专利检索_ .使分子氧还原成两分子水的一对供体氧化专利检索_ .使分子氧还原成两分子水的一对供体氧化专利检索查询

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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
41	Inhibition of delta-6 desaturase for the treatment of cardiometabolic disease	US13902435	2013-05-24	US08952012B2	2015-02-10	Adam J. Chicco
Systems and methods for screening whether a candidate compound inhibits delta-6 desaturase activity are disclosed. Also disclosed is a transgenic mammal which overexpresses a gene encoding delta-6 desaturase and an animal model of a cardiometabolic disorder or disease that includes the transgenic mammal. A method of treating a cardiometabolic disorder or disease is also disclosed.
42	PREPARATION OF 7-DEHYDROCHOLESTEROL AND/OR THE BIOSYNTHETIC INTERMEDIATES AND/OR SECONDARY PRODUCTS THEREOF IN TRANSGENIC ORGANISMS	US13548898	2012-07-13	US20130210072A1	2013-08-15	Christine Lang; Markus Veen
The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves.
43	Algal desaturases	US13458914	2012-04-27	US08440805B2	2013-05-14	Oliver Kilian; Bertrand Vick
Provided herein are exemplary isolated nucleotide sequences encoding polypeptides having desaturase activity, which utilize fatty acids as substrates.
44	NOVEL FATTY ACID DESATURASES AND ELONGASES AND USES THEREOF	US13384277	2010-07-15	US20120124705A1	2012-05-17	Jörg Bauer; Johnathan A. Napier; Olga Sayanova
The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturases and elongases from the organism Emiliana huxleyi. The invention also provides recombinant expression vectors containing desaturase or elongase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g. arachidonic acid (ARA), eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA).
45	DELTA-5 DESATURASES AND THEIR USE IN MAKING POLYUNSATURATED FATTY ACIDS	US12594011	2008-05-01	US20100189868A1	2010-07-29	Howard Glenn Damude; Quinn Qun Zhu
Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-5 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these delta-5 desaturases in plants are disclosed.
46	Method for the production of 7-dehydrocholesterol and/or the biosynthetic intermediate or subsequent products thereof in transgenic organisms	US10503044	2003-01-22	US07608421B2	2009-10-27	Christine Lang; Markus Veen
The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves.
47	DELTA-5 DESATURASES AND THEIR USE IN MAKING POLYUNSATURATED FATTY ACIDS	US12111237	2008-04-29	US20080274521A1	2008-11-06	Howard Glenn Damude; Quinn Qun Zhu
The present invention relates to Δ5 desaturases, which have the ability to convert dihomo-γ-linolenic acid (DGLA; 20:3 ω-6) to arachidonic acid (ARA; 20:4 ω-6) and/or eicosatetraenoic acid (ETA; 20:4 ω-3) to eicosapentaenoic acid (EPA; 20:5 ω-3). Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ5 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these Δ5 desaturases in oleaginous yeast are disclosed.
48	Preparation of 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof in transgenic organisms	US10503044	2003-01-22	US20060240508A1	2006-10-26	Christine Lang; Markus Veen
The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves.
49	BRASSICA EVENTS LBFLFK AND LBFDAU AND METHODS FOR DETECTION THEREOF	US15526443	2015-11-13	US20180298400A1	2018-10-18	Toralf SENGER; Laurent MARTY; Irene KUNZE; Dietrich REIN; Joerg BAUER; Carl ANDRE
The present invention provides transgenic Brassica events LBFLFK and LBFDAU and progeny thereof, and cells, seeds, plants comprising DNA diagnostic for these events. The invention also provides artificial oligonucleotide primers and probes that are diagnostic for the LBFLFK and LBFDAU events and their progeny in a sample, and methods for detecting the presence of the LBFLFK and LBFDAU events and their progeny in a sample. The invention further provides oil and commodity products derived from the LBFLFK and LBFDAU events.
50	Method for producing polyunsaturated fatty acids in transgenic plants	US14823253	2015-08-11	US10035989B2	2018-07-31	Petra Cirpus; Jörg Bauer; Xiao Qiu; Guohai Wu; Nagamani Datla
The present invention relates to a process for the production of polyunsaturated fatty acids in the seed of transgenic plants by introducing, into the organism, nucleic acids which encode polypeptides with a ω3-desaturase, Δ12-desaturase, Δ6-desaturase, Δ6-elongase, Δ5-desaturase, Δ5-elongase and/or Δ4-desaturase activity. The invention furthermore relates to recombinant nucleic acid molecules comprising the nucleic acid sequences which encode the aforementioned polypeptides, either jointly or individually, and transgenic plants which comprise the aforementioned recombinant nucleic acid molecules. Furthermore, the invention relates to the generation of a transgenic plant and to oils, lipids and/or fatty acids with an elevated content of polyunsaturated fatty acids, in particular arachidonic acid, eicosapentaenoic acid and/or docosahexaenoic acid, as the result of the expression of the elongases and desaturases used in the process according to the invention.
51	Enzymes and methods for producing omega-3 fatty acids	US14332202	2014-07-15	US09938486B2	2018-04-10	James Robertson Petrie; Anne Maree Mackenzie; Qing Liu; Pushkar Shrestha; Peter David Nichols; Susan Irene Ellis Blackburn; Maged Peter Mansour; Stanley Suresh Robert; Dion Matthew Frederick Frampton; Xue-Rong Zhou; Surinder Pal Singh; Craig Christopher Wood
The present invention relates generally to the field of recombinant fatty acid synthesis, particularly in transgenic plants. The application describes genes involved in fatty acid synthesis and provides methods and vectors for the manipulation of fatty acid composition of plant oils. In particular, the invention provides constructs for achieving the integration of multiple heterologous genes involved in fatty acid synthesis into the plant genome, such that the resulting plants produce altered levels of polyunsaturated fatty acids. Also described are methods for enhancing the expression of fatty acid biosynthesis enzymes by co-expressing a silencing suppressor within the plant storage organ.
52	Soybean Seed and Oil Compositions and Methods of Making Same	US15726916	2017-10-06	US20180087065A1	2018-03-29	Nicholas William Wagner
Soybean oil compositions with unique fatty acid profiles are disclosed. These oils can be derived by the suppression of endogenous soybean FAD2 and FAD3 genes and the expression of a stearoyl acyl ACP thioesterase. Soybean plants and seeds comprising these oils are also disclosed.
53	ENZYMES AND METHODS FOR PRODUCING OMEGA-3 FATTY ACIDS	US15642223	2017-07-05	US20180087004A1	2018-03-29	James Robertson Petrie; Anne Maree Mackenzie; Qing Liu; Pushkar Shrestha; Peter David Nichols; Susan Irene Ellis Blackburn; Maged Peter Mansour; Stanley Suresh Robert; Dion Matthew Frederick Frampton; Xue-Rong Zhou; Surinder Pal Singh; Craig Christopher Wood
The present invention relates generally to the field of recombinant fatty acid synthesis, particularly in transgenic plants. The application describes genes involved in fatty acid synthesis and provides methods and vectors for the manipulation of fatty acid composition of plant oils. In particular, the invention provides constructs for achieving the integration of multiple heterologous genes involved in fatty acid synthesis into the plant genome, such that the resulting plants produce altered levels of polyunsaturated fatty acids. Also described are methods for enhancing the expression of fatty acid biosynthesis enzymes by co-expressing a silencing suppressor within the plant storage organ.
54	Enzymes, enzyme components and uses thereof	US14416981	2013-07-30	US09879234B2	2018-01-30	Laurent Marty; Toralf Senger
The invention provides nucleic acid molecules which encodes a novel fatty acid desaturase, KCS, KCR and/or LACS from Thraustochytrium aureum and Sphaeroforma arctica. The invention also provides recombinant expression vectors containing the nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g., ARA, EPA and DHA and for screening for delta-4 desaturases.
55	ENZYMES AND METHODS FOR PRODUCING OMEGA-3 FATTY ACIDS	US15661697	2017-07-27	US20180010141A1	2018-01-11	James Robertson Petrie; Anne Maree Mackenzie; Qing Liu; Pushkar Shrestha; Peter David Nichols; Susan Irene Ellis Blackburn; Maged Peter Mansour; Stanley Suresh Robert; Dion Matthew Frederick Frampton; Xue-Rong Zhou; Surinder Pal Singh; Craig Christopher Wood
The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. In particular, the present invention provides ω3 destaurases, Δ5 elongases and Δ6 desaturases with novel activities. Also provided are methods and DNA constructs for transiently and/or stably transforming cells, particularly plant cells, with multiple genes.
56	HIGH OLEIC SEED OIL TRAIT IN COTTON VARIETIES TO ELEVATE OLEIC ACID CONTENT OF COTTONSEED OIL	US15632974	2017-06-26	US20170367293A1	2017-12-28	Kent Chapman; Patrick Horn; Drew Sturtevant; Christopher Kennedy
An identified 90 bp sequence insertion in the GB0331 genome disrupts the coding sequence of the FAD2-1D gene near the 3′ end of the protein coding region. This sequence is not found in reference genomes of other Gossypium species. This DNA segment can be used to track the high oleic fad-2-1D mutant allele for introgression into cotton varieties such as Pima and upland cotton varieties. This enables a non-GMO strategy to elevate the oleic acid content of commercial cottonseed oil.
57	METHOD FOR THE PRODUCTION OF MULTIPLE-UNSATURATED FATTY ACIDS IN TRANSGENIC ORGANISMS	US15237901	2016-08-16	US20170016015A1	2017-01-19	Thorsten Zank; Jörg Bauer; Petra Cirpus; Amine Abbadi; Ernst Heinz; Xiao Qiu; Patricia Vrinten; Petra Sperling; Frederic Domergue; Astrid Meyer; Jelena Kirsch
The present invention relates to a process for the production of polyunsaturated fatty acids in an organism by introducing, into the organism, nucleic acids which encode polypeptides with Δ5-elongase activity. Advantageously, these nucleic acids can be expressed in the organism together with further nucleic acids which encode polypeptides of the biosynthesis of the fatty acid or lipid metabolism. Especially advantageous are nucleic acids which encode Δ6-desaturases, Δ5-desaturases, Δ4-desaturases and/or Δ6-elongases. These desaturases and elongases are advantageously derived from Thalassiosira, Euglena or Ostreococcus. The invention furthermore relates to a process for the production of oils and/or triacylglycerides with an elevated content of long-chain polyunsaturated fatty acids, and oils and/or triacylglycerides thus obtained. The invention also relates to the nucleic acids, and constructs, vectors and transgenic organisms comprising the same, as well as oils, lipids and/or fatty acids produced by the process according to the invention and to their use.
58	METHOD FOR PRODUCING POLYUNSATURATED FATTY ACIDS	US15256914	2016-09-06	US20160369290A1	2016-12-22	Petra Cirpus; Jörg Bauer; Xiao Qiu; Guohai Wu; Bifang Cheng; Martin Truksa; Tom Wetjen
The invention relates to a method for producing eicosapentanoic acid, docosapentanoic acid and/or docohexanoic acid in transgenic plants. According to said method, the plant is provided with at least one nucleic acid sequence coding for a polypetide with a Δ6 desaturase activity, at least one nucleic acid sequence coding for a polypeptide with a Δ6 elongase activity, at least one nucleic acid sequence coding for a polypeptide with a Δ5 desaturase activity, and at least one nucleic acid sequence coding for a polypeptide with a Δ5 elongase activity, the nucleic acid sequence coding for a polypeptide with a Δ5 elongase activity being modified in relation to the nucleic acid sequence in the organism from which the sequence originates, such that it is adapted to the codon use in at least one type of plant. For the production of docosahexanoic acid, at least one nucleic acid sequence coding for a polypeptide with a Δ4 desaturase activity is also introduced into the plant.
59	Fatty acid desaturases and elongases and uses thereof	US13384277	2010-07-15	US09493520B2	2016-11-15	Jörg Bauer; Johnathan A. Napier; Olga Sayanova
The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturases and elongases from the organism Emiliana huxleyi. The invention also provides recombinant expression vectors containing desaturase or elongase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g. arachidonic acid (ARA), eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA).
60	METHODS FOR CONVERSION OF THE SUBSTRATE SPECIFICITY OF DESATURASES	US15105080	2014-12-17	US20160319249A1	2016-11-03	Toralf Senger; Patricia Vrinten; Ze Long Lim
The present invention relates to methods for the conversion of the substrate specificity of desaturases. Specifically, the present invention pertains to a method for the conversion of the substrate specificity of a Δ5 and/or Δ6 desaturase to the substrate specificity of a Δ4 desaturase, the method comprising: identifying regions and/or amino acid residues which control the substrate specificity of (i) the Δ5 and/or Δ6 desaturase and (ii) the Δ4 desaturase; and replacing in the amino acid sequence of the mentioned Δ5 and/or Δ6 desaturase, the regions and/or amino acid residues which control the substrate specificity of the Δ5 and/or Δ6 desaturase, by the corresponding regions and/or amino acid residues which control the substrate specificity of the Δ4 desaturase, thereby converting the substrate specificity of the Δ5 and/or Δ6 desaturase to the substrate specificity of the Δ4 desaturase. The present invention further concerns a method for the conversion of the substrate specificity of a Δ4 desaturase to the substrate specificity of a Δ5 and/or Δ6 desaturase, the method comprising: identifying regions and/or amino acid residues which control the substrate specificity of (i) the Δ4 desaturase and (ii) the Δ5 and/or Δ6 desaturase; and replacing in the amino acid sequence of the indicated Δ4 desaturase, the regions and/or amino acid residues which control the substrate specificity of the Δ4 desaturase, by the corresponding regions and/or amino acid residues which control the substrate specificity of the Δ5 and/or Δ6 desaturase, thereby converting the substrate specificity of the Δ4 desaturase to the substrate specificity of the Δ5 and/or Δ6 desaturase. In addition, the invention encompasses desaturases with converted substrate specificity.

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