| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | METHOD OF PRODUCING POLYUNSATURATED FATTY ACID | US15614896 | 2017-06-06 | US20180346944A1 | 2018-12-06 | Lok Man So; Man Chak Tse; Kai Kin Chi; Yuen Chong Kong; Sin Yu Yeung |
| A method of producing a polyunsaturated fatty acid in a transgenic bacterium, includes: introducing a recombinant plasmid into a bacteria cell to obtain the transgenic bacterium, wherein the recombinant plasmid comprises a polynucleotide encoding one or more elongase and one or more desaturase; incubating the transgenic bacterium in a medium containing a fatty acid substrate; harvesting the transgenic bacterium, and extracting the polyunsaturated fatty acid from the transgenic bacterium. A method of converting linoleic acid to arachidonic acid and a cassette and recombinant plasmid comprising nucleic acid sequences for the above methods are also provided. | ||||||
| 2 | SYNTHESIS OF LONG-CHAIN POLYUNSATURATED FATTY ACIDS BY RECOMBINANT CELL | US15642207 | 2017-07-05 | US20180119184A1 | 2018-05-03 | Surinder Pal Singh; Stanley Suresh Robert; Peter David Nichols; Susan Irene Ellis Blackburn; Xue-Rong Zhou; James Robertson Petrie; Allan Graham Green |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desatorase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
| 3 | SYNTHESIS OF LONG-CHAIN POLYUNSATURATED FATTY ACIDS BY RECOMBINANT CELL | US15274454 | 2016-09-23 | US20170073712A1 | 2017-03-16 | Surinder Pal Singh; Stanley Suresh Robert; Peter David Nichols; Susan Irene Ellis Blackburn; Xue-Rong Zhou; James Robertson Petrie; Allan Graham Green |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desatorase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
| 4 | SYNTHESIS OF LONG-CHAIN POLYUNSATURATED FATTY ACIDS BY RECOMBINANT CELLS | US13093252 | 2011-04-25 | US20110201065A1 | 2011-08-18 | Surinder Pal Singh; Stanley Suresh Robert; Peter David Nichols; Susan Irene Ellis Blackburn; Xue-Rong Zhou; James Robertson Petrie; Allan Graham Green |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
| 5 | Synthesis of long-chain polyunsaturated fatty acids by recombinant cell | US15274454 | 2016-09-23 | US09951357B2 | 2018-04-24 | Surinder Pal Singh; Stanley Suresh Robert; Peter David Nichols; Susan Irene Ellis Blackburn; Xue-Rong Zhou; James Robertson Petrie; Allan Graham Green |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desatorase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
| 6 | Synthesis of long-chain polyunsaturated fatty acids by recombinant cell | US15644647 | 2017-07-07 | US09926579B2 | 2018-03-27 | Surinder Pal Singh; Stanley Suresh Robert; Peter David Nichols; Susan Irene Ellis Blackburn; Xue-Rong Zhou; James Robertson Petrie; Allan Graham Green |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desatorase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
| 7 | SYNTHESIS OF LONG-CHAIN POLYUNSATURATED FATTY ACIDS BY RECOMBINANT CELL | US15644647 | 2017-07-07 | US20170327852A1 | 2017-11-16 | Surinder Pal Singh; Stanley Suresh Robert; Peter David Nichols; Susan Irene Ellis Blackburn; Xue-Rong Zhou; James Robertson Petrie; Allan Graham Green |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desatorase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
| 8 | NOVEL FATTY ACID DESATURASES AND ELONGASES AND USES THEREOF | US15351962 | 2016-11-15 | US20170067070A1 | 2017-03-09 | Jörg Bauer; Johnathan A. Napier; Olga Sayanova |
| The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturases and elongases from the organism Emiliana huxleyi. The invention also provides recombinant expression vectors containing desaturase or elongase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g. arachidonic acid (ARA), eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). | ||||||
| 9 | Synthesis of long-chain polyunsaturated fatty acids by recombinant cell | US14323512 | 2014-07-03 | US09453183B2 | 2016-09-27 | Surinder Pal Singh; Stanley Suresh Robert; Peter David Nichols; Susan Irene Ellis Blackburn; Xue-Rong Zhou; James Robertson Petrie; Allan Graham Green |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desatorase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
| 10 | SYNTHESIS OF LONG-CHAIN POLYUNSATURATED FATTY ACIDS BY RECOMBINANT CELL | US14027727 | 2013-09-16 | US20140011247A1 | 2014-01-09 | Surinder Pal Singh; Stanley Suresh Robert; Peter David Nichols; Susan Irene Ellis Blackburn; Xue-Rong Zhou; James Robertson Petrie; Allan Graham Green |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desatorase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
| 11 | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells | US13448107 | 2012-04-16 | US08535917B2 | 2013-09-17 | Surinder Pal Singh; Stanley Suresh Robert; Peter David Nichols; Susan Irene Ellis Blackburn; Xue-Rong Zhou; James Robertson Petrie; Allan Graham Green |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desatorase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
| 12 | SYNTHESIS OF LONG-CHAIN POLYUNSATURATED FATTY ACIDS BY RECOMBINANT CELLS | US13448107 | 2012-04-16 | US20120215018A1 | 2012-08-23 | Surinder Pal Singh; Stanley Suresh Robert; Peter David Nichols; Susan Irene Ellis Blackburn; Xue-Rong Zhou; James Robertson Petrie; Allan Graham Green |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desatorase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
| 13 | NOVEL FATTY ACID DESATURASES AND ELONGASES AND USES THEREOF | US13384277 | 2010-07-15 | US20120124705A1 | 2012-05-17 | Jörg Bauer; Johnathan A. Napier; Olga Sayanova |
| The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturases and elongases from the organism Emiliana huxleyi. The invention also provides recombinant expression vectors containing desaturase or elongase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g. arachidonic acid (ARA), eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). | ||||||
| 14 | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells | US13311240 | 2011-12-05 | US08158392B1 | 2012-04-17 | Surinder Pal Singh; Stanley Suresh Robert; Peter David Nichols; Susan Irene Ellis Blackburn; Xue-Rong Zhou; James Robertson Petrie; Allan Graham Green |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
| 15 | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells | US12945708 | 2010-11-12 | US07932438B2 | 2011-04-26 | Surinder Pal Singh; Stanley Suresh Robert; Peter David Nichols; Susan Irene Ellis Blackburn; Xue-Rong Zhou; James Robertson Petrie; Allan Graham Green |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
| 16 | Synthesis of long-chain polyunsaturated fatty acids by recombinant cell | US15661768 | 2017-07-27 | US09994880B2 | 2018-06-12 | Surinder Pal Singh; Stanley Suresh Robert; Peter David Nichols; Susan Irene Ellis Blackburn; Xue-Rong Zhou; James Robertson Petrie; Allan Graham Green |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desatorase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
| 17 | Synthesis of long-chain polyunsaturated fatty acids by recombinant cell | US15644656 | 2017-07-07 | US09970033B2 | 2018-05-15 | Surinder Pal Singh; Stanley Suresh Robert; Peter David Nichols; Susan Irene Ellis Blackburn; Xue-Rong Zhou; James Robertson Petrie; Allan Graham Green |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desatorase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
| 18 | SYNTHESIS OF LONG-CHAIN POLYUNSATURATED FATTY ACIDS BY RECOMBINANT CELL | US15661768 | 2017-07-27 | US20170349921A1 | 2017-12-07 | Surinder Pal Singh; Stanley Suresh Robert; Peter David Nichols; Susan Irene Ellis Blackburn; Xue-Rong Zhou; James Robertson Petrie; Allan Graham Green |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desatorase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
| 19 | SYNTHESIS OF LONG-CHAIN POLYUNSATURATED FATTY ACIDS BY RECOMBINANT CELL | US15644656 | 2017-07-07 | US20170321234A1 | 2017-11-09 | Surinder Pal Singh; Stanley Suresh Robert; Peter David Nichols; Susan Irene Ellis Blackburn; Xue-Rong Zhou; James Robertson Petrie; Allan Graham Green |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desatorase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
| 20 | Fatty acid desaturases and elongases and uses thereof | US13384277 | 2010-07-15 | US09493520B2 | 2016-11-15 | Jörg Bauer; Johnathan A. Napier; Olga Sayanova |
| The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturases and elongases from the organism Emiliana huxleyi. The invention also provides recombinant expression vectors containing desaturase or elongase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g. arachidonic acid (ARA), eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). | ||||||
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