| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 21 | DEVICE AND METHOD FOR INDUCING PLURIPOTENT CELLS USING ENERGY | EP15866086 | 2015-12-04 | EP3241896A4 | 2018-05-16 | KIM SOONHAG |
| The present invention relates to a device and a method for inducing pluripotent cells using energy and, more specifically, has an effect of inducing new type pluripotent cells having pluripotent characteristics by applying energy such as ultrasonic waves, lasers or heat treatment to differentiated cells. | ||||||
| 22 | APPARATUS AND METHODS FOR CONTROLLING CELLULAR DEVELOPMENT | EP09767678 | 2009-06-17 | EP2303405A4 | 2017-12-27 | DEISSEROTH KARL; STROH ALBRECHT; SCHNEIDER M BRET; AIRAN RAAG D |
| According to one aspect and example, a method for facilitating cellular interactions in biological tissue provides controllable activation of a selected type of stem cell among a plurality of cell types present in the tissue. The method includes various steps including the introduction of a microbial opsin into a region of the tissue that includes a selected type of stem cell, by expressing the microbial opsin in the stem cell. A light source is then introduced near the stem cell, and the light source is used to controllably activate the light source to direct pulses of illumination from the light source to the selected type of stem cell, for selectively controlling the growth and development of the stem cell in a manner that is independent of the growth and development of the other types of cells. | ||||||
| 23 | CELL-ADHERING LIGHT-CONTROLLABLE SUBSTRATE | EP12771369.1 | 2012-04-11 | EP2698426A1 | 2014-02-19 | FURUTA Toshiaki; SUZUKI Akinobu; SUGIYAMA Hisashi; OZAWA Satoshi; TADA Hiroko |
An object of the present invention is to enable simpler operation in real time and culture while removing unnecessary cells from cultured cells for purification in analyzing, fractionating, and culturing the cells alive and to analyze and fractionate desired cells from the cultured cells to increase the purity, recovery rate, and viability of the cells. The present invention employs a cell-adhesive photocontrollable base material, wherein light irradiation causes the bond dissociation of a photolabile group comprising a coumarinylmethyl skeleton to produce the separation of a cell-adhesive material to leave a non-cell-adhesive material. As a result, cell images can be detected and analyzed to obtain the positional information of desired cells. Based on the positional information thus obtained, the cells can be analyzed and fractionated alive. |
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| 24 | A method for increasing the CoQ10 and CoQH2 content in phototrophic microorganisms | EP10196124.1 | 2010-12-21 | EP2468878A1 | 2012-06-27 | Dürr, Oliver |
A method for increasing the content of ubiquinone (CoQ10) and ubiquinol (CoQH2) in phototrophic microorganisms that were cultivated in a culture medium in a bioreactor under light irradiation, wherein the phototrophic microorganisms are selected from the group consisting of blue algae, green algae and yellow-green algae, comprising a step of inducing oxidative stress. By virtue of the fact that oxidative stress was induced by incubating the phototrophic microorganisms together with Fe3+ in the culture medium, a higher content of CoQ10 and CoQH2 is obtained. Moreover, the microorganisms thus obtained have a higher content of trivalent iron, which is particularly relevant for the human diet. From the phototrophic microorganisms it is possible to produce an oily extract and also a dried algae product. |
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| 25 | APPARATUS AND METHODS FOR CONTROLLING CELLULAR DEVELOPMENT | EP09767678.7 | 2009-06-17 | EP2303405A1 | 2011-04-06 | DEISSEROTH, Karl; STROH, Albrecht; SCHNEIDER, M., Bret; AIRAN, Raag, D. |
| According to one aspect and example, a method for facilitating cellular interactions in biological tissue provides controllable activation of a selected type of stem cell among a plurality of cell types present in the tissue. The method includes various steps including the introduction of a microbial opsin into a region of the tissue that includes a selected type of stem cell, by expressing the microbial opsin in the stem cell. A light source is then introduced near the stem cell, and the light source is used to controllably activate the light source to direct pulses of illumination from the light source to the selected type of stem cell, for selectively controlling the growth and development of the stem cell in a manner that is independent of the growth and development of the other types of cells. | ||||||
| 26 | Cell-culturing device and sorting method using same | EP03253257.4 | 2003-05-23 | EP1365017B1 | 2006-09-06 | Sumaru, Kimio, National Inst. of Advanced Ind.; Kameda, Mitsuyoshi, Nat. Inst. of Advanced Indust.; Kanamori, Toshiyuki, Nat. Inst. of Advanced Ind.; Shinbo, Toshio, National Inst. of Advanced Ind. |
| 27 | CELL CULTURE SUPPORT | US15761375 | 2016-09-23 | US20180273900A1 | 2018-09-27 | Luis Manuel LIZ-MARZÁN; Juan José GINER CASARES; Malou HENRIKSEN-LACEY; Alexander JOHNSON |
| There is provided an adherent cell-culture support comprising gold nanoparticles on the surface where the cells attach to, wherein the size of the nanoparticles is from 5 nm to 2 microns, the distance between the nanoparticles is from 2 nm to 30 nm and the anisotropy aspect ratio is greater than 1. These substrates have improved properties for allowing the culturing and subsequent detachment of cells, with potential applications in a wide range of fields such as stem cell research and tissue engineering. There is also provided a process for their preparation and several uses thereof. | ||||||
| 28 | DEVICE AND METHOD FOR INDUCING PLURIPOTENT CELLS USING ENERGY | US15532032 | 2015-12-04 | US20170327814A1 | 2017-11-16 | Soonhag KIM |
| The present invention relates to a device and a method for inducing pluripotent cells using energy and, more specifically, has an effect of inducing new type pluripotent cells having pluripotent characteristics by applying energy such as ultrasonic waves, lasers or heat treatment to differentiated cells. | ||||||
| 29 | OPTICALLY ACTIVATED RECEPTORS | US15103588 | 2014-12-12 | US20160326219A1 | 2016-11-10 | Robert RIEDLER; Eva REICHHART; Christopher DIFFER; Alvaro Ingles PRIETO; Harald JANOVJAK; Michael GRUSCH; Karin SCHELCH |
| The present invention belongs to the field of biotechnology. More specifically, the invention relates to chimeric fusion proteins comprising a light activated protein domain, e.g., a newly characterized light-oxygen-voltage-sensing (LOV) domain or a light sensing domain of the cyanobacterial phytochrome (PHY) CPH1, wherein the chimeric fusion protein is capable of dimerizing upon excitation with light of a suitable wavelength. Said fusion proteins further comprise the intracellular part of a receptor tyrosine kinase (RTK). The invention further relates to nucleic acid molecules encoding said chimeric fusion proteins; non-human transgenic animals expressing the chimeric fusion protein encoded by said nucleic acid molecules; as well as uses of said chimeric fusion proteins, e.g. in a screening method. | ||||||
| 30 | Method and device for enhancing a directional migration of stem cells | US14068969 | 2013-10-31 | US09382530B2 | 2016-07-05 | Jennifer Hui-Chun Ho |
| The invention provides a method of enhancing a directional migration of stem cells, comprising providing one or more stem cell(s) and irradiating the stem cells with an effective energy of green light thereby enhancing stem cell directionally migrating, wherein the orientation of migration of stem cells is opposite to the green light source. Also provided is a stem cell treated by the method of the invention and a device for enhancing a directional migration of stem cells. | ||||||
| 31 | METHOD | US14776263 | 2013-03-15 | US20160040128A1 | 2016-02-11 | Pål JOHANSEN; Anders HØGSET |
| The present invention provides an in vitro method of expressing an antigenic molecule or a part thereof on the surface of a dendritic cell using a PCI method with TPCS2a at a concentration of 0.020-0.1 μg/ml, using light of a wavelength of between 400 and 500 nm. Methods of treatment such as vaccination comprising this method, together with compositions comprising said cells and uses involving said cells expressing antigenic molecules are also provided. | ||||||
| 32 | GENERATION OF FUNCTIONAL DENDRITIC CELLS | US14767063 | 2014-02-11 | US20150374714A1 | 2015-12-31 | Shanta Dhar; Sean Marrache; Donald A. Harn; Smanla Tundup |
| Nanoparticles containing a photosensitizer configured to generate a reactive oxygen species when exposed to an appropriate wavelength of light can be used to enhance immunogenicity of cancer cells, such as breast cancer cells. Such enhanced immunogenicity cancer cells, or supernatants thereof, can be used to activate dendritic cells or cause dendritic cells to produce INF-gamma. Nanoparticles having mitochondria-targeting moieties are more effective at enhancing the immunogenicity of the cancer cells, or causing the dendritic cells to produce IFN-gamma, than nanoparticle lacking mitochondria-targeting moieties or free photo sensitizer. | ||||||
| 33 | METHOD AND DEVICE FOR ENHANCING A DIRECTIONAL MIGRATION OF STEM CELLS | US14068969 | 2013-10-31 | US20140377831A1 | 2014-12-25 | JENNIFER HUI-CHUN HO |
| The invention provides a method of enhancing a directional migration of stem cells, comprising providing one or more stem cell(s) and irradiating the stem cells with an effective energy of green light thereby enhancing stem cell directionally migrating, wherein the orientation of migration of stem cells is opposite to the green light source. Also provided is a stem cell treated by the method of the invention and a device for enhancing a directional migration of stem cells. | ||||||
| 34 | METHOD FOR INCREASING THE COQ10 AND COQH2 CONTENT IN PHOTOTROPHIC MICROORGANISMS | US13994805 | 2011-12-21 | US20140295530A1 | 2014-10-02 | Oliver Durr |
| A method for increasing the content of ubiquinone (CoQ10) and ubiquinol (CoQH2) in phototrophic microorganisms that were cultivated in a culture medium in a bioreactor under light irradiation, wherein the phototrophic microorganisms are selected from the group consisting of blue algae, green algae and yellow-green algae, comprising a step of inducing oxidative stress. By virtue of the fact that oxidative stress was induced by incubating the phototrophic microorganisms together with Fe3+ in the culture medium, a higher content of CoQ10 and CoQH2 is obtained. Moreover, the microorganisms thus obtained have a higher content of trivalent iron, which is particularly relevant for the human diet. From the phototrophic microorganisms it is possible to produce an oily extract and also a dried algae product. | ||||||
| 35 | Apparatus and Methods for Controlling Cellular Development | US13850709 | 2013-03-26 | US20130330816A1 | 2013-12-12 | Karl Deisseroth; Albrecht Stroh; M. Bret Schneider; Raag D. Airan |
| According to one aspect and example, a method for facilitating cellular interactions in biological tissue provides controllable activation of a selected type of stem cell among a plurality of cell types present in the tissue. The method includes various steps including the introduction of a microbial opsin into a region of the tissue that includes a selected type of stem cell, by expressing the microbial opsin the stem cell. A light source is then introduced near the stem cell, and the light source is used to controllably activate the light source to direct pulses of illumination from the light source to the selected type of stem cell, for selectively controlling the growth and development of the stem cell in a manner that is independent of the growth and development of the other types of cells. | ||||||
| 36 | Photoreactive Regulator of Protein Function and Methods of Use Thereof | US13364105 | 2012-02-01 | US20120190094A1 | 2012-07-26 | EHUD Y. ISACOFF; Richard H. Kramer; Dirk Trauner; Matthew R. Banghart; Matthew Volgraf; Pablo Ignacio Gorostiza Langa; Katharine Borges |
| The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function. | ||||||
| 37 | SPATIO-TEMPORAL CONTROL OF PROTEIN INTERACTIONS USING PHYTOCHROMES | US12993702 | 2009-05-26 | US20110207116A1 | 2011-08-25 | Christopher A. Voigt; Anselm Levskaya |
| The invention provides methods, materials and systems of regulating association between proteins of interest using light. In an aspect, the invention takes advantage of the ability of phytochromes to change conformation upon exposure to appropriate light conditions, and to bind in a conformation-dependent manner to cognate proteins called phytochrome-interacting factors. The invention comprises a method of regulating interaction between a first protein of interest and second protein within a cell by light. Such a method optionally comprises providing in the cell (1) a first protein construct which comprises the first protein, a phytochrome domain (PHD), and (2) providing in the cell a second protein construct which comprises the second protein and a phytochrome domain-interacting peptide (PIP) that can bind selectively to the Pfr state, but not to the Pr state, of the phytochrome domain. | ||||||
| 38 | APPARATUS AND METHODS FOR CONTROLLING CELLULAR DEVELOPMENT | US12997140 | 2009-06-17 | US20110159562A1 | 2011-06-30 | Karl Deisseroth; Albrecht Stroh; M. Bret Schneider; Raag D. Airan |
| According to one aspect and example, a method for facilitating cellular interactions in biological tissue provides controllable activation of a selected type of stem cell among a plurality of cell types present in the tissue. The method includes various steps including the introduction of a microbial opsin into a region of the tissue that includes a selected type of stem cell, by expressing the microbial opsin in the stem cell. A light source is then introduced near the stem cell, and the light source is used to controllably activate the light source to direct pulses of illumination from the light source to the selected type of stem cell, for selectively controlling the growth and development of the stem cell in a manner that is independent of the growth and development of the other types of cells. | ||||||
| 39 | Method of differentiation induction to osteoblasts | US11892061 | 2007-08-20 | US07829335B2 | 2010-11-09 | Akira Inoue; Hitoshi Hatayama; Hiroshi Suganuma; Kunio Awazu; Toshihiro Kushibiki |
| The invention offers a technique that selectively differentiation-induces mesenchymal stem cells, which can differentiate to cells that constitute various tissues and organs, to osteoblasts. In addition, the invention offers a technique that differentiation-induces mesenchymal stem cells to osteoblasts with a simple operation that needs only short time and that is noninvasive. The inventors have found that the switch for the differentiation induction to osteoblasts is turned on by translocating biological clock-relevant factors existing in mesenchymal stem cells from the cells' cytoplasm to the cells' nucleus. The inventors have also found that the switch can be turned on by irradiating the cells for a short time with a lightwave having a specific wavelength that is noninvasive. | ||||||
| 40 | Method of differentiation induction to osteoblasts | US11892061 | 2007-08-20 | US20080057580A1 | 2008-03-06 | Akira Inoue; Hitoshi Hatayama; Hiroshi Suganuma; Kunio Awazu; Toshihiro Kushibiki |
| The invention offers a technique that selectively differentiation-induces mesenchymal stem cells, which can differentiate to cells that constitute various tissues and organs, to osteoblasts. In addition, the invention offers a technique that differentiation-induces mesenchymal stem cells to osteoblasts with a simple operation that needs only short time and that is noninvasive. The inventors have found that the switch for the differentiation induction to osteoblasts is turned on by translocating biological clock-relevant factors existing in mesenchymal stem cells from the cells' cytoplasm to the cells' nucleus. The inventors have also found that the switch can be turned on by irradiating the cells for a short time with a lightwave having a specific wavelength that is noninvasive. | ||||||
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