation | JP2003519413 | 2002-05-24 | JP2005502861A | 2005-01-27 | ルーピン ウー，; エリック ディー． カールソン，; ペイジュン コン，; アール ダニエルソン，; ヘンリー ケイ． チャオ，; ウィリアム エイチ． ジュニア チャンドラー，; ピーター ジェイ． デスロジャース，; ロバート ディー． ドゥーラン， |
| 本発明は、薬物候補の塩および多形体を、高スループット調製およびスクリーニングするための、方法、装置、およびシステムを提供する。 本発明は、薬物開発のために使用される前処方発見プロセスを促進させることに関する。 特に、適切な塩を決定するプロセス、および特定の薬物候補から形成され得る実質的に全ての多形体を発見するプロセスが提供される。 これらのプロセスは、高スループット特徴付けプロセスにおいて、種々の工程を実施するために特別に構成される種々の装置を用いて実行される。 このような装置の１つは、例えば、コンピュータシステムによって作製されるライブラリーモデルに基づいて、複数のライブラリーを合成するように構成される。 | ||||||
| 4 | インビーボスクリーニングに使用されるシステムおよび方法 | JP2012555009 | 2011-01-25 | JP5788417B2 | 2015-09-30 | ヤニク モハメト エフ; ワサーマン スティーブン シー; パード カルロス; チェン ツンヤオ; ギレランド コディ エル |
| 5 | System and method for automated re-usable parallel biological reaction | JP2013532882 | 2011-10-04 | JP2013539978A | 2013-10-31 | エスファンディヤープール，ヘサーム; ビー，パリジ コーザー; エフ．オールダム マーク; エス．ノードマン エリック |
| 【課題】ポリヌクレオチドを抽出、増幅およびシーケンシングするための、改善された系および方法が必要とされている。
【解決手段】 方法は、生物材料（例えば、ＤＮＡ断片または増幅されたＤＮＡの形態であり得る核酸）を担持するビーズを基板の規定位置で磁気的にホールドすることと、ビーズに局所的な電場を印加して生物材料または生物材料の反応の生成物もしくは副生物を隔離することとを含む。 例えば、ビーズを、会合した生物材料を有する他のビーズから隔離する。 種々の実施形態における電場は、増幅またはシーケンシング反応のための試薬を濃縮し、ならびに／または検出可能な反応副生物を濃縮および隔離する。 例えば、個々のビーズ周囲の核酸を隔離することにより、電場は、エマルジョンＰＣＲの代替物としてのクローン増幅を可能とし得る。 【選択図】 図１Ａ |
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| 6 | Apparatus and method for creating and testing pre-formulation, and system therefor | JP2008140198 | 2008-05-28 | JP2008224686A | 2008-09-25 | CARLSON ERIC D; CONG PEIJUN; CHANDLER WILLIAM H JR; CHAU HENRY K; DANIELSON EARL; DESROSIERS PETER J; DOOLAN ROBERT D; WU LUPING |
| <P>PROBLEM TO BE SOLVED: To provide a methods, an apparatus, and a system for performing a high-throughput preparation and a screening of salts and polymorphs of drug candidates. <P>SOLUTION: The method is directed toward enhancing the pre-formulation discovery process used for a drug development. In particular, processes of determining suitable salts and processes of discovering substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members from, for example, a library model generated by a computer system. <P>COPYRIGHT: (C)2008,JPO&INPIT | ||||||
| 7 | Nucleic acid composition and arrays and methods of using them | JP2003587960 | 2002-10-15 | JP2005519634A | 2005-07-07 | カイ、ウェイ−ウェン; カン、ジョスパル・シン; シャー、シシー; モハメッド、マンスー |
| １の側面において、本発明は例えば、染色体異数性、欠失及び増幅等の染色体異常の検出、及び隣接遺伝子異常に関する症候群の診断または予後診断のための核酸の編集物、例えばアレイなどの工業製品及び方法を提供する。 キットも提供する。 | ||||||
| 8 | Reagents and methods | JP2000549625 | 1999-05-17 | JP2002515588A | 2002-05-28 | エルダー、ジョン・ケネス; サザン、エドウィン・メラー; シュチェピノフ、ミハイル・セルゲービッチ; ハウズビー、ジョン・ニコラス; ハミルトン、アラン・ルイス |
| (57)【要約】 【解決手段】 標識された化合物のセットを、好ましくは、粒子状担体の使用により製造する方法であって、担体をロットに分割し、担体の各々のロットに対して異なる化学反応（例えば、化学残基を担体のそのロットに結合させる。）を行い、担体の各々のロットの画分を異なる標識によりタグ付けし、担体のロットを組み合わせることを具備する。 これらの工程は、数回繰り返し、好ましくは、オリゴマーのモノマー単位の性質及び位置を同定し、かつ担体から離脱し得るラベルを担持するオリゴマー分子を構築する。 好ましい標識は、質量分析法により分析に供される荷電基を提供するように解裂することにより化合物から放出され得るものであり、トリチル（トリメチルフェニル）ファミリーの基である。 これらの標識のライブラリー及びアッセイ及び核酸分析方法におけるそれらの使用も特許請求される。 | ||||||
| 9 | 재사용 가능한 자동화 평행 생물 반응 시스템 및 방법 | KR1020137011609 | 2011-10-04 | KR1020140027906A | 2014-03-07 | 에스판디아르푸르,헤사암; 코자르비,파리지; 마크에프.올드햄; 에릭에스.노르드만 |
| 방법은 생물 물질(예를 들어, DNA 단편 또는 증폭된 DNA의 형태일 수 있는 핵산)을 운반하는 비드를 자기력에 의해 기판의 특정 위치에 고정하는 단계와, 비드에 국소적으로 전기장을 인가하여 생물 물질 또는 생물 물질의 반응 생성물 또는 부산물을 격리하는 단계를 포함한다. 예를 들어, 비드는 생물 물질이 회합된 기타 다른 비드로부터 격리된다. 다양한 구체예에서, 전기장은 시약을 증폭 또는 서열 결정 반응용으로 농축하고/농축하거나, 검출 가능한 반응 부산물을 농축 및 격리한다. 예를 들어 개별 비드 주위의 핵산을 격리함으로써, 전기장은 에멀젼 PCR에 대한 대안으로서 클론 증폭을 허용할 수 있다. 다른 구체예에서, 전기장은 비드에 근접하는 나노센서를 격리하여, 국소 pH 변화, 국소 전도도 변화, 국소 전하 농도 변화 및 국소 발열 중 하나 이상의 검출을 용이하게 한다. 비드는 국소화된 자기장 영역 어레이의 형태로 포집될 수 있다. | ||||||
| 10 | ENZYME QUANTIFICATION | EP12792253.2 | 2012-06-01 | EP2714970A2 | 2014-04-09 | LINK, Darren; SAMUELS, Michael |
| The invention generally relates to methods for quantifying an amount of enzyme molecules. Systems and methods of the invention are provided for measuring an amount of target by forming a plurality of fluid partitions, a subset of which include the target, performing an enzyme-catalyzed reaction in the subset, and detecting the number of partitions in the subset. The amount of target can be determined based on the detected number. | ||||||
| 11 | HIGH-THROUGHPUT PLATFORM FOR IN-VIVO SUB-CELLULAR SCREENS ON VERTEBRATE LARVAE | EP11701928.1 | 2011-01-25 | EP2539427A2 | 2013-01-02 | YANIK, Mehmet, F.; WASSERMAN, Steven, C.; PARDO, Carlos; CHANG, Tsung-Yao; GILLELAND, Cody, L. |
| High throughput system for in vivo screens on vertebrate larvae. The system includes a source of vertebrate larvae in a liquid medium and loading tube means for aspirating a larva. A detector assembly is provided to differentiate passage of a larva from bubbles and/or debris. An imaging means is provided for both confocal imaging and wide-field fluorescence imaging of the larva. A laser is provided for optical manipulation of the larva. | ||||||
| 12 | COMPILATIONS OF NUCLEIC ACIDS AND ARRAYS AND METHODS OF USING THEM | EP02807317.9 | 2002-10-15 | EP1451318A1 | 2004-09-01 | MOHAMMED, Mansoor; KANG, Jaspal, Singh; SHAH, Shishir; CAI, Wei-Wen |
| In one aspect the invention provides compilations of nucleic acids, articles of manufacture, e.g., arrays and methods for the detection of chromosomal abnormalities, such as a chromosomal aneuploidies, deletions, amplifications and the like, and the diagnosis or prognosis of syndromes associated with a contiguous gene abnormality. Kits are also provided. | ||||||
| 13 | APPARATUSES AND METHODS FOR CREATING AND TESTING PRE-FORMULATIONS AND SYSTEMS FOR SAME | EP02731970.6 | 2002-05-24 | EP1425577A1 | 2004-06-09 | CARLSON, Eric, D.; CONG, Peijun; CHANDLER, William, H., Jr.; CHAU, Henry, K.; DANIELSON, Earl; DESROSIERS, Peter, J.; DOOLAN, Robert, D.; WU, Luping |
| The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymporphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. | ||||||
| 14 | LIBRARIES OF OLIGOMERS LABELLED WITH DIFFERENT TAGS | EP99922334.0 | 1999-05-17 | EP1068216A2 | 2001-01-17 | SOUTHERN, Edwin Mellor; SHCHEPINOV, Mikhail Sergeevich; HOUSBY, John Nicholas; HAMILTON, Alan Lewis; ELDER, John Kenneth |
| A method of making a set of labelled compounds by the use of a preferably particulate support, comprises dividing the support into lots, performing a different chemical reaction on each lot of the support, e.g. to couple a chemical moiety to that lot of the support, tagging a fraction of each lot of the support with a different label, and combining the said lots of the support. The steps are repeated several times, preferably to build up oligomer molecules carrying labels which identify the nature and position of a monomer unit of the oligomer, and which are releasable from the support. Preferred labels, which are releasable from the compounds by cleavage to provide charged groups for analysis by mass spectrometry, are groups of the trityl (trimethylphenyl) family. Also claimed are libraries of these labels and their use in assays and nucleic acid analysis methods. | ||||||
| 15 | ENZYME QUANTIFICATION | EP12792253 | 2012-06-01 | EP2714970A4 | 2015-10-14 | LINK DARREN; SAMUELS MICHAEL |
| The invention generally relates to methods for quantifying an amount of enzyme molecules. Systems and methods of the invention are provided for measuring an amount of target by forming a plurality of fluid partitions, a subset of which include the target, performing an enzyme-catalyzed reaction in the subset, and detecting the number of partitions in the subset. The amount of target can be determined based on the detected number. | ||||||
| 16 | HIGH-THROUGHPUT PLATFORM FOR IN-VIVO SUB-CELLULAR SCREENS ON VERTEBRATE LARVAE | EP11701928.1 | 2011-01-25 | EP2539427B1 | 2015-05-27 | YANIK, Mehmet, F.; WASSERMAN, Steven, C.; PARDO, Carlos; CHANG, Tsung-Yao; GILLELAND, Cody, L. |
| 17 | SYSTEMS AND METHODS FOR AUTOMATED REUSABLE PARALLEL BIOLOGICAL REACTIONS | EP11831452.5 | 2011-10-04 | EP2625526A2 | 2013-08-14 | ESFANDYARPOUR, Hesaam; PARIZI, Kosar, B; NORDMAN, Eric,S; OLDHAM, Mark, F |
| A method comprises magnetically holding a bead carrying biological material (e.g., nucleic acid, which may be in the form of DNA fragments or amplified DNA) in a specific location of a substrate, and applying an electric field local to the bead to isolate the biological material or products or byproducts of reactions of the biological material. For example, the bead is isolated from other beads having associated biological material. The electric field in various embodiments concentrates reagents for an amplification or sequencing reaction, and/or concentrates and isolates detectable reaction by-products. For example, by isolating nucleic acids around individual beads, the electric field can allow for clonal amplification, as an alternative to emulsion PCR. In other embodiments, the electric field isolates a nanosensor proximate to the bead, to facilitate detection of at least one of local pH change, local conductivity change, local charge concentration change and local heat. The beads may be trapped in the form of an array of localized magnetic field regions. | ||||||
| 18 | COMPILATIONS OF NUCLEIC ACIDS AND ARRAYS AND METHODS OF USING THEM | EP02807317 | 2002-10-15 | EP1451318A4 | 2007-06-27 | MOHAMMED MANSOOR; KANG JASON SINGH; SHAH SHISHIR; CAI WEI-WEN |
| In one aspect the invention provides compilations of nucleic acids, articles of manufacture, e.g., arrays and methods for the detection of chromosomal abnormalities, such as a chromosomal aneuploidies, deletions, amplifications and the like, and the diagnosis or prognosis of syndromes associated with a contiguous gene abnormality. Kits are also provided. | ||||||
| 19 | Libraries of oligomers labelled with different tags | EP03078845.9 | 1999-05-17 | EP1428810A3 | 2004-07-14 | Southern, Edwin Mellor; Shchepinov, Mikhail Sergeevich; Housby, John Nicholas; Hamilton, Alan Lewis; Elder, John Kenneth |
A method of making a set of labelled compounds by the use of a preferably particulate support, comprises dividing the support into lots, performing a different chemical reaction on each lot of the support, e.g. to couple a chemical moiety to that lot of the support, tagging a fraction of each lot of the support with a different label, and combining the said lots of the support. The steps are repeated several times, preferably to build up oligomer molecules carrying labels which identify the nature and position of a monomer unit of the oligomer, and which are releasable from the support. Preferred labels, which are releasable from the compounds by cleavage to provide charged groups for analysis by mass spectrometry, are groups of the trityl (trimethylphenyl) family. Also claimed are libraries of these labels and their use in assays and nucleic acid analysis methods. |
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| 20 | Libraries of oligomers labelled with different tags | EP03078845.9 | 1999-05-17 | EP1428810A2 | 2004-06-16 | Southern, Edwin Mellor; Shchepinov, Mikhail Sergeevich; Housby, John Nicholas; Hamilton, Alan Lewis; Elder, John Kenneth |
A method of making a set of labelled compounds by the use of a preferably particulate support, comprises dividing the support into lots, performing a different chemical reaction on each lot of the support, e.g. to couple a chemical moiety to that lot of the support, tagging a fraction of each lot of the support with a different label, and combining the said lots of the support. The steps are repeated several times, preferably to build up oligomer molecules carrying labels which identify the nature and position of a monomer unit of the oligomer, and which are releasable from the support. Preferred labels, which are releasable from the compounds by cleavage to provide charged groups for analysis by mass spectrometry, are groups of the trityl (trimethylphenyl) family. Also claimed are libraries of these labels and their use in assays and nucleic acid analysis methods. |
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