| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 用于从水性培养基中更好分离出疏水性有机溶液的方法 | CN201210599411.8 | 2012-12-21 | CN103254089A | 2013-08-21 | H-G·亨内曼; S·沙费尔; M·韦泽尔; T·哈斯; J·吉伦; K·贝泽; S·哈夫凯姆艾尔; M·波埃特厄尔; F·厄尔哈特; M·席贝尔胡特 |
| 本申请涉及用于从水性培养基中更好分离出疏水性有机溶液的方法，其包括以下步骤：提供含代谢活性细胞的水性培养基；使水性培养基与疏水性有机溶液接触；从水性培养基中分离疏水性有机溶液，其中与其野生型相比，所述细胞具有至少一种降低了活性的催化脂肪酸的β-氧化反应的酶。本发明还涉及一种代谢活性细胞用于从水性培养基中更好分离出疏水性有机溶液的用途，与其野生型相比，所述细胞具有降低了活性的催化脂肪酸的β-氧化反应的酶，所述酶优选选自FadA、FadB、FadD、FadL和FadE及其变体，更优选FadE变体或其变体。 | ||||||
| 2 | 逆向β氧化途径 | CN201280014706.2 | 2012-02-07 | CN103492560B | 2016-09-28 | R·冈萨雷斯; J·M·克罗姆伯格; C·德勒莫纳科; E·N·米勒 |
| 本发明涉及使用已赋予形成逆向β氧化途径的新用途的基因进行工程化以产生各种化学品的重组微生物。一般而言，通过修饰所需许多循环的各种调节点逆向表达和驱动β氧化循环，然后通过终止酶的作用来将CoA硫酯中间体转化成有用产物。 | ||||||
| 3 | 逆向β氧化途径 | CN201280014706.2 | 2012-02-07 | CN103492560A | 2014-01-01 | R·冈萨雷斯; J·M·克罗姆伯格; C·德勒莫纳科; E·N·米勒 |
| 本发明涉及使用已赋予形成逆向β氧化途径的新用途的基因进行工程化以产生各种化学品的重组微生物。一般而言，通过修饰所需许多循环的各种调节点逆向表达和驱动β氧化循环，然后通过终止酶的作用来将CoA硫酯中间体转化成有用产物。 | ||||||
| 4 | REVERSE BETA OXIDATION PATHWAY | US15237190 | 2016-08-15 | US20170088862A1 | 2017-03-30 | Ramon GONZALEZ; James Clomburg; Clementina DELLOMONACO; Elliot N. MILLER |
| The invention relates to recombinant microorganisms that have been engineered to produce various chemicals using genes that have been repurposed to create a reverse beta oxidation pathway. Generally speaking, the beta oxidation cycle is expressed and driven in reverse by modifying various regulation points for as many cycles as needed, and then the CoA thioester intermediates are converted to useful products by the action of termination enzymes. | ||||||
| 5 | Genetically engineered microbes and uses thereof | US14001299 | 2012-03-01 | US09594869B2 | 2017-03-14 | Desmond Siu Men Lun |
| This invention concerns methods of identifying genetic alterations with which a microbe can be used to produce fatty acids at a large amount for making biofuels. Also disclosed are microbes with such genetic alterations and uses thereof. | ||||||
| 6 | 疎水性の有機溶液と水性の培養培地との改善された分離方法 | JP2012281367 | 2012-12-25 | JP6312117B2 | 2018-04-18 | ハンス−ゲオルク ヘネマン; シュテフェン シャファー; ミリヤ ヴェセル; トーマス ハース; ヤスミン ギーレン; カタリーナ ベアゼ; ザビーネ ハフケマイアー; マルクス ペター; フランク エアハート; マリオン シーベルフート |
| 7 | メタクリル酸及び/又はそのエステルの製造方法 | JP2013546110 | 2013-09-10 | JP6197648B2 | 2017-09-20 | 佐藤 栄治; 山崎 倫子; 中島 永二; 湯 不二夫; 藤田 敏男; 水無 渉 |
| 8 | BIOLOGICAL PRODUCTION OF METHYL METHACRYLATE | US15958859 | 2018-04-20 | US20180346942A1 | 2018-12-06 | Michelle O'MALLEY; Kevin SOLOMON; Wataru MIZUNASHI; Fujio YU |
| The invention relates to an engineered eukaryotic microorganism into which a gene encoding an acyl-CoA dehydrogenase is introduced and a method for producing methacrylic acid esters such as MMA and MMA-CoA and precursors thereof using the microorganism. | ||||||
| 9 | PRODUCTION OF FATTY ACID DERIVATIVES | US14709232 | 2015-05-11 | US20170335295A9 | 2017-11-23 | Alfred GAERTNER |
| Methods and compositions for producing fatty acid derivatives, for example, fatty esters, and commercial fuel compositions comprising fatty acid derivatives are described. | ||||||
| 10 | Reverse beta oxidation pathway | US13983885 | 2012-02-07 | US09416364B2 | 2016-08-16 | Ramon Gonzalez; James Clomburg; Clementina Dellomonaco; Elliot N. Miller |
| The invention relates to recombinant microorganisms that have been engineered to produce various chemicals using genes that have been repurposed to create a reverse beta oxidation pathway. Generally speaking, the beta oxidation cycle is expressed and driven in reverse by modifying various regulation points for as many cycles as needed, and then the CoA thioester intermediates are converted to useful products by the action of termination enzymes. | ||||||
| 11 | Process for the improved separation of a hydrophobic organic solution from an aqueous culture medium | US13721481 | 2012-12-20 | US09249435B2 | 2016-02-02 | Jasmin Gielen; Thomas Haas; Hans-Georg Hennemann; Steffen Schaffer; Mirja Wessel; Katharina Berse; Marion Schiebelhut; Sabine Hafkemeyer; Markus Poetter; Frank Erhardt |
| A process for the improved separation of a hydrophobic organic solution from an aqueous culture medium is provided. The process includes preparing an aqueous culture medium of a metabolically active cell having a decreased activity; contacting of the aqueous culture medium with a hydrophobic organic solution comprising a substrate for biotransformation; conducting a biotransformation of the substrate; and separating the hydrophobic organic solution comprising a biotransformed substrate from the aqueous culture medium. The decreased activity of the metabolically active cell is in comparison to a wild-type of the active cell and the decreased activity is of at least of one enzyme that catalyzes one reaction of β-oxidation of fatty acids. The invention further provides a metabolically active cell that has a decreased activity, compared to its wild-type, of an enzyme that catalyzes one of the reactions of the β-oxidation of fatty acids, including an enzyme selected from FadA, FadB, FadD, FadL and FadE as well as variants thereof. | ||||||
| 12 | Production of fatty acid derivatives | US12889066 | 2010-09-23 | US09133406B2 | 2015-09-15 | Alfred Gaertner |
| Methods and compositions for producing fatty acid derivatives, for example, fatty esters, and commercial fuel compositions comprising fatty acid derivatives are described. | ||||||
| 13 | GENETICALLY ENGINEERED MICROBES AND USES THEREOF | US14001299 | 2012-03-01 | US20140039232A1 | 2014-02-06 | Desmond Siu Men Lun |
| This invention concerns methods of identifying genetic alterations with which a microbe can be used to produce fatty acids at a large amount for making biofuels. Also disclosed are microbes with such genetic alterations and uses thereof. | ||||||
| 14 | PRODUCTION OF FATTY ACID DERIVATIVES | US12889066 | 2010-09-23 | US20110072714A1 | 2011-03-31 | Alfred GAERTNER |
| Methods and compositions for producing fatty acid derivatives, for example, fatty esters, and commercial fuel compositions comprising fatty acid derivatives are described. | ||||||
| 15 | Production of fatty acid derivatives | EP15153935.0 | 2010-09-23 | EP2910630B1 | 2018-10-24 | Gaertner, Alfred |
| Methods and compositions for producing fatty acid derivatives, for example, fatty esters, and commercial fuel compositions comprising fatty acid derivatives are described. | ||||||
| 16 | Verfahren zur verbesserten Abtrennung einer hydrophoben organischen Lösung von einem wässrigen Kulturmedium | EP12197644.3 | 2012-12-18 | EP2607491A1 | 2013-06-26 | Hennemann, Hans-Georg, Dr.; Schaffer, Steffen, Dr.; Wessel, Mirja, Dr.; Haas, Thomas, Dr.; Gielen, Jasmin; Berse, Katharina; Hafkemeyer, Sabine; Pötter, Markus, Dr.; Erhardt, Frank, Dr.; Schiebelhut, Marion |
Die vorliegende Anmeldung betrifft ein Verfahren zur verbesserten Abtrennung einer hydrophoben organischen Lösung von einem wässrigen Kulturmedium umfassend die Schritte, Bereitstellen eines wässrigen Kulturmediums umfassend eine stoffwechselaktive Zelle, Kontaktieren des wässrigen Kulturmediums mit einer hydrophoben organischen Lösung, Abtrennen der hydrophoben organischen Lösung von dem wässrigen Kulturmedium, wobei die Zelle eine ihrem Wildtyp gegenüber verringerte Aktivität wenigstens eines Enzyms aufweist, das eine der Reaktionen der β-Oxidation von Fettsäuren katalysiert. Weiterhin betrifft die Erfindung die Verwendung einer stoffwechselaktiven Zelle, die eine ihrem Wildtyp gegenüber verringerte Aktivität eines Enzyms aufweist, das eine der Reaktionen der β-Oxidation von Fettsäuren katalysiert, bevorzugt eines Enzyms ausgewählt aus der Gruppe umfassend FadA, FadB, FadD, FadL und FadE sowie Varianten davon, bevorzugter FadE oder einer Variante davon, zur verbesserten Abtrennung einer hydrophoben organischen Lösung von einem wässrigen Kulturmedium umfassend die stoffwechselaktive Zelle. |
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| 17 | メチルメタクリレートの生物生産 | JP2016081345 | 2016-10-21 | JPWO2017069267A1 | 2018-09-13 | オマリー,マイケル; ソロモン,ケビン; 水無 渉; 湯 不二夫 |
| 本発明は、アシルCoAデヒドロゲナーゼをコードする遺伝子が導入された組換え真核微生物、及び前記微生物を用いたMMA及びMMA−CoA等のメタクリル酸エステル及びその前駆体の製造方法に関する。 |
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| 18 | メタクリル酸及び／又はそのエステルの製造方法 | JP2013546110 | 2013-09-10 | JPWO2014038216A1 | 2016-08-08 | 佐藤 栄治; 栄治 佐藤; 倫子 山崎; 永二 中島; 不二夫 湯; 敏男 藤田; 渉 水無 |
| 再生可能原料及び/又は該再生可能原料の利用から生じるバイオマスから、直接的に単一工程で効率的にメタクリル酸を生産する方法の提供。炭素源及び/又はエネルギー源としての、再生可能原料及び/又は該再生可能原料の利用から生じるバイオマスから、メタクリル酸生成能を有する微生物を用いてメタクリル酸を製造する方法を提供する。このメタクリル酸の製造方法によれば、メタクリル酸生成能を有する微生物を利用することで、石油由来の原料を使用することなく、バイオマスから安全かつ簡便にメタクリル酸を生産することができる。 | ||||||
| 19 | Improved separation method of hydrophobic organic solution from aqueous culture medium | JP2012281367 | 2012-12-25 | JP2013132295A | 2013-07-08 | HENNEMANN HANS-GEORG; SCHAFFER STEFFEN; WESSEL MIRJA; HAAS THOMAS DR; GIELEN JASMIN; BERSE KATHARINA; HAFKEMEYER SABINE; POETTER MARKUS; ERHARDT FRANK; SCHIEBELHUT MARION |
| PROBLEM TO BE SOLVED: To provide an improved method for producing and manufacturing products formed by bioengineering by means of a two-phase system containing an aqueous culture medium having metabolically active cells and a hydrophobic organic solution.SOLUTION: The method includes a process of providing an aqueous culture medium containing metabolically active cells, a process of bringing the aqueous culture medium into contact with a hydrophobic organic solution, and a process of separating the hydrophobic organic solution from the aqueous culture medium, wherein the cell has at least one kind of enzyme which has decreased activity compared with its wild type, and catalyses one of the reactions of the β-oxidation of fatty acids. | ||||||
| 20 | REVERSE BETA OXIDATION PATHWAY | EP12744268.9 | 2012-02-07 | EP2673369B1 | 2017-04-05 | GONZALEZ, Ramon; CLOMBURG, James, M.; DELLOMONACO, Clementina; MILLER, Elliot N. |
| The invention relates to recombinant microorganisms that have been engineered to produce various chemicals using genes that have been repurposed to create a reverse beta oxidation pathway. Generally speaking, the beta oxidation cycle is expressed and driven in reverse by modifying various regulation points for as many cycles as needed, and then the CoA thioester intermediates are converted to useful products by the action of termination enzymes. | ||||||
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