| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 41 | Enhancement of in vitro culture or vaccine production using electromagnetic energy treatment | US10700355 | 2003-11-03 | US20050009161A1 | 2005-01-13 | Jackson Streeter |
| Disclosed are apparatus and methods for enhancing or improving cell cultures, including cell cultures for the production of monoclonal antibodies, using electromagnetic energy treatment, primarily using light in the near infrared to visible region of the spectrum. The delivery of light energy to a culture, in accordance with preferred embodiments, enhances or improves the cell culture such as by providing for enhanced and accelerated formation of important biological macromolecules, including, but not limited to, antibodies, proteins, collagen, and polysaccharides, and also providing for accelerated cellular replication and an enhancement or prolongation of the life of cells so treated. | ||||||
| 42 | METHODS AND COMPOSITION FOR PRODUCING AND USING IMMUNE CELLS AND STEM CELLS FOR CELL-BASED THERAPIES | US16315153 | 2017-07-14 | US20190209614A1 | 2019-07-11 | Preet M. Chaudhary |
| Described herein are methods for selecting lymphocytes for adoptive cell therapy based on P-glycoprotein expression and compositions comprising same. | ||||||
| 43 | A Method Of Producing High Amount Of Ethanol At High Temperature By Modified Yeast Strain Saccharomyces Cerevisiae | US15776317 | 2016-08-04 | US20180327709A1 | 2018-11-15 | Rajendra Surana; Shashikant Shingdilwar; Pushpa Agrawal |
| The present invention relates to a modified yeast strain of Saccharomyces cerevisiae having MCC accession number 0069 with osmo-tolerant, thermo-tolerant, ethanol tolerant and self-flocculation properties. Further, the present invention relates to a method for obtaining modified yeast strain. The present invention also relates to a method of production of ethanol at high temperature using said yeast strain. The ethanol produced by the method disclosed in the present invention is used as fuel. | ||||||
| 44 | A METHOD OF CULTURING HAEMATOCOCCUS SPECIES FOR MANUFACTURING OF ASTAXANTHIN | US15758143 | 2016-09-09 | US20180245033A1 | 2018-08-30 | Björn Podola; Michael Melkonian; Alice Costa Kiperstok; Petra Sebestyen |
| A method of culturing Haematococcus species for manufacturing of astaxanthin comprising the steps of: providing a substrate, arranging the Haematococcus species on the surface of the substrate, exposing the Haematococcus species arranged on the substrate to high light intensities from the beginning of a culturing process and avoiding a two-step culturing process of the Haematococcus species with a first step which is an initial culturing taking place by exposure of the Haematococcus species to low light energy followed by a second step of subsequent culturing of the Haematococcus species by exposure of the Haematococcus species to higher light energy than applied in the first step to induce astaxanthin formation, and optionally harvesting the cultured Haematococcus species and/or isolating astaxanthin. | ||||||
| 45 | CELL STIMULATION METHOD AND CELL STIMULATION DEVICE | US15896267 | 2018-02-14 | US20180236257A1 | 2018-08-23 | Gen TAKEBE; Yoshiyuki SHIMIZU; Toyohiko YAMAUCHI; Tatsuo DOUGAKIUCHI |
| A cell stimulation method includes continuously emitting mid-infrared light to a living cell and thus changing an ion concentration of the cell or changing ion concentrations of the cell and other cells disposed around the cell. | ||||||
| 46 | METHOD AND SYSTEM FOR ISOLATING ADIPOSE-DERIVED STEM CELLS | US15741232 | 2016-07-04 | US20180195045A1 | 2018-07-12 | Lin KE; Nan ZHANG |
| The present invention refers to a non-invasive method for isolating adipose-derived stem cells from adipose tissue by illuminating the adipose tissue with at least one laser having a wavelength of between 360 nm to 480 nm or between 800 nm to 2 pm for a predetermined time for dissociating fat cells and blood vessels of the adipose tissue to release intact stem cells from the adipose tissue while maintaining the viability of the stem cells. In the preferred embodiment, the adipose tissue is illuminated with pulsed near infra-red (NIR) laser and a continuous wave (CW) diode blue laser. The present invention also contains a system adapted for isolating adipose-derived stem cells from adipose tissue using the method of the present invention. | ||||||
| 47 | METHOD FOR CULTURING ANIMAL CELL COMPOSITION, METHOD FOR PRODUCING ANIMAL CELL COMPOSITION USING SAME, AND ANIMAL CELL COMPOSITION | US15736035 | 2016-06-24 | US20180155673A1 | 2018-06-07 | Tatsuya Shimizu; Yuji Haraguchi; Yuki Kagawa; Katsuhisa Sakaguchi |
| An object of the present invention is to obtain a thicker animal cell composition by a simple and less expensive method. Namely, an object of the present invention is to provide a method for culturing a thicker animal cell composition by eliminating the hypoxia associated with animal cell compositions, a method for producing an animal cell composition containing unicellular algae, and an animal cell composition.The present invention provides a method for culturing an animal cell composition in a culture medium in the presence of unicellular algae and under exposure to light. According to the method of the present invention, oxygen can be continuously supplied in the culture medium, cell damage is alleviated, and a thicker cell composition can be obtained in the absence of a capillary network. | ||||||
| 48 | CULTURE SUBSTRATE | US15265070 | 2016-09-14 | US20170204366A1 | 2017-07-20 | Ryuichiro SASAKI; Toshihiro ASO; Takao HANAWA; Peng CHEN |
| Provided is a culture substrate having a periodic fine structure in the order of micrometers and a periodic fine structure in the order of nanometers on the same surface where stem cells are to be cultured on the surface. | ||||||
| 49 | METHOD FOR OBTAINING IMMUNO-SUPPRESSIVE DENDRITIC CELLS | US14759016 | 2014-01-02 | US20160130552A1 | 2016-05-12 | Karsten HENCO; Gunter BAUER; Justin DUCKWORTH; Adrian HAYDAY; Richard EDELSON; Robert TIGELAAR; Michael GIRARDI |
| The present invention relates to methods for producing immuno-suppressive dendritic cells. The present invention further relates to the use of such cells for treating patients suffering from autoimmune diseases, hypersensitivity diseases, rejection on solid-organ transplantation and/or Graft-versus-Host disease. | ||||||
| 50 | PHOTOREACTIVE REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF | US14592646 | 2015-01-08 | US20150224193A1 | 2015-08-13 | Ehud Y. Isacoff; Richard H. Kramer; Dirk Trauner; Matthew R. Banghart; Matthew Volgraf; Pablo Ignacio Gorostiza Langa; Katharine Borges |
| The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function. | ||||||
| 51 | Photoreactive regulator of protein function and methods of use thereof | US13671908 | 2012-11-08 | US09097707B2 | 2015-08-04 | Ehud Y. Isacoff; Richard H. Kramer; Dirk Trauner; Matthew R. Banghart; Matthew Volgraf; Pablo Ignacio Gorostiza Langa; Katharine Borges |
| The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function. | ||||||
| 52 | METHOD FOR SELECTIVE CELL ATTACHMENT/DETACHMENT, CELL PATTERNIZATION AND CELL HARVESTING BY MEANS OF NEAR INFRARED RAYS | US14342451 | 2013-04-12 | US20150044770A1 | 2015-02-12 | Eun Kyung Kim; Hyun Ok Kim; Jung Mok You; Jeong Hun Kim; Tea Hoon Park; Byeon Gwan Kim; June Seok Heo; Han Soo Kim |
| The present invention relates to a method for selective cell attachment/detachment, cell patternization and cell harvesting by means of near infrared rays. More particularly, conducting polymers or metal oxides having exothermic characteristics upon irradiation of near infrared light is used as a cell culture scaffold, thus selectively attaching/detaching cells without an enzyme treatment. The scaffold has an effect of promoting proliferation or differentiation of stem cells, and therefore, can be used as a stem cell culture scaffold. The scaffold enables cell attachment/detachment without temporal or spatial restrictions, thus enabling cell patternization. | ||||||
| 53 | Photoreactive Regulator of Protein Function and Methods of Use Thereof | US13671908 | 2012-11-08 | US20130137113A1 | 2013-05-30 | Ehud Y. Isacoff; Richard H. Kramer; Dirk Trauner; Matthew R. Banghart; Matthew Volgraf; Pablo Ignacio Gorostiza Langa; Katharine Borges |
| The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function. | ||||||
| 54 | Photoreactive regulator of protein function and methods of use thereof | US11601591 | 2006-11-17 | US08114843B2 | 2012-02-14 | Ehud Y. Isacoff; Richard H. Kramer; Dirk Trauner; Matthew Banghart; Matthew Volgraf; Pablo Ignacio Gorostiza Langa; Katharine Borges |
| The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function. | ||||||
| 55 | Enhancement of in vitro culture or vaccine production in bioreactors using electromagnetic energy | US11339993 | 2006-01-26 | US20060223155A1 | 2006-10-05 | Jackson Streeter |
| Disclosed are apparatus and methods for enhancing or improving cell cultures, including cell cultures for the production of monoclonal antibodies, using electromagnetic energy treatment, primarily using electromagnetic radiation in the near infrared to visible region of the spectrum. The delivery of electromagnetic energy to a culture, in accordance with preferred embodiments, enhances or improves the cell culture such as by providing for enhanced and accelerated formation of important biological macromolecules, including, but not limited to, antibodies, proteins, collagen, and polysaccharides, and also providing for accelerated cellular replication and an enhancement or prolongation of the life of cells so treated. | ||||||
| 56 | Cell-culturing device and sorting method using same | US10443983 | 2003-05-23 | US20030219889A1 | 2003-11-27 | Kimio Sumaru; Mitsuyoshi Kameda; Toshiyuki Kanamori; Toshio Shinbo |
| The present invention provides a photo-responsive composition comprising a photo-responsive material having the property of differential adhesiveness in response to changes in light irradiation. The photo-responsive composition is used as an adhesive surface for the growth anchorage-dependent cells in a culturing dish. The position of a particular cell on the photo-responsive composition is irradiated with light to release only the cell attached at that position, and the released cell may be sortingly collected. According to the present invention, cells including anchorage-dependent cells can be sortingly collected through a simple operation while maintaining the extracellular matrix and membrane proteins of the cells, as well as the organ-specific functions of the cells, and thus without damage to the cells. | ||||||
| 57 | Optical cell guidance method and apparatus | US10293142 | 2002-11-13 | US20030109040A1 | 2003-06-12 | Josef Kas; Mark Raizen; Valery Milner; Timo Betz; Allen Ehrlicher |
| Embodiments of the invention include Optical Cell Guidance (OCG) methods and apparatus to control cell growth. This system guides the leading edge of motile cells with an optical gradient, which biases the cell's motion into the light by pulling on proteins, which act like soft dielectrics in the electromagnetic field. OCG differs from those devices described above in that it controls the direction of cell motility. This is an entirely new field, and the first device to directly manipulate cell motility. OCG differs from current approaches in that it does not trap or hold particles. Instead of trapping and pulling the cell, the goal of OCG is to influence, direct, and control the growth of a growth cone. | ||||||
| 58 | METHOD FOR ELIMINATING STEM CELLS, METHOD FOR PROTECTING DIFFERENTIATED CELLS, AND CULTURE MEDIUM COMPOSITION | EP16776540.3 | 2016-04-06 | EP3282011A1 | 2018-02-14 | YOSHIDA, Shunsuke; INAMURA, Mitsuru; TANAKA, Tohru; ISHIKAWA, Hiroyuki; ITO, Hidenori |
A stem cell removing method that certainly-removes an undifferentiated stem cell is provided. For this object, a cell group including a stem cell and a somatic cell performed differentiation induction is cultivated in culture medium composition including photosensitizer. Light of a specific wavelength is irradiated with the cell group, and the stem cell is removed, selectively. The stem cell is a pluripotent stem cell or a somatic stem cell. The pluripotent stem cell includes either an ES cell (Embryonic Stem Cell) or an iPS cell (induced Pluripotent Stem Cell). Also, somatic stem cell includes any one of a germ stem cell, a productive cell, a pluripotent stem cell and a stem cell having unipotency. |
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| 59 | OPTICALLY ACTIVATED RECEPTORS | EP14825278.6 | 2014-12-12 | EP3080165A1 | 2016-10-19 | RIEDLER, Robert; REICHHART, Eva; DIFFER, Christopher; PRIETO, Alvaro Ingles; JANOVJAK, Harald; GRUSCH, Michael; SCHELCH, Karin |
| The present invention belongs to the field of biotechnology. More specifically, the invention relates to chimeric fusion proteins comprising a light activated protein domain, e.g., a newly characterized light-oxygen-voltage-sensing (LOV) domain or a light sensing domain of the cyanobacterial phytochrome (PHY) CPH1, wherein the chimeric fusion protein is capable of dimerizing upon excitation with light of a suitable wavelength. Said fusion proteins further comprise the intracellular part of a receptor tyrosine kinase (RTK). The invention further relates to nucleic acid molecules encoding said chimeric fusion proteins; non-human transgenic animals expressing the chimeric fusion protein encoded by said nucleic acid molecules; as well as uses of said chimeric fusion proteins, e.g. in a screening method. | ||||||
| 60 | A METHOD OF PRODUCING EXOSOMES | EP14850195.0 | 2014-10-02 | EP3052616A1 | 2016-08-10 | PASPALIARIS, Bill |
| The present application relates to methods of producing exosomes or extracts thereof for use in the treatment of diseases or disorders. In particular, the present invention relates to a method of producing exosomes or extracts thereof comprising the steps of: (a) exposing a population of isolated mammalian cells to light between 500 nm to 820 nm for sufficient time to enable said cells to produce and excrete said exosomes; and (b) separating said exosomes from other cellular components based on molecular weight, size, shape, composition or biological activity. | ||||||
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