| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 具有修饰的生物碱含量的大红罂粟 | CN201280073863.0 | 2012-04-30 | CN104487576A | 2015-04-01 | 贾斯廷·泰勒·库姆斯; 贾罗德·戴维·里奇; 马克·阿尔弗雷德·特斯特; 达明·莱特富特; 迪帕·杰哈 |
| 本发明涉及遗传修饰的大红罂粟(Papaver bracteatum)物种植物，其中由所述植物产生一种或多种生物碱的类型或量已被改变。具体地，相对于野生型大红罂粟(P.bracteatum)，所述遗传修饰的植物具有蒂巴因6-O-脱甲基酶、可待因O-脱甲基酶和/或可待因酮还原酶中的一种或多种的增加的表达，从而使所述遗传修饰的罂粟植物相对于野生型大红罂粟产生增加量的选自可待因、东罂粟碱和/或吗啡的生物碱。还提供以上述遗传修饰的罂粟植物作为亲本的子代植物；上述植物的突变体或衍生植物；来源于上述植物的繁殖材料，由上述植物产生的秆，由上述植物产生的秆浓缩物，来源于上述植物的胶乳，或来源于上述植物的一种或多种分离的细胞。还提供由上述植物产生生物碱的方法以及6-O-脱甲基酶和可待因O-脱甲基酶基因的核酸和氨基酸序列变体。 | ||||||
| 2 | PAPAVER BRACTEATUM WITH MODIFIED ALKALOID CONTENT | US13834979 | 2013-03-15 | US20140013465A1 | 2014-01-09 | Justin Taylor Coombs; Jarrod David Ritchie; Mark Alfred Tester; Damien Lightfoot; Deepa Jha |
| The present invention relates to genetically modified plants of the species Papaver bracteatum wherein the type or amount of one or more alkaloids produced by the plants has been modified. Specifically, the genetically modified plants have an increased expression of one or more of thebaine 6-O-demethylase, codeine O-demethylase and/or codeinone reductase relative to wild type P. bracteatum such that the genetically modified poppy plants produce an increased quantity of an alkaloid selected from codeine, oripavine and/or morphine relative to a wild type P. bracteatum. Also provided are progeny plants having the genetically modified poppy plants described above as a parent; mutant or derivative plants of the aforementioned plants; reproductive material derived from, straw produced from, straw concentrate produced from, latex derived from, or one or more isolated cells derived from, the aforementioned plants. Methods for producing an alkaloid from the aforementioned plants are also provided, together with nucleic acid and amino acid sequence variants of the 6-O-demethylase and codeine O-demethylase genes. | ||||||
| 3 | PAPAVER BRACTEATUM WITH MODIFIED ALKALOID CONTENT | EP11837323 | 2011-10-31 | EP2635107A4 | 2014-04-23 | COOMBS JUSTIN TAYLOR; RITCHIE JARROD DAVID; TESTER MARK ALFRED; LIGHTFOOT DAMIEN; JHA DEEPA |
| 4 | PAPAVER BRACTEATUM WITH MODIFIED ALKALOID CONTENT | EP11837323.2 | 2011-10-31 | EP2635107A1 | 2013-09-11 | COOMBS, Justin, Taylor; RITCHIE, Jarrod, David; TESTER, Mark, Alfred; LIGHTFOOT, Damien; JHA, Deepa |
| The present invention relates to genetically modified plants of the species Papaver bracteatum wherein the type or amount of one or more alkaloids produced by the plants has been modified. Specifically, the genetically modified plants have an increased expression of one or more of thebaine 6-O-demethylase, codeine O- demethylase and/or codeinone reductase relative to wild type P. bracteatum such that the genetically modified poppy plants produce an increased quantity of an alkaloid selected from codeine, oripavine and/or morphine relative to a wild type P. bracteatum. Also provided are progeny plants having the genetically modified poppy plants described above as a parent; mutant or derivative plants of the aforementioned plants; reproductive material derived from, straw produced from, straw concentrate produced from, latex derived from, or one or more isolated cells derived from, the aforementioned plants. Methods for producing an alkaloid from the aforementioned plants are also provided, together with nucleic acid and amino acid sequence variants of the 6-O-demethylase and codeine O-demethylase genes. | ||||||
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