专利检索_ .2- 酮戊二酸作为一个供体并每一个氧原子结合到两个供体专利检索_ .2- 酮戊二酸作为一个供体并每一个氧原子结合到两个供体专利检索查询

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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
161	CHLOROPLAST TRANSIT PEPTIDE	EP13744103.6	2013-02-01	EP2809145A1	2014-12-10	LIRA, Justin M.; CICCHILLO, Robert M.; YERKES, Carla; ROBINSON, Andrew E.
The present disclosure relates to nucleic acid molecules encoding a having 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) activity and transgenic plants, cells or tissues containing the same.
162	BIOTECHNOLOGICAL PRODUCTION OF ALCOHOLS AND DERIVATIVES THEREOF	EP12812555.6	2012-12-14	EP2794850A1	2014-10-29	HAAS, Thomas; THUM, Oliver; PFEFFER, Jan Christoph; ENGEL, Philip; GEHRING, Christian; PÖTTER, Markus
The present invention relates to a microorganism having a reduced fatty acid degradation capacity and expressing a recombinant alkane oxidase, a method for oxidizing an alkyl, comprising a contacting the alkyl with an aqueous solution comprising the inventive cell.
163	PLANTS HAVING ENHANCED YIELD-RELATED TRAITS AND A METHOD FOR MAKING THE SAME	EP08767542.7	2008-05-02	EP2069509B1	2013-09-18	SANZ MOLINERO, Ana, Isabel; HATZFELD, Yves; VANDENABEELE, Steven; SHIRLEY, Amber; DARNIELLE, Lalitree; MCKERSIE, Bryan; FRANKARD, Valerie
The present invention relates generally to the field of molecular biology and concerns a method for enhancing yield-related traits and/or improving various plant growth characteristics by modulating expression in a plant of a nucleic acid encoding a GRP (Growth Regulating Protein). The GRP is selected from a LOB-domain comprising protein (LOB: Lateral Organ Boundaries), herein abbreviated as LBD polypeptide, a JMJC (JUMONJI-C) polypeptide, a CKI 10 (Casein Kinase I) polypeptide, a bHLH11-like (basic Helix-Loop-Helix 11) protein, a plant homeodomain finger-homeodomain (PHDf-HD) polypeptide, an ASR (abscisic acid-, stress-, and ripening-induced) polypeptide and/or a Squamosa promoter binding protein-like (SPL11) transcription factor polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding a GRP, which plants have improved growth characteristics relative to corresponding wild type plants or other control plants. The invention also provides novel GRP nucleic acids and GRP polypeptides as well as constructs useful in the methods of the invention.
164	Biotechnological production of alcohols and derivatives thereof	EP11195222.2	2011-12-22	EP2607479A1	2013-06-26	Haas, Thomas; Thum, Oliver; Pfeffer, Jan Christoph; Engel, Philip; Gehring, Christian; Pötter, Markus
The present invention relates to a microorganism having a reduced fatty acid degradation capacity and expressing a recombinant alkane oxidase, a method for oxidizing an alkyl, comprising a contacting the alkyl with an aqueous solution comprising the inventive cell.
165	Plants having enhanced yield-related traits and a method for making the same	EP10181988.6	2008-05-02	EP2316956A2	2011-05-04	Sanz Molinero, Ana Isabel
The present invention relates generally to the field of molecular biology and concerns a method for enhancing various economically important yield-related traits in plants. More specifically, the present invention concerns a method for enhancing yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a JMJC polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding a JMJC polypeptide, which plants have enhanced yield-related traits relative to control plants. The invention also provides constructs comprising JMJC nucleic acids, useful in performing the methods of the invention.
166	PLANTS HAVING ENHANCED YIELD-RELATED TRAITS AND A METHOD FOR MAKING THE SAME	EP08767542.7	2008-05-02	EP2069509A2	2009-06-17	SANZ MOLINERO, Ana, Isabel; HATZFELD, Yves; VANDENABEELE, Steven; SHIRLEY, Amber; DARNIELLE, Lalitree; MCKERSIE, Bryan; FRANKARD, Valerie
The present invention relates generally to the field of molecular biology and concerns a method for enhancing yield-related traits and/or improving various plant growth characteristics by modulating expression in a plant of a nucleic acid encoding a GRP (Growth Regulating Protein). The GRP is selected from a LOB-domain comprising protein (LOB: Lateral Organ Boundaries), herein abbreviated as LBD polypeptide, a JMJC (JUMONJI-C) polypeptide, a CKI 10 (Casein Kinase I) polypeptide, a bHLH11-like (basic Helix-Loop-Helix 11) protein, a plant homeodomain finger-homeodomain (PHDf-HD) polypeptide, an ASR (abscisic acid-, stress-, and ripening-induced) polypeptide and/or a Squamosa promoter binding protein-like (SPL11) transcription factor polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding a GRP, which plants have improved growth characteristics relative to corresponding wild type plants or other control plants. The invention also provides novel GRP nucleic acids and GRP polypeptides as well as constructs useful in the methods of the invention.
167	CAS9 PROTEINS INCLUDING LIGAND-DEPENDENT INTEINS	PCT/US2015042770	2015-07-30	WO2016022363A2	2016-02-11	LIU DAVID R; DAVIS KEVIN
Some aspects of this disclosure provide compositions, methods, systems, and kits for controlling the activity of RNA-programmable endonucleases, such as Cas9, or for controlling the activity of proteins comprising a Cas9 variant fused to a functional effector domain, such as a nuclease, nickase, recombinase, deaminase, transcriptional activator, transcriptional repressor, or epigenetic modifying domain. For example, the inventive proteins provided comprise a ligand-dependent intein, the presence of which inhibits one or more activities of the protein (e.g., gRNA binding, enzymatic activity, target DNA binding). The binding of a ligand to the intein results in self-excision of the intein, restoring the activity of the protein.
168	INCREASING SPECIFICITY FOR RNA-GUIDED GENOME EDITING	PCT/US2014029304	2014-03-14	WO2014144761A3	2015-10-29	JOUNG J KEITH; ANGSTMAN JAMES; SANDER JEFFRY D; MAEDER MORGAN; TSAI SHENGDAR
Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.
169	COMPOSITIONS AND METHODS FOR MODULATING IMMUNODEFICIENCY VIRUS TRANSCRIPTION	PCT/US2011054715	2011-10-04	WO2012047852A3	2012-06-21	OTT MELANIE; SAKANE NAOKI
The present disclosure provides methods of modulating immunodeficiency virus transcription, involving modulating enzymatic activity and/or levels of a lysine-specific demethylase-1 (LSD1) polypeptide and/or LSD1-mediated demethylation of methylated Tat. The present disclosure also provides method of identifying agents that modulate LSD1-mediated demethylation of a human immunodeficiency virus (HIV) Tat polypeptide.
170	USING RNA-GUIDED FOKI NUCLEASES (RFNS) TO INCREASE SPECIFICITY FOR RNA-GUIDED GENOME EDITING	EP14764159.1	2014-03-14	EP2971041B1	2018-11-28	JOUNG, J. Keith; TSAI, Shengdar
Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.
171	METHOD FOR PRODUCING HYDROXY-L-LYSINE EMPLOYING AN L-LYSINE HYDROXYLASE AND METHOD FOR PRODUCING HYDROXY-L-PIPECOLIC ACID	EP14754464	2014-02-18	EP2889378B1	2018-01-10	KINO KUNIKI; HARA RYOTARO; MIYAKE RYOMA; KAWABATA HIROSHI
The present invention aims to provide a method for efficiently producing hydroxy-L-lysine. The present invention provides a method for producing hydroxy-L-lysine, the method comprising allowing 2-oxoglutarate-dependent L-lysine hydroxylase, a cell containing 2-oxoglutarate-dependent L-lysine hydroxylase, a processed product of the cell, and/or a culture broth obtained by culturing the cell, to act on L-lysine to produce hydroxy-L-lysine represented by the following General Formula (I) (wherein each of R 1 , R 2 and R 3 represents a hydrogen atom or hydroxyl group, with the proviso that at least one of R 1 , R 2 and R 3 represents a hydroxyl group).
172	COMPOSITIONS FOR MODULATING CANCER STEM CELLS AND USES THEREFOR	EP15835730	2015-08-25	EP3185858A4	2017-12-27	RAO SUDHA; ZAFAR ANJUM
Disclosed are compositions and methods for modulating cancer stem cells. More particularly, the present invention discloses the use of lysine demethylase (LSD) inhibitors and protein kinase C theta inhibitors (PKC-θ) for inhibiting the growth of LSD- and/or PKC-θ-overexpressing cells including cancer stem cells, for enhancing the biological effects of chemotherapeutic drugs or irradiation on cancer cells, for treating cancer, including non-metastatic and metastatic cancer and/or for preventing cancer recurrence.
173	COMPOSITIONS FOR MODULATING CANCER STEM CELLS AND USES THEREFOR	EP15835730.1	2015-08-25	EP3185858A1	2017-07-05	RAO, Sudha; ZAFAR, Anjum
Disclosed are compositions and methods for modulating cancer stem cells. More particularly, the present invention discloses the use of lysine demethylase (LSD) inhibitors and protein kinase C theta inhibitors (PKC-θ) for inhibiting the growth of LSD- and/or PKC-θ-overexpressing cells including cancer stem cells, for enhancing the biological effects of chemotherapeutic drugs or irradiation on cancer cells, for treating cancer, including non-metastatic and metastatic cancer and/or for preventing cancer recurrence.
174	USING RNA-GUIDED FOKI NUCLEASES (RFNS) TO INCREASE SPECIFICITY FOR RNA-GUIDED GENOME EDITING	EP14764159	2014-03-14	EP2971041A4	2016-09-07	JOUNG J KEITH; TSAI SHENGDAR
Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.
175	RNA-GUIDED TARGETING OF GENETIC AND EPIGENOMIC REGULATORY PROTEINS TO SPECIFIC GENOMIC LOCI	EP14768877	2014-03-14	EP2970986A4	2016-09-07	JOUNG J KEITH; MAEDER MORGAN
Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.
176	USING TRUNCATED GUIDE RNAS (TRU-GRNAS) TO INCREASE SPECIFICITY FOR RNA-GUIDED GENOME EDITING	EP14763916	2014-03-14	EP2971125A4	2016-08-24	JOUNG J KEITH; SANDER JEFFRY D; FU YANFANG; MAEDER MORGAN

177	METHOD OF MANUFACTURING DIFFERENTIATED PLURIPOTENT STEM CELL	EP13851495	2013-10-29	EP2913396A4	2016-05-18	KATO HIDEMASA; MORIYAMA YOSUKE; HIRAKI KEIKO; OKUDA AKIHIKO
The present invention allows a TET1 protein to be more stably expressed in human pluripotent stem cells than in the past by, inter alia, substituting the second amino acid from the amino terminal of a TET1 protein with a different amino acid. Furthermore upon differentiation of said pluripotent stem cells, it is possible to quickly eliminate the expression of, inter alia, NANOG, which is an inhibitor of differentiation and promote the expression of factors related to differentiation by introducing a variant TET1 protein to a pluripotent stem cell. The present invention provides a method for manufacturing pluripotent stem cells with increased differentiation potential, and a substance that is useful to said method.
178	PRODUCTION METHOD FOR L-LYSINE HYDROXYLASE AND HYDROXY-L-LYSINE USING SAME, AND PRODUCTION METHOD FOR HYDROXY-L-PIPECOLIC ACID	EP14754464	2014-02-18	EP2889378A4	2016-03-09	KINO KUNIKI; HARA RYOTARO; MIYAKE RYOMA; KAWABATA HIROSHI
The present invention aims to provide a method for efficiently producing hydroxy-L-lysine. The present invention provides a method for producing hydroxy-L-lysine, the method comprising allowing 2-oxoglutarate-dependent L-lysine hydroxylase, a cell containing 2-oxoglutarate-dependent L-lysine hydroxylase, a processed product of the cell, and/or a culture broth obtained by culturing the cell, to act on L-lysine to produce hydroxy-L-lysine represented by the following General Formula (I) (wherein each of R 1 , R 2 and R 3 represents a hydrogen atom or hydroxyl group, with the proviso that at least one of R 1 , R 2 and R 3 represents a hydroxyl group).
179	INCREASING SPECIFICITY FOR RNA-GUIDED GENOME EDITING	EP14764117.9	2014-03-14	EP2970208A2	2016-01-20	JOUNG, J. Keith; ANGSTMAN, James; SANDER, Jeffry D.; MAEDER, Morgan; TSAI, Shengdar
Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems, using truncated guide RNAs (tru-gRNAs).
180	SYNTHETIC BRASSICA-DERIVED CHLOROPLAST TRANSIT PEPTIDES	EP13744313	2013-02-01	EP2809148A4	2015-12-09	LIRA JUSTIN M; CICCHILLO ROBERT M; YERKES CARLA; ROBINSON ANDREW E
The present disclosure relates to nucleic acid molecules encoding a having 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) activity and transgenic plants, cells or tissues containing the same.

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