| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 61 | CELL CULTURE | EP13825728 | 2013-07-29 | EP2879794A4 | 2016-04-06 | VIASNOFF VIRGILE NICOLAS ROBERT; LI QIUSHI |
| The disclosure relates to the fabrication of a three dimensional [3-D] cell culture membrane comprising one or more functionalized surfaces adapted to provide cell culture conditions suitable for the analysis of proliferation, differentiation or function of cells, typically eukaryotic or prokaryotic cells. | ||||||
| 62 | METHOD FOR OBTAINING IMMUNO-STIMULATORY DENDRITIC CELLS | EP14700025.1 | 2014-01-02 | EP2941483A1 | 2015-11-11 | HENCO, Karsten; BAUER, Günter; DUCKWORTH, Justin; HAYDAY, Adrian; EDELSON, Richard; TIGELAAR, Robert; GIRARDI, Michael |
| The present invention relates to methods for producing immuno-stimulatory autologous dendritic cells. The present invention further relates to the use of such cells for treating patients suffering from hyper-proliferative disease such as cancer. | ||||||
| 63 | CELL-ADHERING LIGHT-CONTROLLABLE SUBSTRATE | EP12771369 | 2012-04-11 | EP2698426A4 | 2015-02-18 | FURUTA TOSHIAKI; SUZUKI AKINOBU; SUGIYAMA HISASHI; OZAWA SATOSHI; TADA HIROKO |
| 64 | OPTICAL CELL GUIDANCE METHOD | EP02789630.7 | 2002-11-13 | EP1455670B1 | 2014-04-02 | KÄS, Josef, Univ. Leipzig Fakultat fur Physik und; RAIZEN, Mark; MILNER, Valery; BETZ, Timo; EHRLICHER, Allen |
| 65 | OPTICAL CELL GUIDANCE METHOD AND APPARATUS | EP02789630 | 2002-11-13 | EP1455670A4 | 2008-03-05 | KAES JOSEF; RAIZEN MARK; MILNER VALERY; BETZ TIMO; EHRLICHER ALLEN |
| Embodiments of the invention include Optical Cell Guidance (OCG) methods and apparatus to control cell growth. This system guides the leading edge of motile cells with an optical gradient, which biases the cell's motion into the light by pulling on proteins, which act like soft dielectrics in the electromagnetic field. OCG differs from those devices described above in that it controls the direction of cell motility. This is an entirely new field, and the first device to directly manipulate cell motility. OCG differs from current approaches in that it does not trap or hold particles. Instead of trapping and pulling the cell, the goal of OCG is to influence, direct, and control the growth of a growth cone. | ||||||
| 66 | Method of differentiation induction to osteoblasts | EP07253301.1 | 2007-08-21 | EP1892290A1 | 2008-02-27 | Inoue, Akira, Yokohama Works of Sumitomo Electric Ind., Ltd.; Hatayama, Hitoshi Yokohama Works of Sumitomo Electric Ind., Ltd.; Suganuma, Hiroshi, Tokyo Head Office of Sumitomo Electr. Ind., Ltd.; Awazu, Kunio; Kushibiki, Toshihiro |
The invention offers a technique that selectively differentiation-induces mesenchymal stem cells, which can differentiate to cells that constitute various tissues and organs, to osteoblasts. In addition, the invention offers a technique that differentiation-induces mesenchymal stem cells to osteoblasts with a simple operation that needs only short time and that is noninvasive. The inventors have found that the switch for the differentiation induction to osteoblasts is turned on by translocating biological clock-relevant factors existing in mesenchymal stem cells from the cells' cytoplasm to the cells' nucleus. The inventors have also found that the switch can be turned on by irradiating the cells for a short time with a lightwave having a specific wavelength that is noninvasive.
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| 67 | CRYSTALLINE MATERIALS ON BIOLOGICAL TISSUE AND METHODS FOR MAKING THE SAME | US15991515 | 2018-05-29 | US20180273931A1 | 2018-09-27 | Charles M. LUKEHART; Borislav L. IVANOV; Jeremiah C. BEAM; Matthew S. WELLONS; Andrew G. HARRIS |
| Provided are compositions including a direct interface between a biological tissue and a crystalline material, wherein the crystalline material has a crystallization temperature that exceeds the temperature at which the biological tissue incurs thermal damage. Also provided are methods for producing said compositions. | ||||||
| 68 | STEM CELL REMOVING METHOD, DIFFERENTIATED CELL PROTECTIVE METHOD, AND CULTURE MEDIUM COMPOSITION | US15565422 | 2016-04-06 | US20180127726A1 | 2018-05-10 | Shunsuke YOSHIDA; Mitsuru INAMURA; Tohru TANAKA; Hiroyuki ISHIKAWA; Hidenori ITO |
| A stem cell removing method that certainly-removes an undifferentiated stem cell is provided. For this object, a cell group including a stem cell and a somatic cell performed differentiation induction is cultivated in culture medium composition including photosensitizer. Light of a specific wavelength is irradiated with the cell group, and the stem cell is removed, selectively. The stem cell is a pluripotent stem cell or a somatic stem cell. The pluripotent stem cell includes either an ES cell (Embryonic Stem Cell) or an iPS cell (induced Pluripotent Stem Cell). Also, somatic stem cell includes any one of a germ stem cell, a productive cell, a pluripotent stem cell and a stem cell having unipotency. | ||||||
| 69 | HIGH-SPEED PHOTO-CROSS-LINKING LINKER FOR MOLECULAR INTERACTION ANALYSIS AND IN VITRO SELECTION, AND IN VITRO SELECTION METHOD USING LINKER | US15719979 | 2017-09-29 | US20180100146A1 | 2018-04-12 | Naoto Nemoto; Yuki Mochizuki; Shigefumi Kumachi |
| Provided is a linker for both screening assessment of the candidate clones without using enzymes, and to provide an in vitro selection method using thereof. Also, provided is a high-speed photo-crosslinking linker for molecular interaction analysis and in vitro selection comprising a backbone and a side chain. The backbone comprises a solid-phase binding site located at the 5′ terminus for forming a bond with a solid-phase; a solid-phase cleavage site for releasing the entire solid-phase at the site; a side chain linking site for linking a side chain; a high-speed photo-crosslinking site for linking the backbone to mRNA having a sequence complementary thereof via photo-cros slinking; and a reverse transcription initiation region located adjacent to the side chain linking site at the 3′ terminus of the backbone. The side chain comprises a fluorescent label, a protein binding site located at the free terminus thereof; and a binding site with the backbone. | ||||||
| 70 | Cell culture | US14416330 | 2013-07-29 | US09828576B2 | 2017-11-28 | Virgile Nicolas Robert Viasnoff; Qiushi Li |
| The disclosure relates to the fabrication of a three dimensional [3-D] cell culture membrane comprising one or more functionalized surfaces adapted to provide cell culture conditions suitable for the analysis of proliferation, differentiation or function of cells, typically eukaryotic or prokaryotic cells. | ||||||
| 71 | APPARATUS AND METHODS FOR CONTROLLING CELLULAR DEVELOPMENT | US15465397 | 2017-03-21 | US20170211040A1 | 2017-07-27 | Karl Deisseroth; Albrecht Stroh; M. Bret Schneider; Raag D. Airan |
| According to one aspect and example, a method for facilitating cellular interactions in biological tissue provides controllable activation of a selected type of stem cell among a plurality of cell types present in the tissue. The method includes various steps including the introduction of a microbial opsin into a region of the tissue that includes a selected type of stem cell, by expressing the microbial opsin in the stem cell. A light source is then introduced near the stem cell, and the light source is used to controllably activate thejight source to direct pulses of illumination from the light source to the selected type of stem cell, for selectively controlling the growth and development of the stem cell in a manner that is independent of the growth and development of the other types of cells. | ||||||
| 72 | Photoreactive regulator of protein function and methods of use thereof | US14592646 | 2015-01-08 | US09629911B2 | 2017-04-25 | Ehud Y. Isacoff; Richard H. Kramer; Dirk Trauner; Matthew R. Banghart; Matthew Volgraf; Pablo Ignacio Gorostiza Langa; Katharine Borges |
| The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function. | ||||||
| 73 | METHODS OF SELECTIVE CELL ATTACHMENT/DETACHMENT, CELL PATTERNIZATION AND CELL HARVESTING BY MEANS OF NEAR INFRARED RAYS | US15363300 | 2016-11-29 | US20170073627A1 | 2017-03-16 | Eun Kyung KIM; Hyun Ok Kim; Jung Mok You; Jeong Hun Kim; Tea Hoon Park; Byeong Gwan Kim; June Seok Heo; Han Soo Kim |
| The present invention relates to a method for selective cell attachment/detachment, cell patternization and cell harvesting by means of near infrared rays. More particularly, conducting polymers or metal oxides having exothermic characteristics upon irradiation of near infrared light is used as a cell culture scaffold, thus selectively attaching/detaching cells without an enzyme treatment. The scaffold has an effect of promoting proliferation or differentiation of stem cells, and therefore, can be used as a stem cell culture scaffold. The scaffold enables cell attachment/detachment without temporal or spatial restrictions, thus enabling cell patternization. | ||||||
| 74 | TUMOR MODEL FOR BREAST CANCER CELL MIGRATION STUDIES AND RELATED METHODS | US15252777 | 2016-08-31 | US20170067025A1 | 2017-03-09 | Mehdi Nikkhah; Feba Sam; Nitish Peela |
| A method for creating a tumor model includes encapsulating cancer cells in a first solution, disposing the first solution on a spacer, cross-linking the first solution and creating one or more high stiffness constructs, disposing a second solution around the one or more high stiffness constructs, and cross-linking the second solution and creating a low stiffness matrix surrounding the one or more low stiffness constructs. | ||||||
| 75 | METHOD FOR OBTAINING IMMUNO-STIMULATORY DENDRITIC CELLS | US14759012 | 2014-01-02 | US20160298082A1 | 2016-10-13 | Karsten HENCO; Gunter BAUER; Justin DUCKWORTH; Adrian HAYDAY; Richard EDELSON; Robert TIGELAAR; Michael GIRARDI |
| The present invention relates to methods for producing immuno-stimulatory autologous dendritic cells. The present invention further relates to the use of such cells for treating patients suffering from hyper-proliferative disease such as cancer. | ||||||
| 76 | A METHOD OF PRODUCING EXOSOMES | US15026858 | 2014-10-02 | US20160296560A1 | 2016-10-13 | Bill PASPALIARIS |
| The present application relates to methods of producing exosomes or extracts thereof for use in the treatment of diseases or disorders. In particular, the present invention relates to a method of producing exosomes or extracts thereof comprising the steps of: (a) exposing a population of isolated mammalian cells to light between 500 nm to 820 nm for sufficient time to enable said cells to produce and excrete said exosomes; and (b) separating said exosomes from other cellular components based on molecular weight, size, shape, composition or biological activity. | ||||||
| 77 | Method for increasing the CoQ10 and CoQH2 content in phototrophic microorganisms | US13994805 | 2011-12-21 | US09376660B2 | 2016-06-28 | Oliver Durr |
| A method for increasing the content of ubiquinone (CoQ10) and ubiquinol (CoQH2) in phototrophic microorganisms that were cultivated in a culture medium in a bioreactor under light irradiation, wherein the phototrophic microorganisms are selected from the group consisting of blue algae, green algae and yellow-green algae, comprising a step of inducing oxidative stress. By virtue of the fact that oxidative stress was induced by incubating the phototrophic microorganisms together with Fe3+ in the culture medium, a higher content of CoQ10 and CoQH2 is obtained. Moreover, the microorganisms thus obtained have a higher content of trivalent iron, which is particularly relevant for the human diet. From the phototrophic microorganisms it is possible to produce an oily extract and also a dried algae product. | ||||||
| 78 | METHOD FOR TARGETTING GROWTH AND DEATH OF NEOPLASTIC CELLS BY BURSTS OF ENERGIES FROM CELLULAR ENERGY EMISSIONS | US14873204 | 2015-10-02 | US20160025708A1 | 2016-01-28 | Mahmood Mirhoseini; Mary Cayton Mirhoseini; Aria Manasheri |
| The embodiments herein disclose a non-invasive method of using bursts of energies/electromagnetic field energies from cells to reduce or arrest the growth rate, proliferation of cancer cells/neoplastic cells. The energy from cells induces apoptosis in cancer cells, without harming normal cells beyond their physiologic threshold of survival are provided. The embodiments herein disclose a method for treatment of cancer/neoplastic cell in human or animals within the context of cancer therapeutics. A cell culture plate is incubated. This plate serves as the source of bursts energies/electromagnetic field energies. Further with a device the bursts of energies are targeted to another plate having cells for one week. After one week the microscopic examination is done. The rate of growth of cell is six to seven pulsatile cells per square centimetre. The energy from cells kills cancer cells, induce apoptosis, stimulate growth phase in cell culture and enables harmonics therapy. | ||||||
| 79 | Stem cell differentiation using novel light-responsive hydrogels | US13314891 | 2011-12-08 | US09234171B2 | 2016-01-12 | Ki-Bum Lee; Shreyas Shah |
| This application discloses a light-responsive hydrogel-based platform that can modulate multiple microenvironmental signals to direct the differentiation of human induced pluripotent stem cell-derived neural progenitor cells (hiPSC-NPCs) into neuronal cells. The invention provides novel methods for directing differentiation of neural stem cells into neurons useful for treatment of degenerative diseases or disorders, including but not limited to Alzheimer's, Parkinson's, or spinal cord injury (SCI). | ||||||
| 80 | CRYSTALLINE MATERIALS ON BIOLOGICAL TISSUE AND METHODS FOR MAKING THE SAME | US14766535 | 2014-02-07 | US20150368632A1 | 2015-12-24 | Charles M. LUKEHART; Borislav L. IVANOV; Jeremiah C. BEAM; Matthew S. WELLONS; Andrew G. HARRIS |
| Provided are compositions including a direct interface between a biological tissue and a crystalline material, wherein the crystalline material has a crystallization temperature that exceeds the temperature at which the biological tissue incurs thermal damage. Also provided are methods for producing said compositions. The ability to apply crystalline materials to biological tissues has wide applicability, e.g., with cyborg applications. Extensive challenges exist, however, in applying crystalline materials to biological tissue substrates. | ||||||
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