| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 121 | Continuous process for the production of combinatorial libraries of materials | US09824330 | 2001-04-02 | US07514263B2 | 2009-04-07 | James Michael Nelson; Robert Stephen Davidson; Jeffrey Jacob Cernohous; Michael John Annen; James Robert McNerney; Robert Wade Ferguson; Anthony Robert Maistrovich; James Alan Higgins |
| A system is provided wherein a plug flow reactor is used to make combinatorial libraries of materials. Examples of plug flow reactors include stirred tube reactors, extruders, and static mixers. | ||||||
| 122 | METHODS AND APPARATUS FOR SPECTROSCOPIC IMAGING OF MATERIALS IN AN ARRAY | US12110562 | 2008-04-28 | US20090002708A1 | 2009-01-01 | Eric W. McFarland; William Archibald |
| A system for monitoring infrared absorption of each of a plurality of materials contained in an array has an infrared transparent substrate for the array of materials. An infrared radiation source irradiates the materials in the array with infrared radiation. An infrared detection system monitors material absorption of the infrared radiation by the materials. A method of monitoring the infrared absorption spectrum of a library of materials includes synthesizing an array of material on a substrate. The materials are irradiated with infrared radiation and the absorption of the infrared radiation by the materials is monitored for each material. | ||||||
| 123 | Selection of polymerization catalysts and apparatus for carrying this out | US10528268 | 2003-09-16 | US07468279B2 | 2008-12-23 | Wolfgang Rohde; Marc Oliver Kristen; Dieter Lilge |
| In a method of selecting polymerization catalysts, in particular Phillips catalysts for the polymerization of olefins, from a multiplicity of catalysts on the basis of their catalytic properties, a multiplicity of catalyst precursors or catalyst supports are converted in parallel into polymerization catalysts in a pretreatment step in an array of reactors, where the pretreatment comprises at least one thermal treatment step at from 250 to 1200° C. Furthermore, at least one starting material is converted with the aid of the respective polymerization catalysts under prescribed polymerization conditions into at least one polymer product in a polymerization step and, finally, analysis of the polymer product or products is carried out to determine its composition and/or chosen properties. This makes it possible to carry out a thermal pretreatment of polymerization catalysts quickly under defined conditions which can be varied. | ||||||
| 124 | Preparation and screening of crystalline inorganic materials | US10772894 | 2004-02-04 | US07442665B2 | 2008-10-28 | Peter G. Schultz; Xiaodong Xiang; Isy Goldwasser; Gabriel Brice{hacek over (n)}o; Xiao-Dong Sun; Kai-An Wang |
| Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties. | ||||||
| 125 | MAGNETIC NANOPARTICLES, MAGNETIC DETECTOR ARRAYS, AND METHODS FOR THIER USE IN DETECTING BIOLOGICAL MOLECULES | US11938187 | 2007-11-09 | US20080255006A1 | 2008-10-16 | Shan X. Wang; Robert L. White; Chris D. Webb; Guanxiong Li |
| Magnetic nanoparticles and methods for their use in detecting biological molecules are disclosed. The magnetic nanoparticles can be attached to nucleic acid molecules, which are then captured by a complementary sequence attached to a detector, such as a spin valve detector or a magnetic tunnel junction detector. The detection of the bound magnetic nanoparticle can be achieved with high specificity and sensitivity. | ||||||
| 126 | Microfluidic reaction support having three flow levels and a transparent cover layer | US12003826 | 2008-01-02 | US20080132430A1 | 2008-06-05 | Cord Fredrich Stahler; Manfred Muller; Peer Friedrich Stahler; Ralf (Peter) Mauritz |
| The present invention relates to a microfluid reaction carrier intended for the purely fluid or light-controlled synthesis or analysis of oligomers or polymers. The reaction carrier comprises a structure of flow channels for the fluids, while supply channels and discharge channels parallel to the latter form an angle relative to the plane of the structure of the flow channels (reaction areas). | ||||||
| 127 | Method And Apparatus For Screening Combinatorial Libraries For Semiconducting Properties | US11774509 | 2007-07-06 | US20080011111A1 | 2008-01-17 | William Archibald; Marc Hornbostel |
| This invention discloses methods, materials, and devices for making and screening combinatorial libraries to identify semi-conducting and thermoelectric materials. The disclosed method includes preparing a combinatorial library of materials, and identifying library members that are semiconductors. The method may include determining a thermoelectric figure of merit, ZT, for each member of a second combinatorial library of materials. The method determines ZT by applying an oscillatory voltage across the library members, measuring power dissipated by library members, and calculating ZT from the power dissipated. The method may also include isolating single-phase materials of the semiconducting library members. The present invention also discloses an apparatus for discovering thermoelectric materials using combinatorial techniques. The apparatus includes a first combinatorial library of materials comprised of thin films arrayed on a substrate, and a device for identifying semiconducting members of the first combinatorial library. In addition, the apparatus may include a device for measuring ZT—a voltage source for applying an oscillatory electrical potential across members of a second combinatorial library arrayed on a substrate, and a device for measuring the resulting power dissipated by library members. The apparatus may also include a device for isolating single-phase materials of library members that were identified as semiconductors. | ||||||
| 128 | Microfluidic platform of arrayed switchable spin-valve elements for high-throughput sorting and manipulation of magnetic particles and biomolecules | US11705889 | 2007-02-13 | US20070141728A1 | 2007-06-21 | John Moreland; Elizabeth Mirowski; Stephen Russek |
| Arrays of spin-valve elements that can be selectively activated to trap, hold, manipulate and release magnetically tagged biological and chemical particles, including molecules and polymers. The spin-valve elements that can be selectively activated and deactivated by applying a momentary applied magnetic field thereto. The spin valve element array can be used for selectively sorting and transporting magnetic particles one particle at a time within the array. As the magnetically tagged particles are held by the spin-valve elements, application of an auxiliary magnetic field can be used to apply tension or torsion to the held particles or to move, e.g. rotate, the trapped particles. The arrays of spin-valve elements can be used in a variety of applications including drug screening, nucleic acid sequencing, structural control and analysis of RNA/DNA and protiens, medical diagnosis, and magnetic particle susceptibility and size homogenization for other medical applications. | ||||||
| 129 | Compositionally different polymer-based sensor elements and methods for preparing same | US09770089 | 2001-01-24 | US20060099113A1 | 2006-05-11 | Nathan Lewis; Robert Grubbs; Robert Sanner; Eric Severin |
| The present invention provides a combinatorial approach for preparing arrays of chemically sensitive polymer-based sensors which are capable of detecting the presence of a chemical analyte in a fluid in contact therewith. The described methods and devices comprise combining varying ratios of at least first and second organic materials which, when combined, form a polymer or polymer blend that is capable of absorbing a chemical analyte, thereby providing a detectable response. The detectable response of the sensors prepared by this method is not linearly related to the mole fraction of at least one of the polymer-based components of the sensors, thereby making arrays of these sensors useful for a variety of sensing tasks. | ||||||
| 130 | Combinatorial synthesis and screening of non-biological polymers | US10074745 | 2002-02-11 | US07034091B2 | 2006-04-25 | Peter G. Schultz; Xiao-Dong Xiang; Isy Goldwasser; Gabriel Briceno; Xiao-Dong Sun; Kai-An Wang |
| Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties. | ||||||
| 131 | UV curable coating compositions and uses thereof | US10747713 | 2003-12-23 | US06998425B2 | 2006-02-14 | Bret Ja Chisholm; James Norman Cawse; Chris Anthony Molaison; Michael Jorlath Brennan, Jr. |
| The present invention is directed to curable acrylate coating compositions and coated articles resulting therefrom. The curable acrylate coating composition comprises at least two polyfunctional acrylate derivatives, at least one photoinitiator and at least one nanoscale filler. | ||||||
| 132 | Apparatus and methods of depositing fluid | US11027817 | 2004-12-29 | US20050190243A1 | 2005-09-01 | Stefan Matysiak |
| Apparatus comprising a plurality of channels and a plurality of deposition units and methods for depositing fluids on a support are disclosed. | ||||||
| 133 | Microfluidic platform of arrayed switchable spin-valve elements for high-throughput sorting and manipulation of magnetic particles and biomolecules | US11061461 | 2005-02-18 | US20050170418A1 | 2005-08-04 | John Moreland; Elizabeth Mirowski; Stephen Russek |
| Arrays of spin-valve elements that can be selectively activated to trap, hold, manipulate and release magnetically tagged biological and chemical particles, including molecules and polymers. The spin-valve elements that can be selectively activated and deactivated by applying a momentary applied magnetic field thereto. The spin valve element array can be used for selectively sorting and transporting magnetic particles one particle at a time within the array. As the magnetically tagged particles are held by the spin-valve elements, application of an auxiliary magnetic field can be used to apply tension or torsion to the held particles or to move, e.g. rotate, the trapped particles. The arrays of spin-valve elements can be used in a variety of applications including drug screening, nucleic acid sequencing, structural control and analysis of RNA/DNA and protiens, medical diagnosis, and magnetic particle susceptibility and size homogenization for other medical applications. | ||||||
| 134 | Parallel reactor with internal sensing and method of using same | US10229424 | 2002-08-28 | US06924149B2 | 2005-08-02 | Howard Turner; G. Cameron Dales; Lynn VanErden; Johannes A. M. Van Beek; Damian A. Hajduk; Ralph B. Nielsen; William C. Rust |
| Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight Computer-based methods are disclosed for process monitoring and control, and for data display and analysis. | ||||||
| 135 | Apparatus and methods for parallel processing of multiple reaction mixtures | US10040988 | 2002-01-07 | US06913934B2 | 2005-07-05 | G. Cameron Dales; Gary Diamond; Trevor G. Frank; J. Christopher Freitag; Kenneth S. Higashihara; Dave Huffman; Jonah R. Troth |
| A cannula for use in transferring small volumes of fluid materials, such as in a parallel reaction process. The cannula comprises a long thin needle having various end (port) configurations, and an adapter for connecting the needle to a fluid line. The adapter may include the combination of a reservoir and transition, or simply a transition. | ||||||
| 136 | Substituted pyridyl amine complexes, and catalysts | US09992630 | 2001-11-06 | US06900321B2 | 2005-05-31 | Thomas R. Boussie; Gary M. Diamond; Christopher Goh; Keith A. Hall; Anne M. LaPointe; Margarete K. Leclerc; Cheryl Lund; Vince Murphy |
| New ligands, compositions, metal-ligand complexes and arrays with pyridylamine ligands are disclosed that catalyze the polymerization of monomers into polymers. Certain of these catalysts with hafnium metal centers have high performance characteristics, including higher comonomer incorporation into ethylene/olefin copolymers, where such olefins are for example, 1-octene, isobutylene or styrene. Certain of the catalysts are particularly effective at polymerizing propylene to high molecular weight isotactic polypropylene in a solution process at a variety of polymerization conditions. | ||||||
| 137 | Preparation and screening of crystalline zeolite and hydrothermally-synthesized materials | US09881036 | 2001-06-13 | US06864201B2 | 2005-03-08 | Peter G. Schultz; Xiaodong Xiang; Isy Goldwasser; Gabriel Briceno; Xiao-Dong Sun; Kai-An Wang |
| Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties. | ||||||
| 138 | Parallel reactor with internal sensing and method of using same | US09723926 | 2000-11-28 | US06864092B1 | 2005-03-08 | Howard Turner; G. Cameron Dales; Lynn VanErden; Johannes A. M. VanBeek; Damian A. Hajduk; Ralph B. Nielsen; Paul Mansky; Leonid Matsiev; Pei Wang; Eric McFarland |
| Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis. | ||||||
| 139 | Methods for characterization of polymers using multi-dimensional liquid chromatography with parallel second-dimension sampling | US10231316 | 2002-08-28 | US06855258B2 | 2005-02-15 | Miroslav Petro; Son Hoai Nguyen; Eric D. Carlson |
| Methods and apparatus for characterizing a polymer sample and in preferred embodiments, libraries of polymer samples, in a comprehensive, directly-coupled multi-dimensional liquid chromatography system are disclosed. The first and second dimensions are preferably high-performance liquid chromatography dimensions, such as for example, a first dimension adapted for determining composition (e.g. adapted for mobile-phase gradient elution chromatography, including reverse phase chromatography, adsorption chromatography and the like), and a second dimension adapted for determining molecular weight or particle size (e.g., adapted for size exclusion chromatography, including gel permeation chromatography). | ||||||
| 140 | Optical systems and methods for rapid screening of libraries of different materials | US10913569 | 2004-08-06 | US20050009081A1 | 2005-01-13 | Eric McFarland; Earl Danielson; William Archibald |
| Methods and apparatus for screening diverse arrays of materials are provided. In particular, techniques for rapidly characterizing compounds in arrays of materials in order to discover and/or optimize new materials with specific desired properties are provided The substrate can be screened for materials having useful properties, and/or the resulting materials can be ranked, or otherwise compared, for relative performance with respect to useful properties or other characterizations. In particular, systems and methods are provided for screening a library of magnetic materials for their bulk magnetization, saturation magnetizaton, and coercivity by imaging their individual optical Kerr rotation, screening a library of dielectric materials for their dielectric coefficients by imaging their individual electro-optical rotation and screening a library of luminescent materials by imaging their individual luminescent properties under a variety of excitation conditions. Optical or visible luminescence systems are also provided as well as their application to screening libraries of different materials. | ||||||
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