专利检索_ .2- 酮戊二酸作为一个供体并每一个氧原子结合到两个供体专利检索_ .2- 酮戊二酸作为一个供体并每一个氧原子结合到两个供体专利检索查询

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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
81	HERBICIDE-DETOXIFYING ENZYMES AND USES THEREOF	US16043477	2018-07-24	US20190024109A1	2019-01-24	Brian Thompson
Herbicide-detoxifying enzymes, compositions containing one or more of the enzymes, and plant seeds treated with the enzymes are provided. The enzymes can be used in methods for detoxifying auxin herbicides or degrading auxin plant regulators, including in methods for decontaminating surface of an apparatus used in agriculture or pesticide manufacturing, methods for decontaminating water, soil, soilless media, or sludge, and methods for protecting a plant from an auxin herbicide, improving a plant's tolerance to an auxin herbicide, or removing an auxin herbicide from the surface of a plant.
82	Using RNA-guided FokI Nucleases (RFNs) to Increase Specificity for RNA-Guided Genome Editing	US16003973	2018-06-08	US20180340189A1	2018-11-29	J. Keith Joung; Shengdar Tsai
Many studies have shown that CRISPR-Cas nucleases can tolerate up to five mismatches and still cleave; it is hard to predict the effects of any given single or combination of mismatches on activity. Taken together, these nucleases can show significant off-target effects but it can be challenging to predict these sites. Described herein are methods for increasing the specificity of genome editing using the CRISPR/Cas system, e.g., using RNA-guided Foki Nucleases (RFNs), e.g., FokI-Cas9 or Foki-dCas9-based fusion proteins.
83	DISEASE RESISTANT PLANTS	US15975670	2018-05-09	US20180320191A1	2018-11-08	Mireille Maria Augusta VAN DAMME; Augustinus Franciscus Johannes Maria VAN DEN ACKERVEKEN
The present invention relates to a plant, which is resistant to a pathogen of viral, bacterial, fungal or oomycete origin, wherein the plant has a reduced level, reduced activity or complete absence of DMR6 protein as compared to a plant that is not resistant to the said pathogen, in particular organisms of the Fungi or the phylum Oomycota. The invention further relates to a method for obtaining a plant, which is resistant to a pathogen of viral, bacterial, fungal or oomycete origin, comprising reducing the endogenous level or activity of DMR6 protein in the plant. In addition, the invention relates to the use of a DMR6 promotor for providing disease resistant plants.
84	Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing	US14775930	2014-03-14	US10119133B2	2018-11-06	J. Keith Joung; Jeffry D. Sander; Yan-fang Fu; Morgan Maeder
CRISPR-Cas genome editing uses a guide RNA, which includes both a complementarity region, which binds the target DNA by base-pairing, and a Cas9-binding region, to direct a Cas9 nuclease to a target DNA. Further disclosed are methods for increasing specificity of RNA-guided genome editing using CRISPR/Cas9 systems by using truncated guide RNAs (tru-gRNAs).
85	Compositions and Methods for Determining Modified Cytosines by Sequencing	US15771275	2016-10-28	US20180312914A1	2018-11-01	Romualdas Vaisvila; Zhiyi Sun; Shengxi Guan; Lana Saleh; Laurence Ettwiller; Theodore B. Davis
A method for identifying the location and phasing of modified cytosines (C) in long stretches of nucleic acids is provided. In some embodiments, the method may comprise (a) reacting a first portion of a nucleic acid sample containing at least one C and/or at least one modified C with a DNA glucosyltransferase and a cytidine deaminase to produce a first product and optionally reacting a second portion of the sample with a dioxygenase and a cytidine deaminase to produce a second product and; (b) comparing the sequences from the first and optionally the second product obtained in (a), or amplification products thereof, with each other and/or an untreated reference sequence to determine which Cs in the initial nucleic acid fragment are modified. A modified TET methylcytosine dioxygenase that is more efficient at converting methylcytosine to carboxymethylcytosine is also provided.
86	L-threonine and L-tryptophan producing bacteria strain and method of making same	US14370500	2013-01-07	US10041099B2	2018-08-07	Ki Yong Cheong; Seok Myung Lee; Young Bin Hwang; Keun Cheol Lee; Kwang Ho Lee
The present invention relates to a microorganism able to produce L-threonine or L-tryptophan, and to a method for producing L-threonine or L-tryptophan by using same. More specifically, the present invention relates to: recombinant Escherichia coli which is more efficient in producing L-threonine or L-tryptophan by increasing the ability to produce ATP which is used as the most plentiful energy source in cells when producing L-threonine or L-tryptophan; and a method for producing L-threonine or L-tryptophan by using same.
87	Compositions and Methods for Analyzing Modified Nucleotides	US15893373	2018-02-09	US20180171397A1	2018-06-21	Romualdas Vaisvila; Theodore B. Davis; Shengxi Guan; Zhiyi Sun; Laurence Ettwiller; Lana Saleh
Methods and compositions are provided for identifying any of the presence, location and phasing of methylated and/or hydroxymethylated cytosines in nucleic acids including long stretches of DNA. In some embodiments, the method may comprise reacting a first portion (aliquot) of a nucleic acid sample with a dioxygenase and optionally a glucosyltransferase in a reaction mixture containing the nucleic acid followed by a reaction with a cytidine deaminase to detect and optionally map 5mC in a DNA. Optionally, a second portion can be reacted with glucosyltransferase followed by reaction with a cytidine deaminase to detect and optionally map 5hmC in a DNA.
88	Disease resistant grape plants	US15190675	2016-06-23	US09994861B2	2018-06-12	Mireille Maria Augusta Van Damme; Augustinus Franciscus Johannes Maria Van Den Ackerveken
The present invention relates to a plant, which is resistant to a pathogen of viral, bacterial, fungal or oomycete origin, wherein the plant has a reduced level, reduced activity or complete absence of DMR6 protein as compared to a plant that is not resistant to the said pathogen, in particular organisms of the Fungi or the phylum Oomycota. The invention further relates to a method for obtaining a plant, which is resistant to a pathogen of viral, bacterial, fungal or oomycete origin, comprising reducing the endogenous level or activity of DMR6 protein in the plant. In addition, the invention relates to the use of a DMR6 promotor for providing disease resistant plants.
89	Variants of CRISPR from Prevotella and Francisella 1 (Cpf1)	US15659499	2017-07-25	US20180030425A1	2018-02-01	J. Keith Joung; Benjamin Kleinstiver
Engineered CRISPR from Prevotella and Francisella 1 (Cpf1) nucleases with altered and improved target specificity and their use in genomic engineering, epigenomic engineering, genome targeting, genome editing, and in vitro diagnostics.
90	Glyphosate resistant plants and associated methods	US13757474	2013-02-01	US09873883B2	2018-01-23	Justin M. Lira; Robert M. Cicchillo; Carla N. Yerkes; Andrew E. Robinson
Provided are plants having glyphosate resistance comprising a nucleic acid encoding a polypeptide having at least 90% identity with SEQ ID NO:1, and parts, organs, seeds, and/or cells of such plants. Also provided are methods for making and growing such a plant, and methods of controlling weeds in a field or area under cultivation containing such plants. For example, some methods comprise the application of multiple herbicides to such plants.
91	Method for producing pluripotent stem cells	US14439037	2013-10-29	US09868934B2	2018-01-16	Hidemasa Kato; Yosuke Moriyama; Keiko Hiraki; Akihiko Okuda
The present invention allows a TET1 protein to be more stably expressed in human pluripotent stem cells than in the past by, inter alia, substituting the second amino acid from the amino terminal of a TET1 protein with a different amino acid. Furthermore upon differentiation of said pluripotent stem cells, it is possible to quickly eliminate the expression of, inter alia, NANOG, which is an inhibitor of differentiation and promote the expression of factors related to differentiation by introducing a variant TET1 protein to a pluripotent stem cell. The present invention provides a method for manufacturing pluripotent stem cells with increased differentiation potential, and a substance that is useful to said method.
92	METHOD OF INCREASING RESISTANCE AGAINST SOYBEAN RUST IN TRANSGENIC PLANTS BY INCREASING THE SCOPOLETIN CONTENT	US15548145	2016-02-01	US20180010144A1	2018-01-11	Holger Schultheiss; Uwe Conrath; Caspar Langenbach
A method for increasing fungal resistance in a plant, a plant part, or a plant cell wherein the method comprises the step of increasing the production and/or accumulation of scopoletin and/or a derivative thereof in the plant, plant part, or plant cell in comparison to a wild type plant, wild type plant part, or wild type plant cell.
93	L-threonine and L-tryptophan producing bacteria strain and method of making same	US15465881	2017-03-22	US20170198317A1	2017-07-13	Ki Yong Cheong; Seok Myung Lee; Young Bin Hwang; Keun Cheol Lee; Kwang Ho Lee
The present invention relates to a microorganism able to produce L-threonine or L-tryptophan, and to a method for producing L-threonine or L-tryptophan by using same. More specifically, the present invention relates to: recombinant Escherichia coli which is more efficient in producing L-threonine or L-tryptophan by increasing the ability to produce ATP which is used as the most plentiful energy source in cells when producing L-threonine or L-tryptophan; and a method for producing L-threonine or L-tryptophan by using same.
94	METHODS FOR TREATING T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA	US15237049	2016-08-15	US20170042904A1	2017-02-16	Iannis AIFANTIS; Panagiotis NTZIACHRISTOS
The present invention is directed to methods of treating T-ALL that involve administering an inhibitor of jumonji D3 (JMJD3) demethylase. Another embodiment of the invention relates to methods inhibiting T-ALL cell proliferation and/or survival that involves administering an inhibitor of jumonji D3 (JMJD3) demethylase to a population of T-ALL cells.
95	Synthetic chloroplast transit peptides	US13757639	2013-02-01	US09506077B2	2016-11-29	Justin M Lira; Robert Cicchillo; Carla N Yerkes; Andrew E Robinson
This disclosure concerns compositions and methods for targeting peptides, polypeptides, and proteins to plastids of plastid-containing cells. In some embodiments, the disclosure concerns chloroplast transit peptides that may direct a polypeptide to a plastid, and nucleic acid molecules encoding the same. In some embodiments, the disclosure concerns methods for producing a transgenic plant material (e.g., a transgenic plant) comprising a chloroplast transit peptide, as well as plant materials produced by such methods, and plant commodity products produced therefrom.
96	Disease Resistant Grape Plants	US15190675	2016-06-23	US20160326544A1	2016-11-10	Mireille Maria Augusta Van Damme; Augustinus Franciscus Johannes Maria Van Den Ackerveken
The present invention relates to a plant, which is resistant to a pathogen of viral, bacterial, fungal or oomycete origin, wherein the plant has a reduced level, reduced activity or complete absence of DMR6 protein as compared to a plant that is not resistant to the said pathogen, in particular organisms of the Fungi or the phylum Oomycota. The invention further relates to a method for obtaining a plant, which is resistant to a pathogen of viral, bacterial, fungal or oomycete origin, comprising reducing the endogenous level or activity of DMR6 protein in the plant. In addition, the invention relates to the use of a DMR6 promotor for providing disease resistant plants.
97	Disease Resistant Tobacco Plants	US15190542	2016-06-23	US20160326543A1	2016-11-10	Mireille Maria Augusta Van Damme; Augustinus Franciscus Johannes Maria Van Den Ackerveken
The present invention relates to a plant, which is resistant to a pathogen of viral, bacterial, fungal or oomycete origin, wherein the plant has a reduced level, reduced activity or complete absence of DMR6 protein as compared to a plant that is not resistant to the said pathogen, in particular organisms of the Fungi or the phylum Oomycota. The invention further relates to a method for obtaining a plant, which is resistant to a pathogen of viral, bacterial, fungal or oomycete origin, comprising reducing the endogenous level or activity of DMR6 protein in the plant. In addition, the invention relates to the use of a DMR6 promotor for providing disease resistant plants.
98	Mapping Cytosine Modifications	US14993590	2016-01-12	US20160138079A1	2016-05-19	Shengxi Guan; Nan Dai; Zhenyu Zhu; Ivan R. Correa, JR.; Aine Quimby; Janine Borgaro
Methods, compositions and kits for selectively altering and detecting modified cytosine residues are provided.
99	Increasing Specificity for RNA-Guided Genome Editing	US14776620	2014-03-14	US20160024524A1	2016-01-28	J. Keith Joung; James Angstman; Jeffry D. Sander; Morgan Maeder; Shengdar Tsai
Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.
100	Method for Producing Pluripotent Stem Cells	US14439037	2013-10-29	US20150275171A1	2015-10-01	Hidemasa Kato; Yosuke Moriyama; Keiko Hiraki; Akihiko Okuda
The present invention allows a TET1 protein to be more stably expressed in human pluripotent stem cells than in the past by, inter alia, substituting the second amino acid from the amino terminal of a TET1 protein with a different amino acid. Furthermore upon differentiation of said pluripotent stem cells, it is possible to quickly eliminate the expression of, inter alia, NANOG, which is an inhibitor of differentiation and promote the expression of factors related to differentiation by introducing a variant TET1 protein to a pluripotent stem cell. The present invention provides a method for manufacturing pluripotent stem cells with increased differentiation potential, and a substance that is useful to said method.

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