专利检索_ .2- 酮戊二酸作为一个供体并每一个氧原子结合到两个供体专利检索_ .2- 酮戊二酸作为一个供体并每一个氧原子结合到两个供体专利检索查询

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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
141	CHLOROPLAST TRANSIT PEPTIDE	EP13744103	2013-02-01	EP2809145A4	2015-09-16	LIRA JUSTIN M; CICCHILLO ROBERT M; YERKES CARLA; ROBINSON ANDREW E
The present disclosure relates to nucleic acid molecules encoding a having 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) activity and transgenic plants, cells or tissues containing the same.
142	SYNTHETIC CHLOROPLAST TRANSIT PEPTIDES	EP13743027	2013-02-01	EP2809142A4	2015-09-16	LIRA JUSTIN M; CICCHILLO ROBERT M; YERKES CARLA; ROBINSON ANDREW E
The present disclosure relates to nucleic acid molecules encoding a having 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) activity and transgenic plants, cells or tissues containing the same.
143	GLYPHOSATE RESISTANT PLANTS AND ASSOCIATED METHODS	EP13744288	2013-02-01	EP2809147A4	2015-08-05	LIRA JUSTIN M; CICCHILLO ROBERT M; YERKES CARLA; ROBINSON ANDREW E
The present disclosure relates to nucleic acid molecules encoding a having 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) activity and transgenic plants, cells or tissues containing the same.
144	PRODUCTION METHOD FOR L-LYSINE HYDROXYLASE AND HYDROXY-L-LYSINE USING SAME, AND PRODUCTION METHOD FOR HYDROXY-L-PIPECOLIC ACID	EP14754464.7	2014-02-18	EP2889378A1	2015-07-01	KINO, Kuniki; HARA, Ryotaro; MIYAKE, Ryoma; KAWABATA, Hiroshi
The present invention aims to provide a method for efficiently producing hydroxy-L-lysine. The present invention provides a method for producing hydroxy-L-lysine, the method comprising allowing 2-oxoglutarate-dependent L-lysine hydroxylase, a cell containing 2-oxoglutarate-dependent L-lysine hydroxylase, a processed product of the cell, and/or a culture broth obtained by culturing the cell, to act on L-lysine to produce hydroxy-L-lysine represented by the following General Formula (I) (wherein each of R¹, R² and R³ represents a hydrogen atom or hydroxyl group, with the proviso that at least one of R¹, R² and R³ represents a hydroxyl group).
145	GLYPHOSATE RESISTANT PLANTS AND ASSOCIATED METHODS	EP13744288.5	2013-02-01	EP2809147A1	2014-12-10	LIRA, Justin M.; CICCHILLO, Robert M.; YERKES, Carla; ROBINSON, Andrew E.
The present disclosure relates to nucleic acid molecules encoding a having 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) activity and transgenic plants, cells or tissues containing the same.
146	Plants having enhanced yield-related traits and a method for making the same	EP11192693.7	2008-05-02	EP2505652A1	2012-10-03	Sanz Molinero, Ana Isabel; Hatzfeld, Yves; Vandenabeele, Steven; Shirley, Amber; Darnielle, Lalitree; McKersie, Bryan; Frankard, Valerie
The present invention relates generally to the field of molecular biology and concerns a method for enhancing yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a plant homeodomain finger-homeodomain (PHDf-HD) polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding a PHDf-HD, which plants have enhanced yield-related traits relative to corresponding wild type plants or other control plants. The invention also provides constructs useful in the methods of the invention.
147	Plants having enhanced yield-related traits and a method for making the same	EP09178578.2	2008-05-02	EP2230310A1	2010-09-22	Hatzfeld, Yves; Sanz Molinero, Ana Isabel; Shirley, Amber; Darnielle, Lalitree; Frankard, Valerie; Vandenabeele, Steven; McKersie, Bryan
The present invention relates generally to the field of molecular biology and concerns a method for enhancing yield-related traits and/or improving various plant growth characteristics by modulating expression in a plant of a nucleic acid encoding a GRP (Growth Regulating Protein). The GRP is selected from a LOB-domain comprising protein (LOB: Lateral Organ Boundaries), herein abbreviated as LBD polypeptide, a JMJC (JUMONJI-C) polypeptide, a CKI 10 (Casein Kinase I) polypeptide, a bHLH11-like (basic Helix-Loop-Helix 11) protein, a plant homeodomain finger-homeodomain (PHDf-HD) polypeptide, an ASR (abscisic acid-, stress-, and ripening-induced) polypeptide and/or a Squamosa promoter binding protein-like (SPL11) transcription factor polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding a GRP, which plants have improved growth characteristics relative to corresponding wild type plants or other control plants. The invention also provides novel GRP nucleic acids and GRP polypeptides as well as constructs useful in the methods of the invention.
148	Plants having enhanced yield-related traits and a method for making the same	EP09178941.2	2008-05-02	EP2228386A1	2010-09-15	Hatzfeld, Yves; Sanz Molinero, Ana Isabel; Shirley, Amber; Darnielle, Lalitree; Frankard, Valerie; Vandenabeele, Steven; McKersie, Bryan
The present invention relates generally to the field of molecular biology and concerns a method for enhancing yield-related traits and/or improving various plant growth characteristics by modulating expression in a plant of a nucleic acid encoding a GRP (Growth Regulating Protein). The GRP is selected from a LOB-domain comprising protein (LOB: Lateral Organ Boundaries), herein abbreviated as LBD polypeptide, a JMJC (JUMONJI-C) polypeptide, a CKI 10 (Casein Kinase I) polypeptide, a bHLH11-like (basic Helix-Loop-Helix 11) protein, a plant homeodomain finger-homeodomain (PHDf-HD) polypeptide, an ASR (abscisic acid-, stress-, and ripening-induced) polypeptide and/or a Squamosa promoter binding protein-like (SPL11) transcription factor polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding a GRP, which plants have improved growth characteristics relative to corresponding wild type plants or other control plants. The invention also provides novel GRP nucleic acids and GRP polypeptides as well as constructs useful in the methods of the invention.
149	MICROORGANISM ABLE TO PRODUCE L-AMINO ACID, AND METHOD FOR PRODUCING L-AMINO ACID BY USING SAME	PCT/KR2013000072	2013-01-07	WO2013103268A3	2013-09-19	CHEONG KI YONG; LEE SEOK MYUNG; HWANG YOUNG BIN; LEE KEUN CHEOL; LEE KWANG HO
The present invention relates to a microorganism able to produce L-threonine or L-tryptophan, and to a method for producing L-threonine or L-tryptophan by using same. More specifically, the present invention relates to: recombinant Escherichia coli which is more efficient in producing L-threonine or L-tryptophan by increasing the ability to produce ATP which is used as the most plentiful energy source in cells when producing L-threonine or L-tryptophan; and a method for producing L-threonine or L-tryptophan by using same.
150	PLANTS HAVING ENHANCED YIELD-RELATED TRAITS AND A METHOD FOR MAKING THE SAME	PCT/US2008005732	2008-05-02	WO2008137108A2	2008-11-13	SANZ MOLINERO ANA ISABEL; HATZFELD YVES; VANDENABEELE STEVEN; SHIRLEY AMBER; DARNIELLE LALITREE; MCKERSIE BRYAN; FRANKARD VALERIE
The present invention relates generally to the field of molecular biology and concerns a method for enhancing yield-related traits and/or improving various plant growth characteristics by modulating expression in a plant of a nucleic acid encoding a GRP (Growth Regulating Protein). The GRP is selected from a LOB-domain comprising protein (LOB: Lateral Organ Boundaries), herein abbreviated as LBD polypeptide, a JMJC (JUMONJI-C) polypeptide, a CKI (Casein Kinase I) polypeptide, a bHLH11-like (basic Helix-Loop-Helix 11 ) protein, a plant homeodomain finger-homeodomain (PHDf-HD) polypeptide, an ASR (abscisic acid-, stress-, and ripening-induced) polypeptide and/or a Squamosa promoter binding protein-like 1 1 (SPL11 ) transcription factor polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding a GRP, which plants have improved growth characteristics relative to corresponding wild type plants or other control plants. The invention also provides novel GRP nucleic acids and GRP polypeptides as well as constructs useful in the methods of the invention.
151	CAS9 PROTEINS INCLUDING LIGAND-DEPENDENT INTEINS	EP15830407	2015-07-30	EP3177718A4	2018-04-04	LIU DAVID R; DAVIS KEVIN
Some aspects of this disclosure provide compositions, methods, systems, and kits for controlling the activity of RNA-programmable endonucleases, such as Cas9, or for controlling the activity of proteins comprising a Cas9 variant fused to a functional effector domain, such as a nuclease, nickase, recombinase, deaminase, transcriptional activator, transcriptional repressor, or epigenetic modifying domain. For example, the inventive proteins provided comprise a ligand-dependent intein, the presence of which inhibits one or more activities of the protein (e.g., gRNA binding, enzymatic activity, target DNA binding). The binding of a ligand to the intein results in self-excision of the intein, restoring the activity of the protein.
152	METHODS RELATING TO THE PREVENTION AND TREATMENT OF DRUG RESISTANCE	EP16796971	2016-05-12	EP3294313A1	2018-03-21	WHETSTINE JOHNATHAN R
Described herein are methods, assays, and compositions relating to the treatment and/or prevention of drug-resistance, e.g, by inhibiting the activity of KDM4A-like enzymes.
153	VECTORS AND METHODS FOR REGENERATIVE THERAPY	EP16783775	2016-04-20	EP3285871A1	2018-02-28	MACLELLAN W ROBB; EL-NACHEF DANNY
An expression vector capable of disrupting the silencing of cell cycle genes in adult cells, such as adult cardiac myocytes and other quiescent cells in terminally differentiated tissues, comprising: (a) a nucleic acid sequence encoding lysine-specific demethylase 4D (KDM4D); (b) a promoter that induces or effects overexpression of KDM4D, wherein the promoter is operably linked to the nucleic acid sequence; and (c) a regulatory element that inducibly represses the overexpression of KDM4D. The vector can be administered to a subject in a method for inducing tissue-specific hyperplasia in a mammal, including cardiomyocyte proliferation. The method provides for regenerative therapy, including improving cardiac function after myocardial infarct and other forms of cardiac damage.
154	METHODS AND COMPOSITIONS FOR DISCRIMINATION BETWEEN CYTOSINE AND MODIFICATIONS THEREOF, AND FOR METHYLOME ANALYSIS	EP16185577.0	2013-03-14	EP3124605A1	2017-02-01	VAISVILA, Romualdas; JOHNSON, Heidi Erika; VAINAUSKAS, Saulius; DAVIS, Theodore B.
Compositions and methods are provided for discrimination between cytosine and modifications thereof using cytidine deaminases. Variants of wild type cytidine deaminases are described which show reduced bias with respect to adjacent nucleotides upstream of the cytosine. The methods provide a rapid and convenient use of enzymes to obtain methylomes.
155	METHODS AND COMPOSITIONS FOR DISCRIMINATION BETWEEN CYTOSINE AND MODIFICATIONS THEREOF, AND FOR METHYLOME ANALYSIS	EP13715047.0	2013-03-14	EP2825645B1	2016-10-12	VAISVILA, Romualdas; JOHNSON, Heidi, Erika; VAINAUSKAS, Saulius; DAVIS, Theodore B.
Compositions and methods are provided for discrimination between cytosine and modifications thereof using cytidine deaminases. Variants of wild type cytidine deaminases are described which show reduced bias with respect to adjacent nucleotides upstream of the cytosine. The methods provide a rapid and convenient use of enzymes to obtain methylomes.
156	BIOLOGICAL METHOD FOR PRODUCING CIS-5-HYDROXY-L-PIPECOLINIC ACID	EP13804143	2013-06-12	EP2873730A4	2016-05-11	FUJII TADASHI; TAMURA KEISUKE
The present invention provides a method for producing cis-5-hydroxy-L-pipecolic acid. In the production method of the present invention, a gene recombinant microorganism enabling direct production of cis-5-hydroxy-L-pipecolic acid can be used. The present invention also provides such a gene recombinant microorganism. A preferred embodiment of the present invention is characterized in that a gene recombinant microorganism having DNAs encoding proteins involved in the biosynthesis of L-pipecolic acid and a DNA encoding a protein having the L-pipecolic acid cis-5-hydroxylase activity is cultured in a medium, and cis-5-hydroxy-L-pipecolic acid is collected from the medium.
157	USING RNA-GUIDED FOKI NUCLEASES (RFNS) TO INCREASE SPECIFICITY FOR RNA-GUIDED GENOME EDITING	EP14764159.1	2014-03-14	EP2971041A1	2016-01-20	JOUNG, J. Keith; TSAI, Shengdar
Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems, using truncated guide RNAs (tru-gRNAs).
158	MICROORGANISM ABLE TO PRODUCE L-AMINO ACID, AND METHOD FOR PRODUCING L-AMINO ACID BY USING SAME	EP13733718	2013-01-07	EP2801611A4	2015-10-28	CHEONG KI YONG; LEE SEOK MYUNG; HWANG YOUNG BIN; LEE KEUN CHEOL; LEE KWANG HO
The present invention relates to a microorganism able to produce L-threonine or L-tryptophan, and to a method for producing L-threonine or L-tryptophan by using same. More specifically, the present invention relates to: recombinant Escherichia coli which is more efficient in producing L-threonine or L-tryptophan by increasing the ability to produce ATP which is used as the most plentiful energy source in cells when producing L-threonine or L-tryptophan; and a method for producing L-threonine or L-tryptophan by using same.
159	Plants having enhanced yield-related traits and a method for making the same	EP10181988.6	2008-05-02	EP2316956B1	2015-04-22	Sanz Molinero, Ana Isabel
The present invention relates generally to the field of molecular biology and concerns a method for enhancing yield-related traits and/or improving various plant growth characteristics by modulating expression in a plant of a nucleic acid encoding a GRP (Growth Regulating Protein). The GRP is selected from a LOB-domain comprising protein (LOB: Lateral Organ Boundaries), herein abbreviated as LBD polypeptide, a JMJC (JUMONJI-C) polypeptide, a CKI 10 (Casein Kinase I) polypeptide, a bHLH11-like (basic Helix-Loop-Helix 11) protein, a plant homeodomain finger-homeodomain (PHDf-HD) polypeptide, an ASR (abscisic acid-, stress-, and ripening-induced) polypeptide and/or a Squamosa promoter binding protein-like (SPL11) transcription factor polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding a GRP, which plants have improved growth characteristics relative to corresponding wild type plants or other control plants. The invention also provides novel GRP nucleic acids and GRP polypeptides as well as constructs useful in the methods of the invention.
160	Plants having enhanced yield-related traits and a method for making the same	EP09178941.2	2008-05-02	EP2228386B1	2015-03-18	Hatzfeld, Yves; Sanz Molinero, Ana Isabel; Shirley, Amber; Darnielle, Lalitree; Frankard, Valerie; Vandenabeele, Steven; McKersie, Bryan
The present invention relates generally to the field of molecular biology and concerns a method for enhancing yield-related traits and/or improving various plant growth characteristics by modulating expression in a plant of a nucleic acid encoding a GRP (Growth Regulating Protein). The GRP is selected from a LOB-domain comprising protein (LOB: Lateral Organ Boundaries), herein abbreviated as LBD polypeptide, a JMJC (JUMONJI-C) polypeptide, a CKI 10 (Casein Kinase I) polypeptide, a bHLH11-like (basic Helix-Loop-Helix 11) protein, a plant homeodomain finger-homeodomain (PHDf-HD) polypeptide, an ASR (abscisic acid-, stress-, and ripening-induced) polypeptide and/or a Squamosa promoter binding protein-like (SPL11) transcription factor polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding a GRP, which plants have improved growth characteristics relative to corresponding wild type plants or other control plants. The invention also provides novel GRP nucleic acids and GRP polypeptides as well as constructs useful in the methods of the invention.

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