| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 161 | Parallel reactor with internal sensing and method of using same | US09177170 | 1998-10-22 | US06548026B1 | 2003-04-15 | G. Cameron Dales; Johannes A. M. van Beek; Damian A. Hajduk; Ralph B. Nielsen; Paul Mansky |
| An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. | ||||||
| 162 | Method and device for producing oligonucleotide arrays | US09969887 | 2001-10-04 | US20030068621A1 | 2003-04-10 | Jonathan Briggs |
| The present invention relates to a method for producing a nucleic acid, polynucleotide, oligonucleotide, or polymer array and device therefore, wherein the method includes synthesizing a plurality of positionally addressable nucleic acids, polynucleotides, oligonucleotides, or polymers in a reaction array, and transferring these positionally addressable substances from the reaction array directly to a substrate to form the desired product array. | ||||||
| 163 | Systems and methods for the deposition and curing of coating compositions | US09682832 | 2001-10-23 | US06544334B1 | 2003-04-08 | Radislav Alexandrovich Potyrailo; Daniel Robert Olson; Michael Jarvath Brennan; Jay Raghunandan Akhave; Mark Anthony Licon; Ali Reza Mehrabi; Dennis Lee Saunders; Bret Ja Chisholm |
| Systems and methods for creating a combinatorial coating library including a coating system operatively coupled to at least one of a plurality of materials suitable for forming at least one coating layer on a surface of one or more substrates. The systems and methods also including a curing system operative to apply at least one of a plurality of curing environments to each of a plurality of regions associated with the at least one coating layer, the curing system comprising a plurality of waveguides each having a first end corresponding to at least one of the plurality of regions and a second end associated with at least one curing source. The combinatorial coating library comprising a predetermined combination of at least one of the plurality of materials and at least one of the plurality of curing environments associated with each of the plurality of regions. | ||||||
| 164 | Infrared spectroscopic imaging of libraries | US08946135 | 1997-10-07 | US06541271B1 | 2003-04-01 | Eric W. McFarland; William Archibald |
| Methods and apparatus for screening diverse arrays of materials using infrared imaging techniques are provided. Typically, each of the individual materials on the array will be screened or interrogated for the same material characteristic. Once screened, the individual materials may be ranked or otherwise compared relative to each other with respect to the material characteristic under investigation. According to one aspect, infrared imaging techniques are used to identify the active sites within an array of compounds by monitoring the temperature change resulting from a reaction. This same technique can also be used to quantify the stability of each new material within an array of compounds. According to another aspect, identification and characterization of condensed phase products is achieved, wherein library elements are activated by a heat source serially, or in parallel. According to another aspect, a Fourier transform infrared spectrometer is used to rapidly characterize a large number of chemical reactions contained within a combinatorial library. | ||||||
| 165 | Parallel screen for rapid thermal characterization of materials | US09414744 | 1999-10-08 | US06536944B1 | 2003-03-25 | William B. Archibald; Marc Hornbostel |
| A method and apparatus for high-throughput determination of phase change points of combinatorial libraries of metal alloys uses an infrared camera to monitor temperature-dependent changes in emissivity/reflectivity of the alloys. An infrared focal plane array monitors the emissivity/reflectivity changes over time, and the intensity of each heated member over time is correlated with temperature to detect the phase change points of the members. | ||||||
| 166 | High throughput mechanical rapid serial property testing of materials libraries | US10225793 | 2002-08-22 | US20030054740A1 | 2003-03-20 | Paul Mansky |
| A library of materials is screened for mechanical properties such as strength, tack or other properties. A library of materials is provided. A stimulus such as a stress or force is provided to each member of the library. A response (e.g., a strain) of each of the materials due to the stimulus is measured and the response, the stimulus or both are recorded and related to provide data. Thereafter, the data is analyzed to reach conclusions regarding properties of the material samples. | ||||||
| 167 | High throughput mechanical property testing of materials libraries using capacitance | US09939263 | 2001-08-24 | US20030041671A1 | 2003-03-06 | Damian A. Hajduk; Eric D. Carlson; J. Christopher Freitag; Oleg Kolosov; James R. Engstrom; Adam Safir; Ravi Srinivasan; Leonid Matsiev |
| A method for high throughput mechanical property testing of materials libraries using capacitance. The method monitors the responses of a plurality of samples on a substrate to a force induced by a capacitor. | ||||||
| 168 | Multi-temperature modular reactor and method of using same | US09417125 | 1998-11-19 | US06528026B2 | 2003-03-04 | Damian A. Hajduk; Ralph B. Nielsen; Adam Safir; Leonid Matsiev; Eric McFarland; Paul Mansky |
| An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. | ||||||
| 169 | High throughput mechanical rapid serial property testing of materials libraries | US09939252 | 2001-08-24 | US20030037620A1 | 2003-02-27 | Paul Mansky |
| A library of materials is screened for mechanical properties such as strength, tack or other properties. A library of materials is provided. A stimulus such as a stress or force is provided to each member of the library. A response (e.g., a strain) of each of the materials due to the stimulus is measured and the response, the stimulus or both are recorded and related to provide data. Thereafter, the data is analyzed to reach conclusions regarding properties of the material samples. | ||||||
| 170 | High throughput rheological testing of materials | US09939149 | 2001-08-24 | US20030037601A1 | 2003-02-27 | Paul Mansky; Damian A. Hajduk |
| A library of materials is screened for viscosity. A library of materials is provided. The library is contacted with at least one capillary for applying a force through the materials. The relative flow resistance of the materials is measured in response to the force; and the materials in the library are ranked based on the monitored flow resistance. | ||||||
| 171 | Apparatus and method for mixing a film of fluid | US09782542 | 2001-02-12 | US06513968B2 | 2003-02-04 | Carol T. Schembri |
| A method and apparatus is provided for mixing a film of fluid, particularly a film of chemical, biochemical, or biological fluids undergoing a reaction. The apparatus comprises a means for nucleating a bubble using a discrete heat source, such as a resistor, and moving the bubble in the fluid by creating a temperature gradient, thereby mixing the fluid. | ||||||
| 172 | Method and apparatus for synthesizing characterizing and assaying combinatorial libraries | US09248541 | 1999-02-11 | US06500609B1 | 2002-12-31 | Yves Ribeill; Pierre Monnet; Jaleh Azmi Abedi; Henry David Smith, III; Susan Marie McComb |
| Devices and processes for synthesizing, purifying and analyzing large numbers of compounds for use in combinatorial libraries, are disclosed. The processes involve generating a series of compounds in multi-well plates or multi-tube racks, purifying the reaction mixtures, analyzing the purified compounds, and optionally performing bioassays on the compounds. The information regarding the compounds is stored in a central database. The devices include one or more multi-tube arrays, a purification device, means for transferring the contents of the tubes, a solvent evaporator, analytical instrumentation, and, optionally, a weighing instrument. The multi-tube array(s) optionally include a cover, which can be placed on or removed from the array by computer control. By correlating the orientation of tubes from one stage to the next, it is possible to use a single bar code or other identifying mark for each multi-tube array rather than for each individual tube. This simplifies data collection for large numbers of compounds. | ||||||
| 173 | Method of forming polymer libraries on a substrate and characterization methods with same | US10210915 | 2002-08-02 | US20020197454A1 | 2002-12-26 | Thomas R. Boussie; Martin Devenney |
| This invention relates to a method to characterize an array of polymeric materials comprising: depositing unsilanizable material onto a silanizable substrate in at least 10 regions, thereafter contacting the substrate with an organosilane agent thereby silanizing the substrate but not the unsilanizable material in said regions, optionally, partially or completely removing the unsilanizable material, depositing at least 10 polymeric materials onto said regions, and characterizing the materials. This invention also relates to method for forming an array of polymeric materials to be characterized onto a substrate comprising: (a) selecting ten or more polymers, (b) dissolving or suspending each polymer in a separate liquid, and (c) depositing a uniform amount of each of the ten or more polymer containing liquids onto a substrate in individual hydrophilic and/or hydrophobic regions. Likewise this invention also relates to an array of polymeric materials for use in characterization, comprising: (a) a substrate having multiple regions on the substrate that are not coated with an organosilane and wherein the uncoated regions have a boarder of an organosilane agent coated on the substrate, and (b) a polymer deposited on the regions not coated with an organosilane agent. | ||||||
| 174 | Substituted pyridyl amine ligands | US09993031 | 2001-11-06 | US20020177711A1 | 2002-11-28 | Anne M. LaPointe; Eric D. Carlson; Thomas Crevier |
| New ligands, compositions, metal-ligand complexes and arrays with pyridyl-amine ligands are disclosed that catalyze the polymerization of monomers into polymers. Certain of these catalysts with hafnium metal centers have high performance characteristics, including higher comonomer incorporation into ethylene/olefin copolymers, where such olefins are for example, 1-octene, isobutylene or styrene. Certain of the catalysts are particularly effective at polymerizing propylene to high molecular weight isotactic polypropylene in a solution process at a variety of polymerization conditions. | ||||||
| 175 | Methods of polymerizing ethylene and styrene copolymers with substituted pyridyl amine catalysts and catalysts therefor | US09992148 | 2001-11-06 | US20020173419A1 | 2002-11-21 | Thomas R. Boussie; Gary M. Diamond; Christopher Goh; Keith A. Hall; Anne M. LaPointe; Margarete K. Leclerc; Cheryl Lund; Vince Murphy |
| New ligands, compositions, metal-ligand complexes and arrays with pyridyl-amine ligands are disclosed that catalyze the polymerization of monomers into polymers. Certain of these catalysts with hafnium metal centers have high performance characteristics, including higher comonomer incorporation into ethylene/olefin copolymers, where such olefins are for example, 1-octene, isobutylene or styrene. Certain of the catalysts are particularly effective at polymerizing propylene to high molecular weight isotactic polypropylene in a solution process at a variety of polymerization conditions. | ||||||
| 176 | Combinatorial library comprising pouches as packages for library members and method therefor | US09793666 | 2001-02-26 | US20020160527A1 | 2002-10-31 | Jeffrey J. Cernohous; JingJing Ma; Michael P. Daniels; Stephen B. Roscoe; Lester H. McIntosh III; Steven D. Koecher; Brook F. Duerr; William H. Sikorski JR. |
| A combinatorial array comprises fluid-impervious, sealed or sealable, flexible, self-supported pouches, each pouch comprising therein one or more members of a library of materials. A method for producing the members of the library is also disclosed. The method can utilize an automated process for introducing components into the pouches. Analysis of products can be by destructive or non-destructive methods. | ||||||
| 177 | Multi-temperature modular reactor and method of using same | US10134556 | 2002-04-29 | US20020155036A1 | 2002-10-24 | Damian A. Hajduk; Ralph B. Nielsen; Adam Safir; Leonid Matsiev; Eric McFarland; Paul Mansky |
| An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. | ||||||
| 178 | Potential masking systems and methods for combinatorial library synthesis | US08941170 | 1997-09-30 | US06468806B1 | 2002-10-22 | Eric McFarland; Earl Danielson; Martin Devenney; Christopher J. Warren |
| Methods and apparatus are provided for the preparation of a substrate having an array of diverse materials, the materials being deposited at spatially addressable, predefined regions. In particular, potential masking systems are provided which generate spatially and temporally varying electric, magnetic and chemical potentials across a substrate. These varying potentials are used to deposit components of source materials onto a substrate in a combinatorial fashion, thus creating arrays of materials that differ slightly in chemical composition, concentration, stoichiometry, and/or thickness. The diverse materials may be organized in discrete arrays, or they may vary continuously over the surface of the substrate. The shape of the potential allows the determination of the composition of the resulting materials at all locations on the substrate. | ||||||
| 179 | Substituted pyridyl amine catalysts and processes for polymerizing and polymers | US09992385 | 2001-11-06 | US20020147288A1 | 2002-10-10 | Thomas R. Boussie; Gary M. Diamond; Christopher Goh; Keith A. Hall; Anne M. LaPointe; Margarete K. Leclerc; Cheryl Lund; Vince Murphy |
| New ligands, compositions, metal-ligand complexes and arrays with pyridyl-amine ligands are disclosed that catalyze the polymerization of monomers into polymers. Certain of these catalysts with hafnium metal centers have high performance characteristics, including higher comonomer incorporation into ethylene/olefin copolymers, where such olefins are for example, 1-octene, isobutylene or styrene. Certain of the catalysts are particularly effective at polymerizing propylene to high molecular weight isotactic polypropylene in a solution process at a variety of polymerization conditions. | ||||||
| 180 | Substrate for array printing | US09245142 | 1999-02-04 | US06461734B1 | 2002-10-08 | Alain R. E. Carre |
| A substrate for use in supporting high density biological or chemical arrays that is made from borosilicate or boroaluminosilicate glass. It has been demonstrated that a functionalized coating used to immobilize oligonucleotides for example, retains its functionality when exposed to environmental stresses when it is applied to a slide composed of a glass material having a low sodium oxide content. | ||||||
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