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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
1	用于生物合成异丁烯酸盐的方法	CN201480053694.3	2014-08-28	CN105705650A	2016-06-22	A.L.博特斯; A.V.E.康拉迪
本文件描述了使用酶(诸如一种或多种硫酯酶、转移酶或脱氢酶)以及表达一种或多种此类酶的重组宿主经由异丁醛和异丁酰基-CoA从前体(诸如丙酮酸)生成异丁烯酸盐的生物化学途径。
2	产生有气味物质的地衣芽孢杆菌新基因产物以及在其基础上改进的生物技术生产方法	CN200580021803.4	2005-06-17	CN101356266A	2009-01-28	科尼利厄斯·贝斯勒; 约尔格·费舍; 斯特凡·埃弗斯; 卡尔-海因茨·毛雷尔; 阿尔明·埃伦赖希; 比吉特·法伊特; 海科·利泽冈; 安克·亨纳; 克里斯蒂娜·赫茨伯格; 格哈德·戈特沙尔克
本发明涉及25个以前没有描述过的地衣芽孢杆菌基因和从它们衍生的基因产物，以及所有与它们具有足够的同源性的核酸和蛋白。它们在5个不同的代谢途径中参与有气味物质的形成。所指的代谢途径用于合成：1)异戊酸(作为亮氨酸代谢的一部分)，2)2－甲基丁酸和/或异丁酸(作为缬氨酸和/或异亮氨酸代谢的一部分)，3)丁醇和/或丁酸(作为丁酸代谢的一部分)，4)丙酸(作为丙酸代谢的一部分)和/或5)尸胺和/或腐胺(作为赖氨酸和/或精氨酸代谢的一部分)。这些基因的鉴定使得可以开发出改进的生物技术生产方法，在这些核酸的帮助下，通过对用于生物技术生产的微生物中相应的基因进行失活，使经由这些代谢途径合成的有气味物质的形成得以减少。此外，根据它们各自生物化学性质，这些基因产物可以用于制备反应或方法。
3	メタクリル酸及び／又はそのエステルの製造方法	JP2013546110	2013-09-10	JPWO2014038216A1	2016-08-08	佐藤　栄治; 栄治佐藤; 倫子山崎; 永二中島; 不二夫湯; 敏男藤田; 渉水無
再生可能原料及び/又は該再生可能原料の利用から生じるバイオマスから、直接的に単一工程で効率的にメタクリル酸を生産する方法の提供。炭素源及び/又はエネルギー源としての、再生可能原料及び/又は該再生可能原料の利用から生じるバイオマスから、メタクリル酸生成能を有する微生物を用いてメタクリル酸を製造する方法を提供する。このメタクリル酸の製造方法によれば、メタクリル酸生成能を有する微生物を利用することで、石油由来の原料を使用することなく、バイオマスから安全かつ簡便にメタクリル酸を生産することができる。
4	COMPOSITIONS AND METHODS OF BIOSYNTHESIZING XANTHOPHYLLS	US15694443	2017-09-01	US20180105839A1	2018-04-19	Yechun Wang
The present invention relates to compositions and methods of producing xanthophylls in microorganisms.
5	METHODS FOR BIOSYNTHESIZING METHACRYLATE	US15051989	2016-02-24	US20160237461A1	2016-08-18	Adriana Leonora Botes; Alex Van Eck Conradie
This document describes biochemical pathways for producing methacrylate from precursors such as pyruvate via isobutyraldehyde and isobutyryl-CoA, using enzymes such as one or more thioesterases, transferases, or dehydrogenases, as well as recombinant hosts expressing one or more of such enzymes.
6	Gene products of Bacillus licheniformis which form odorous substances and improved biotechnological production methods based thereon	US11616319	2006-12-27	US09394528B2	2016-07-19	Cornelius Bessler; Jörg Feesche; Stefan Evers; Karl-Heinz Maurer; Armin Ehrenreich; Birgit Veith; Heiko Liesegang; Anke Henne; Christina Herzberg; Gerhard Gottschalk
The present invention relates to 25 hitherto undescribed genes of B. licheniformis and gene products derived therefrom and all sufficiently homologous nucleic acids and proteins thereof. They occur in five different metabolic pathways for the formation of odorous substances. The metabolic pathways in question are for the synthesis of: 1) isovalerian acid (as part of the catabolism of leucine), 2) 2-methylbutyric acid and/or isobutyric acid (as part of the catabolism of valine and/or isoleucine), 3) butanol and/or butyric acid (as part of the metabolism of butyric acid), 4) propyl acid (as part of the metabolism of propionate) and/or 5) cadaverine and/or putrescine (as parts of the catabolism of lysine and/or arginine). The identification of these genes allows biotechnological production methods to be developed that are improved to the extent that, to assist these nucleic acids, the formation of the odorous substances synthesized via these metabolic pathways can be reduced by deactivating the corresponding genes in the micro-organism used for the biotechnological production. In addition, these gene products are thus available for preparing reactions or for methods according to their respective biochemical properties.
7	PRODUCTION OF FATTY ALCOHOLS FROM ENGINEERED MICROORGANISMS	US14415665	2013-07-19	US20150176040A1	2015-06-25	Jonathan Vroom; Svetlana Balatskaya; Yoram Barak; Louis Clark; Trish Choudhary; Kristian Karlshoej; Fernando Valle; Kaman Chan
Recombinant microorganisms are provided which have been engineered to produce fatty alcohols. Also provided are recombinant microorganisms which comprise a heterologous polynucleotide encoding a fatty alcohol reductase enzyme and an introduced polynucleotide encoding a β-ketoacyl acyl carrier protein synthase.
8	COMPOSITIONS AND METHODS OF BIOSYNTHESIZING CAROTENOIDS AND THEIR DERIVATIVES	US15560951	2016-03-23	US20180080031A1	2018-03-22	Yechun WANG
The present invention relates to compositions and methods of producing carotenoids and carotenoid derivatives.
9	METHODS FOR BIOSYNTHESIZING METHACRYLATE	US14914113	2014-08-28	US20160201094A1	2016-07-14	Adriana Leonora Botes; Alex Van Eck Conradie
This document describes biochemical pathways for producing methacrylate from precursors such as pyruvate via isobutyraldehyde and isobutyryl-CoA, using enzymes such as one or more thioesterases, transferases, or dehydrogenases, as well as recombinant hosts expressing one or more of such enzymes.
10	METHOD FOR PRODUCING METHACRYLIC ACID AND/OR ESTER THEREOF	US14419575	2013-09-10	US20150191756A1	2015-07-09	Eiji Sato; Michiko Yamazaki; Eiji Nakajima; Fujio Yu; Toshio Fujita; Wataru Mizunashi
To provide a method for directly and efficiently producing methacrylic acid in a single step from renewable raw materials and/or biomass arising from the utilization of the renewable raw materials. Further provided is a method for producing methacrylic acid using microbes having the ability to produce methacrylic acid, from renewable raw materials and/or biomass arising from the utilization of the renewable raw materials, as a carbon source and/or energy source. The method for producing methacrylic acid enables methacrylic acid to be safely and easily produced from biomass, without using petroleum-derived raw materials, by utilizing microbes having the ability to produce methacrylic acid.
11	メタクリル酸及び/又はそのエステルの製造方法	JP2013546110	2013-09-10	JP6197648B2	2017-09-20	佐藤栄治; 山崎倫子; 中島永二; 湯不二夫; 藤田敏男; 水無渉

12	Novel Bacillus licheniformis gene product and improved biotechnological production method based on it to produce an odor substance	JP2007519651	2005-06-17	JP2008504829A	2008-02-21	アルミン・エーレンライヒ; アンケ・ヘンネ; イエルク・フェーシェ; カール−ハインツ・マウラー; クリスティーナ・ヘルツベルク; ゲルハルト・ゴットシャルク; コルネリウス・ベスラー; シュテファン・エーフェルス; ハイコ・リーゼガング; ビルギット・ファイト
本発明は、今までに記述されていない２５種のバシラス・リケニホルミス遺伝子およびそれらから派生する遺伝子産物、ならびにその十分に相同的なすべての核酸およびタンパク質に関する。これらは、臭気物質を生成する５種類の異なる代謝経路に存在する。目的とする代謝経路は、１）イソ吉草酸（ロイシン異化の一部として）、２）２−メチル酪酸および／またはイソ酪酸（バリンおよび／またはイソロイシン異化の一部として）、３）ブタノールおよび／または酪酸（酪酸代謝の一部として）、４）プロピル酸（プロピオン酸代謝の一部として）、および／または５）カダベリンおよび／またはプトレシン（リジンおよび／またはアルギニン異化の一部として）の合成のためのものである。これらの遺伝子を同定して、これらの核酸の助けを借りると、生物工学的な生産に使用される微生物中の対応する遺伝子を不活性化することで、改良された生物工学的生産法の開発が、これらの代謝経路によって合成される臭気物質の生成を低減できる程度まで可能になる。さらに、これらの遺伝子産物はしたがって、反応物の調製またはそのそれぞれの生化学的性質に従う方法に利用できる。
13	BIOCONVERSION OF SHORT-CHAIN HYDROCARBONS TO FUELS AND CHEMICALS	US15562606	2016-03-31	US20180355394A1	2018-12-13	Ramon Gonzales
An engineered microorganism(s) with novel pathways for the conversion of short-chain hydrocarbons to fuels and chemicals (e.g. carboxylic acids, alcohols, hydrocarbons, and their alpha-, beta-, and omega-functionalized derivatives) is described. Key to this approach is the use of hydrocarbon activation enzymes able to overcome the high stability and low reactivity of hydrocarbon compounds through the cleavage of an inert C—H bond. Oxygen-dependent or oxygen-independent activation enzymes can be exploited for this purpose, which when combined with appropriate pathways for the conversion of activated hydrocarbons to key metabolic intermediates, enables the generation of product precursors that can subsequently be converted to desired compounds through established pathways. These novel engineered microorganism(s) provide a route for the production of fuels and chemicals from short chain hydrocarbons such as methane, ethane, propane, butane, and pentane.
14	Production of fatty alcohols from engineered microorganisms	US14415665	2013-07-19	US09650655B2	2017-05-16	Jonathan Vroom; Svetlana Balatskaya; Yoram Barak; Louis Clark; Trish Choudhary; Kristian Karlshoej; Fernando Valle; Kaman Chan
Recombinant microorganisms are provided which have been engineered to produce fatty alcohols. Also provided are recombinant microorganisms which comprise a heterologous polynucleotide encoding a fatty alcohol reductase enzyme and an introduced polynucleotide encoding a β-ketoacyl acyl carrier protein synthase.
15	Gene Products of Bacillus Licheniformis Which Form Odorous Substances and Improved Biotechnological Production Methods Based Thereon	US15182839	2016-06-15	US20170067064A1	2017-03-09	Cornelius Bessler; Jorg Feesche; Stefan Evers; Karl-Heinz Maurer; Armin Ehrenreich; Birgit Veith; Heiko Liesegang; Anke Henne; Christina Herzberg; Gerhard Gottschalk
The present invention relates to 25 hitherto undescribed genes of B. licheniformis and gene products derived thereform and all sufficiently homologous nucleic acids and proteins thereof. They occur in five different metabolic pathways for the formation of odorous substances. The metabolic pathways in question are for the synthesis of: 1) isovalerian acid (as part of the catabolism of leucine), 2) 2-methylbutyric acid and/or isobutyric acid (as part of the catabolism of valine and/or isoleucine), 3) butanol and/or butyric acid (as part of the metabolism of butyric acid), 4) propyl acid (as part of the metabolism of propionate) and/or 5) cadaverine and/or putrescine (as parts of the catabolism of lysine and/or arginine). The identification of these genes allows biotechnological production methods to be developed that are improved to the extent that, to assist these nucleic acids, the formation of the odorous substances synthesised via these metabolic pathways can be reduced by deactivating the corresponding genes in the micro-organism used for the biotechnological production. In addition, these gene products are thus available for preparing reactions or for methods according to their respective biochemical properties.
16	Methods for Recombinant Production of Saffron Compounds	US15123198	2015-03-06	US20170067063A1	2017-03-09	A.S. Sathish Kumar
Recombinant microorganisms and methods for producing saffron compounds including crocetin, crocetin dialdehyde, crocin or picrocrocin are disclosed herein.
17	GENES PROVIDING TOLERANCE TO PDS INHIBITORS	US14169370	2014-01-31	US20140342913A1	2014-11-20	Quideng Que; John Luther Dawson; Zhongying Chen
The present invention relates to DNA molecules encoding a PDS inhibitor tolerant phytoene desaturease enzymes as well as constructs and plants comprising said enzymes. Also included are methods of using said enzymes, including use as a selectable marker, use to make transgenic plants resistant to PDS inhibitor herbicides and methods of controlling weeds.
18	GENE PRODUCTS OF BACILLUS LICHENIFORMIS WHICH FORM ODOROUS SUBSTANCES AND IMPROVED BIOTECHNOLOGICAL PRODUCTION METHODS BASED THEREON	US11616319	2006-12-27	US20070190605A1	2007-08-16	Cornelius Bessler; Jorg Feesche; Stefan Evers; Karl-Heinz Maurer; Armin Ehrenreich; Birgit Veith; Heiko Liesegang; Anke Henne; Christina Herzberg; Gerhard Gottschalk
The present invention relates to 25 hitherto undescribed genes of B. licheniformis and gene products derived therefrom and all sufficiently homologous nucleic acids and proteins thereof. They occur in five different metabolic pathways for the formation of odorous substances. The metabolic pathways in question are for the synthesis of: 1) isovalerian acid (as part of the catabolism of leucine), 2) 2-methylbutyric acid and/or isobutyric acid (as part of the catabolism of valine and/or isoleucine), 3) butanol and/or butyric acid (as part of the metabolism of butyric acid), 4) propyl acid (as part of the metabolism of propionate) and/or 5) cadaverine and/or putrescine (as parts of the catabolism of lysine and/or arginine). The identification of these genes allows biotechnological production methods to be developed that are improved to the extent that, to assist these nucleic acids, the formation of the odorous substances synthesized via these metabolic pathways can be reduced by deactivating the corresponding genes in the micro-organism used for the biotechnological production. In addition, these gene products are thus available for preparing reactions or for methods according to their respective biochemical properties.
19	METHODS FOR BIOSYNTHESIZING METHACRYLATE	EP14766071.6	2014-08-28	EP3039151A2	2016-07-06	BOTES, Adriana Leonora; CONRADIE, Alex Van Eck
This document describes biochemical pathways for producing methacrylate from precursors such as pyruvate via isobutyraldehyde and isobutyryl-CoA, using enzymes such as one or more thioesterases, transferases, or dehydrogenases, as well as recombinant hosts expressing one or more of such enzymes.
20	Neue, Geruchsstoffe bildende Genprodukte von Bacillus licheniformis und darauf aufbauende verbesserte biotechnologische Produktionsverfahren	EP10174635.2	2005-06-17	EP2264153A3	2011-10-26	Bessler, Cornelius; Feesche, Jörg; Evers, Stefan; Maurer, Karl-Heinz; Ehrenreich, Armin; Veith, Birgit; Liesegang, Heiko; Singer, Anke; Herzberg, Christina; Gottschalk, Gerhard
Die Bildung unangenehmer Gerüche bei der Fermentation von Mikroorganismen soll verringert werden und es sollen Gene identifiziert werden, die für Proteine codieren, die an der Bildung unangenehm riechender Verbindungen beteiligt sind. Dies gelingt durch eine Nukleinsäure gemäß SEQ ID NO. 31, die für ein an der Synthese von Butanol und/oder Buttersäure beteiligtes Genprodukt (wahrscheinliche Phosphat-Butyryl-Transferase; E.C. 2.3.1.19) codiert sowie alle hinreichend homologen Nukleinsäuren hierzu. Die Identifizierung dieses Gens ermöglicht biotechnologische Produktionsverfahren, die insofern verbessert sind, als mithilfe derartiger Nukleinsäuren die Bildung der über diese Stoffwechselwege synthetisierten Geruchsstoffe durch Inaktivierung des zugehörigen Gens in dem für die biotechnologische Produktion verwendeten Mikroorganismus verringert werden kann.

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