| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 101 | 미세조류 이용한 이산화탄소 고정화 방법 | KR1020100030563 | 2010-04-02 | KR1020110111150A | 2011-10-10 | 이재화; 김지윤 |
| 본 발명은 미세조류를 이용한 이산화탄소 고정화 방법에 관한 것으로, 보다 상세하게는 비닐 재질의 광배양기를 포함하는 광생물반응기를 이용하여 스피루리나 플라텐시스 NIES 39(
Spirulina
platensis NIES 39, KCTC AG30033)의 배양을 통해 이산화탄소를 고정화하는 방법에 관한 것이다.
본 발명은 기존 광생물반응기의 단점으로 지적되는 고가의 시설비용에 관한 문제를 해결하기 위하여, 광배양기의 재질을 비닐 재질로 제조하고, 각 단계의 최적화 조건을 확립하여 상기 비닐 재질의 광배양기를 포함한 광생물반응기를 이용한 이산화탄소 고정법을 제공함으로써, 토지 면적이 좁고, 4계절을 가진 기후 조건을 갖는 우리나라에서 효과적으로 이산화탄소를 고정화함으로써 이산화탄소를 저감할 수 있는 효과적인 방법을 제공한다. |
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| 102 | 할로박테리움 속 미생물을 이용한 박테리오로돕신의제조방법 | KR1020010056290 | 2001-09-12 | KR1020010102872A | 2001-11-17 | 박문환 |
| 본 발명은 할로박테리움 속( Halobacterium sp.) 미생물을 이용한 박테리오로돕신의 제조방법에 관한 것이다. 구체적으로, 본 발명은 할로박테리움 속 미생물을 대수기 말기까지 회분배양한 다음 배양액의 일부는 박테리오로돕신을 발현시키는데 사용하고 나머지 배양액은 할로박테리움 속 미생물의 고농도 생산에 사용함으로써 연속적으로 박테리오로돕신을 제조하는 방법에 관한 것이다. 본 발명의 박테리오로돕신 제조방법은 할로박테리움 속 미생물의 배양과 박테리오로돕신의 발현을 구별하여 실시함으로써 고농도의 할로박테리움 속 미생물 및 박테리오로돕신을 단시간내에 연속적으로 대량생산하는데 유효하게 사용될 수 있다. | ||||||
| 103 | METHODS AND SYSTEMS FOR GENERATION, USE, AND DELIVERY OF ACTIVATED STEM CELLS | EP16865155.2 | 2016-11-11 | EP3373996A1 | 2018-09-19 | STRACHAN, John, Scott; OVOKAITYS, Todd, Frank |
| Harvested stem cells are activated by treating them with an amplitude modulated laser beam having a wavelength lying in the range of 405 to 980 nanometers. The frequency of the laser beam is modulated within a range of 8 to 12 MHz. Using the activated stem cells, tissue can be repaired and regenerated by preparing the unactivated stem cells, treating the unactivated stem cells with an amplitude modulated laser beam having a pre-determined frequency for obtaining activated stem cells, administering the activated stem cells into a body containing the tissue, and using a homing beam to guide the activated stem cells within the body to the location of the tissue. | ||||||
| 104 | CELL CULTURE SUPPORT | EP16777605.3 | 2016-09-23 | EP3353276A1 | 2018-08-01 | LIZ-MARZÁN, Luis Manuel; GINER CASARES, Juan José; HENRIKSEN-LACEY, Malou; JOHNSON, Alexander |
| There is provided an adherent cell-culture support comprising gold nanoparticles on the surface where the cells attach to, wherein the size of the nanoparticles is from 5 nm to 2 microns, the distance between the nanoparticles is from 2 nm to 30 nm and the anisotropy aspect ratio is greater than 1. These substrates have improved properties for allowing the culturing and subsequent detachment of cells, with potential applications in a wide range of fields such as stem cell research and tissue engineering. There is also provided a process for their preparation and several uses thereof. | ||||||
| 105 | DEVICE AND METHOD FOR INDUCING PLURIPOTENT CELLS USING ENERGY | EP15866086.0 | 2015-12-04 | EP3241896A1 | 2017-11-08 | KIM, Soonhag |
The present invention relates to a device and a method for inducing pluripotent cells using energy and, more specifically, has an effect of inducing new type pluripotent cells having pluripotent characteristics by applying energy such as ultrasonic waves, lasers or heat treatment to differentiated cells. |
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| 106 | A METHOD OF PRODUCING EXOSOMES | EP14850195 | 2014-10-02 | EP3052616A4 | 2017-03-29 | PASPALIARIS BILL |
| The present application relates to methods of producing exosomes or extracts thereof for use in the treatment of diseases or disorders. In particular, the present invention relates to a method of producing exosomes or extracts thereof comprising the steps of: (a) exposing a population of isolated mammalian cells to light between 500 nm to 820 nm for sufficient time to enable said cells to produce and excrete said exosomes; and (b) separating said exosomes from other cellular components based on molecular weight, size, shape, composition or biological activity. | ||||||
| 107 | A METHOD FOR INCREASING THE COQ10 AND COQH2 CONTENT IN PHOTOTROPHIC MICROORGANISMS | EP11802415.7 | 2011-12-21 | EP2655649B1 | 2017-03-15 | DÜRR, Oliver |
| 108 | Method of differentiation induction to osteoblasts | EP07253301.1 | 2007-08-21 | EP1892290B1 | 2016-11-30 | Inoue, Akira, Yokohama Works of Sumitomo Electric Ind., Ltd.; Hatayama, Hitoshi Yokohama Works of Sumitomo Electric Ind., Ltd.; Suganuma, Hiroshi, Tokyo Head Office of Sumitomo Electr. Ind., Ltd.; Awazu, Kunio; Kushibiki, Toshihiro |
| 109 | CELL CULTURE | EP13825728.2 | 2013-07-29 | EP2879794A1 | 2015-06-10 | VIASNOFF, Virgile Nicolas Robert; LI, Qiushi |
| The disclosure relates to the fabrication of a three dimensional [3-D] cell culture membrane comprising one or more functionalized surfaces adapted to provide cell culture conditions suitable for the analysis of proliferation, differentiation or function of cells, typically eukaryotic or prokaryotic cells. | ||||||
| 110 | A METHOD FOR INCREASING THE COQ10 AND COQH2 CONTENT IN PHOTOTROPHIC MICROORGANISMS | EP11802415.7 | 2011-12-21 | EP2655649A1 | 2013-10-30 | DÜRR, Oliver |
| A method for increasing the content of ubiquinone (CoQ10) and ubiquinol (CoQH2) in phototrophic microorganisms that were cultivated in a culture medium in a bioreactor under light irradiation, wherein the phototrophic microorganisms are selected from the group consisting of blue algae, green algae and yellow-green algae, comprising a step of inducing oxidative stress. By virtue of the fact that oxidative stress was induced by incubating the phototrophic microorganisms together with Fe 3+ in the culture medium, a higher content of CoQ10 and CoQH2 is obtained. Moreover, the microorganisms thus obtained have a higher content of trivalent iron, which is particularly relevant for the human diet. From the phototrophic microorganisms it is possible to produce an oily extract and also a dried algae product. | ||||||
| 111 | Method of differentiation induction to osteoblasts | EP10006959.0 | 2007-08-21 | EP2248888A1 | 2010-11-10 | Inoue, Akira; Hatayama, Hitoshi; Suganuma, Hiroshi; Awazu, Kunio; Kushibiki, Toshihiro |
An in vitro method of differentiation-inducing mesenchymal stem cells to osteoblasts by translocating biological clock-relevant factors of the mesenchymal stem cells from the cells' cytoplasm to the cells' nucleus, the method comprising irradiating the mesenchymal stem cells with light having a wavelength of 350 to 500 nm, and after irradiation, culturing the cells in a medium prepared by adding 10 nM dexamethasone, 2 mM β-glycerol phosphoric acid, and 50 µg/mL ascorbic acid to a DMEM medium containing 10% FBS, wherein the biological clock-relevant factors comprise cryptochrome.
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| 112 | OPTICAL CELL GUIDANCE METHOD AND APPARATUS | EP02789630.7 | 2002-11-13 | EP1455670A2 | 2004-09-15 | KÄS, Josef,Univ. Leipzig Fakultat fur Physik und; RAIZEN, Mark; MILNER, Valery; BETZ, Timo; EHRLICHER, Allen |
| Embodiments of the invention include Optical Cell Guidance (OCG) methods and apparatus to control cell growth. This system guides the leading edge of motile cells with an optical gradient, which biases the cell's motion into the light by pulling on proteins, which act like soft dielectrics in the electromagnetic field. OCG differs from those devices described above in that it controls the direction of cell motility. This is an entirely new field, and the first device to directly manipulate cell motility. OCG differs from current approaches in that it does not trap or hold particles. Instead of trapping and pulling the cell, the goal of OCG is to influence, direct, and control the growth of a growth cone. | ||||||
| 113 | Cell-culturing device and sorting method using same | EP03253257.4 | 2003-05-23 | EP1365017A1 | 2003-11-26 | Sumaru, Kimio, National Inst. of Advanced Ind.; Kameda, Mitsuyoshi, Nat. Inst. of Advanced Indust.; Kanamori, Toshiyuki, Nat. Inst. of Advanced Ind.; Shinbo, Toshio, National Inst. of Advanced Ind. |
The present invention provides a photo-responsive composition comprising a photo-responsive material having the property of differential adhesiveness in response to changes in light irradiation. The photo-responsive composition is used as an adhesive surface for the growth anchorage-dependent cells in a culturing dish. The position of a particular cell on the photo-responsive composition is irradiated with light to release only the cell attached at that position, and the released cell may be sortingly collected. According to the present invention, cells including anchorage-dependent cells can be sortingly collected through a simple operation while maintaining the extracellular matrix and membrane proteins of the cells, as well as the organ-specific functions of the cells, and thus without damage to the cells. |
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| 114 | SPATIO-TEMPORAL CONTROL OF PROTEIN INTERACTIONS USING PHYTOCHROMES | PCT/US2009045204 | 2009-05-26 | WO2009151948A3 | 2010-06-24 | VOIGT CHRISTOPHER A; LEVSKAYA ANSELM; LIM WENDELL |
| The invention provides methods, materials and systems of regulating association between proteins of interest using light. In an aspect, the invention takes advantage of the ability of phytochromes to change conformation upon exposure to appropriate light conditions, and to bind in a conformation-dependent manner to cognate proteins called phytochrome -interacting factors. The invention comprises a method of regulating interaction between a first protein of interest and second protein within a cell by light. Such a method optionally comprises providing in the cell (1) a first protein construct which comprises the first protein, a phytochrome domain (PHD), and (2) providing in the cell a second protein construct which comprises the second protein and a phytochrome domain- interacting peptide (PIP) that can bind selectively to the Pfr state, but not to the Pr state, of the phytochrome domain. | ||||||
| 115 | ENHANCEMENT OF IN VITRO CULTURE OR VACCINE PRODUCTION IN BIOREACTORS USING ELECTROMAGNETIC ENERGY | PCT/US2007002271 | 2007-01-26 | WO2007087438A2 | 2007-08-02 | STREETER JACKSON |
| Disclosed are apparatus and methods for enhancing or improving cell cultures, including cell cultures for the production of monoclonal antibodies, using electromagnetic energy treatment, primarily using electromagnetic radiation in the near infrared to visible region of the spectrum. The delivery of electromagnetic energy to a culture, in accordance with preferred embodiments, enhances or improves the cell culture such as by providing for enhanced and accelerated formation of important biological macromolecules, including, but not limited to, antibodies, proteins, collagen, and polysaccharides, and also providing for accelerated cellular replication and an enhancement or prolongation of the life of cells so treated. | ||||||
| 116 | 세포 리프로그래밍 장치 | KR1020180102042 | 2018-08-29 | KR1020180100512A | 2018-09-11 | |
| 발명은환경유입을촉진할수 있는에너지를이용한세포리프로그래밍장치에관한것으로, 보다상세하게는분화된세포에초음파, 레이저또는열 처리등의에너지를가하여다능성특성을가진새로운타입의다능성세포또는상기분화된세포와표현형이상이한임의의분화세포로의리프로그래밍을유도하는효과를갖는다. | ||||||
| 117 | 광 감응성입자가 도포된 세포배양기판을 이용하여 국소적 신경활성 억제를 위한 광 패턴 조사 시스템 및 조사 방법 | KR1020170022106 | 2017-02-20 | KR1020180096840A | 2018-08-30 | 남윤기; 정현준 |
| 본발명은세포의국소적인영역에신경활성억제가가능한광 패턴조사시스템에있어서, 광감응성나노입자의표면플라즈몬효과를일으키는광을출력하는광조사장치; 광조사장치에서출력된광을입력받아패턴의균일도를보정하여하기의기판으로광 패턴을입사시키는 DMD 모듈; 및광 감응성나노입자가코팅되고, 광감응성나노입자의상부에세포가마련되며, 광패턴이광 감응성나노입자에조사되어발생된광열효과로세포를부분적으로가열시켜세포의국소적인신경활성억제를유도하는기판을포함하는것을특징으로한다. 본발명은광 감응성나노입자가코팅된기판상에레이저광을조사하여플라즈모닉효과를일으키고이로인해발생하는광열효과로인하여신경세포의국소부위의활동, 발화, 활동전위를억제시킬수 있는이점이있다. | ||||||
| 118 | 헤마토코쿠스 플루비알리스의 세포발아 유도를 통한 아스타잔틴의 제조방법 | KR1020150039268 | 2015-03-20 | KR1020160112877A | 2016-09-28 | 심상준; 최윤영 |
| 본발명은헤마토코쿠스플루비알리스(Haematococcus pluvialis)의세포발아를유도하는것을특징으로하는아스타잔틴의제조방법에관한것으로, 구체적으로성숙한포자형태의헤마토코쿠스플루비알리스(Haematococcus pluvialis)에높은광도와질소원을제공하여발아를유도하고세포내 C/N(탄소/질소)비조절을통해세포벽을약화시켜아스타잔틴수득을높이는방법에관한것이다. | ||||||
| 119 | 광감응제가 도입된 고분자 담체 및 이를 이용한 혈관구성세포의 증식 촉진방법 | KR1020150028874 | 2015-03-02 | KR1020160106255A | 2016-09-12 | 박종철; 김용록; 이미희; 구민아; 권병주; 김민성; 왕강균; 김봉진 |
| 본발명은광감응제가도입된고분자담체및 이를이용한혈관구성세포의증식촉진방법에관한것이다. 본발명에따른고분자담체는고분자물질에광감응제가도입된것으로서, 광조사에의해활성산소종을생성하는것이가능하다. 이러한본 발명은약물형태의광감응제를세포에직접적으로투여하여세포내활성산소종의형성을자극하는기존의방법과는차별성이있다. 그리고활성산소종의생성량을혈관구성세포를증식할수 있는정도로조절하는것이가능하여혈관구성세포의증식을촉진할수 있다. 이렇게혈관구성세포의증식촉진을조절하는것은인공혈관이식의성공률을향상시키는방안으로활용될수 있다. | ||||||
| 120 | 에너지를 이용한 다능성 세포 유도 장치 및 방법 | KR1020150172501 | 2015-12-04 | KR1020160067805A | 2016-06-14 | 김순학 |
| 본발명은에너지를이용한다능성세포유도장치및 방법에관한것으로, 보다상세하게는분화된세포에초음파, 레이저또는열 처리등의에너지를가하여다능성특성을가진새로운타입의다능성세포를유도하는효과가있다. | ||||||
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