专利检索_ .2- 酮戊二酸作为一个供体并每一个氧原子结合到两个供体专利检索_ .2- 酮戊二酸作为一个供体并每一个氧原子结合到两个供体专利检索查询

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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
181	NOVEL METHOD	EP13808199.7	2013-12-17	EP2931881A1	2015-10-21	REIK, Wolf; PEAT, Julian; HORE, Timothy; KRUEGER, Christel
The invention relates to a method of enhancing the potency of a cell (for example, to a totipotent state), by introducing a TET family gene, derivative or fragment thereof into the cell. The invention also relates to methods and kits for preparing cells with enhanced potency, and uses of said cells.
182	NOVEL CLASS OF GLYPHOSATE RESISTANCE GENES	EP13743493	2013-02-01	EP2809144A4	2015-10-21	LIRA JUSTIN M; CICCHILLO ROBERT M; NAIR SATISH K
The present disclosure relates to nucleic acid molecules encoding a having 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) activity and transgenic plants, cells or tissues containing the same.
183	Plants having enhanced yield-related traits and a method for making the same	EP11192693.7	2008-05-02	EP2505652B1	2015-10-14	Sanz Molinero, Ana Isabel; Hatzfeld, Yves; Vandenabeele, Steven; Shirley, Amber; Darnielle, Lalitree; McKersie, Bryan; Frankard, Valerie
The present invention relates generally to the field of molecular biology and concerns a method for enhancing yield-related traits and/or improving various plant growth characteristics by modulating expression in a plant of a nucleic acid encoding a GRP (Growth Regulating Protein). The GRP is selected from a LOB-domain comprising protein (LOB: Lateral Organ Boundaries), herein abbreviated as LBD polypeptide, a JMJC (JUMONJI-C) polypeptide, a CKI 10 (Casein Kinase I) polypeptide, a bHLH11-like (basic Helix-Loop-Helix 11) protein, a plant homeodomain finger-homeodomain (PHDf-HD) polypeptide, an ASR (abscisic acid-, stress-, and ripening-induced) polypeptide and/or a Squamosa promoter binding protein-like (SPL11) transcription factor polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding a GRP, which plants have improved growth characteristics relative to corresponding wild type plants or other control plants. The invention also provides novel GRP nucleic acids and GRP polypeptides as well as constructs useful in the methods of the invention.
184	METHOD OF MANUFACTURING DIFFERENTIATED PLURIPOTENT STEM CELL	EP13851495.5	2013-10-29	EP2913396A1	2015-09-02	KATO, Hidemasa; MORIYAMA, Yosuke; HIRAKI, Keiko; OKUDA, Akihiko
The present invention allows a TET1 protein to be more stably expressed in human pluripotent stem cells than in the past by, inter alia, substituting the second amino acid from the amino terminal of a TET1 protein with a different amino acid. Furthermore upon differentiation of said pluripotent stem cells, it is possible to quickly eliminate the expression of, inter alia, NANOG, which is an inhibitor of differentiation and promote the expression of factors related to differentiation by introducing a variant TET1 protein to a pluripotent stem cell. The present invention provides a method for manufacturing pluripotent stem cells with increased differentiation potential, and a substance that is useful to said method.
185	BIOLOGICAL METHOD FOR PRODUCING CIS-5-HYDROXY-L-PIPECOLINIC ACID	EP13804143.9	2013-06-12	EP2873730A1	2015-05-20	FUJII, Tadashi; TAMURA, Keisuke
The present invention provides a method for producing cis-5-hydroxy-L-pipecolic acid. In the production method of the present invention, a gene recombinant microorganism enabling direct production of cis-5-hydroxy-L-pipecolic acid can be used. The present invention also provides such a gene recombinant microorganism. A preferred embodiment of the present invention is characterized in that a gene recombinant microorganism having DNAs encoding proteins involved in the biosynthesis of L-pipecolic acid and a DNA encoding a protein having the L-pipecolic acid cis-5-hydroxylase activity is cultured in a medium, and cis-5-hydroxy-L-pipecolic acid is collected from the medium.
186	METHODS AND COMPOSITIONS FOR DISCRIMINATION BETWEEN CYTOSINE AND MODIFICATIONS THEREOF, AND FOR METHYLOME ANALYSIS	EP13715047.0	2013-03-14	EP2825645A2	2015-01-21	VAISVILA, Romualdas; JOHNSON, Heidi, Erika; VAINAUSKAS, Saulius; DAVIS, Theodore B.
Compositions and methods are provided for discrimination between cytosine and modifications thereof using cytidine deaminases. Variants of wild type cytidine deaminases are described which show reduced bias with respect to adjacent nucleotides upstream of the cytosine. The methods provide a rapid and convenient use of enzymes to obtain methylomes.
187	SYNTHETIC BRASSICA-DERIVED CHLOROPLAST TRANSIT PEPTIDES	EP13744313.1	2013-02-01	EP2809148A1	2014-12-10	LIRA, Justin, M.; CICCHILLO, Robert, M.; YERKES, Carla; ROBINSON, Andrew, E.
The present disclosure relates to nucleic acid molecules encoding a having 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) activity and transgenic plants, cells or tissues containing the same.
188	GLYPHOSATE RESISTANT PLANTS AND ASSOCIATED METHODS	EP13743263.9	2013-02-01	EP2809143A1	2014-12-10	LIRA, Justin M.; CICCHILLO, Robert M.; YERKES, Carla; ROBINSON, Andrew E.
The present disclosure relates to nucleic acid molecules encoding a having 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) activity and transgenic plants, cells or tissues containing the same.
189	SYNTHETIC CHLOROPLAST TRANSIT PEPTIDES	EP13743027.8	2013-02-01	EP2809142A1	2014-12-10	LIRA, Justin M.; CICCHILLO, Robert M.; YERKES, Carla; ROBINSON, Andrew E.
The present disclosure relates to nucleic acid molecules encoding a having 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) activity and transgenic plants, cells or tissues containing the same.
190	MICROORGANISM ABLE TO PRODUCE L-AMINO ACID, AND METHOD FOR PRODUCING L-AMINO ACID BY USING SAME	EP13733718.4	2013-01-07	EP2801611A2	2014-11-12	CHEONG, Ki Yong; LEE, Seok Myung; HWANG, Young Bin; LEE, Keun Cheol; LEE, Kwang Ho
The present invention relates to a microorganism able to produce L-threonine or L-tryptophan, and to a method for producing L-threonine or L-tryptophan by using same. More specifically, the present invention relates to: recombinant Escherichia coli which is more efficient in producing L-threonine or L-tryptophan by increasing the ability to produce ATP which is used as the most plentiful energy source in cells when producing L-threonine or L-tryptophan; and a method for producing L-threonine or L-tryptophan by using same.
191	Plants having enhanced yield-related traits and a method for making the same	EP09178578.2	2008-05-02	EP2230310B1	2013-01-16	Hatzfeld, Yves; Sanz Molinero, Ana Isabel; Shirley, Amber; Darnielle, Lalitree; Frankard, Valerie; Vandenabeele, Steven; McKersie, Bryan
The present invention relates generally to the field of molecular biology and concerns a method for enhancing yield-related traits and/or improving various plant growth characteristics by modulating expression in a plant of a nucleic acid encoding a GRP (Growth Regulating Protein). The GRP is selected from a LOB-domain comprising protein (LOB: Lateral Organ Boundaries), herein abbreviated as LBD polypeptide, a JMJC (JUMONJI-C) polypeptide, a CKI 10 (Casein Kinase I) polypeptide, a bHLH11-like (basic Helix-Loop-Helix 11) protein, a plant homeodomain finger-homeodomain (PHDf-HD) polypeptide, an ASR (abscisic acid-, stress-, and ripening-induced) polypeptide and/or a Squamosa promoter binding protein-like (SPL11) transcription factor polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding a GRP, which plants have improved growth characteristics relative to corresponding wild type plants or other control plants. The invention also provides novel GRP nucleic acids and GRP polypeptides as well as constructs useful in the methods of the invention.
192	Plants having enhanced yield-related traits and a method for making the same	EP10181988.6	2008-05-02	EP2316956A3	2011-08-24	Sanz Molinero, Ana Isabel
The present invention relates generally to the field of molecular biology and concerns a method for enhancing various economically important yield-related traits in plants. More specifically, the present invention concerns a method for enhancing yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a JMJC polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding a JMJC polypeptide, which plants have enhanced yield-related traits relative to control plants. The invention also provides constructs comprising JMJC nucleic acids, useful in performing the methods of the invention.
193	CAS9 PROTEINS INCLUDING LIGAND-DEPENDENT INTEINS	PCT/US2015042770	2015-07-30	WO2016022363A3	2016-05-26	LIU DAVID R; DAVIS KEVIN
Some aspects of this disclosure provide compositions, methods, systems, and kits for controlling the activity of RNA-programmable endonucleases, such as Cas9, or for controlling the activity of proteins comprising a Cas9 variant fused to a functional effector domain, such as a nuclease, nickase, recombinase, deaminase, transcriptional activator, transcriptional repressor, or epigenetic modifying domain. For example, the inventive proteins provided comprise a ligand-dependent intein, the presence of which inhibits one or more activities of the protein (e.g., gRNA binding, enzymatic activity, target DNA binding). The binding of a ligand to the intein results in self-excision of the intein, restoring the activity of the protein.
194	RNA-GUIDED TARGETING OF GENETIC AND EPIGENOMIC REGULATORY PROTEINS TO SPECIFIC GENOMIC LOCI	PCT/US2014027335	2014-03-14	WO2014152432A3	2015-10-29	JOUNG J KEITH; MAEDER MORGAN
Methods and constructs for RNA-guided targeting of heterologous functional domains such as transcriptional activators to specific genomic loci. This invention relates to methods and constructs for RNA-guided targeting of genetic and epigenomic regulatory proteins, e.g., transcriptional activators, histone modification enzymes, DNA methylation modifiers, to specific genomic loci. At least in part, the present invention is based on the development of a fusion protein including a heterologous functional domain (e.g., a transcriptional activation domain) fused to a Cas9 nuclease that has had its nuclease activity inactivated by mutations (also known as "dCas9").
195	USING TRUNCATED GUIDE RNAS (TRU-GRNAS) TO INCREASE SPECIFICITY FOR RNA-GUIDED GENOME EDITING	PCT/US2014029068	2014-03-14	WO2014144592A3	2014-12-31	JOUNG J KEITH; SANDER JEFFRY D; FU YANFANG; MAEDER MORGAN
CRISPR-Cas genome editing uses a guide RNA, which includes both a complementarity region, which binds the target DNA by base- pairing, and a Cas9-binding region, to direct a Cas9 nuclease to a target DNA. Further disclosed are methods for increasing specificity of RNA-guided genome editing using CRISPR/Cas9 systems by using truncated guide RNAs (tru-gRNAs).
196	METHODS AND COMPOSITIONS FOR DISCRIMINATION BETWEEN CYTOSINE AND MODIFICATIONS THEREOF, AND FOR METHYLOME ANALYSIS	PCT/US2013031620	2013-03-14	WO2013138644A3	2013-11-07	VAISVILA ROMUALDAS; JOHNSON HEIDI ERIKA; VAINAUSKAS SAULIUS; DAVIS THEODORE B
Compositions and methods are provided for discrimination between cytosine and modifications thereof using cytidine deaminases and/or oxygenases. Variants of wild type cytidine deaminases are described which show reduced bias with respect to adjacent nucleotides upstream of the cytosine. The methods provide a rapid and convenient use of enzymes to obtain methylomes.

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