| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 181 | Parallel high-performance liquid chromatography with post-separation treatment | US09670503 | 2000-09-26 | US06436292B1 | 2002-08-20 | Miroslav Petro |
| High-performance liquid chromatography (HPLC) methods and systems are disclosed that combine parallel chromatographic separation of a plurality of samples with a detection technique that involves post-separation treatment of the plurality of samples to enhance one or more properties of the sample or of a component thereof, followed by detection of the one or more enhanced properties. Selective, tunable detection schemes are achievable, and are particularly advantageous as applied in connection with combinatorial chemistry, combinatorial material science and more particularly, combinatorial synthesis and screening of polymeric materials. | ||||||
| 182 | Apparatus and methods for parallel processing of multiple reaction mixtures | US10040988 | 2002-01-07 | US20020110493A1 | 2002-08-15 | G. Cameron Dales; Gary Diamond; Trevor G. Frank; J. Christopher Freitag; Kenneth S. Higashihara; Dave Huffman; Jonah R. Troth |
| A cannula for use in transferring small volumes of fluid materials, such as in a parallel reaction process. The cannula comprises a long thin needle having various end (port) configurations, and an adapter for connecting the needle to a fluid line. The adapter may include the combination of a reservoir and transition, or simply a transition. | ||||||
| 183 | Use of gradient mixtures for screening and optimization of catalysts for the production of condensation polymers | US09729938 | 2000-12-06 | US20020102735A1 | 2002-08-01 | John Patrick Lemmon; Ronald James Wroczynski; Oltea Puica Siclovan |
| A method of making and screening an array of catalysts, said method comprising: (a) combining a first polymerization precursor material, a second polymerization precursor material and a first catalyst in a first region on a substrate; (b) combining a first polymerization precursor material, a second polymerization precursor material and a second catalyst in a second region on a substrate; (c) reacting the first and second polymerization material in said first and second regions; and (d) screening said first and second regions of said substrate for a measurable property or properties. | ||||||
| 184 | Combinatorial sythesis of organometallic materials | US09127660 | 1998-07-31 | US06420179B1 | 2002-07-16 | Peter G. Schultz; Xiaodong Xiang; Isy Goldwasser |
| Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties. | ||||||
| 185 | Combinatorial screening of inorganic and organometallic materials | US09122932 | 1998-07-27 | US06410331B1 | 2002-06-25 | Peter G. Schultz; Xiaodong Xiang; Isy Goldwasser |
| Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties. | ||||||
| 186 | Structure identification methods using mass measurements | US09776184 | 2001-02-02 | US20020051999A1 | 2002-05-02 | Nikolai F. Sepetov; Olga L. Issakova |
| Methods of identifying predicted or actual structures of members of a chemical or physical library are provided. The methods provide for the direct identification of compound structure following combinatorial synthesis using molecular mass measurements of individual compounds, thereby eliminating the necessity of encoding synthetic steps. The analysis of mass spectrometric data for sets of related compounds reveals compounds that are missing in a group of related compounds and identifies compounds that do not belong to a group of related compounds due to unexpected chemical, physical, or biological transformations. The methods may be applied to any group of compounds originating from chemical reactions where one reactant is common to the synthetic transformation. One particular application of these methods is in the analysis of the products of combinatorial synthesis. Systems, computer programs products, and kits are additionally provided. | ||||||
| 187 | Preparation of biopolymer arrays | US09820476 | 2001-03-28 | US06372483B2 | 2002-04-16 | Arthur Schleifer; Carol T. Schembri; Michael P. Caren |
| A method and apparatus for fabricating an array of biopolymers on a substrate using a biopolymer or biomonomer fluid, and using a fluid dispensing head. The head has at least one jet which can dispense droplets onto a substrate, the jet including a chamber with an orifice, and including an ejector which, when activated, causes a droplet to be ejected from the orifice. The method includes positioning the head with the orifice facing the substrate. Multiple droplets of the biopolymer or biomonomer fluid are dispensed from the head orifice so as to form an array of droplets on the substrate. A gas flow is directed through a venturi which has a throat opening communicating with the dispensing head chamber. A venturi control valve which particularly communicate with an outlet of the venturi, is adjusted to alter the chamber pressure. The venturi may be driven by a source of inert anhydrous compressed gas which assists in maintaining fluid in the head isolated from moisture. | ||||||
| 188 | MULTI-TEMPERATURE MODULAR REACTOR AND METHOD OF USING SAME | US09417125 | 1998-11-19 | US20020001538A1 | 2002-01-03 | DAMIAN A. HAJDUK; RALPH B. NIELSEN; ADAM SAFIR |
| An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. | ||||||
| 189 | Preparation and screening of crystalline materials | US09881036 | 2001-06-13 | US20010055775A1 | 2001-12-27 | Peter G. Schultz; Xiaodong Xiang; Isy Goldwasser |
| Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties. | ||||||
| 190 | Optical systems and methods for rapid screening of libraries of different materials | US09874758 | 2001-06-05 | US20010033375A1 | 2001-10-25 | Eric W. McFarland; Earl Danielson; William Archibald |
| Methods and apparatus for screening diverse arrays of materials are provided. In particular, techniques for rapidly characterizing compounds in arrays of materials in order to discover and/or optimize new materials with specific desired properties are provided. The substrate can be screened for materials having useful properties, and/or the resulting materials can be ranked, or otherwise compared, for relative performance with respect to useful properties or other characterizations. In particular, systems and methods are provided for screening a library of magnetic materials for their bulk magnetization, saturation magnetization, and coercivity by imaging their individual optical Kerr rotation, screening a library of dielectric materials for their dielectric coefficients by imaging their individual electro-optical rotation and screening a library of luminescent materials by imaging their individual luminescent properties under a variety of excitation conditions. Optical or visible luminescence systems are also provided as well as their application to screening libraries of different materials. | ||||||
| 191 | Parallel reactor with internal sensing | US09211982 | 1998-12-14 | US06306658B1 | 2001-10-23 | Howard W. Turner; G. Cameron Dales; Lynn VanErden; Johannes A. M. van Beek |
| An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. | ||||||
| 192 | Methods and reagents for capping ruthenium or osmium carbene-catalyzed ROMP products | US09336121 | 1999-06-17 | US06291616B1 | 2001-09-18 | Laura L. Kiessling; Eva J. Gordon; Laura E. Strong |
| Methods of preparing a telechelic polymer (mono- or bi-telechelic) that use a ruthenium or osmium carbene catalyst and a capping agent, at least one of which is functionalized. | ||||||
| 193 | Compositionally different polymer-based sensor elements and method for preparing same | US09106791 | 1998-06-29 | US06290911B1 | 2001-09-18 | Nathan S. Lewis; Robert H. Grubbs; Robert D. Sanner; Eric J. Severin |
| The present invention provides a combinatorial approach for preparing arrays of chemically sensitive polymer-based sensors which are capable of detecting the presence of a chemical analyte in a fluid in contact therewith. The described methods and devices comprise combining varying ratios of at least first and second organic materials which, when combined, form a polymer or polymer blend that is capable of absorbing a chemical analyte, thereby providing a detectable response. The detectable response of the sensors prepared by this method is not linearly related to the mole fraction of at least one of the polymer-based components of the sensors, thereby making arrays of these sensors useful for a variety of sensing tasks. | ||||||
| 194 | Apparatus and method for mixing a film of fluid | US09782542 | 2001-02-12 | US20010010661A1 | 2001-08-02 | Carol T. Schembri |
| A method and apparatus is provided for mixing a film of fluid, particularly a film of chemical, biochemical, or biological fluids undergoing a reaction. The apparatus comprises a means for nucleating a bubble using a discrete heat source, such as a resistor, and moving the bubble in the fluid by creating a temperature gradient, thereby mixing the fluid. | ||||||
| 195 | Combinatorial synthesis and analysis of organometallic compounds and homogeneous catalysts | US09390001 | 1999-09-03 | US06248540B1 | 2001-06-19 | W. Henry Weinberg; Eric McFarland; Isy Goldwasser; Thomas Boussie; Howard Turner; Johannes A. M. Van Beek; Vince Murphy; Timothy Powers |
| The present invention relates, inter alia, to methodologies for the synthesis, screening and characterization of organometailic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention provide for the combinatorial synthesis, screening and characterization of libraries of supported and unsupported organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention can be applied to the preparation and screening of large niumbers of organometallic compounds which can be used not only as catalysts (e.g., homogeneous catalysts), but also as additives and therapeutic agents. | ||||||
| 196 | Preparation of biopolymer arrays | US09302899 | 1999-04-30 | US06242266B1 | 2001-06-05 | Arthur Schleifer; Carol T. Schembri; Michael P. Caren |
| A method and apparatus for fabricating an array of biopolymers on a substrate using a biopolymer or biomonomer fluid, and using a fluid dispensing head. The head has at least one jet which can dispense droplets onto a substrate, the jet including a chamber with an orifice, and including an ejector which, when activated, causes a droplet to be ejected from the orifice. The method includes positioning the head with the orifice facing the substrate. Multiple droplets of the biopolymer or biomonomer fluid are dispensed from the head orifice so as to form an array of droplets on the substrate. A gas flow is directed through a venturi which has a throat opening communicating with the dispensing head chamber. A venturi control valve which particularly communicate with an outlet of the venturi, is adjusted to alter the chamber pressure. The venturi may be driven by a source of inert anhydrous compressed gas which assists in maintaining fluid in the head isolated from moisture. | ||||||
| 197 | Apparatus and method for mixing a film of fluid | US09137963 | 1998-08-21 | US06186659B1 | 2001-02-13 | Carol T. Schembri |
| A method and apparatus is provided for mixing a film of fluid, particularly a film of chemical, biochemical, or biological fluids undergoing a reaction. The apparatus comprises a means for nucleating a bubble using a discrete heat source, such as a resistor, and moving the bubble in the fluid by creating a temperature gradient, thereby mixing the fluid. | ||||||
| 198 | Copolymers of tyrosine-based polyarlates and poly(alkylene oxides) | US85571 | 1998-05-27 | US6048521A | 2000-04-11 | Joachim B. Kohn; Chun Yu |
| Implantable medical devices and drug delivery implants containing polyarylate random block copolymers are disclosed, along with methods for drug delivery and for preventing the formation of adhesions between injured tissues employing the polyarylate random block copolymers. | ||||||
| 199 | Optical systems and methods for rapid screening of libraries of different materials | US947085 | 1997-10-08 | US6034775A | 2000-03-07 | Eric W. McFarland; Earl Danielson; William Archibald |
| Methods and apparatus for screening diverse arrays of materials are provided. In particular, techniques for rapidly characterizing compounds in arrays of materials in order to discover and/or optimize new materials with specific desired properties are provided. The substrate can be screened for materials having useful properties, and/or the resulting materials can be ranked, or otherwise compared, for relative performance with respect to useful properties or other characterizations. In particular, systems and methods are provided for screening a library of magnetic materials for their bulk magnetization, saturation magnetization, and coercivity by imaging their individual optical Kerr rotation, screening a library of dielectric materials for their dielectric coefficients by imaging their individual electro-optical rotation and screening a library of luminescent materials by imaging their individual luminescent properties under a variety of excitation conditions. Optical or visible luminescence systems are also provided as well as their application to screening libraries of different materials. | ||||||
| 200 | Combinatorial synthesis of novel materials | US327513 | 1994-10-18 | US5985356A | 1999-11-16 | Peter G. Schultz; Xiaodong Xiang; Isy Goldwasser |
| Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties. | ||||||
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