专利检索_ .使分子氧还原成两分子水的一对供体氧化专利检索_ .使分子氧还原成两分子水的一对供体氧化专利检索查询

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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
81	ESSENTIAL FATTY ACID-PRODUCING NONHUMAN TRANSGENIC ANIMALS AND USES THEREOF	US15127295	2015-03-20	US20170172118A1	2017-06-22	Jing X. KANG
Various aspects provided herein relate to compositions and methods for altering the content of polyunsaturated fatty acids in animals, e.g., non-human animals. Transgenic animals (e.g., non-human animals) that are capable of converting carbohydrates and/or saturated fats to polyunsaturated fatty acids (e.g., n-6 and/or n-3 fatty acids) and uses thereof are also provided herein.
82	Soybean Seed and Oil Compositions and Methods of Making Same	US15267649	2016-09-16	US20170002372A1	2017-01-05	Nicholas William Wagner
Soybean oil compositions with unique fatty acid profiles are disclosed. These oils can be derived by the suppression of endogenous soybean FAD2 and FAD3 genes and the expression of a stearoyl acyl ACP thioesterase. Soybean plants and seeds comprising these oils are also disclosed.
83	Method for the production of multiple-unsaturated fatty acids in transgenic organisms	US10566944	2004-07-16	US09433228B2	2016-09-06	Thorsten Zank; Jörg Bauer; Petra Cirpus; Amine Abbadi; Ernst Heinz; Xiao Qiu; Patricia Vrinten; Petra Sperling; Frederic Domergue; Astrid Meyer; Jelena Kirsch
The invention relates to a method for the production of multiply-unsaturated fatty acids in an organism, into which nucleic acids have been introduced, which code for polypeptides with Δ-5 elongase activity. Said nucleic acid sequences, optionally with further nucleic acid sequences, coding for polypeptides for the biosynthesis of fatty acids and lipid metabolism, are advantageously expressed in the organism. Nucleic acid sequences coding for a Δ-6 desaturase, a Δ-5 desaturase, Δ-4 desaturase and/or Δ-6 elongase activity are particularly advantageous and, advantageously, said saturases and elongases are derived from Thalassiosira, Euglena or Ostreococcus. The invention further relates to a method for the production of oils and/or triacylglycerides with an increased content of long-chain, multiply-unsaturated fatty acids. A particular embodiment of the invention is a method for the production of unsaturated ω-3 fatty acids and a method for the production of triglycerides with an increased content of unsaturated fatty acids, in particular, of Δ-3 fatty acids with more than three double bonds. Also disclosed is the production of a transgenic organism, preferably a transgenic plant, or a transgenic microorganism with increased content of ω-3 fatty acids, oils or lipids with ω-3 double bonds as a result of the expression of the elongases and desaturases employed in the above method, preferably in combination with ω-3 desaturases, for example a ω-3 desaturase from fungi of the family Pythiaceae such as the genus Phytophtora, for example, the genus and species Phytophtora infestans, or a ω-3 desaturase from algae such as the family Prasinophyceae, for example, the genus Ostreococcus and, particularly, the genus and species Ostreococcus tauri or diatomaceæ such as the genus Thalassiosira and, particularly, the genus and species Thalassiosira pseudonana. The invention also relates to the nucleic acid sequences, nucleic acid constructs, vectors and organisms containing the nucleic acid sequences and/or the nucleic acid constructs and transgenic organisms containing said nucleic acid sequences, nucleic acid constructs and/or vectors. A further part of the invention relates to oils, lipids and/or fatty acids produced according to the above method and use thereof and, furthermore, unsaturated fatty acids and triglycerides with an increased content of unsaturated fatty acids and use thereof.
84	GENETICALLY ENGINEERED AND ACID-RESISTANT YEAST CELL WITH ENHANCED ERG5 ACTIVITY AND METHOD OF PRODUCING LACTATE BY USING THE YEAST CELL	US14657637	2015-03-13	US20160024536A1	2016-01-28	Wooyong Lee; Soyoung Lee; Huisub Lim; Jiyoon Song; Kwangmyung Cho; Sunghaeng LEE
Provided is a recombinant acid resistance yeast cell that is genetically engineered to increase ERG5 activity and a method of producing lactate by using the yeast cell.
85	METHOD FOR PRODUCING POLYUNSATURATED FATTY ACIDS IN TRANSGENIC PLANTS	US14823253	2015-08-11	US20150361404A1	2015-12-17	Petra Cirpus; Jörg Bauer; Xiao Qiu; Guohai Wu; Nagamani Datla
The present invention relates to a process for the production of polyunsaturated fatty acids in the seed of transgenic plants by introducing, into the organism, nucleic acids which encode polypeptides with a ω3-desaturase, Δ12-desaturase, Δ6-desaturase, Δ6-elongase, Δ5-desaturase, Δ5-elongase and/or Δ4-desaturase activity. The invention furthermore relates to recombinant nucleic acid molecules comprising the nucleic acid sequences which encode the aforementioned polypeptides, either jointly or individually, and transgenic plants which comprise the aforementioned recombinant nucleic acid molecules. Furthermore, the invention relates to the generation of a transgenic plant and to oils, lipids and/or fatty acids with an elevated content of polyunsaturated fatty acids, in particular arachidonic acid, eicosapentaenoic acid and/or docosahexaenoic acid, as the result of the expression of the elongases and desaturases used in the process according to the invention.
86	PREPARATION OF 7-DEHYDROCHOLESTEROL AND/OR THE BIOSYNTHETIC INTERMEDIATES AND/OR SECONDARY PRODUCTS THEREOF IN TRANSGENIC ORGANISMS	US14583418	2014-12-26	US20150353980A1	2015-12-10	Christine Lang; Markus Veen
The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves.
87	Novel Enzymes, Enzyme Components and Uses Thereof	US14416981	2013-07-30	US20150203826A1	2015-07-23	Laurent Marty; Toralf Senger
The invention provides nucleic acid molecules which encodes a novel fatty acid desaturase, KCS, KCR and/or LACS from Thraustochytrium aureum and Sphaeroforma arctica. The invention also provides recombinant expression vectors containing said nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g., ARA, EPA and DHA and for screening for delta-4 desaturases.
88	INHIBITION OF DELTA-6 DESATURASE FOR THE TREATMENT OF CARDIOMETABOLIC DISEASE	US14592131	2015-01-08	US20150181845A1	2015-07-02	Adam J. Chicco
Systems and methods for screening whether a candidate compound inhibits delta-6 desaturase activity are disclosed. Also disclosed is a transgenic mammal which overexpresses a gene encoding delta-6 desaturase and an animal model of a cardiometabolic disorder or disease that includes the transgenic mammal. A method of treating a cardiometabolic disorder or disease is also disclosed.
89	Microorganisms, Compositions, and Methods for Producing Fatty Acids	US14335071	2014-07-18	US20150057352A1	2015-02-26	Subhayu Basu; Gaozhong Shen; Brett Adam Boghigian; David M. Young; David Arthur Berry; Geoffrey von Maltzahn
Methods of producing an unsaturated free fatty acid comprising at least 18 carbon atoms are provided. In some embodiments, the methods comprise culturing an engineered microorganism in a culture medium, wherein the engineered microorganism comprises at least one recombinant enzyme selected from acyl-lipid desaturase delta-9 (EC:1.14.19.1), acyl-lipid desaturase delta-12 (EC:1.14.19.6), acyl-lipid desaturase delta-15 (EC:1.14.19.-), and thioesterase (EC:3.1.2.14). Engineered microorganisms comprising at least one of those recombinant enzymes are also provided. The methods and organisms can be used to produce at least one free fatty acid selected from oleic acid, linoleic acid and α-linolenic acid.
90	Delta-5 desaturase and its use in making polyunsaturated fatty acids	US11749889	2007-05-17	US08962917B2	2015-02-24	Howard Glenn Damude; Quinn Qun Zhu
Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-5 desaturase along with a method of making long chain polyunsaturated fatty acids (PUFAs) using this delta-5 desaturase in plants and oleaginous yeast are disclosed.
91	Delta-5 desaturases and their use in making polyunsaturated fatty acids	US12111228	2008-04-29	US08957280B2	2015-02-17	Howard Glenn Damude; Quinn Qun Zhu
Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-5 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these delta-5 desaturases in plants are disclosed.
92	INHIBITION OF DELTA-6 DESATURASE FOR THE TREATMENT OF CARDIOMETABOLIC DISEASE	US13902435	2013-05-24	US20130317039A1	2013-11-28	ADAM J. CHICCO
Systems and methods for screening whether a candidate compound inhibits delta-6 desaturase activity are disclosed. Also disclosed is a transgenic mammal which overexpresses a gene encoding delta-6 desaturase and an animal model of a cardiometabolic disorder or disease that includes the transgenic mammal. A method of treating a cardiometabolic disorder or disease is also disclosed.
93	HIGH OLEIC ACID OILS	US13869763	2013-04-24	US20130288318A1	2013-10-31	Craig Christopher WOOD; Qing LIU; Xue-Rong ZHOU; Allan GREEN; Surinder Pal SINGH; Shijiang CAO
The present invention relates to extracted lipid with high levels, for example 90% to 95% by weight, oleic acid. The present invention also provides genetically modified plants, particularly oilseeds such as safflower, which can used to produce the lipid. Furthermore, provided are methods for genotyping and selecting plants which can be used to produce the lipid.
94	DESATURASES OF A GREEN MICROALGA AND USES THEREOF	US13520607	2011-01-05	US20130019341A1	2013-01-17	Iskandarov Umidjon; Inna Khozin Goldberg; Zvi Hacohen
Isolated proteins which are at least partially encoded by polynucleotide sequences encoding novel desaturases are provided together with a composition which includes these isolated proteins. A transgenic plant, a transgenic alga, or a transgenic seed transformed by the polynucleotides encoding proteins which are at least partially encoded by novel desaturases are also provided. The invention also includes a process for making a very long-chain polyunsaturated fatty acid in a transformed cell, a transgenic alga, or a transgenic plant expressing the isolated protein or proteins which are at least partially encoded by the polynucleotide sequences encoding novel Δ5, Δ6, or Δ12 desaturases.
95	MICROORGANISMS AND METHODS FOR PRODUCING UNSATURATED FATTY ACIDS	US13326211	2011-12-14	US20120116108A1	2012-05-10	Subhayu Basu; Gaozhong Shen; Brett Boghigian
Methods of producing an unsaturated free fatty acid comprising at least 18 carbon atoms are provided. In some embodiments, the methods comprise culturing an engineered microorganism in a culture medium, wherein the engineered microorganism comprises at least one recombinant enzyme selected from acyl-lipid desaturase delta-9 (EC:1.14.19.1), acyl-lipid desaturase delta-12 (EC:1.14.19.6), acyl-lipid desaturase delta-15 (EC:1.14.19.-), and thioesterase (EC:3.1.2.14). Engineered microorganisms comprising at least one of those recombinant enzymes are also provided. The methods and organisms can be used to produce at least one free fatty acid selected from oleic acid, linoleic acid and α-linolenic acid.
96	PREPARATION OF 7-DEHYDROCHOLESTEROL AND/OR THE BIOSYNTHETIC INTERMEDIATES AND/OR SECONDARY PRODUCTS THEREOF IN TRANSGENIC ORGANISMS	US12607017	2009-10-27	US20110151509A1	2011-06-23	Christine Lang; Markus Veen
The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves.
97	Δ-5 desaturases and their use in making polyunsaturated fatty acids	US12111237	2008-04-29	US07943365B2	2011-05-17	Howard Glenn Damude; Quinn Qun Zhu
The present invention relates to Δ5 desaturases, which have the ability to convert dihomo-γ-linolenic acid (DGLA; 20:3 ω-6) to arachidonic acid (ARA; 20:4 ω-6) and/or eicosatetraenoic acid (ETA; 20:4 ω-3) to eicosapentaenoic acid (EPA; 20:5 ω-3). Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ5 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these Δ5 desaturases in oleaginous yeast are disclosed.
98	Soybean Seed and Oil Compositions and Methods of Making Same	US12882579	2010-09-15	US20110067149A1	2011-03-17	Nicholas William Wagner
Soybean oil compositions with unique fatty acid profiles are disclosed. These oils can be derived by the suppression of endogenous soybean FAD2 and FADS genes and the expression of a stearoyl acyl ACP thioesterase. Soybean plants and seeds comprising these oils are also disclosed.
99	Method For Producing Polyunsaturated Fatty Acids	US12280090	2007-02-21	US20100227924A1	2010-09-09	Petra Cirpus; Jörg Bauer; Xiao Qiu; Guohai Wu; Bifang Cheng; Martin Truksa; Tom Wetjen
The invention relates to a method for producing eicosapentanoic acid, docosapentanoic acid and/or docohexanoic acid in transgenic plants. According to said method, the plant is provided with at least one nucleic acid sequence coding for a polypeptide with a Δ6 desaturase activity, at least one nucleic acid sequence coding for a polypeptide with a Δ6 elongase activity, at least one nucleic acid sequence coding for a polypeptide with a Δ5 desaturase activity, and at least one nucleic acid sequence coding for a polypeptide with a Δ5 elongase activity, the nucleic acid sequence coding for a polypeptide with a Δ5 elongase activity being modified in relation to the nucleic acid sequence in the organism from which the sequence originates, such that it is adapted to the codon use in at least one type of plant. For the production of docosahexanoic acid, at least one nucleic acid sequence coding for a polypeptide with a Δ4 desaturase activity is also introduced into the plant.
100	Δ 5 desaturase and its use in making polyunsaturated fatty acids	US11748629	2007-05-15	US07678560B2	2010-03-16	Howard Glenn Damude; Dana M. Walters Pollak; Zhixiong Xue; Quinn Qun Zhu
The present invention relates to a Δ5 desaturase, which has the ability to convert dihomo-γ-linolenic acid (DGLA; 20:3 ω-6) to arachidonic acid (ARA; 20:4 ω-6) and/or eicosatetraenoic acid (ETA; 20:4 ω-3) to eicosapentaenoic acid (EPA; 20:5 ω-3). Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ5 desaturase along with a method of making long chain polyunsaturated fatty acids (PUFAs) using this Δ5 desaturase in oleaginous yeast are disclosed.

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